ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for MOK

Gene summary

Gene information	Gene symbol	MOK
	Gene ID	5891
	Gene name	MOK protein kinase
	Synonyms	RAGE\|RAGE-1\|RAGE1\|STK30
	Cytomap	14q32.31
	Type of gene	protein-coding
	Description	MAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1
	Modification date	20180523
	UniProtAcc	Q9UQ07
	Context	PubMed: MOK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

Exon skipping events across known transcript of Ensembl for MOK from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for MOK

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for MOK

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENSG00000080823.17	ENST00000559138.1
exon_skip_116021	14	102690992:102691131:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000559838.1
exon_skip_116031	14	102692621:102692745:102698871:102699008:102700024:102700126	102698871:102699008	ENSG00000080823.17	ENST00000561150.1
exon_skip_116032	14	102692621:102692745:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000559138.1,ENST00000193029.6
exon_skip_116038	14	102695956:102695988:102698043:102698158:102698871:102698919	102698043:102698158	ENSG00000080823.17	ENST00000524120.1
exon_skip_116042	14	102695914:102695994:102698043:102698158:102698871:102698903	102698043:102698158	ENSG00000080823.17	ENST00000521766.1,ENST00000519477.1,ENST00000524214.1,ENST00000361847.2,ENST00000518686.1,ENST00000519569.1,ENST00000523485.1,ENST00000520252.1,ENST00000522874.1
exon_skip_116052	14	102695914:102695994:102698871:102699008:102700024:102700126	102698871:102699008	ENSG00000080823.17	ENST00000523231.1
exon_skip_116053	14	102695914:102695994:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000522537.1,ENST00000524370.1,ENST00000517966.1,ENST00000522534.1,ENST00000519058.1
exon_skip_116063	14	102698082:102698158:102698871:102699008:102700024:102700126	102698871:102699008	ENSG00000080823.17	ENST00000519477.1,ENST00000524120.1,ENST00000520252.1,ENST00000520046.1
exon_skip_116064	14	102698082:102698158:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000524214.1,ENST00000361847.2,ENST00000519569.1,ENST00000523485.1,ENST00000522874.1
exon_skip_116065	14	102700097:102700126:102704654:102704701:102706788:102706958	102704654:102704701	ENSG00000080823.17	ENST00000517966.1
exon_skip_116067	14	102717231:102717324:102717780:102717947:102718092:102718141	102717780:102717947	ENSG00000080823.17	ENST00000517537.1,ENST00000523485.1
exon_skip_116069	14	102717231:102717324:102718092:102718141:102718253:102718332	102718092:102718141	ENSG00000080823.17	ENST00000518399.1,ENST00000522874.1
exon_skip_116072	14	102717303:102717327:102718092:102718141:102718253:102718332	102718092:102718141	ENSG00000080823.17	ENST00000562292.1,ENST00000521766.1,ENST00000193029.6,ENST00000524214.1,ENST00000361847.2,ENST00000518686.1,ENST00000522093.1
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENSG00000080823.17	ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000524207.1,ENST00000522874.1
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENSG00000080823.17	ENST00000524214.1,ENST00000524019.1
exon_skip_116082	14	102718253:102718332:102732159:102732249:102749814:102749929	102732159:102732249	ENSG00000080823.17	ENST00000562292.1
exon_skip_116085	14	102718297:102718332:102744942:102745031:102749814:102749929	102744942:102745031	ENSG00000080823.17	ENST00000522093.1
exon_skip_116087	14	102718297:102718332:102749814:102749929:102771298:102771471	102749814:102749929	ENSG00000080823.17	ENST00000521766.1,ENST00000518482.1,ENST00000521493.1,ENST00000519877.1,ENST00000521388.1,ENST00000518399.1
exon_skip_116090	14	102729882:102729953:102732159:102732249:102744942:102745031	102732159:102732249	ENSG00000080823.17	ENST00000524207.1
exon_skip_116092	14	102729882:102729953:102732159:102732249:102749814:102749929	102732159:102732249	ENSG00000080823.17	ENST00000521966.1,ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000522874.1
exon_skip_116104	14	102732159:102732249:102744942:102745031:102749814:102749929	102744942:102745031	ENSG00000080823.17	ENST00000524207.1

