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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RGS7 |
 Gene summary |
| Gene information | Gene symbol | RGS7 | Gene ID | 6000 |
| Gene name | regulator of G protein signaling 7 | |
| Synonyms | - | |
| Cytomap | 1q43|1q23.1 | |
| Type of gene | protein-coding | |
| Description | regulator of G-protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7 | |
| Modification date | 20180522 | |
| UniProtAcc | P49802 | |
| Context | PubMed: RGS7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RGS7 | GO:0043547 | positive regulation of GTPase activity | 10521509 |
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Exon skipping events across known transcript of Ensembl for RGS7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RGS7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RGS7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_38417 | 1 | 240931553:240931578:240963940:240964021:240966203:240966293 | 240963940:240964021 | ENSG00000182901.11 | ENST00000331110.7 |
| exon_skip_38418 | 1 | 240939462:240939513:240963940:240964021:240964754:240964808 | 240963940:240964021 | ENSG00000182901.11 | ENST00000440928.1 |
| exon_skip_38419 | 1 | 240939462:240939513:240963940:240964021:240966203:240966293 | 240963940:240964021 | ENSG00000182901.11 | ENST00000366563.1,ENST00000348120.2,ENST00000446183.2 |
| exon_skip_38420 | 1 | 240939462:240939513:240964754:240964808:240966203:240966293 | 240964754:240964808 | ENSG00000182901.11 | ENST00000366565.1 |
| exon_skip_38421 | 1 | 240963946:240964021:240964754:240964808:240966203:240966293 | 240964754:240964808 | ENSG00000182901.11 | ENST00000440928.1,ENST00000407727.1 |
| exon_skip_38422 | 1 | 240969439:240969626:240975217:240975343:240976917:240977028 | 240975217:240975343 | ENSG00000182901.11 | ENST00000440928.1,ENST00000366562.4,ENST00000407727.1,ENST00000366563.1,ENST00000348120.2,ENST00000366565.1,ENST00000331110.7,ENST00000366564.1,ENST00000446183.2,ENST00000401882.1 |
| exon_skip_38423 | 1 | 240975217:240975343:240976917:240977028:240978015:240978077 | 240976917:240977028 | ENSG00000182901.11 | ENST00000440928.1,ENST00000366562.4,ENST00000407727.1,ENST00000366563.1,ENST00000348120.2,ENST00000366565.1,ENST00000331110.7,ENST00000366564.1,ENST00000446183.2,ENST00000401882.1 |
| exon_skip_38424 | 1 | 241099899:241100006:241146378:241146429:241261965:241262062 | 241146378:241146429 | ENSG00000182901.11 | ENST00000366562.4,ENST00000407727.1,ENST00000366563.1,ENST00000366565.1,ENST00000331110.7,ENST00000366564.1 |
| exon_skip_38425 | 1 | 241146378:241146429:241235772:241235930:241261965:241262062 | 241235772:241235930 | ENSG00000182901.11 | ENST00000446183.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RGS7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_38417 | 1 | 240931553:240931578:240963940:240964021:240966203:240966293 | 240963940:240964021 | ENSG00000182901.11 | ENST00000331110.7 |
| exon_skip_38418 | 1 | 240939462:240939513:240963940:240964021:240964754:240964808 | 240963940:240964021 | ENSG00000182901.11 | ENST00000440928.1 |
| exon_skip_38419 | 1 | 240939462:240939513:240963940:240964021:240966203:240966293 | 240963940:240964021 | ENSG00000182901.11 | ENST00000348120.2,ENST00000366563.1,ENST00000446183.2 |
| exon_skip_38420 | 1 | 240939462:240939513:240964754:240964808:240966203:240966293 | 240964754:240964808 | ENSG00000182901.11 | ENST00000366565.1 |
| exon_skip_38421 | 1 | 240963946:240964021:240964754:240964808:240966203:240966293 | 240964754:240964808 | ENSG00000182901.11 | ENST00000440928.1,ENST00000407727.1 |
| exon_skip_38422 | 1 | 240969439:240969626:240975217:240975343:240976917:240977028 | 240975217:240975343 | ENSG00000182901.11 | ENST00000331110.7,ENST00000440928.1,ENST00000348120.2,ENST00000366563.1,ENST00000366564.1,ENST00000366565.1,ENST00000446183.2,ENST00000366562.4,ENST00000407727.1,ENST00000401882.1 |
| exon_skip_38423 | 1 | 240975217:240975343:240976917:240977028:240978015:240978077 | 240976917:240977028 | ENSG00000182901.11 | ENST00000331110.7,ENST00000440928.1,ENST00000348120.2,ENST00000366563.1,ENST00000366564.1,ENST00000366565.1,ENST00000446183.2,ENST00000366562.4,ENST00000407727.1,ENST00000401882.1 |
| exon_skip_38424 | 1 | 241099899:241100006:241146378:241146429:241261965:241262062 | 241146378:241146429 | ENSG00000182901.11 | ENST00000331110.7,ENST00000366563.1,ENST00000366564.1,ENST00000366565.1,ENST00000366562.4,ENST00000407727.1 |
| exon_skip_38425 | 1 | 241146378:241146429:241235772:241235930:241261965:241262062 | 241235772:241235930 | ENSG00000182901.11 | ENST00000446183.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RGS7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for RGS7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RGS7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-VQ-A8DT-01 | exon_skip_38422 | 240975218 | 240975343 | 240975304 | 240975304 | Frame_Shift_Del | A | - | p.F332fs |
| STAD | TCGA-VQ-A8DT-01 | exon_skip_38422 | 240975218 | 240975343 | 240975304 | 240975304 | Frame_Shift_Del | A | - | p.G333fs |
| LUAD | TCGA-78-7155-01 | exon_skip_38422 | 240975218 | 240975343 | 240975230 | 240975230 | Nonsense_Mutation | G | T | p.S357* |
| HNSC | TCGA-CV-7432-01 | exon_skip_38422 | 240975218 | 240975343 | 240975267 | 240975267 | Nonsense_Mutation | C | A | p.E345* |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_38424 | 241146379 | 241146429 | 241146388 | 241146388 | Nonsense_Mutation | C | A | p.E73* |
| UCEC | TCGA-AP-A059-01 | exon_skip_38423 | 240976918 | 240977028 | 240977029 | 240977029 | Splice_Site | C | A | e12-1 |
| LUSC | TCGA-18-4083-01 | exon_skip_38424 | 241146379 | 241146429 | 241146430 | 241146430 | Splice_Site | C | T | p.G59_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH250_LUNG | 240976918 | 240977028 | 240976931 | 240976931 | Frame_Shift_Del | C | - | p.E315fs |
| NUGC3_STOMACH | 240963941 | 240964021 | 240963955 | 240963955 | Missense_Mutation | G | T | p.L494M |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 240963941 | 240964021 | 240964012 | 240964012 | Missense_Mutation | T | G | p.I475L |
| MM426_SKIN | 240975218 | 240975343 | 240975282 | 240975282 | Missense_Mutation | C | T | p.D340N |
| SKMES1_LUNG | 240975218 | 240975343 | 240975314 | 240975314 | Missense_Mutation | C | T | p.R329Q |
| DU145_PROSTATE | 240976918 | 240977028 | 240976990 | 240976990 | Missense_Mutation | G | T | p.P295Q |
| NCIH2286_LUNG | 241146379 | 241146429 | 241146391 | 241146391 | Missense_Mutation | T | C | p.I72V |
| COLO668_LUNG | 240976918 | 240977028 | 240976918 | 240976918 | Splice_Site | C | T | p.S319N |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 241146379 | 241146429 | 241146428 | 241146428 | Splice_Site | A | C | p.G59G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RGS7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RGS7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RGS7 |
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RelatedDrugs for RGS7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RGS7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RGS7 | C3714756 | Intellectual Disability | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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