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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAPK13 |
 Gene summary |
| Gene information | Gene symbol | MAPK13 | Gene ID | 5603 |
| Gene name | mitogen-activated protein kinase 13 | |
| Synonyms | MAPK 13|MAPK-13|PRKM13|SAPK4|p38delta | |
| Cytomap | 6p21.31 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase 13MAP kinase 13MAP kinase p38 deltamitogen-activated protein kinase p38 deltastress-activated protein kinase 4 | |
| Modification date | 20180523 | |
| UniProtAcc | O15264 | |
| Context | PubMed: MAPK13 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAPK13 | GO:0006970 | response to osmotic stress | 9731215 |
| MAPK13 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| MAPK13 | GO:0034644 | cellular response to UV | 9218798 |
| MAPK13 | GO:0051403 | stress-activated MAPK cascade | 9218798 |
| MAPK13 | GO:0070301 | cellular response to hydrogen peroxide | 9218798 |
| MAPK13 | GO:0071347 | cellular response to interleukin-1 | 9218798 |
| MAPK13 | GO:0072709 | cellular response to sorbitol | 9218798 |
| MAPK13 | GO:0072740 | cellular response to anisomycin | 9218798 |
| MAPK13 | GO:1903936 | cellular response to sodium arsenite | 9218798 |
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Exon skipping events across known transcript of Ensembl for MAPK13 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPK13 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPK13 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_451097 | 6 | 36098439:36098478:36099047:36099177:36100397:36100456 | 36099047:36099177 | ENSG00000156711.12 | ENST00000373766.5,ENST00000476951.1,ENST00000211287.4,ENST00000373761.6,ENST00000373759.1 |
| exon_skip_451100 | 6 | 36099047:36099177:36100397:36100456:36103529:36103609 | 36100397:36100456 | ENSG00000156711.12 | ENST00000373766.5,ENST00000476951.1,ENST00000490334.1,ENST00000211287.4,ENST00000373761.6,ENST00000373759.1 |
| exon_skip_451103 | 6 | 36103529:36103638:36103795:36103825:36104260:36104292 | 36103795:36103825 | ENSG00000156711.12 | ENST00000373766.5,ENST00000490334.1,ENST00000211287.4,ENST00000373759.1 |
| exon_skip_451104 | 6 | 36103529:36103638:36104260:36104308:36104432:36104547 | 36104260:36104308 | ENSG00000156711.12 | ENST00000373761.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPK13 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_451097 | 6 | 36098439:36098478:36099047:36099177:36100397:36100456 | 36099047:36099177 | ENSG00000156711.12 | ENST00000476951.1,ENST00000211287.4,ENST00000373761.6,ENST00000373766.5,ENST00000373759.1 |
| exon_skip_451100 | 6 | 36099047:36099177:36100397:36100456:36103529:36103609 | 36100397:36100456 | ENSG00000156711.12 | ENST00000476951.1,ENST00000211287.4,ENST00000373761.6,ENST00000373766.5,ENST00000373759.1,ENST00000490334.1 |
| exon_skip_451103 | 6 | 36103529:36103638:36103795:36103825:36104260:36104292 | 36103795:36103825 | ENSG00000156711.12 | ENST00000211287.4,ENST00000373766.5,ENST00000373759.1,ENST00000490334.1 |
| exon_skip_451104 | 6 | 36103529:36103638:36104260:36104308:36104432:36104547 | 36104260:36104308 | ENSG00000156711.12 | ENST00000373761.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK13 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000211287 | 36099047 | 36099177 | Frame-shift |
| ENST00000211287 | 36100397 | 36100456 | Frame-shift |
| ENST00000211287 | 36103795 | 36103825 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000211287 | 36099047 | 36099177 | Frame-shift |
| ENST00000211287 | 36100397 | 36100456 | Frame-shift |
| ENST00000211287 | 36103795 | 36103825 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK13 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000211287 | 2069 | 365 | 36103795 | 36103825 | 680 | 709 | 139 | 149 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000211287 | 2069 | 365 | 36103795 | 36103825 | 680 | 709 | 139 | 149 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15264 | 139 | 149 | 1 | 365 | Chain | ID=PRO_0000186286;Note=Mitogen-activated protein kinase 13 |
| O15264 | 139 | 149 | 25 | 308 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15264 | 139 | 149 | 124 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNO |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15264 | 139 | 149 | 1 | 365 | Chain | ID=PRO_0000186286;Note=Mitogen-activated protein kinase 13 |
| O15264 | 139 | 149 | 25 | 308 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15264 | 139 | 149 | 124 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YNO |
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SNVs in the skipped exons for MAPK13 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MYM12_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36099048 | 36099177 | 36099143 | 36099144 | In_Frame_Ins | - | GCT | p.76_77insL |
| RCC10RGB_KIDNEY | 36099048 | 36099177 | 36099143 | 36099144 | In_Frame_Ins | - | GCT | p.76_77insL |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36099048 | 36099177 | 36099083 | 36099083 | Missense_Mutation | C | T | p.A52V |
| LNCAPCLONEFGC_PROSTATE | 36099048 | 36099177 | 36099169 | 36099169 | Missense_Mutation | C | A | p.H81N |
| SNU1040_LARGE_INTESTINE | 36100398 | 36100456 | 36100440 | 36100440 | Missense_Mutation | C | T | p.R98C |
| SNU1040_LARGE_INTESTINE | 36100398 | 36100456 | 36100440 | 36100441 | Missense_Mutation | CG | TA | p.R98Y |
| SNU1040_LARGE_INTESTINE | 36100398 | 36100456 | 36100441 | 36100441 | Missense_Mutation | G | A | p.R98H |
| NCIH1876_LUNG | 36099048 | 36099177 | 36099176 | 36099176 | Splice_Site | A | G | p.N83S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK13 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK13 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK13 |
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RelatedDrugs for MAPK13 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O15264 | DB12010 | Fostamatinib | Mitogen-activated protein kinase 13 | small molecule | approved|investigational |
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RelatedDiseases for MAPK13 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAPK13 | C0008370 | Cholestasis | 1 | CTD_human |
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