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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PRDM11 |
 Gene summary |
| Gene information | Gene symbol | PRDM11 | Gene ID | 56981 |
| Gene name | PR/SET domain 11 | |
| Synonyms | PFM8 | |
| Cytomap | 11p11.2 | |
| Type of gene | protein-coding | |
| Description | PR domain-containing protein 11PR-domain containing protein 11 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9NQV5 | |
| Context | PubMed: PRDM11 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for PRDM11 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PRDM11 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PRDM11 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_58561 | 11 | 45203427:45203436:45203796:45203900:45204411:45204674 | 45203796:45203900 | ENSG00000019485.8 | ENST00000530656.1,ENST00000534751.2,ENST00000526442.1,ENST00000424263.2,ENST00000263765.4 |
| exon_skip_58564 | 11 | 45226261:45226329:45230424:45230846:45234019:45236264 | 45230424:45230846 | ENSG00000019485.8 | ENST00000534751.2 |
| exon_skip_58568 | 11 | 45226261:45226329:45241120:45241308:45245767:45246459 | 45241120:45241308 | ENSG00000019485.8 | ENST00000530656.1,ENST00000424263.2,ENST00000263765.4 |
| exon_skip_58569 | 11 | 45226261:45226329:45241120:45241308:45247545:45247734 | 45241120:45241308 | ENSG00000019485.8 | ENST00000528980.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PRDM11 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_58564 | 11 | 45226261:45226329:45230424:45230846:45234019:45236264 | 45230424:45230846 | ENSG00000019485.8 | ENST00000534751.2 |
| exon_skip_58568 | 11 | 45226261:45226329:45241120:45241308:45245767:45246459 | 45241120:45241308 | ENSG00000019485.8 | ENST00000263765.4,ENST00000530656.1,ENST00000424263.2 |
| exon_skip_58569 | 11 | 45226261:45226329:45241120:45241308:45247545:45247734 | 45241120:45241308 | ENSG00000019485.8 | ENST00000528980.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PRDM11 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000530656 | 45203796 | 45203900 | Frame-shift |
| ENST00000530656 | 45241120 | 45241308 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000530656 | 45241120 | 45241308 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PRDM11 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PRDM11 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45203797 | 45203900 | 45203856 | 45203856 | Missense_Mutation | G | A | p.R94H |
| MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45203797 | 45203900 | 45203867 | 45203867 | Missense_Mutation | G | A | p.V98M |
| MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45241121 | 45241308 | 45241179 | 45241179 | Missense_Mutation | G | A | p.E239K |
| IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45241121 | 45241308 | 45241183 | 45241183 | Missense_Mutation | G | A | p.R240H |
| HDQP1_BREAST | 45241121 | 45241308 | 45241261 | 45241261 | Missense_Mutation | G | A | p.R266H |
| LK2_LUNG | 45241121 | 45241308 | 45241281 | 45241281 | Missense_Mutation | G | A | p.E273K |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45241121 | 45241308 | 45241294 | 45241294 | Missense_Mutation | G | A | p.R277H |
| MZ7MEL_SKIN | 45241121 | 45241308 | 45241278 | 45241278 | Nonsense_Mutation | C | T | p.Q272* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRDM11 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRDM11 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRDM11 |
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RelatedDrugs for PRDM11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRDM11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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