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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAPK8 |
 Gene summary |
| Gene information | Gene symbol | MAPK8 | Gene ID | 5599 |
| Gene name | mitogen-activated protein kinase 8 | |
| Synonyms | JNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c | |
| Cytomap | 10q11.22 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase 8JUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1mitogen-activated protein kinase 8 isoform JNK1 alpha1mitogen-activated protein kinase 8 isoform JNK1 beta2stress-activated protein kinase 1stress-activated | |
| Modification date | 20180527 | |
| UniProtAcc | P45983 | |
| Context | PubMed: MAPK8 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAPK8 | GO:0006468 | protein phosphorylation | 21856198 |
| MAPK8 | GO:0007254 | JNK cascade | 8654373 |
| MAPK8 | GO:0007258 | JUN phosphorylation | 14967141|21095239 |
| MAPK8 | GO:0009411 | response to UV | 14967141 |
| MAPK8 | GO:0018105 | peptidyl-serine phosphorylation | 15850461|20027304|21095239 |
| MAPK8 | GO:0018107 | peptidyl-threonine phosphorylation | 21095239 |
| MAPK8 | GO:0032091 | negative regulation of protein binding | 21095239 |
| MAPK8 | GO:0032880 | regulation of protein localization | 20027304 |
| MAPK8 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| MAPK8 | GO:0043066 | negative regulation of apoptotic process | 14967141|21095239 |
| MAPK8 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| MAPK8 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
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Exon skipping events across known transcript of Ensembl for MAPK8 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPK8 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPK8 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_41325 | 10 | 49516258:49516331:49533939:49534008:49609654:49609825 | 49533939:49534008 | ENSG00000107643.11 | ENST00000432379.1,ENST00000426557.1 |
| exon_skip_41328 | 10 | 49609654:49609825:49612894:49613024:49617921:49617980 | 49612894:49613024 | ENSG00000107643.11 | ENST00000432379.1,ENST00000374176.4,ENST00000374174.1,ENST00000395611.3,ENST00000374182.3,ENST00000476134.1,ENST00000360332.3,ENST00000374179.3,ENST00000374189.1,ENST00000426557.1 |
| exon_skip_41330 | 10 | 49617921:49617980:49618072:49618211:49628197:49628289 | 49618072:49618211 | ENSG00000107643.11 | ENST00000374176.4,ENST00000374174.1,ENST00000395611.3,ENST00000374182.3,ENST00000429041.1,ENST00000360332.3,ENST00000374179.3,ENST00000374189.1 |
| exon_skip_41331 | 10 | 49618072:49618211:49628197:49628363:49632556:49632628 | 49628197:49628363 | ENSG00000107643.11 | ENST00000374176.4,ENST00000374179.3 |
| exon_skip_41334 | 10 | 49635122:49635186:49639235:49639313:49642921:49642938 | 49639235:49639313 | ENSG00000107643.11 | ENST00000469110.1,ENST00000395611.3,ENST00000374182.3,ENST00000469879.2,ENST00000374179.3 |
| exon_skip_41335 | 10 | 49635122:49635186:49639235:49639313:49642926:49643173 | 49639235:49639313 | ENSG00000107643.11 | ENST00000374176.4,ENST00000360332.3,ENST00000374189.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPK8 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_41323 | 10 | 49514732:49514864:49609654:49609825:49617921:49617980 | 49609654:49609825 | ENSG00000107643.11 | ENST00000429041.1 |
| exon_skip_41325 | 10 | 49516258:49516331:49533939:49534008:49609654:49609825 | 49533939:49534008 | ENSG00000107643.11 | ENST00000432379.1,ENST00000426557.1 |
| exon_skip_41328 | 10 | 49609654:49609825:49612894:49613024:49617921:49617980 | 49612894:49613024 | ENSG00000107643.11 | ENST00000432379.1,ENST00000374189.1,ENST00000426557.1,ENST00000476134.1,ENST00000374182.3,ENST00000374179.3,ENST00000360332.3,ENST00000374176.4,ENST00000374174.1,ENST00000395611.3 |
| exon_skip_41330 | 10 | 49617921:49617980:49618072:49618211:49628197:49628289 | 49618072:49618211 | ENSG00000107643.11 | ENST00000429041.1,ENST00000374189.1,ENST00000374182.3,ENST00000374179.3,ENST00000360332.3,ENST00000374176.4,ENST00000374174.1,ENST00000395611.3 |
| exon_skip_41331 | 10 | 49618072:49618211:49628197:49628363:49632556:49632628 | 49628197:49628363 | ENSG00000107643.11 | ENST00000374179.3,ENST00000374176.4 |