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for MOK

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENSG00000080823.17	ENST00000559138.1
exon_skip_116021	14	102690992:102691131:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000559838.1
exon_skip_116031	14	102692621:102692745:102698871:102699008:102700024:102700126	102698871:102699008	ENSG00000080823.17	ENST00000561150.1
exon_skip_116032	14	102692621:102692745:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000559138.1,ENST00000193029.6
exon_skip_116038	14	102695956:102695988:102698043:102698158:102698871:102698919	102698043:102698158	ENSG00000080823.17	ENST00000524120.1
exon_skip_116042	14	102695914:102695994:102698043:102698158:102698871:102698903	102698043:102698158	ENSG00000080823.17	ENST00000521766.1,ENST00000523485.1,ENST00000519569.1,ENST00000522874.1,ENST00000518686.1,ENST00000361847.2,ENST00000524214.1,ENST00000519477.1,ENST00000520252.1
exon_skip_116052	14	102695914:102695994:102698871:102699008:102700024:102700126	102698871:102699008	ENSG00000080823.17	ENST00000523231.1
exon_skip_116053	14	102695914:102695994:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000517966.1,ENST00000524370.1,ENST00000519058.1,ENST00000522534.1,ENST00000522537.1
exon_skip_116063	14	102698082:102698158:102698871:102699008:102700024:102700126	102698871:102699008	ENSG00000080823.17	ENST00000519477.1,ENST00000520252.1,ENST00000524120.1,ENST00000520046.1
exon_skip_116064	14	102698082:102698158:102698871:102699045:102700024:102700126	102698871:102699045	ENSG00000080823.17	ENST00000523485.1,ENST00000519569.1,ENST00000522874.1,ENST00000361847.2,ENST00000524214.1
exon_skip_116067	14	102717231:102717324:102717780:102717947:102718092:102718141	102717780:102717947	ENSG00000080823.17	ENST00000523485.1,ENST00000517537.1
exon_skip_116069	14	102717231:102717324:102718092:102718141:102718253:102718332	102718092:102718141	ENSG00000080823.17	ENST00000522874.1,ENST00000518399.1
exon_skip_116072	14	102717303:102717327:102718092:102718141:102718253:102718332	102718092:102718141	ENSG00000080823.17	ENST00000193029.6,ENST00000521766.1,ENST00000518686.1,ENST00000361847.2,ENST00000524214.1,ENST00000562292.1,ENST00000522093.1
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENSG00000080823.17	ENST00000193029.6,ENST00000519569.1,ENST00000522874.1,ENST00000518686.1,ENST00000361847.2,ENST00000517537.1,ENST00000524207.1
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENSG00000080823.17	ENST00000524214.1,ENST00000524019.1
exon_skip_116082	14	102718253:102718332:102732159:102732249:102749814:102749929	102732159:102732249	ENSG00000080823.17	ENST00000562292.1
exon_skip_116085	14	102718297:102718332:102744942:102745031:102749814:102749929	102744942:102745031	ENSG00000080823.17	ENST00000522093.1
exon_skip_116087	14	102718297:102718332:102749814:102749929:102771298:102771471	102749814:102749929	ENSG00000080823.17	ENST00000521766.1,ENST00000521388.1,ENST00000521493.1,ENST00000518399.1,ENST00000518482.1,ENST00000519877.1
exon_skip_116090	14	102729882:102729953:102732159:102732249:102744942:102745031	102732159:102732249	ENSG00000080823.17	ENST00000524207.1
exon_skip_116092	14	102729882:102729953:102732159:102732249:102749814:102749929	102732159:102732249	ENSG00000080823.17	ENST00000193029.6,ENST00000519569.1,ENST00000522874.1,ENST00000518686.1,ENST00000361847.2,ENST00000517537.1,ENST00000521966.1
exon_skip_116097	14	102729882:102729953:102743635:102743787:102744942:102745031	102743635:102743787	ENSG00000080823.17	ENST00000520238.1
exon_skip_116104	14	102732159:102732249:102744942:102745031:102749814:102749929	102744942:102745031	ENSG00000080823.17	ENST00000524207.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for MOK

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000361847	102698043	102698158	Frame-shift
ENST00000361847	102718092	102718141	Frame-shift
ENST00000361847	102729882	102729953	Frame-shift
ENST00000361847	102698871	102699045	In-frame
ENST00000361847	102732159	102732249	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000361847	102698043	102698158	Frame-shift
ENST00000361847	102718092	102718141	Frame-shift
ENST00000361847	102729882	102729953	Frame-shift
ENST00000361847	102698871	102699045	In-frame
ENST00000361847	102732159	102732249	In-frame

Top

Infer the effects of exon skipping event on protein functional features for MOK

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361847	1957	419	102732159	102732249	355	444	41	70
ENST00000361847	1957	419	102698871	102699045	925	1098	231	288

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361847	1957	419	102732159	102732249	355	444	41	70
ENST00000361847	1957	419	102698871	102699045	925	1098	231	288

