ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for STK3

Gene summary

Gene information	Gene symbol	STK3
	Gene ID	6788
	Gene name	serine/threonine kinase 3
	Synonyms	KRS1\|MST2
	Cytomap	8q22.2
	Type of gene	protein-coding
	Description	serine/threonine-protein kinase 3KB-1458E12.1MST-2STE20-like kinase MST2mammalian STE20-like protein kinase 2serine/threonine kinase 3 (STE20 homolog, yeast)serine/threonine kinase 3 (Ste20, yeast homolog)serine/threonine-protein kinase Krs-1
	Modification date	20180523
	UniProtAcc	Q13188
	Context	PubMed: STK3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
STK3	GO:0006468	protein phosphorylation	8566796\|19525978\|20086174\|20231902
STK3	GO:0032092	positive regulation of protein binding	22292086
STK3	GO:0035329	hippo signaling	20412773
STK3	GO:0035556	intracellular signal transduction	8566796

Top

Exon skipping events across known transcript of Ensembl for STK3 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for STK3

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for STK3

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_491122	8	99466922:99468228:99538969:99539145:99560196:99560389	99538969:99539145	ENSG00000104375.11	ENST00000523601.1,ENST00000419617.2
exon_skip_491127	8	99538969:99539145:99560196:99560389:99591891:99592017	99560196:99560389	ENSG00000104375.11	ENST00000523601.1,ENST00000419617.2
exon_skip_491132	8	99560318:99560389:99591891:99592017:99608259:99608397	99591891:99592017	ENSG00000104375.11	ENST00000518165.1,ENST00000518582.1,ENST00000523159.1,ENST00000523601.1,ENST00000419617.2
exon_skip_491135	8	99591986:99592017:99607088:99607273:99608259:99608397	99607088:99607273	ENSG00000104375.11	ENST00000520053.1
exon_skip_491136	8	99591986:99592017:99608259:99608397:99718694:99718862	99608259:99608397	ENSG00000104375.11	ENST00000523601.1,ENST00000419617.2
exon_skip_491137	8	99607200:99607346:99607829:99607978:99608259:99608397	99607829:99607978	ENSG00000104375.11	ENST00000520653.1
exon_skip_491141	8	99608259:99608397:99650687:99650788:99718694:99718862	99650687:99650788	ENSG00000104375.11	ENST00000424861.2
exon_skip_491143	8	99608259:99608397:99761503:99761618:99779470:99779599	99761503:99761618	ENSG00000104375.11	ENST00000518165.1
exon_skip_491146	8	99719374:99719539:99733301:99733388:99734970:99735197	99733301:99733388	ENSG00000104375.11	ENST00000424861.2
exon_skip_491149	8	99719374:99719539:99761503:99761618:99779470:99779599	99761503:99761618	ENSG00000104375.11	ENST00000523601.1,ENST00000419617.2
exon_skip_491150	8	99761503:99761618:99779470:99779599:99786966:99787047	99779470:99779599	ENSG00000104375.11	ENST00000518165.1,ENST00000424861.2,ENST00000523601.1,ENST00000419617.2
exon_skip_491153	8	99779470:99779599:99786966:99787047:99837742:99837874	99786966:99787047	ENSG00000104375.11	ENST00000518165.1,ENST00000424861.2,ENST00000521649.1,ENST00000419617.2
exon_skip_491155	8	99895981:99896062:99902002:99902130:99954605:99954799	99902002:99902130	ENSG00000104375.11	ENST00000523960.1,ENST00000523601.1

