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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for PNO1 |
Gene summary |
Gene information | Gene symbol | PNO1 | Gene ID | 56902 |
Gene name | partner of NOB1 homolog | |
Synonyms | KHRBP1|RRP20 | |
Cytomap | 2p14 | |
Type of gene | protein-coding | |
Description | RNA-binding protein PNO1KH-type RNA-binding protein 1RNA binding protein | |
Modification date | 20180523 | |
UniProtAcc | Q9NRX1 | |
Context | PubMed: PNO1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for PNO1 from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PNO1 |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PNO1 |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_326110 | 2 | 68385511:68385661:68388346:68388494:68388814:68388898 | 68388346:68388494 | ENSG00000115946.3 | ENST00000430742.1 |
exon_skip_326111 | 2 | 68385511:68385661:68388814:68388898:68389396:68389405 | 68388814:68388898 | ENSG00000115946.3 | ENST00000263657.2 |
exon_skip_326113 | 2 | 68388814:68388898:68389396:68389457:68389677:68389795 | 68389396:68389457 | ENSG00000115946.3 | ENST00000263657.2 |
exon_skip_326115 | 2 | 68389677:68389795:68400478:68400549:68401866:68402096 | 68400478:68400549 | ENSG00000115946.3 | ENST00000263657.2 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PNO1 |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_326110 | 2 | 68385511:68385661:68388346:68388494:68388814:68388898 | 68388346:68388494 | ENSG00000115946.3 | ENST00000430742.1 |
exon_skip_326111 | 2 | 68385511:68385661:68388814:68388898:68389396:68389405 | 68388814:68388898 | ENSG00000115946.3 | ENST00000263657.2 |
exon_skip_326113 | 2 | 68388814:68388898:68389396:68389457:68389677:68389795 | 68389396:68389457 | ENSG00000115946.3 | ENST00000263657.2 |
exon_skip_326115 | 2 | 68389677:68389795:68400478:68400549:68401866:68402096 | 68400478:68400549 | ENSG00000115946.3 | ENST00000263657.2 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PNO1 |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000263657 | 68389396 | 68389457 | Frame-shift |
ENST00000263657 | 68400478 | 68400549 | Frame-shift |
ENST00000263657 | 68388814 | 68388898 | In-frame |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000263657 | 68389396 | 68389457 | Frame-shift |
ENST00000263657 | 68400478 | 68400549 | Frame-shift |
ENST00000263657 | 68388814 | 68388898 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PNO1 |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000263657 | 2303 | 252 | 68388814 | 68388898 | 449 | 532 | 119 | 147 |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000263657 | 2303 | 252 | 68388814 | 68388898 | 449 | 532 | 119 | 147 |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NRX1 | 119 | 147 | 1 | 252 | Chain | ID=PRO_0000270540;Note=RNA-binding protein PNO1 |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NRX1 | 119 | 147 | 1 | 252 | Chain | ID=PRO_0000270540;Note=RNA-binding protein PNO1 |
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SNVs in the skipped exons for PNO1 |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
PCPG | TCGA-QR-A6GT-01 | exon_skip_326115 | 68400479 | 68400549 | 68400518 | 68400518 | Frame_Shift_Del | G | - | p.M220fs |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
SW48_LARGE_INTESTINE | 68400479 | 68400549 | 68400487 | 68400487 | Missense_Mutation | A | G | p.H210R |
SCABER_URINARY_TRACT | 68400479 | 68400549 | 68400493 | 68400493 | Missense_Mutation | T | C | p.L212P |
PCI6A_UPPER_AERODIGESTIVE_TRACT | 68400479 | 68400549 | 68400523 | 68400523 | Missense_Mutation | G | A | p.R222K |
MFE319_ENDOMETRIUM | 68400479 | 68400549 | 68400540 | 68400540 | Missense_Mutation | C | A | p.L228I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PNO1 |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PNO1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PNO1 |
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RelatedDrugs for PNO1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PNO1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |