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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MAPK1

check button Gene summary
Gene informationGene symbol

MAPK1

Gene ID

5594

Gene namemitogen-activated protein kinase 1
SynonymsERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK
Cytomap

22q11.22

Type of geneprotein-coding
Descriptionmitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
Modification date20180529
UniProtAcc

P28482

ContextPubMed: MAPK1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
MAPK1

GO:0006468

protein phosphorylation

23184662

MAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

MAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

MAPK1

GO:0034198

cellular response to amino acid starvation

11096076

MAPK1

GO:0038127

ERBB signaling pathway

15133037

MAPK1

GO:0051403

stress-activated MAPK cascade

11096076

MAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

MAPK1

GO:0070849

response to epidermal growth factor

18794356


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Exon skipping events across known transcript of Ensembl for MAPK1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for MAPK1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for MAPK1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3677672222118272:22118529:22123483:22123609:22127161:2212727122123483:22123609ENSG00000100030.10ENST00000215832.6
exon_skip_3677702222127161:22127271:22142545:22142677:22142982:2214309722142545:22142677ENSG00000100030.10ENST00000398822.3,ENST00000215832.6
exon_skip_3677722222127161:22127271:22142982:22143097:22153300:2215341722142982:22143097ENSG00000100030.10ENST00000544786.1
exon_skip_3677732222142545:22142677:22142982:22143097:22153300:2215341722142982:22143097ENSG00000100030.10ENST00000398822.3,ENST00000215832.6
exon_skip_3677742222142982:22143097:22153300:22153417:22160138:2216032822153300:22153417ENSG00000100030.10ENST00000398822.3,ENST00000544786.1,ENST00000215832.6

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for MAPK1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3677672222118272:22118529:22123483:22123609:22127161:2212727122123483:22123609ENSG00000100030.10ENST00000215832.6
exon_skip_3677702222127161:22127271:22142545:22142677:22142982:2214309722142545:22142677ENSG00000100030.10ENST00000215832.6,ENST00000398822.3
exon_skip_3677722222127161:22127271:22142982:22143097:22153300:2215341722142982:22143097ENSG00000100030.10ENST00000544786.1
exon_skip_3677732222142545:22142677:22142982:22143097:22153300:2215341722142982:22143097ENSG00000100030.10ENST00000215832.6,ENST00000398822.3
exon_skip_3677742222142982:22143097:22153300:22153417:22160138:2216032822153300:22153417ENSG00000100030.10ENST00000215832.6,ENST00000398822.3,ENST00000544786.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MAPK1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000021583222123483221236095CDS-5UTR
ENST000002158322214298222143097Frame-shift
ENST000003988222214298222143097Frame-shift
ENST000002158322214254522142677In-frame
ENST000003988222214254522142677In-frame
ENST000002158322215330022153417In-frame
ENST000003988222215330022153417In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000021583222123483221236095CDS-5UTR
ENST000002158322214298222143097Frame-shift
ENST000003988222214298222143097Frame-shift
ENST000002158322214254522142677In-frame
ENST000003988222214254522142677In-frame
ENST000002158322215330022153417In-frame
ENST000003988222215330022153417In-frame

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Infer the effects of exon skipping event on protein functional features for MAPK1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000215832110393602215330022153417682798164203
ENST0000039882215043602215330022153417733849164203
ENST000002158321103936022142545221426779141045241285
ENST00000398822150436022142545221426779651096241285

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000215832110393602215330022153417682798164203
ENST0000039882215043602215330022153417733849164203
ENST000002158321103936022142545221426779141045241285
ENST00000398822150436022142545221426779651096241285

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P28482164203163165Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203163165Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203201203Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K4I
P28482164203201203Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K4I
P28482164203166166Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P28482164203166166Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P28482164203167167Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P28482164203167167Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P284821642032360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P284821642032360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P2848216420325313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P2848216420325313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P28482164203168170HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I5Z
P28482164203168170HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I5Z
P28482164203176178HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203176178HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203191193HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203191193HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203196200HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203196200HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203185185Modified residueNote=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482164203185185Modified residueNote=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482164203187187Modified residueNote=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO
P28482164203187187Modified residueNote=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO
P28482164203190190Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
P28482164203190190Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
P28482164203185187MotifNote=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482164203185187MotifNote=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482164203176179MutagenesisNote=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203176179MutagenesisNote=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203185185MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203185185MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203187187MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203187187MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203181185TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y9Q
P28482164203181185TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y9Q
P28482241285242285Alternative sequenceID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
P28482241285242285Alternative sequenceID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
P28482241285280282Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NHO
P28482241285280282Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NHO
P284822412852360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P284822412852360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482241285259277DNA binding.
P28482241285259277DNA binding.
P2848224128525313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P2848224128525313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P28482241285235244HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285235244HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285249253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285249253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285258265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285258265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285275278HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285275278HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285284293HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285284293HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285246246Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285246246Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285284284Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
P28482241285284284Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P28482164203163165Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203163165Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203201203Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K4I
P28482164203201203Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5K4I
P28482164203166166Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P28482164203166166Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P28482164203167167Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P28482164203167167Binding siteNote=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16139248,ECO:0000269|PubMed:16242327,ECO:0000269|PubMed:17194451,ECO:0000269|PubMed:17300186,ECO:0000269|PubMed:19827834,ECO:0
P284821642032360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P284821642032360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P2848216420325313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P2848216420325313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P28482164203168170HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I5Z
P28482164203168170HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3I5Z
P28482164203176178HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203176178HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203191193HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203191193HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203196200HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203196200HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482164203185185Modified residueNote=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482164203185185Modified residueNote=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482164203187187Modified residueNote=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO
P28482164203187187Modified residueNote=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO
P28482164203190190Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
P28482164203190190Modified residueNote=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19060905;Dbxref=PMID:19060905
P28482164203185187MotifNote=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482164203185187MotifNote=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482164203176179MutagenesisNote=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203176179MutagenesisNote=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203185185MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203185185MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203187187MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203187187MutagenesisNote=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18794356;Dbxref=PMID:18794356
P28482164203181185TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y9Q
P28482164203181185TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y9Q
P28482241285242285Alternative sequenceID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
P28482241285242285Alternative sequenceID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
P28482241285280282Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NHO
P28482241285280282Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5NHO
P284822412852360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P284822412852360ChainID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482241285259277DNA binding.
P28482241285259277DNA binding.
P2848224128525313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P2848224128525313DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P28482241285235244HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285235244HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285249253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285249253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285258265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285258265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285275278HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285275278HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285284293HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285284293HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4ZZN
P28482241285246246Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285246246Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18760948;Dbxref=PMID:18760948
P28482241285284284Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
P28482241285284284Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195


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SNVs in the skipped exons for MAPK1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
MAPK1_SKCM_exon_skip_367770_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_367773
exon_skip_367772
22142983221430972214298522142985Frame_Shift_DelA-p.L241fs
LIHCTCGA-DD-A39Y-01exon_skip_367774
22153301221534172215331822153318Frame_Shift_DelT-p.I198fs
UCECTCGA-AX-A05Z-01exon_skip_367767
22123484221236092212354322123543Nonsense_MutationCAp.E345*
SKCMTCGA-EE-A29V-06exon_skip_367770
22142546221426772214267822142678Splice_SiteCT.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
MAPK1_22127161_22127271_22142545_22142677_22142982_22143097_TCGA-EE-A29V-06Sample: TCGA-EE-A29V-06
Cancer type: SKCM
ESID: exon_skip_367770
Skipped exon start: 22142546
Skipped exon end: 22142677
Mutation start: 22142678
Mutation end: 22142678
Mutation type: Splice_Site
Reference seq: C
Mutation seq: T
AAchange: .
exon_skip_367770_SKCM_TCGA-EE-A29V-06.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
HEC59_ENDOMETRIUM22123484221236092212360322123603Missense_MutationCTp.A325T
SARC9371_BONE22142546221426772214256422142564Missense_MutationGAp.P280S
CW2_LARGE_INTESTINE22142983221430972214306722143067Missense_MutationCTp.V214I
MDAMB415_BREAST22142983221430972214307422143074Missense_MutationACp.I211M
SNU1040_LARGE_INTESTINE22153301221534172215335722153357Missense_MutationTCp.T185A
BICR6_UPPER_AERODIGESTIVE_TRACT22153301221534172215340922153409Missense_MutationGCp.D167E

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPK1


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RelatedDrugs for MAPK1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P28482DB01064IsoprenalineMitogen-activated protein kinase 1small moleculeapproved|investigational
P28482DB01169Arsenic trioxideMitogen-activated protein kinase 1small moleculeapproved|investigational

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RelatedDiseases for MAPK1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
MAPK1C0020429Hyperalgesia2CTD_human
MAPK1C0024121Lung Neoplasms2CTD_human
MAPK1C0236736Cocaine-Related Disorders2CTD_human
MAPK1C0005586Bipolar Disorder1PSYGENET
MAPK1C0007137Squamous cell carcinoma1CTD_human
MAPK1C0007786Brain Ischemia1CTD_human
MAPK1C0017639Gliosis1CTD_human
MAPK1C0018671Head and Neck Neoplasms1CTD_human
MAPK1C0020564Hypertrophy1CTD_human
MAPK1C0021361Female infertility1CTD_human
MAPK1C0022665Kidney Neoplasm1CTD_human
MAPK1C0027626Neoplasm Invasiveness1CTD_human
MAPK1C0027627Neoplasm Metastasis1CTD_human
MAPK1C0027746Nerve Degeneration1CTD_human
MAPK1C0036341Schizophrenia1PSYGENET
MAPK1C0036920Sezary Syndrome1CTD_human
MAPK1C0038356Stomach Neoplasms1CTD_human
MAPK1C0038587Substance Withdrawal Syndrome1CTD_human
MAPK1C0040997Trigeminal Neuralgia1CTD_human
MAPK1C0155862Streptococcal pneumonia1CTD_human
MAPK1C0178417Anhedonia1PSYGENET
MAPK1C0243026Sepsis1CTD_human
MAPK1C0878544Cardiomyopathies1CTD_human
MAPK1C0919267ovarian neoplasm1CTD_human
MAPK1C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
MAPK1C3495559Juvenile arthritis1CTD_human