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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAPK11 |
 Gene summary |
| Gene information | Gene symbol | MAPK11 | Gene ID | 5600 |
| Gene name | mitogen-activated protein kinase 11 | |
| Synonyms | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta | |
| Cytomap | 22q13.33 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase 11MAP kinase 11MAP kinase p38 betamitogen-activated protein kinase p38 betamitogen-activated protein kinase p38-2stress-activated protein kinase-2stress-activated protein kinase-2b | |
| Modification date | 20180523 | |
| UniProtAcc | Q15759 | |
| Context | PubMed: MAPK11 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAPK11 | GO:0051403 | stress-activated MAPK cascade | 8663524 |
| MAPK11 | GO:0071347 | cellular response to interleukin-1 | 8663524 |
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Exon skipping events across known transcript of Ensembl for MAPK11 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPK11 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPK11 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_370557 | 22 | 50703749:50703923:50704010:50704089:50704654:50704734 | 50704010:50704089 | ENSG00000185386.10 | ENST00000395764.1,ENST00000330651.6,ENST00000417877.1 |
| exon_skip_370559 | 22 | 50705555:50705603:50705685:50705715:50705799:50705911 | 50705685:50705715 | ENSG00000185386.10 | ENST00000395764.1,ENST00000449719.2,ENST00000330651.6 |
| exon_skip_370560 | 22 | 50705799:50705911:50705997:50706056:50706248:50706314 | 50705997:50706056 | ENSG00000185386.10 | ENST00000395764.1,ENST00000330651.6,ENST00000417877.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPK11 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_370557 | 22 | 50703749:50703923:50704010:50704089:50704654:50704734 | 50704010:50704089 | ENSG00000185386.10 | ENST00000330651.6,ENST00000395764.1,ENST00000417877.1 |
| exon_skip_370558 | 22 | 50705555:50705603:50705681:50705715:50705799:50705911 | 50705681:50705715 | ENSG00000185386.10 | ENST00000417877.1 |
| exon_skip_370559 | 22 | 50705555:50705603:50705685:50705715:50705799:50705911 | 50705685:50705715 | ENSG00000185386.10 | ENST00000330651.6,ENST00000395764.1,ENST00000449719.2 |
| exon_skip_370560 | 22 | 50705799:50705911:50705997:50706056:50706248:50706314 | 50705997:50706056 | ENSG00000185386.10 | ENST00000330651.6,ENST00000395764.1,ENST00000417877.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK11 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000330651 | 50704010 | 50704089 | Frame-shift |
| ENST00000330651 | 50705997 | 50706056 | Frame-shift |
| ENST00000330651 | 50705685 | 50705715 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000330651 | 50704010 | 50704089 | Frame-shift |
| ENST00000330651 | 50705997 | 50706056 | Frame-shift |
| ENST00000330651 | 50705685 | 50705715 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK11 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000330651 | 2448 | 364 | 50705685 | 50705715 | 519 | 548 | 139 | 149 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000330651 | 2448 | 364 | 50705685 | 50705715 | 519 | 548 | 139 | 149 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MAPK11 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_370557 | 50704011 | 50704089 | 50704089 | 50704089 | Frame_Shift_Del | C | - | p.A255fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCT116_LARGE_INTESTINE | 50704011 | 50704089 | 50704060 | 50704060 | Frame_Shift_Del | G | - | p.P264fs |
| GP2D_LARGE_INTESTINE | 50704011 | 50704089 | 50704059 | 50704060 | Frame_Shift_Ins | - | G | p.M265fs |
| GP5D_LARGE_INTESTINE | 50704011 | 50704089 | 50704059 | 50704060 | Frame_Shift_Ins | - | G | p.M265fs |
| NCIH1155_LUNG | 50704011 | 50704089 | 50704057 | 50704057 | Missense_Mutation | C | T | p.M265I |
| SNU407_LARGE_INTESTINE | 50705998 | 50706056 | 50706002 | 50706002 | Missense_Mutation | C | T | p.E101K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK11 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK11 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK11 |
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RelatedDrugs for MAPK11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q15759 | DB08896 | Regorafenib | Mitogen-activated protein kinase 11 | small molecule | approved |
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RelatedDiseases for MAPK11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAPK11 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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