| exon_skip_41334 | 10 | 49635122:49635186:49639235:49639313:49642921:49642938 | 49639235:49639313 | ENSG00000107643.11 | ENST00000374182.3,ENST00000374179.3,ENST00000395611.3,ENST00000469879.2,ENST00000469110.1 |
| exon_skip_41335 | 10 | 49635122:49635186:49639235:49639313:49642926:49643173 | 49639235:49639313 | ENSG00000107643.11 | ENST00000374189.1,ENST00000360332.3,ENST00000374176.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK8 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374189 | 49612894 | 49613024 | Frame-shift |
| ENST00000374189 | 49618072 | 49618211 | Frame-shift |
| ENST00000374189 | 49639235 | 49639313 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374189 | 49612894 | 49613024 | Frame-shift |
| ENST00000374189 | 49618072 | 49618211 | Frame-shift |
| ENST00000374189 | 49639235 | 49639313 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK8 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374189 | 5813 | 427 | 49639235 | 49639313 | 1242 | 1319 | 353 | 379 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374189 | 5813 | 427 | 49639235 | 49639313 | 1242 | 1319 | 353 | 379 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MAPK8 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_41328 | 49612895 | 49613024 | 49612978 | 49612978 | Frame_Shift_Del | G | - | p.R69fs |
| STAD | TCGA-BR-8368-01 | exon_skip_41328 | 49612895 | 49613024 | 49613018 | 49613019 | Frame_Shift_Ins | - | A | p.H82fs |
| STAD | TCGA-BR-8368-01 | exon_skip_41328 | 49612895 | 49613024 | 49613019 | 49613020 | Frame_Shift_Ins | - | A | p.H82fs |
| UCEC | TCGA-D1-A17Q-01 | exon_skip_41328 | 49612895 | 49613024 | 49612989 | 49612989 | Nonsense_Mutation | G | T | p.E73* |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_41334 exon_skip_41335 | 49639236 | 49639313 | 49639235 | 49639235 | Splice_Site | G | T | e10-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC6_ENDOMETRIUM | 49612895 | 49613024 | 49612977 | 49612977 | Missense_Mutation | C | T | p.R69W |
| CW2_LARGE_INTESTINE | 49612895 | 49613024 | 49613008 | 49613008 | Missense_Mutation | G | A | p.C79Y |
| NCIH596_LUNG | 49618073 | 49618211 | 49618096 | 49618096 | Missense_Mutation | A | G | p.D112G |
| RT4_URINARY_TRACT | 49618073 | 49618211 | 49618207 | 49618207 | Missense_Mutation | A | G | p.H149R |
| NCIH1581_LUNG | 49628198 | 49628363 | 49628216 | 49628216 | Missense_Mutation | A | G | p.I157V |
| NCIH2077_LUNG | 49628198 | 49628363 | 49628216 | 49628216 | Missense_Mutation | A | G | p.I157V |
| HEC251_ENDOMETRIUM | 49628198 | 49628363 | 49628310 | 49628310 | Missense_Mutation | C | A | p.T188N |
| OC316_OVARY | 49628198 | 49628363 | 49628346 | 49628346 | Missense_Mutation | T | C | p.M200T |
| OC314_OVARY | 49628198 | 49628363 | 49628346 | 49628346 | Missense_Mutation | T | C | p.M200T |
| NUGC3_STOMACH | 49628198 | 49628363 | 49628276 | 49628276 | Nonsense_Mutation | G | T | p.G177* |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 49612895 | 49613024 | 49612895 | 49612895 | Splice_Site | C | T | p.C41C |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 49612895 | 49613024 | 49612895 | 49612895 | Splice_Site | C | T | p.C41C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK8 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK8 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK8 |
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RelatedDrugs for MAPK8 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK8 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAPK8 | C0011570 | Mental Depression | 2 | PSYGENET |
| MAPK8 | C0011581 | Depressive disorder | 2 | PSYGENET |
| MAPK8 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| MAPK8 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| MAPK8 | C0020429 | Hyperalgesia | 1 | CTD_human |
| MAPK8 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| MAPK8 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| MAPK8 | C0036341 | Schizophrenia | 1 | PSYGENET |
| MAPK8 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| MAPK8 | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
| MAPK8 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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