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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAPK7 |
 Gene summary |
| Gene information | Gene symbol | MAPK7 | Gene ID | 5598 |
| Gene name | mitogen-activated protein kinase 7 | |
| Synonyms | BMK1|ERK4|ERK5|PRKM7 | |
| Cytomap | 17p11.2 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase 7BMK-1BMK1 kinaseERK-5MAP kinase 7MAPK 7big MAP kinase 1extracellular-signal-regulated kinase 5 | |
| Modification date | 20180523 | |
| UniProtAcc | Q13164 | |
| Context | PubMed: MAPK7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAPK7 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 18588859 |
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Exon skipping events across known transcript of Ensembl for MAPK7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPK7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPK7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_149836 | 17 | 19282208:19282445:19282905:19282918:19283094:19283258 | 19282905:19282918 | ENSG00000166484.15 | ENST00000581260.1 |
| exon_skip_149844 | 17 | 19283102:19283260:19283796:19283814:19283920:19283936 | 19283796:19283814 | ENSG00000166484.15 | ENST00000603493.1 |
| exon_skip_149845 | 17 | 19285093:19285779:19286125:19286259:19286390:19286652 | 19286125:19286259 | ENSG00000166484.15 | ENST00000299612.7,ENST00000490660.2,ENST00000395602.4,ENST00000395604.3,ENST00000308406.5,ENST00000570306.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPK7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_149836 | 17 | 19282208:19282445:19282905:19282918:19283094:19283258 | 19282905:19282918 | ENSG00000166484.15 | ENST00000581260.1 |
| exon_skip_149844 | 17 | 19283102:19283260:19283796:19283814:19283920:19283936 | 19283796:19283814 | ENSG00000166484.15 | ENST00000603493.1 |
| exon_skip_149845 | 17 | 19285093:19285779:19286125:19286259:19286390:19286652 | 19286125:19286259 | ENSG00000166484.15 | ENST00000308406.5,ENST00000299612.7,ENST00000395602.4,ENST00000395604.3,ENST00000570306.1,ENST00000490660.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308406 | 19286125 | 19286259 | Frame-shift |
| ENST00000395602 | 19286125 | 19286259 | Frame-shift |
| ENST00000395604 | 19286125 | 19286259 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308406 | 19286125 | 19286259 | Frame-shift |
| ENST00000395602 | 19286125 | 19286259 | Frame-shift |
| ENST00000395604 | 19286125 | 19286259 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MAPK7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MAPK7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_149845 | 19286126 | 19286259 | 19286141 | 19286141 | Frame_Shift_Del | C | - | p.P728fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IGROV1_OVARY | 19286126 | 19286259 | 19286134 | 19286134 | Frame_Shift_Del | C | - | p.D724fs |
| IM95_STOMACH | 19286126 | 19286259 | 19286129 | 19286129 | Missense_Mutation | G | A | p.E723K |
| CW2_LARGE_INTESTINE | 19286126 | 19286259 | 19286131 | 19286131 | Missense_Mutation | G | T | p.E723D |
| HCT15_LARGE_INTESTINE | 19286126 | 19286259 | 19286145 | 19286145 | Missense_Mutation | C | A | p.P728H |
| HRT18_LARGE_INTESTINE | 19286126 | 19286259 | 19286145 | 19286145 | Missense_Mutation | C | A | p.P728H |
| NCIBL128_MATCHED_NORMAL_TISSUE | 19286126 | 19286259 | 19286237 | 19286237 | Missense_Mutation | G | A | p.V759M |
| NCIH128_LUNG | 19286126 | 19286259 | 19286237 | 19286237 | Missense_Mutation | G | A | p.V759M |
| NCIH2795_PLEURA | 19286126 | 19286259 | 19286243 | 19286243 | Missense_Mutation | G | A | p.D761N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK7 |
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RelatedDrugs for MAPK7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q13164 | DB12010 | Fostamatinib | Mitogen-activated protein kinase 7 | small molecule | approved|investigational |
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RelatedDiseases for MAPK7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAPK7 | C0020429 | Hyperalgesia | 1 | CTD_human |
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