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for STK3

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_491127	8	99538969:99539145:99560196:99560389:99591891:99592017	99560196:99560389	ENSG00000104375.11	ENST00000419617.2,ENST00000523601.1
exon_skip_491132	8	99560318:99560389:99591891:99592017:99608259:99608397	99591891:99592017	ENSG00000104375.11	ENST00000419617.2,ENST00000523601.1,ENST00000518582.1,ENST00000523159.1,ENST00000518165.1
exon_skip_491135	8	99591986:99592017:99607088:99607273:99608259:99608397	99607088:99607273	ENSG00000104375.11	ENST00000520053.1
exon_skip_491136	8	99591986:99592017:99608259:99608397:99718694:99718862	99608259:99608397	ENSG00000104375.11	ENST00000419617.2,ENST00000523601.1
exon_skip_491137	8	99607200:99607346:99607829:99607978:99608259:99608397	99607829:99607978	ENSG00000104375.11	ENST00000520653.1
exon_skip_491141	8	99608259:99608397:99650687:99650788:99718694:99718862	99650687:99650788	ENSG00000104375.11	ENST00000424861.2
exon_skip_491143	8	99608259:99608397:99761503:99761618:99779470:99779599	99761503:99761618	ENSG00000104375.11	ENST00000518165.1
exon_skip_491146	8	99719374:99719539:99733301:99733388:99734970:99735197	99733301:99733388	ENSG00000104375.11	ENST00000424861.2
exon_skip_491149	8	99719374:99719539:99761503:99761618:99779470:99779599	99761503:99761618	ENSG00000104375.11	ENST00000419617.2,ENST00000523601.1
exon_skip_491150	8	99761503:99761618:99779470:99779599:99786966:99787047	99779470:99779599	ENSG00000104375.11	ENST00000419617.2,ENST00000523601.1,ENST00000518165.1,ENST00000424861.2
exon_skip_491153	8	99779470:99779599:99786966:99787047:99837742:99837874	99786966:99787047	ENSG00000104375.11	ENST00000419617.2,ENST00000518165.1,ENST00000521649.1,ENST00000424861.2
exon_skip_491155	8	99895981:99896062:99902002:99902130:99954605:99954799	99902002:99902130	ENSG00000104375.11	ENST00000523601.1,ENST00000523960.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for STK3

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000419617	99538969	99539145	Frame-shift
ENST00000419617	99560196	99560389	Frame-shift
ENST00000419617	99761503	99761618	Frame-shift
ENST00000419617	99591891	99592017	In-frame
ENST00000419617	99608259	99608397	In-frame
ENST00000419617	99779470	99779599	In-frame
ENST00000419617	99786966	99787047	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000419617	99560196	99560389	Frame-shift
ENST00000419617	99761503	99761618	Frame-shift
ENST00000419617	99591891	99592017	In-frame
ENST00000419617	99608259	99608397	In-frame
ENST00000419617	99779470	99779599	In-frame
ENST00000419617	99786966	99787047	In-frame

Top

Infer the effects of exon skipping event on protein functional features for STK3

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000419617	2837	491	99786966	99787047	168	248	9	35
ENST00000419617	2837	491	99779470	99779599	249	377	36	78
ENST00000419617	2837	491	99608259	99608397	826	963	228	274
ENST00000419617	2837	491	99591891	99592017	964	1089	274	316

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000419617	2837	491	99786966	99787047	168	248	9	35
ENST00000419617	2837	491	99779470	99779599	249	377	36	78
ENST00000419617	2837	491	99608259	99608397	826	963	228	274
ENST00000419617	2837	491	99591891	99592017	964	1089	274	316

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13188	9	35	27	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	9	35	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	9	35	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	9	35	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	9	35	17	20	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LGD
Q13188	9	35	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	9	35	15	15	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q13188	9	35	33	41	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	36	78	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AO5
Q13188	36	78	40	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	36	78	52	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	36	78	56	56	Binding site	Note=ATP
Q13188	36	78	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	36	78	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	36	78	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	36	78	64	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	36	78	56	56	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16930133;Dbxref=PMID:16930133
Q13188	36	78	60	60	Natural variant	ID=VAR_041122;Note=In an ovarian clear cell carcinoma sample%3B somatic mutation. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q13188	36	78	33	41	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	36	78	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	228	274	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	228	274	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	228	274	226	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	249	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	263	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	269	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	274	316	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	274	316	287	328	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13188	274	316	308	314	Compositional bias	Note=Poly-Glu
Q13188	274	316	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	274	316	276	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	284	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	288	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	316	316	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,E
Q13188	274	316	303	303	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q13188	274	316	308	311	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AO5

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13188	9	35	27	34	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	9	35	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	9	35	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	9	35	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	9	35	17	20	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LGD
Q13188	9	35	23	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	9	35	15	15	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q13188	9	35	33	41	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	36	78	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AO5
Q13188	36	78	40	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	36	78	52	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	36	78	56	56	Binding site	Note=ATP
Q13188	36	78	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	36	78	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	36	78	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	36	78	64	76	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	36	78	56	56	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16930133;Dbxref=PMID:16930133
Q13188	36	78	60	60	Natural variant	ID=VAR_041122;Note=In an ovarian clear cell carcinoma sample%3B somatic mutation. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q13188	36	78	33	41	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	36	78	47	49	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	228	274	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	228	274	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	228	274	226	235	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	244	246	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	249	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	263	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	228	274	269	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	1	491	Chain	ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3
Q13188	274	316	1	322	Chain	ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit
Q13188	274	316	287	328	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13188	274	316	308	314	Compositional bias	Note=Poly-Glu
Q13188	274	316	27	278	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q13188	274	316	276	279	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	284	287	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	288	306	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4LG4
Q13188	274	316	316	316	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,E
Q13188	274	316	303	303	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q13188	274	316	308	311	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AO5

