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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for WNK3 |
Gene summary |
Gene information | Gene symbol | WNK3 | Gene ID | 65267 |
Gene name | WNK lysine deficient protein kinase 3 | |
Synonyms | PRKWNK3 | |
Cytomap | Xp11.22 | |
Type of gene | protein-coding | |
Description | serine/threonine-protein kinase WNK3protein kinase with no lysine 3 | |
Modification date | 20180523 | |
UniProtAcc | Q9BYP7 | |
Context | PubMed: WNK3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
WNK3 | GO:0010765 | positive regulation of sodium ion transport | 16275913 |
WNK3 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16275913 |
WNK3 | GO:0032414 | positive regulation of ion transmembrane transporter activity | 16275913 |
WNK3 | GO:0046777 | protein autophosphorylation | 16275913 |
WNK3 | GO:1903078 | positive regulation of protein localization to plasma membrane | 16275913 |
WNK3 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 16275913 |
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Exon skipping events across known transcript of Ensembl for WNK3 from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for WNK3 |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for WNK3 |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_515172 | X | 54228423:54228626:54255146:54255176:54259241:54259453 | 54255146:54255176 | ENSG00000196632.6 | ENST00000354646.2,ENST00000375159.2 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for WNK3 |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_515172 | X | 54228423:54228626:54255146:54255176:54259241:54259453 | 54255146:54255176 | ENSG00000196632.6 | ENST00000354646.2,ENST00000375159.2 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for WNK3 |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000354646 | 54255146 | 54255176 | In-frame |
ENST00000375159 | 54255146 | 54255176 | In-frame |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000354646 | 54255146 | 54255176 | In-frame |
ENST00000375159 | 54255146 | 54255176 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WNK3 |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000354646 | 11358 | 1800 | 54255146 | 54255176 | 5280 | 5309 | 1613 | 1623 |
ENST00000375159 | 5420 | 1800 | 54255146 | 54255176 | 4841 | 4870 | 1613 | 1623 |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000354646 | 11358 | 1800 | 54255146 | 54255176 | 5280 | 5309 | 1613 | 1623 |
ENST00000375159 | 5420 | 1800 | 54255146 | 54255176 | 4841 | 4870 | 1613 | 1623 |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9BYP7 | 1613 | 1623 | 1614 | 1624 | Alternative sequence | ID=VSP_041933;Note=In isoform 3 and isoform 2. GKSCLINELEN->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11571656;Dbxref=PMID:10997877,PMID:11571656 |
Q9BYP7 | 1613 | 1623 | 1614 | 1624 | Alternative sequence | ID=VSP_041933;Note=In isoform 3 and isoform 2. GKSCLINELEN->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11571656;Dbxref=PMID:10997877,PMID:11571656 |
Q9BYP7 | 1613 | 1623 | 1 | 1800 | Chain | ID=PRO_0000086823;Note=Serine/threonine-protein kinase WNK3 |
Q9BYP7 | 1613 | 1623 | 1 | 1800 | Chain | ID=PRO_0000086823;Note=Serine/threonine-protein kinase WNK3 |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9BYP7 | 1613 | 1623 | 1614 | 1624 | Alternative sequence | ID=VSP_041933;Note=In isoform 3 and isoform 2. GKSCLINELEN->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11571656;Dbxref=PMID:10997877,PMID:11571656 |
Q9BYP7 | 1613 | 1623 | 1614 | 1624 | Alternative sequence | ID=VSP_041933;Note=In isoform 3 and isoform 2. GKSCLINELEN->D;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10997877,ECO:0000303|PubMed:11571656;Dbxref=PMID:10997877,PMID:11571656 |
Q9BYP7 | 1613 | 1623 | 1 | 1800 | Chain | ID=PRO_0000086823;Note=Serine/threonine-protein kinase WNK3 |
Q9BYP7 | 1613 | 1623 | 1 | 1800 | Chain | ID=PRO_0000086823;Note=Serine/threonine-protein kinase WNK3 |
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SNVs in the skipped exons for WNK3 |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WNK3 |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WNK3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WNK3 |
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RelatedDrugs for WNK3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WNK3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
WNK3 | C0036341 | Schizophrenia | 1 | PSYGENET |