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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for SLC6A4 |
Gene summary |
Gene information | Gene symbol | SLC6A4 | Gene ID | 6532 |
Gene name | solute carrier family 6 member 4 | |
Synonyms | 5-HTT|5-HTTLPR|5HTT|HTT|OCD1|SERT|SERT1|hSERT | |
Cytomap | 17q11.2 | |
Type of gene | protein-coding | |
Description | sodium-dependent serotonin transporter5-hydroxytryptamine (serotonin) transporter5HT transporterNa+/Cl- dependent serotonin transporterserotonin transporter 1solute carrier family 6 (neurotransmitter transporter), member 4solute carrier family 6 (ne | |
Modification date | 20180527 | |
UniProtAcc | P31645 | |
Context | PubMed: SLC6A4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
SLC6A4 | GO:0006837 | serotonin transport | 19270731 |
SLC6A4 | GO:0009636 | response to toxic substance | 17575980 |
SLC6A4 | GO:0015844 | monoamine transport | 16024787 |
SLC6A4 | GO:0051610 | serotonin uptake | 8987735|16870614|17506858|18227069|19270731 |
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Exon skipping events across known transcript of Ensembl for SLC6A4 from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC6A4 |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC6A4 |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_288045 | 17 | 28530189:28530357:28534749:28534850:28536160:28536260 | 28534749:28534850 | ENSG00000108576.5 | ENST00000401766.2,ENST00000394821.2,ENST00000261707.3 |
exon_skip_288046 | 17 | 28530189:28530357:28534749:28534850:28537532:28537664 | 28534749:28534850 | ENSG00000108576.5 | ENST00000579221.1 |
exon_skip_288048 | 17 | 28534749:28534850:28536160:28536260:28537532:28537664 | 28536160:28536260 | ENSG00000108576.5 | ENST00000401766.2,ENST00000394821.2,ENST00000261707.3 |
exon_skip_288049 | 17 | 28545135:28545355:28545814:28545949:28548633:28549099 | 28545814:28545949 | ENSG00000108576.5 | ENST00000401766.2,ENST00000394821.2,ENST00000261707.3 |
exon_skip_288051 | 17 | 28548889:28549099:28549836:28549933:28562630:28562716 | 28549836:28549933 | ENSG00000108576.5 | ENST00000394821.2,ENST00000261707.3 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC6A4 |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_288045 | 17 | 28530189:28530357:28534749:28534850:28536160:28536260 | 28534749:28534850 | ENSG00000108576.5 | ENST00000401766.2,ENST00000261707.3,ENST00000394821.2 |
exon_skip_288046 | 17 | 28530189:28530357:28534749:28534850:28537532:28537664 | 28534749:28534850 | ENSG00000108576.5 | ENST00000579221.1 |
exon_skip_288048 | 17 | 28534749:28534850:28536160:28536260:28537532:28537664 | 28536160:28536260 | ENSG00000108576.5 | ENST00000401766.2,ENST00000261707.3,ENST00000394821.2 |
exon_skip_288049 | 17 | 28545135:28545355:28545814:28545949:28548633:28549099 | 28545814:28545949 | ENSG00000108576.5 | ENST00000401766.2,ENST00000261707.3,ENST00000394821.2 |
exon_skip_288051 | 17 | 28548889:28549099:28549836:28549933:28562630:28562716 | 28549836:28549933 | ENSG00000108576.5 | ENST00000261707.3,ENST00000394821.2 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC6A4 |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000261707 | 28549836 | 28549933 | 3UTR-3UTR |
ENST00000261707 | 28534749 | 28534850 | Frame-shift |
ENST00000401766 | 28534749 | 28534850 | Frame-shift |
ENST00000261707 | 28536160 | 28536260 | Frame-shift |
ENST00000401766 | 28536160 | 28536260 | Frame-shift |
ENST00000261707 | 28545814 | 28545949 | In-frame |
ENST00000401766 | 28545814 | 28545949 | In-frame |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000261707 | 28549836 | 28549933 | 3UTR-3UTR |
ENST00000261707 | 28534749 | 28534850 | Frame-shift |
ENST00000401766 | 28534749 | 28534850 | Frame-shift |
ENST00000261707 | 28536160 | 28536260 | Frame-shift |
ENST00000401766 | 28536160 | 28536260 | Frame-shift |
ENST00000261707 | 28545814 | 28545949 | In-frame |
ENST00000401766 | 28545814 | 28545949 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC6A4 |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000261707 | 4533 | 630 | 28545814 | 28545949 | 888 | 1022 | 114 | 159 |
ENST00000401766 | 6560 | 630 | 28545814 | 28545949 | 857 | 991 | 114 | 159 |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000261707 | 4533 | 630 | 28545814 | 28545949 | 888 | 1022 | 114 | 159 |
ENST00000401766 | 6560 | 630 | 28545814 | 28545949 | 857 | 991 | 114 | 159 |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P31645 | 114 | 159 | 1 | 630 | Chain | ID=PRO_0000214757;Note=Sodium-dependent serotonin transporter |
P31645 | 114 | 159 | 1 | 630 | Chain | ID=PRO_0000214757;Note=Sodium-dependent serotonin transporter |
P31645 | 114 | 159 | 114 | 117 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 114 | 117 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 118 | 127 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 118 | 127 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 129 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 129 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 149 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 149 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 156 | 159 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 156 | 159 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 142 | 142 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21992875;Dbxref=PMID:21992875 |
