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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SRPK1 |
 Gene summary |
| Gene information | Gene symbol | SRPK1 | Gene ID | 6732 |
| Gene name | SRSF protein kinase 1 | |
| Synonyms | SFRSK1 | |
| Cytomap | 6p21.31 | |
| Type of gene | protein-coding | |
| Description | SRSF protein kinase 1SFRS protein kinase 1SR-protein-specific kinase 1serine/arginine-rich splicing factor kinase 1serine/threonine-protein kinase SRPK1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q96SB4 | |
| Context | PubMed: SRPK1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SRPK1 | GO:0006468 | protein phosphorylation | 9237760|11509566 |
| SRPK1 | GO:0007059 | chromosome segregation | 15034300 |
| SRPK1 | GO:0035556 | intracellular signal transduction | 11509566 |
| SRPK1 | GO:0045070 | positive regulation of viral genome replication | 20498328 |
| SRPK1 | GO:0045071 | negative regulation of viral genome replication | 12417631 |
| SRPK1 | GO:0050684 | regulation of mRNA processing | 8208298 |
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Exon skipping events across known transcript of Ensembl for SRPK1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SRPK1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SRPK1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_459001 | 6 | 35803204:35803265:35806113:35806206:35810311:35810381 | 35806113:35806206 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000423325.2,ENST00000346162.6 |
| exon_skip_459002 | 6 | 35800810:35803265:35806482:35806575:35810311:35810381 | 35806482:35806575 | ENSG00000096063.10 | ENST00000373822.1 |
| exon_skip_459005 | 6 | 35810311:35810381:35825037:35825145:35836786:35836887 | 35825037:35825145 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000423325.2,ENST00000346162.6 |
| exon_skip_459006 | 6 | 35837443:35837678:35838057:35838271:35838710:35838732 | 35838057:35838271 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000373822.1,ENST00000423325.2,ENST00000346162.6,ENST00000510290.1 |
| exon_skip_459010 | 6 | 35838710:35838736:35840339:35840505:35842009:35842116 | 35840339:35840505 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000373822.1,ENST00000423325.2,ENST00000346162.6 |
| exon_skip_459014 | 6 | 35854559:35854588:35855800:35855888:35856591:35856700 | 35855800:35855888 | ENSG00000096063.10 | ENST00000508473.1,ENST00000373821.2,ENST00000373825.2,ENST00000512445.1,ENST00000361690.3,ENST00000373822.1,ENST00000423325.2,ENST00000346162.6 |
| exon_skip_459017 | 6 | 35858725:35858790:35872655:35872751:35888244:35888305 | 35872655:35872751 | ENSG00000096063.10 | ENST00000508473.1 |
| exon_skip_459018 | 6 | 35858725:35858790:35887841:35888305:35888820:35888849 | 35887841:35888305 | ENSG00000096063.10 | ENST00000507909.1 |
| exon_skip_459019 | 6 | 35858725:35858790:35888244:35888305:35888820:35888849 | 35888244:35888305 | ENSG00000096063.10 | ENST00000513367.1,ENST00000373822.1 |
| exon_skip_459021 | 6 | 35858671:35858818:35872655:35872751:35888244:35888305 | 35872655:35872751 | ENSG00000096063.10 | ENST00000512445.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SRPK1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_459001 | 6 | 35803204:35803265:35806113:35806206:35810311:35810381 | 35806113:35806206 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000346162.6,ENST00000423325.2 |
| exon_skip_459002 | 6 | 35800810:35803265:35806482:35806575:35810311:35810381 | 35806482:35806575 | ENSG00000096063.10 | ENST00000373822.1 |
| exon_skip_459005 | 6 | 35810311:35810381:35825037:35825145:35836786:35836887 | 35825037:35825145 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000346162.6,ENST00000423325.2 |
| exon_skip_459006 | 6 | 35837443:35837678:35838057:35838271:35838710:35838732 | 35838057:35838271 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000346162.6,ENST00000423325.2,ENST00000373822.1,ENST00000510290.1 |
| exon_skip_459010 | 6 | 35838710:35838736:35840339:35840505:35842009:35842116 | 35840339:35840505 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000346162.6,ENST00000423325.2,ENST00000373822.1 |
| exon_skip_459014 | 6 | 35854559:35854588:35855800:35855888:35856591:35856700 | 35855800:35855888 | ENSG00000096063.10 | ENST00000373825.2,ENST00000361690.3,ENST00000346162.6,ENST00000423325.2,ENST00000373822.1,ENST00000373821.2,ENST00000508473.1,ENST00000512445.1 |
| exon_skip_459017 | 6 | 35858725:35858790:35872655:35872751:35888244:35888305 | 35872655:35872751 | ENSG00000096063.10 | ENST00000508473.1 |
