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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TEAD1 |
 Gene summary |
| Gene information | Gene symbol | TEAD1 | Gene ID | 7003 |
| Gene name | TEA domain transcription factor 1 | |
| Synonyms | AA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1 | |
| Cytomap | 11p15.3 | |
| Type of gene | protein-coding | |
| Description | transcriptional enhancer factor TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)protein GT-IICtranscription factor 13transcriptional enhancer factor 1 | |
| Modification date | 20180523 | |
| UniProtAcc | P28347 | |
| Context | PubMed: TEAD1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TEAD1 | GO:0035329 | hippo signaling | 18579750|19324877 |
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Exon skipping events across known transcript of Ensembl for TEAD1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TEAD1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TEAD1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_57052 | 11 | 12696163:12696381:12696955:12697108:12785725:12785981 | 12696955:12697108 | ENSG00000187079.10 | ENST00000527636.1 |
| exon_skip_57053 | 11 | 12697049:12697108:12785725:12785981:12883796:12883861 | 12785725:12785981 | ENSG00000187079.10 | ENST00000527575.1,ENST00000361905.4,ENST00000334310.6,ENST00000527636.1 |
| exon_skip_57059 | 11 | 12883800:12883861:12886384:12886447:12901254:12901389 | 12886384:12886447 | ENSG00000187079.10 | ENST00000527575.1,ENST00000361905.4,ENST00000361985.2,ENST00000527636.1 |
| exon_skip_57069 | 11 | 12886384:12886447:12900435:12900447:12901254:12901389 | 12900435:12900447 | ENSG00000187079.10 | ENST00000334310.6 |
| exon_skip_57072 | 11 | 12886384:12886447:12901254:12901389:12902551:12902598 | 12901254:12901389 | ENSG00000187079.10 | ENST00000527575.1,ENST00000361905.4,ENST00000361985.2,ENST00000527636.1 |
| exon_skip_57073 | 11 | 12900435:12900447:12901254:12901389:12902551:12902598 | 12901254:12901389 | ENSG00000187079.10 | ENST00000334310.6 |
| exon_skip_57074 | 11 | 12904547:12904672:12923486:12923660:12946458:12946599 | 12923486:12923660 | ENSG00000187079.10 | ENST00000526600.1,ENST00000361905.4,ENST00000361985.2,ENST00000527636.1 |
| exon_skip_57075 | 11 | 12923486:12923660:12946458:12946599:12951720:12951873 | 12946458:12946599 | ENSG00000187079.10 | ENST00000526600.1,ENST00000361905.4,ENST00000361985.2,ENST00000527636.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TEAD1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_57052 | 11 | 12696163:12696381:12696955:12697108:12785725:12785981 | 12696955:12697108 | ENSG00000187079.10 | ENST00000527636.1 |
| exon_skip_57053 | 11 | 12697049:12697108:12785725:12785981:12883796:12883861 | 12785725:12785981 | ENSG00000187079.10 | ENST00000361905.4,ENST00000527636.1,ENST00000527575.1,ENST00000334310.6 |
| exon_skip_57059 | 11 | 12883800:12883861:12886384:12886447:12901254:12901389 | 12886384:12886447 | ENSG00000187079.10 | ENST00000361905.4,ENST00000527636.1,ENST00000527575.1,ENST00000361985.2 |
| exon_skip_57069 | 11 | 12886384:12886447:12900435:12900447:12901254:12901389 | 12900435:12900447 | ENSG00000187079.10 | ENST00000334310.6 |
| exon_skip_57072 | 11 | 12886384:12886447:12901254:12901389:12902551:12902598 | 12901254:12901389 | ENSG00000187079.10 | ENST00000361905.4,ENST00000527636.1,ENST00000527575.1,ENST00000361985.2 |
| exon_skip_57073 | 11 | 12900435:12900447:12901254:12901389:12902551:12902598 | 12901254:12901389 | ENSG00000187079.10 | ENST00000334310.6 |
| exon_skip_57074 | 11 | 12904547:12904672:12923486:12923660:12946458:12946599 | 12923486:12923660 | ENSG00000187079.10 | ENST00000361905.4,ENST00000527636.1,ENST00000361985.2,ENST00000526600.1 |