P31645 | 114 | 159 | 142 | 142 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21992875;Dbxref=PMID:21992875 |
P31645 | 114 | 159 | 113 | 115 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 113 | 115 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 136 | 160 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 136 | 160 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 116 | 135 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27049939;Dbxref=PMID:27049939 |
P31645 | 114 | 159 | 116 | 135 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27049939;Dbxref=PMID:27049939 |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P31645 | 114 | 159 | 1 | 630 | Chain | ID=PRO_0000214757;Note=Sodium-dependent serotonin transporter |
P31645 | 114 | 159 | 1 | 630 | Chain | ID=PRO_0000214757;Note=Sodium-dependent serotonin transporter |
P31645 | 114 | 159 | 114 | 117 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 114 | 117 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 118 | 127 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 118 | 127 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 129 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 129 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 149 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 149 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 156 | 159 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 156 | 159 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5I6X |
P31645 | 114 | 159 | 142 | 142 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21992875;Dbxref=PMID:21992875 |
P31645 | 114 | 159 | 142 | 142 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21992875;Dbxref=PMID:21992875 |
P31645 | 114 | 159 | 113 | 115 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 113 | 115 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 136 | 160 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 136 | 160 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P31645 | 114 | 159 | 116 | 135 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27049939;Dbxref=PMID:27049939 |
P31645 | 114 | 159 | 116 | 135 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27049939;Dbxref=PMID:27049939 |
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SNVs in the skipped exons for SLC6A4 |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
ESCA | TCGA-IG-A7DP-01 | exon_skip_288049 | 28545815 | 28545949 | 28545833 | 28545833 | Frame_Shift_Del | T | - | p.I154fs |
LUSC | TCGA-22-5480-01 | exon_skip_288049 | 28545815 | 28545949 | 28545947 | 28545947 | Frame_Shift_Del | C | - | p.A116fs |
SKCM | TCGA-FW-A3R5-06 | exon_skip_288046 exon_skip_288045 | 28534750 | 28534850 | 28534796 | 28534796 | Nonsense_Mutation | C | T | p.W535* |
UCEC | TCGA-AX-A05Z-01 | exon_skip_288049 | 28545815 | 28545949 | 28545857 | 28545857 | Nonsense_Mutation | C | A | p.G146* |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
MERO14_LUNG | 28534750 | 28534850 | 28534764 | 28534765 | Frame_Shift_Ins | - | GC | p.P546fs |
KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 28534750 | 28534850 | 28534804 | 28534804 | Missense_Mutation | G | T | p.S532R |
SNU1040_LARGE_INTESTINE | 28536161 | 28536260 | 28536179 | 28536179 | Missense_Mutation | C | T | p.A511T |
YD8_UPPER_AERODIGESTIVE_TRACT | 28536161 | 28536260 | 28536197 | 28536197 | Missense_Mutation | C | T | p.A505T |
HEC59_ENDOMETRIUM | 28545815 | 28545949 | 28545881 | 28545881 | Missense_Mutation | C | T | p.A138T |
NCIH661_LUNG | 28534750 | 28534850 | 28534850 | 28534850 | Splice_Site | C | A | p.G517V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC6A4 |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC6A4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC6A4 |
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RelatedDrugs for SLC6A4 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
P31645 | DB00215 | Citalopram | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00245 | Benzatropine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00285 | Venlafaxine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00289 | Atomoxetine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00321 | Amitriptyline | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00344 | Protriptyline | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00370 | Mirtazapine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00408 | Loxapine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00454 | Meperidine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00458 | Imipramine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00476 | Duloxetine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00514 | Dextromethorphan | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00540 | Nortriptyline | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00543 | Amoxapine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00661 | Verapamil | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00726 | Trimipramine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00805 | Minaprine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00852 | Pseudoephedrine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00988 | Dopamine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB01104 | Sertraline | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB01114 | Chlorphenamine | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB06204 | Tapentadol | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB09016 | Butriptyline | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB09167 | Dosulepin | Sodium-dependent serotonin transporter | small molecule | approved | |