| exon_skip_459018 | 6 | 35858725:35858790:35887841:35888305:35888820:35888849 | 35887841:35888305 | ENSG00000096063.10 | ENST00000507909.1 |
| exon_skip_459019 | 6 | 35858725:35858790:35888244:35888305:35888820:35888849 | 35888244:35888305 | ENSG00000096063.10 | ENST00000373822.1,ENST00000513367.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SRPK1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for SRPK1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SRPK1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_459006 | 35838058 | 35838271 | 35838062 | 35838062 | Frame_Shift_Del | T | - | p.K329fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_459006 | 35838058 | 35838271 | 35838062 | 35838062 | Frame_Shift_Del | T | - | p.K329fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_459006 | 35838058 | 35838271 | 35838076 | 35838076 | Frame_Shift_Del | T | - | p.M325fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_459006 | 35838058 | 35838271 | 35838145 | 35838145 | Frame_Shift_Del | T | - | p.R302fs |
| LIHC | TCGA-BC-A10T-01 | exon_skip_459001 | 35806114 | 35806206 | 35806145 | 35806146 | Frame_Shift_Ins | - | C | p.E584fs |
| ESCA | TCGA-L5-A43J-01 | exon_skip_459006 | 35838058 | 35838271 | 35838144 | 35838145 | Frame_Shift_Ins | - | T | p.R302fs |
| ESCA | TCGA-L5-A43J-01 | exon_skip_459006 | 35838058 | 35838271 | 35838144 | 35838145 | Frame_Shift_Ins | - | T | p.T302fs |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_459010 | 35840340 | 35840505 | 35840373 | 35840373 | Nonsense_Mutation | G | A | p.R240* |
| COAD | TCGA-D5-6924-01 | exon_skip_459010 | 35840340 | 35840505 | 35840499 | 35840499 | Nonsense_Mutation | G | A | p.Q198X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PACADD119_PANCREAS | 35806114 | 35806206 | 35806122 | 35806122 | Missense_Mutation | G | T | p.T592N |
| HEC59_ENDOMETRIUM | 35806114 | 35806206 | 35806197 | 35806197 | Missense_Mutation | G | A | p.A567V |
| SNUC2A_LARGE_INTESTINE | 35825038 | 35825145 | 35825042 | 35825042 | Missense_Mutation | C | T | p.C539Y |
| SNUC2B_LARGE_INTESTINE | 35825038 | 35825145 | 35825042 | 35825042 | Missense_Mutation | C | T | p.C539Y |
| HA7EBV_MATCHED_NORMAL_TISSUE | 35825038 | 35825145 | 35825072 | 35825072 | Missense_Mutation | T | G | p.N529T |
| HA7RCC_KIDNEY | 35825038 | 35825145 | 35825072 | 35825072 | Missense_Mutation | T | G | p.N529T |
| SKUT1_SOFT_TISSUE | 35825038 | 35825145 | 35825105 | 35825105 | Missense_Mutation | C | T | p.R518H |
| SNU81_LARGE_INTESTINE | 35825038 | 35825145 | 35825134 | 35825134 | Missense_Mutation | G | T | p.F508L |
| YT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 35838058 | 35838271 | 35838231 | 35838231 | Missense_Mutation | T | C | p.K273R |
| NCIH841_LUNG | 35838058 | 35838271 | 35838246 | 35838246 | Missense_Mutation | T | C | p.K268R |
| DIFI_LARGE_INTESTINE | 35838058 | 35838271 | 35838248 | 35838248 | Missense_Mutation | C | A | p.K267N |
| LNCAPCLONEFGC_PROSTATE | 35840340 | 35840505 | 35840357 | 35840357 | Missense_Mutation | G | A | p.P245L |
| CORL88_LUNG | 35840340 | 35840505 | 35840366 | 35840366 | Missense_Mutation | C | A | p.G242V |
| CORL88_LUNG | 35840340 | 35840505 | 35840366 | 35840367 | Missense_Mutation | CC | AT | p.G242I |
| CORL88_LUNG | 35840340 | 35840505 | 35840367 | 35840367 | Missense_Mutation | C | T | p.G242R |
| CAPAN1_PANCREAS | 35840340 | 35840505 | 35840369 | 35840369 | Missense_Mutation | G | A | p.S241F |
| SNU1040_LARGE_INTESTINE | 35840340 | 35840505 | 35840469 | 35840469 | Missense_Mutation | G | A | p.R208C |
| TYKNU_OVARY | 35855801 | 35855888 | 35855814 | 35855814 | Missense_Mutation | C | T | p.R126Q |
| KYSE140_OESOPHAGUS | 35888245 | 35888305 | 35888291 | 35888291 | Missense_Mutation | C | A | p.A10S |
| KYSE140_OESOPHAGUS | 35887842 | 35888305 | 35888291 | 35888291 | Missense_Mutation | C | A | p.A10S |
| IM95_STOMACH | 35806114 | 35806206 | 35806115 | 35806115 | Splice_Site | T | - | p.K594fs |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SRPK1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_459018 | 6 | 35858725:35858790:35887841:35888305:35888820:35888849 | 35887841:35888305 | ENST00000507909.1 | HNSC | rs662713 | chr6:35888067 | G/C | 4.55e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SRPK1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SRPK1 |
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RelatedDrugs for SRPK1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRPK1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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