| exon_skip_57075 | 11 | 12923486:12923660:12946458:12946599:12951720:12951873 | 12946458:12946599 | ENSG00000187079.10 | ENST00000361905.4,ENST00000527636.1,ENST00000361985.2,ENST00000526600.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TEAD1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TEAD1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TEAD1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| THCA | TCGA-MK-A84Z-01 | exon_skip_57074 | 12923487 | 12923660 | 12923583 | 12923583 | Frame_Shift_Del | T | - | p.F251fs |
| ACC | TCGA-OR-A5LJ-01 | exon_skip_57074 | 12923487 | 12923660 | 12923632 | 12923632 | Frame_Shift_Del | A | - | p.Q267fs |
| ACC | TCGA-OR-A5LJ-01 | exon_skip_57074 | 12923487 | 12923660 | 12923632 | 12923632 | Frame_Shift_Del | A | - | p.Q282fs |
| UCEC | TCGA-A5-A0GA-01 | exon_skip_57074 | 12923487 | 12923660 | 12923632 | 12923632 | Frame_Shift_Del | A | - | p.Q282fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_57074 | 12923487 | 12923660 | 12923651 | 12923651 | Frame_Shift_Del | A | - | p.V273fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_57075 | 12946459 | 12946599 | 12946497 | 12946497 | Frame_Shift_Del | T | - | p.A289fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_57075 | 12946459 | 12946599 | 12946532 | 12946532 | Frame_Shift_Del | A | - | p.E301fs |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_57075 | 12946459 | 12946599 | 12946496 | 12946497 | Frame_Shift_Ins | - | T | p.A304fs |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_57075 | 12946459 | 12946599 | 12946496 | 12946497 | Frame_Shift_Ins | - | T | p.V289fs |
| BRCA | TCGA-E2-A152-01 | exon_skip_57053 | 12785726 | 12785981 | 12785961 | 12785961 | Nonsense_Mutation | C | G | p.S46* |
| CESC | TCGA-IR-A3LH-01 | exon_skip_57073 exon_skip_57072 | 12901255 | 12901389 | 12901304 | 12901304 | Nonsense_Mutation | C | G | p.S112* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNUC2B_LARGE_INTESTINE | 12785726 | 12785981 | 12785806 | 12785806 | Missense_Mutation | T | G | p.S9R |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 12785726 | 12785981 | 12785835 | 12785835 | Missense_Mutation | T | C | p.M19T |
| NCIH2135_LUNG | 12785726 | 12785981 | 12785877 | 12785877 | Missense_Mutation | G | T | p.G33V |
| NCIH650_LUNG | 12785726 | 12785981 | 12785924 | 12785924 | Missense_Mutation | A | G | p.I49V |
| HUCCT1_BILIARY_TRACT | 12785726 | 12785981 | 12785924 | 12785924 | Missense_Mutation | A | C | p.I49L |
| OC316_OVARY | 12785726 | 12785981 | 12785937 | 12785937 | Missense_Mutation | G | A | p.C53Y |
| OC314_OVARY | 12785726 | 12785981 | 12785937 | 12785937 | Missense_Mutation | G | A | p.C53Y |
| LS411N_LARGE_INTESTINE | 12785726 | 12785981 | 12785963 | 12785963 | Missense_Mutation | G | A | p.D62N |
| MZ7MEL_SKIN | 12886385 | 12886447 | 12886416 | 12886416 | Missense_Mutation | G | A | p.R100K |
| SW480_LARGE_INTESTINE | 12901255 | 12901389 | 12901348 | 12901348 | Missense_Mutation | C | A | p.L46M |
| KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 12923487 | 12923660 | 12923597 | 12923597 | Missense_Mutation | A | T | p.K174N |
| SNU81_LARGE_INTESTINE | 12946459 | 12946599 | 12946588 | 12946588 | Nonsense_Mutation | G | T | p.E239* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TEAD1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEAD1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEAD1 |
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RelatedDrugs for TEAD1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEAD1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TEAD1 | C1862382 | SVEINSSON CHORIORETINAL ATROPHY | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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