P31645 | DB00191 | Phentermine | Sodium-dependent serotonin transporter | small molecule | approved|illicit | |
P31645 | DB00907 | Cocaine | Sodium-dependent serotonin transporter | small molecule | approved|illicit | |
P31645 | DB01577 | Metamfetamine | Sodium-dependent serotonin transporter | small molecule | approved|illicit | |
P31645 | DB00182 | Amphetamine | Sodium-dependent serotonin transporter | small molecule | approved|illicit|investigational | |
P31645 | DB00574 | Fenfluramine | Sodium-dependent serotonin transporter | small molecule | approved|illicit|investigational|withdrawn | |
P31645 | DB01105 | Sibutramine | Sodium-dependent serotonin transporter | small molecule | approved|illicit|investigational|withdrawn | |
P31645 | DB01191 | Dexfenfluramine | Sodium-dependent serotonin transporter | small molecule | approved|illicit|investigational|withdrawn | |
P31645 | DB00176 | Fluvoxamine | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB00193 | Tramadol | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB00422 | Methylphenidate | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB00579 | Mazindol | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB00656 | Trazodone | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB00715 | Paroxetine | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB01142 | Doxepin | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB01151 | Desipramine | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB01175 | Escitalopram | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB04896 | Milnacipran | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB06148 | Mianserin | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB06700 | Desvenlafaxine | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB06701 | Dexmethylphenidate | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB09068 | Vortioxetine | Sodium-dependent serotonin transporter | small molecule | approved|investigational | |
P31645 | DB01242 | Clomipramine | Sodium-dependent serotonin transporter | small molecule | approved|investigational|vet_approved | |
P31645 | DB09225 | Zotepine | Sodium-dependent serotonin transporter | small molecule | approved|investigational|withdrawn | |
P31645 | DB00472 | Fluoxetine | Sodium-dependent serotonin transporter | small molecule | approved|vet_approved | |
P31645 | DB01149 | Nefazodone | Sodium-dependent serotonin transporter | small molecule | approved|withdrawn | |
P31645 | DB04821 | Nomifensine | Sodium-dependent serotonin transporter | small molecule | approved|withdrawn | |
P31645 | DB04832 | Zimelidine | Sodium-dependent serotonin transporter | small molecule | approved|withdrawn |
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RelatedDiseases for SLC6A4 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
SLC6A4 | C0011581 | Depressive disorder | 9 | CTD_human;PSYGENET |
SLC6A4 | C0001973 | Alcoholic Intoxication, Chronic | 7 | CTD_human;PSYGENET |
SLC6A4 | C0005586 | Bipolar Disorder | 7 | CTD_human;PSYGENET |
SLC6A4 | C0525045 | Mood Disorders | 6 | CTD_human;PSYGENET |
SLC6A4 | C1269683 | Major Depressive Disorder | 6 | CTD_human;PSYGENET |
SLC6A4 | C0004352 | Autistic Disorder | 5 | CTD_human |
SLC6A4 | C0011570 | Mental Depression | 5 | PSYGENET |
SLC6A4 | C0025193 | Melancholia | 5 | PSYGENET |
SLC6A4 | C0041696 | Unipolar Depression | 5 | PSYGENET |
SLC6A4 | C0085159 | Seasonal Affective Disorder | 5 | PSYGENET |
SLC6A4 | C0221074 | Depression, Postpartum | 5 | PSYGENET |
SLC6A4 | C0344315 | Depressed mood | 5 | PSYGENET |
SLC6A4 | C0581391 | Chronic depression | 4 | PSYGENET |
SLC6A4 | C0600427 | Cocaine Dependence | 4 | PSYGENET |
SLC6A4 | C0221480 | Recurrent depression | 3 | PSYGENET |
SLC6A4 | C0233477 | Dysphoric mood | 3 | PSYGENET |
SLC6A4 | C2063866 | Depressive Disorder, Treatment-Resistant | 3 | PSYGENET |
SLC6A4 | C0001723 | Affective Disorders, Psychotic | 2 | PSYGENET |
SLC6A4 | C0005587 | Depression, Bipolar | 2 | PSYGENET |
SLC6A4 | C0025261 | Memory Disorders | 2 | CTD_human |
SLC6A4 | C0085762 | Alcohol abuse | 2 | PSYGENET |
SLC6A4 | C0178417 | Anhedonia | 2 | PSYGENET |
SLC6A4 | C0338715 | Drug-induced depressive state | 2 | PSYGENET |
SLC6A4 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
SLC6A4 | C0003469 | Anxiety Disorders | 1 | CTD_human |
SLC6A4 | C0009241 | Cognition Disorders | 1 | CTD_human |
SLC6A4 | C0013415 | Dysthymic Disorder | 1 | PSYGENET |
SLC6A4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
SLC6A4 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
SLC6A4 | C0028768 | Obsessive-Compulsive Disorder | 1 | CTD_human |
SLC6A4 | C0031212 | Personality Disorders | 1 | CTD_human |
SLC6A4 | C0036341 | Schizophrenia | 1 | CTD_human |
SLC6A4 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
SLC6A4 | C0038644 | Sudden infant death syndrome | 1 | CTD_human |
SLC6A4 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
SLC6A4 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
SLC6A4 | C0236792 | Asperger Syndrome | 1 | CTD_human |
SLC6A4 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
SLC6A4 | C0588008 | Severe depression | 1 | PSYGENET |
SLC6A4 | C3160814 | Cannabis use | 1 | PSYGENET |