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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PRKG2 |
 Gene summary |
| Gene information | Gene symbol | PRKG2 | Gene ID | 5593 |
| Gene name | protein kinase cGMP-dependent 2 | |
| Synonyms | PKG2|PRKGR2|cGK2|cGKII | |
| Cytomap | 4q21.21 | |
| Type of gene | protein-coding | |
| Description | cGMP-dependent protein kinase 2cGMP-dependent protein kinase IIprotein kinase, cGMP-dependent, type IItesticular tissue protein Li 99 | |
| Modification date | 20180519 | |
| UniProtAcc | Q13237 | |
| Context | PubMed: PRKG2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for PRKG2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PRKG2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PRKG2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_430376 | 4 | 82026966:82027089:82031601:82031765:82056308:82056450 | 82031601:82031765 | ENSG00000138669.5 | ENST00000395578.1,ENST00000545647.1,ENST00000509169.1,ENST00000264399.1,ENST00000509474.1,ENST00000418486.2 |
| exon_skip_430380 | 4 | 82095946:82096113:82125740:82126214:82136089:82136218 | 82125740:82126214 | ENSG00000138669.5 | ENST00000418486.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PRKG2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_430376 | 4 | 82026966:82027089:82031601:82031765:82056308:82056450 | 82031601:82031765 | ENSG00000138669.5 | ENST00000395578.1,ENST00000264399.1,ENST00000418486.2,ENST00000509169.1,ENST00000545647.1,ENST00000509474.1 |
| exon_skip_430380 | 4 | 82095946:82096113:82125740:82126214:82136089:82136218 | 82125740:82126214 | ENSG00000138669.5 | ENST00000418486.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PRKG2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000264399 | 82031601 | 82031765 | Frame-shift |
| ENST00000395578 | 82031601 | 82031765 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000264399 | 82031601 | 82031765 | Frame-shift |
| ENST00000395578 | 82031601 | 82031765 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PRKG2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PRKG2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| GBM | TCGA-28-6450-01 | exon_skip_430380 | 82125741 | 82126214 | 82125748 | 82125748 | Frame_Shift_Del | C | - | p.D152fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_430380 | 82125741 | 82126214 | 82125843 | 82125843 | Frame_Shift_Del | C | - | p.G120fs |
| BRCA | TCGA-AR-A1AV-01 | exon_skip_430380 | 82125741 | 82126214 | 82125820 | 82125820 | Nonsense_Mutation | C | A | p.E128* |
| SKCM | TCGA-EE-A2GC-06 | exon_skip_430380 | 82125741 | 82126214 | 82125919 | 82125919 | Nonsense_Mutation | G | A | p.Q95* |
| SKCM | TCGA-EE-A2GC-06 | exon_skip_430380 | 82125741 | 82126214 | 82125919 | 82125919 | Nonsense_Mutation | G | A | p.Q95X |
| LUAD | TCGA-50-6594-01 | exon_skip_430380 | 82125741 | 82126214 | 82125934 | 82125934 | Nonsense_Mutation | C | A | p.G90* |
| SKCM | TCGA-W3-AA1V-06 | exon_skip_430380 | 82125741 | 82126214 | 82125970 | 82125970 | Nonsense_Mutation | G | A | p.Q78* |
| ESCA | TCGA-L5-A8NF-01 | exon_skip_430380 | 82125741 | 82126214 | 82126024 | 82126024 | Nonsense_Mutation | T | A | p.K60* |
| ESCA | TCGA-L5-A8NF-01 | exon_skip_430380 | 82125741 | 82126214 | 82126024 | 82126024 | Nonsense_Mutation | T | A | p.K60X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 82125741 | 82126214 | 82125788 | 82125788 | Frame_Shift_Del | T | - | p.K138fs |
| 2313287_STOMACH | 82125741 | 82126214 | 82126093 | 82126094 | Frame_Shift_Ins | - | CT | p.L37fs |
| NCIH1568_LUNG | 82031602 | 82031765 | 82031606 | 82031606 | Missense_Mutation | C | A | p.G646C |
| JHUEM7_ENDOMETRIUM | 82031602 | 82031765 | 82031745 | 82031745 | Missense_Mutation | C | A | p.K599N |
| KM12_LARGE_INTESTINE | 82125741 | 82126214 | 82125754 | 82125754 | Missense_Mutation | T | C | p.R150G |
| KYSE220_OESOPHAGUS | 82125741 | 82126214 | 82125825 | 82125825 | Missense_Mutation | G | A | p.S126F |
| HCC95_LUNG | 82125741 | 82126214 | 82125838 | 82125838 | Missense_Mutation | T | G | p.K122Q |
| SNU1040_LARGE_INTESTINE | 82125741 | 82126214 | 82125882 | 82125882 | Missense_Mutation | C | T | p.R107Q |
| WIL2NS_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 82125741 | 82126214 | 82125931 | 82125931 | Missense_Mutation | C | T | p.G91R |
| SNU81_LARGE_INTESTINE | 82125741 | 82126214 | 82126006 | 82126006 | Missense_Mutation | C | T | p.A66T |
| MDAMB468_BREAST | 82125741 | 82126214 | 82126054 | 82126054 | Missense_Mutation | G | T | p.H50N |
| NCIH1793_LUNG | 82125741 | 82126214 | 82126062 | 82126062 | Missense_Mutation | C | A | p.R47L |
| MOLP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 82125741 | 82126214 | 82126097 | 82126097 | Missense_Mutation | T | G | p.R35S |
| NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 82125741 | 82126214 | 82126122 | 82126122 | Missense_Mutation | C | T | p.R27Q |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 82125741 | 82126214 | 82126126 | 82126126 | Missense_Mutation | G | T | p.L26M |
| DJM1_SKIN | 82125741 | 82126214 | 82125919 | 82125919 | Nonsense_Mutation | G | A | p.Q95* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRKG2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRKG2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRKG2 |
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RelatedDrugs for PRKG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q13237 | DB12010 | Fostamatinib | cGMP-dependent protein kinase 2 | small molecule | approved|investigational |
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RelatedDiseases for PRKG2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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