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9UQ07	41	70	1	346	Alternative sequence	ID=VSP_009143;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	41	70	1	234	Alternative sequence	ID=VSP_009142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	41	70	42	71	Alternative sequence	ID=VSP_054734;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9UQ07	41	70	1	419	Chain	ID=PRO_0000086341;Note=MAPK/MAK/MRK overlapping kinase
Q9UQ07	41	70	4	285	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9UQ07	231	288	1	346	Alternative sequence	ID=VSP_009143;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	231	288	1	234	Alternative sequence	ID=VSP_009142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	231	288	232	419	Alternative sequence	ID=VSP_009144;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9UQ07	231	288	1	419	Chain	ID=PRO_0000086341;Note=MAPK/MAK/MRK overlapping kinase
Q9UQ07	231	288	4	285	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9UQ07	231	288	248	248	Natural variant	ID=VAR_042014;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34299975,PMID:17344846
Q9UQ07	231	288	272	272	Natural variant	ID=VAR_042015;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q9UQ07	231	288	269	269	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9UQ07	41	70	1	346	Alternative sequence	ID=VSP_009143;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	41	70	1	234	Alternative sequence	ID=VSP_009142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	41	70	42	71	Alternative sequence	ID=VSP_054734;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9UQ07	41	70	1	419	Chain	ID=PRO_0000086341;Note=MAPK/MAK/MRK overlapping kinase
Q9UQ07	41	70	4	285	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9UQ07	231	288	1	346	Alternative sequence	ID=VSP_009143;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	231	288	1	234	Alternative sequence	ID=VSP_009142;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8781117;Dbxref=PMID:8781117
Q9UQ07	231	288	232	419	Alternative sequence	ID=VSP_009144;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9UQ07	231	288	1	419	Chain	ID=PRO_0000086341;Note=MAPK/MAK/MRK overlapping kinase
Q9UQ07	231	288	4	285	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9UQ07	231	288	248	248	Natural variant	ID=VAR_042014;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34299975,PMID:17344846
Q9UQ07	231	288	272	272	Natural variant	ID=VAR_042015;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q9UQ07	231	288	269	269	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Top

SNVs in the skipped exons for MOK

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A3A0-01	exon_skip_116063 exon_skip_116031 exon_skip_116052	102698872	102699008	102698889	102698889	Frame_Shift_Del	G	-	p.P283fs
LIHC	TCGA-DD-A3A0-01	exon_skip_116021 exon_skip_116032 exon_skip_116064 exon_skip_116053	102698872	102699045	102698889	102698889	Frame_Shift_Del	G	-	p.P283fs
LIHC	TCGA-DD-A3A0-01	exon_skip_116087	102749815	102749929	102749857	102749857	Frame_Shift_Del	C	-	p.G27fs
LIHC	TCGA-BC-A112-01	exon_skip_116087	102749815	102749929	102749921	102749922	Frame_Shift_Ins	-	T	p.NN5fs

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
HEC1B_ENDOMETRIUM	102698044	102698158	102698102	102698102	Missense_Mutation	G	T	p.P308H
YD8_UPPER_AERODIGESTIVE_TRACT	102698872	102699008	102698897	102698897	Missense_Mutation	G	T	p.Q281K
YD8_UPPER_AERODIGESTIVE_TRACT	102698872	102699045	102698897	102698897	Missense_Mutation	G	T	p.Q281K
NCIH630_LARGE_INTESTINE	102698872	102699008	102698980	102698980	Missense_Mutation	T	C	p.N253S
NCIH630_LARGE_INTESTINE	102698872	102699045	102698980	102698980	Missense_Mutation	T	C	p.N253S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	102698872	102699008	102698984	102698984	Missense_Mutation	T	C	p.T252A
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	102698872	102699045	102698984	102698984	Missense_Mutation	T	C	p.T252A
KP2_PANCREAS	102718093	102718141	102718110	102718110	Missense_Mutation	C	T	p.E132K
NCIH524_LUNG	102732160	102732249	102732166	102732166	Missense_Mutation	A	T	p.V69E
MDAPCA2B_PROSTATE	102732160	102732249	102732200	102732200	Missense_Mutation	T	C	p.N58D
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	102732160	102732249	102732205	102732205	Missense_Mutation	C	T	p.R56H
LU134A_LUNG	102732160	102732249	102732248	102732248	Splice_Site	T	A	p.I42F