Top

SNVs in the skipped exons for STK3

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A1EG-01	exon_skip_491122	99538970	99539145	99539012	99539012	Frame_Shift_Del	A	-	p.F453fs
LIHC	TCGA-DD-A39Y-01	exon_skip_491122	99538970	99539145	99539012	99539012	Frame_Shift_Del	A	-	p.F453fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_491122	99538970	99539145	99539012	99539012	Frame_Shift_Del	A	-	p.F453fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_491132	99591892	99592017	99591896	99591896	Frame_Shift_Del	T	-	p.N343fs
LIHC	TCGA-DD-A3A0-01	exon_skip_491136	99608260	99608397	99608375	99608375	Frame_Shift_Del	T	-	p.N264fs
LIHC	TCGA-DD-A39Y-01	exon_skip_491153	99786967	99787047	99786993	99786993	Frame_Shift_Del	A	-	p.F55fs
SKCM	TCGA-D9-A6EA-06	exon_skip_491136	99608260	99608397	99608308	99608308	Nonsense_Mutation	A	T	p.C258X
SKCM	TCGA-D9-A6EA-06	exon_skip_491136	99608260	99608397	99608308	99608308	Nonsense_Mutation	A	T	p.C286*
BLCA	TCGA-FD-A3B3-01	exon_skip_491149 exon_skip_491143	99761504	99761618	99761532	99761532	Nonsense_Mutation	G	C	p.S108*
BLCA	TCGA-FD-A3B3-01	exon_skip_491149 exon_skip_491143	99761504	99761618	99761532	99761532	Nonsense_Mutation	G	C	p.S136*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
COV644_OVARY	99560197	99560389	99560248	99560248	Frame_Shift_Del	T	-	p.T364fs
KMH2_THYROID	99608260	99608397	99608312	99608312	Frame_Shift_Del	T	-	p.K257fs
CW2_LARGE_INTESTINE	99538970	99539145	99539100	99539100	Missense_Mutation	T	C	p.Y396C
HN_UPPER_AERODIGESTIVE_TRACT	99560197	99560389	99560257	99560257	Missense_Mutation	C	T	p.D361N
NCIH810_LUNG	99560197	99560389	99560288	99560288	Missense_Mutation	C	A	p.M350I
HRT18_LARGE_INTESTINE	99560197	99560389	99560323	99560323	Missense_Mutation	C	T	p.A339T
MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	99560197	99560389	99560326	99560326	Missense_Mutation	G	A	p.R338W
NCIH810_LUNG	99560197	99560389	99560383	99560383	Missense_Mutation	C	G	p.D319H
PWR1E_PROSTATE	99591892	99592017	99591906	99591906	Missense_Mutation	C	T	p.E312K
JHUEM1_ENDOMETRIUM	99591892	99592017	99591992	99591992	Missense_Mutation	G	A	p.P283L
NCIH2141_LUNG	99608260	99608397	99608315	99608315	Missense_Mutation	T	C	p.K256R
HOP92_LUNG	99761504	99761618	99761542	99761542	Missense_Mutation	C	A	p.G105C
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	99761504	99761618	99761545	99761545	Missense_Mutation	C	T	p.A104T
P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	99761504	99761618	99761545	99761545	Missense_Mutation	C	T	p.A104T
SUIT2_PANCREAS	99761504	99761618	99761559	99761559	Missense_Mutation	A	G	p.M99T
LN229_CENTRAL_NERVOUS_SYSTEM	99779471	99779599	99779531	99779531	Missense_Mutation	G	C	p.P59R
CA922_UPPER_AERODIGESTIVE_TRACT	99779471	99779599	99779547	99779547	Missense_Mutation	C	T	p.A54T
HCC2998_LARGE_INTESTINE	99779471	99779599	99779547	99779547	Missense_Mutation	C	T	p.A54T
HEC50B_ENDOMETRIUM	99786967	99787047	99786977	99786977	Missense_Mutation	G	A	p.L33F
NCIH810_LUNG	99560197	99560389	99560344	99560344	Nonsense_Mutation	C	A	p.E332*
HCC2998_LARGE_INTESTINE	99591892	99592017	99591893	99591893	Splice_Site	G	A	p.S316L

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK3

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK3

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK3

Top

RelatedDrugs for STK3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	Q13188	DB12010	Fostamatinib	Serine/threonine-protein kinase 3	small molecule	approved\|investigational

Top

RelatedDiseases for STK3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact