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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAN |
 Gene summary |
| Gene information | Gene symbol | RAN | Gene ID | 5901 |
| Gene name | RAN, member RAS oncogene family | |
| Synonyms | ARA24|Gsp1|TC4 | |
| Cytomap | 12q24.33 | |
| Type of gene | protein-coding | |
| Description | GTP-binding nuclear protein RanGTPase RanOK/SW-cl.81RanGTPaseandrogen receptor-associated protein 24guanosine triphosphatase Ranmember RAS oncogene familyras-like protein TC4ras-related nuclear protein | |
| Modification date | 20180526 | |
| UniProtAcc | P62826 | |
| Context | PubMed: RAN [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RAN | GO:0006606 | protein import into nucleus | 9822603 |
| RAN | GO:0006611 | protein export from nucleus | 16449645 |
| RAN | GO:0032092 | positive regulation of protein binding | 16449645 |
| RAN | GO:0046039 | GTP metabolic process | 26272610 |
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Exon skipping events across known transcript of Ensembl for RAN from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAN |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAN |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_88530 | 12 | 131356640:131356671:131357128:131357162:131357380:131357457 | 131357128:131357162 | ENSG00000132341.7 | ENST00000535090.1 |
| exon_skip_88532 | 12 | 131356640:131356671:131357128:131357174:131357380:131357457 | 131357128:131357174 | ENSG00000132341.7 | ENST00000392367.3 |
| exon_skip_88537 | 12 | 131356640:131356671:131357128:131357465:131357547:131357673 | 131357128:131357465 | ENSG00000132341.7 | ENST00000477395.1 |
| exon_skip_88539 | 12 | 131356640:131356671:131357380:131357457:131357547:131357673 | 131357380:131357457 | ENSG00000132341.7 | ENST00000541630.1 |
| exon_skip_88540 | 12 | 131356640:131356671:131357380:131357465:131357547:131357673 | 131357380:131357465 | ENSG00000132341.7 | ENST00000448750.3,ENST00000536606.1,ENST00000254675.3 |
| exon_skip_88547 | 12 | 131357128:131357174:131357380:131357465:131357547:131357673 | 131357380:131357465 | ENSG00000132341.7 | ENST00000543796.1,ENST00000392369.2,ENST00000392367.3 |
| exon_skip_88551 | 12 | 131357547:131357673:131358578:131358629:131359090:131359278 | 131358578:131358629 | ENSG00000132341.7 | ENST00000392367.3 |
| exon_skip_88552 | 12 | 131357547:131357673:131359090:131359278:131360156:131360184 | 131359090:131359278 | ENSG00000132341.7 | ENST00000541630.1,ENST00000543796.1,ENST00000477395.1,ENST00000392369.2,ENST00000448750.3,ENST00000535090.1,ENST00000254675.3 |
| exon_skip_88553 | 12 | 131357547:131357673:131359095:131359278:131360156:131360184 | 131359095:131359278 | ENSG00000132341.7 | ENST00000536606.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAN |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_88530 | 12 | 131356640:131356671:131357128:131357162:131357380:131357457 | 131357128:131357162 | ENSG00000132341.7 | ENST00000535090.1 |
| exon_skip_88532 | 12 | 131356640:131356671:131357128:131357174:131357380:131357457 | 131357128:131357174 | ENSG00000132341.7 | ENST00000392367.3 |
| exon_skip_88537 | 12 | 131356640:131356671:131357128:131357465:131357547:131357673 | 131357128:131357465 | ENSG00000132341.7 | ENST00000477395.1 |
| exon_skip_88539 | 12 | 131356640:131356671:131357380:131357457:131357547:131357673 | 131357380:131357457 | ENSG00000132341.7 | ENST00000541630.1 |
| exon_skip_88540 | 12 | 131356640:131356671:131357380:131357465:131357547:131357673 | 131357380:131357465 | ENSG00000132341.7 | ENST00000448750.3,ENST00000536606.1,ENST00000254675.3 |
| exon_skip_88547 | 12 | 131357128:131357174:131357380:131357465:131357547:131357673 | 131357380:131357465 | ENSG00000132341.7 | ENST00000543796.1,ENST00000392369.2,ENST00000392367.3 |
| exon_skip_88551 | 12 | 131357547:131357673:131358578:131358629:131359090:131359278 | 131358578:131358629 | ENSG00000132341.7 | ENST00000392367.3 |
| exon_skip_88552 | 12 | 131357547:131357673:131359090:131359278:131360156:131360184 | 131359090:131359278 | ENSG00000132341.7 | ENST00000543796.1,ENST00000448750.3,ENST00000541630.1,ENST00000477395.1,ENST00000392369.2,ENST00000254675.3,ENST00000535090.1 |
| exon_skip_88553 | 12 | 131357547:131357673:131359095:131359278:131360156:131360184 | 131359095:131359278 | ENSG00000132341.7 | ENST00000536606.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAN |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392369 | 131357380 | 131357465 | Frame-shift |
| ENST00000543796 | 131357380 | 131357465 | Frame-shift |
| ENST00000392369 | 131359090 | 131359278 | Frame-shift |
| ENST00000543796 | 131359090 | 131359278 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392369 | 131357380 | 131357465 | Frame-shift |
| ENST00000543796 | 131357380 | 131357465 | Frame-shift |
| ENST00000392369 | 131359090 | 131359278 | Frame-shift |
| ENST00000543796 | 131359090 | 131359278 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RAN |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RAN |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
RAN_COAD_exon_skip_88552_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CQ-5334-01 | exon_skip_88552 exon_skip_88553 | 131359091 | 131359278 | 131359130 | 131359133 | Frame_Shift_Del | TTAC | - | p.V96fs |
| HNSC | TCGA-CQ-5334-01 | exon_skip_88552 exon_skip_88553 | 131359091 | 131359278 | 131359130 | 131359133 | Frame_Shift_Del | TTAC | - | p.VT96fs |
| HNSC | TCGA-CQ-5334-01 | exon_skip_88552 exon_skip_88553 | 131359096 | 131359278 | 131359130 | 131359133 | Frame_Shift_Del | TTAC | - | p.V96fs |
| HNSC | TCGA-CQ-5334-01 | exon_skip_88552 exon_skip_88553 | 131359096 | 131359278 | 131359130 | 131359133 | Frame_Shift_Del | TTAC | - | p.VT96fs |
| BRCA | TCGA-D8-A140-01 | exon_skip_88552 exon_skip_88553 | 131359091 | 131359278 | 131359172 | 131359172 | Frame_Shift_Del | G | - | p.R110fs |
| BRCA | TCGA-D8-A140-01 | exon_skip_88552 exon_skip_88553 | 131359096 | 131359278 | 131359172 | 131359172 | Frame_Shift_Del | G | - | p.R110fs |
| COAD | TCGA-A6-6650-01 | exon_skip_88552 exon_skip_88553 | 131359091 | 131359278 | 131359261 | 131359261 | Nonsense_Mutation | C | T | p.R140X |
| COAD | TCGA-A6-6650-01 | exon_skip_88552 exon_skip_88553 | 131359096 | 131359278 | 131359261 | 131359261 | Nonsense_Mutation | C | T | p.R140X |
| SKCM | TCGA-EE-A3J4-06 | exon_skip_88539 | 131357381 | 131357457 | 131357380 | 131357380 | Splice_Site | G | T | . |
| SKCM | TCGA-EE-A3J4-06 | exon_skip_88540 exon_skip_88547 | 131357381 | 131357465 | 131357380 | 131357380 | Splice_Site | G | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-A6-6650-01 |
| Cancer type: COAD | |
| ESID: exon_skip_88553 | |
| Skipped exon start: 131359091 | |
| Skipped exon end: 131359278 | |
| Mutation start: 131359261 | |
| Mutation end: 131359261 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R140X | |
| Sample: TCGA-A6-6650-01 |
| Cancer type: COAD | |
| ESID: exon_skip_88553 | |
| Skipped exon start: 131359096 | |
| Skipped exon end: 131359278 | |
| Mutation start: 131359261 | |
| Mutation end: 131359261 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R140X | |
exon_skip_62194_COAD_TCGA-A6-6650-01.png | |
exon_skip_88552_COAD_TCGA-A6-6650-01.png | |
 | Sample: TCGA-EE-A3J4-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_88539 | |
| Skipped exon start: 131357381 | |
| Skipped exon end: 131357457 | |
| Mutation start: 131357380 | |
| Mutation end: 131357380 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: . | |
| Sample: TCGA-EE-A3J4-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_88547 | |
| Skipped exon start: 131357381 | |
| Skipped exon end: 131357465 | |
| Mutation start: 131357380 | |
| Mutation end: 131357380 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: . | |
exon_skip_346530_SKCM_TCGA-EE-A3J4-06.png | |
exon_skip_88547_SKCM_TCGA-EE-A3J4-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131359091 | 131359278 | 131359103 | 131359103 | Missense_Mutation | T | A | p.I87N |
| DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131359096 | 131359278 | 131359103 | 131359103 | Missense_Mutation | T | A | p.I87N |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131359091 | 131359278 | 131359172 | 131359172 | Missense_Mutation | G | A | p.R110Q |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131359096 | 131359278 | 131359172 | 131359172 | Missense_Mutation | G | A | p.R110Q |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAN |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAN |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAN |
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RelatedDrugs for RAN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RAN | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| RAN | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| RAN | C0019693 | HIV Infections | 1 | CTD_human |
| RAN | C0022548 | Keloid | 1 | CTD_human |
| RAN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
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