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MOK

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	BLCA	rs8022651	chr14:102692657	T/C	7.17e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	BLCA	rs80143347	chr14:102691959	T/C	1.05e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	BLCA	rs6575901	chr14:102691854	A/G	1.41e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	KIRP	rs8022651	chr14:102692657	T/C	9.41e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	LGG	rs8022651	chr14:102692657	T/C	8.10e-06
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	LGG	rs8022651	chr14:102692657	T/C	8.10e-06
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	LGG	rs6575901	chr14:102691854	A/G	3.39e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	LGG	rs6575901	chr14:102691854	A/G	3.39e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	KIRC	rs6575901	chr14:102691854	A/G	2.27e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	KIRC	rs8022651	chr14:102692657	T/C	1.08e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	LUAD	rs80143347	chr14:102691959	T/C	1.21e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	LUAD	rs8022651	chr14:102692657	T/C	1.95e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	PCPG	rs80143347	chr14:102691959	T/C	1.20e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	PAAD	rs8022651	chr14:102692657	T/C	2.53e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	PAAD	rs6575901	chr14:102691854	A/G	3.02e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	PAAD	rs78709784	chr14:102692487	G/A	6.91e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	PAAD	rs78709784	chr14:102692487	G/A	6.91e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	PRAD	rs78709784	chr14:102692487	G/A	2.07e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	SKCM	rs8022651	chr14:102692657	T/C	1.95e-06
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	SKCM	rs6575901	chr14:102691854	A/G	2.39e-06
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	THCA	rs8022651	chr14:102692657	T/C	5.82e-07
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	THCA	rs6575901	chr14:102691854	A/G	8.39e-05
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	THCA	rs6575901	chr14:102691854	A/G	5.18e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	THCA	rs6575901	chr14:102691854	A/G	5.44e-04
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	THCA	rs8022651	chr14:102692657	T/C	1.02e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	THCA	rs8022651	chr14:102692657	T/C	1.07e-03
exon_skip_116011	14	102690992:102691131:102691431:102692745:102698871:102698919	102691431:102692745	ENST00000559138.1	UCEC	rs8022651	chr14:102692657	T/C	5.67e-04
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENST00000524214.1,ENST00000524019.1	BLCA	rs56377169	chr14:102729881	A/G	6.14e-04
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENST00000524214.1,ENST00000524019.1	KIRC	rs56377169	chr14:102729881	A/G	3.28e-03
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENST00000524214.1,ENST00000524019.1	PCPG	rs56377169	chr14:102729881	A/G	7.82e-04
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENST00000524214.1,ENST00000524019.1	PRAD	rs34931752	chr14:102729886	G/A	2.97e-03
exon_skip_116078	14	102718297:102718332:102729882:102729953:102749814:102749929	102729882:102729953	ENST00000524214.1,ENST00000524019.1	THCA	rs56377169	chr14:102729881	A/G	3.16e-03
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000524207.1,ENST00000522874.1	BLCA	rs56377169	chr14:102729881	A/G	6.14e-04
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000524207.1,ENST00000522874.1	KIRC	rs56377169	chr14:102729881	A/G	3.28e-03
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000524207.1,ENST00000522874.1	PCPG	rs56377169	chr14:102729881	A/G	7.82e-04
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000524207.1,ENST00000522874.1	PRAD	rs34931752	chr14:102729886	G/A	2.97e-03
exon_skip_116074	14	102718253:102718332:102729882:102729953:102732159:102732249	102729882:102729953	ENST00000193029.6,ENST00000361847.2,ENST00000517537.1,ENST00000518686.1,ENST00000519569.1,ENST00000524207.1,ENST00000522874.1	THCA	rs56377169	chr14:102729881	A/G	3.16e-03
exon_skip_116038	14	102695956:102695988:102698043:102698158:102698871:102698919	102698043:102698158	ENST00000524120.1	BLCA	rs7152550	chr14:102698131	G/A	1.03e-03
exon_skip_116038	14	102695956:102695988:102698043:102698158:102698871:102698919	102698043:102698158	ENST00000524120.1	PCPG	rs7152550	chr14:102698131	G/A	7.82e-04
exon_skip_116042	14	102695914:102695994:102698043:102698158:102698871:102698903	102698043:102698158	ENST00000521766.1,ENST00000519477.1,ENST00000524214.1,ENST00000361847.2,ENST00000518686.1,ENST00000519569.1,ENST00000523485.1,ENST00000520252.1,ENST00000522874.1	BLCA	rs7152550	chr14:102698131	G/A	1.03e-03
exon_skip_116042	14	102695914:102695994:102698043:102698158:102698871:102698903	102698043:102698158	ENST00000521766.1,ENST00000519477.1,ENST00000524214.1,ENST00000361847.2,ENST00000518686.1,ENST00000519569.1,ENST00000523485.1,ENST00000520252.1,ENST00000522874.1	PCPG	rs7152550	chr14:102698131	G/A	7.82e-04

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MOK

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MOK

Top

RelatedDrugs for MOK

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for MOK

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MOK	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact