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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PKN2 |
 Gene summary |
| Gene information | Gene symbol | PKN2 | Gene ID | 5586 |
| Gene name | protein kinase N2 | |
| Synonyms | PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7 | |
| Cytomap | 1p22.2 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q16513 | |
| Context | PubMed: PKN2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PKN2 | GO:0006468 | protein phosphorylation | 17332740 |
| PKN2 | GO:0010631 | epithelial cell migration | 21754995 |
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Exon skipping events across known transcript of Ensembl for PKN2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PKN2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PKN2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_7702 | 1 | 89150255:89150311:89206670:89206971:89225904:89226059 | 89206670:89206971 | ENSG00000065243.14 | ENST00000370513.5,ENST00000370521.3 |
| exon_skip_7703 | 1 | 89225904:89226059:89236034:89236152:89237103:89237249 | 89236034:89236152 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370513.5,ENST00000370505.3,ENST00000370521.3 |
| exon_skip_7706 | 1 | 89236034:89236152:89237103:89237249:89237345:89237562 | 89237103:89237249 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370513.5,ENST00000370505.3,ENST00000370521.3 |
| exon_skip_7709 | 1 | 89237345:89237562:89250321:89250507:89251786:89251896 | 89250321:89250507 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370513.5,ENST00000370505.3,ENST00000370521.3 |
| exon_skip_7711 | 1 | 89251786:89251896:89270073:89270217:89270528:89270577 | 89270073:89270217 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1,ENST00000436111.1 |
| exon_skip_7712 | 1 | 89271179:89271354:89271573:89271700:89272995:89273126 | 89271573:89271700 | ENSG00000065243.14 | ENST00000370513.5,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1 |
| exon_skip_7714 | 1 | 89273366:89273458:89279239:89279416:89287623:89287686 | 89279239:89279416 | ENSG00000065243.14 | ENST00000370513.5,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1 |
| exon_skip_7715 | 1 | 89279239:89279416:89287623:89287686:89289992:89290069 | 89287623:89287686 | ENSG00000065243.14 | ENST00000370513.5,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1 |
| exon_skip_7716 | 1 | 89294163:89294306:89298426:89298534:89298759:89298840 | 89298426:89298534 | ENSG00000065243.14 | ENST00000370513.5,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PKN2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_7702 | 1 | 89150255:89150311:89206670:89206971:89225904:89226059 | 89206670:89206971 | ENSG00000065243.14 | ENST00000370521.3,ENST00000370513.5 |
| exon_skip_7703 | 1 | 89225904:89226059:89236034:89236152:89237103:89237249 | 89236034:89236152 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370521.3,ENST00000370505.3,ENST00000370513.5 |
| exon_skip_7706 | 1 | 89236034:89236152:89237103:89237249:89237345:89237562 | 89237103:89237249 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370521.3,ENST00000370505.3,ENST00000370513.5 |
| exon_skip_7709 | 1 | 89237345:89237562:89250321:89250507:89251786:89251896 | 89250321:89250507 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370521.3,ENST00000370505.3,ENST00000370513.5 |
| exon_skip_7711 | 1 | 89251786:89251896:89270073:89270217:89270528:89270577 | 89270073:89270217 | ENSG00000065243.14 | ENST00000316005.7,ENST00000370521.3,ENST00000370505.3,ENST00000436111.1,ENST00000544045.1 |
| exon_skip_7712 | 1 | 89271179:89271354:89271573:89271700:89272995:89273126 | 89271573:89271700 | ENSG00000065243.14 | ENST00000370521.3,ENST00000370505.3,ENST00000370513.5,ENST00000544045.1 |
| exon_skip_7714 | 1 | 89273366:89273458:89279239:89279416:89287623:89287686 | 89279239:89279416 | ENSG00000065243.14 | ENST00000370521.3,ENST00000370505.3,ENST00000370513.5,ENST00000544045.1 |
| exon_skip_7715 | 1 | 89279239:89279416:89287623:89287686:89289992:89290069 | 89287623:89287686 | ENSG00000065243.14 | ENST00000370521.3,ENST00000370505.3,ENST00000370513.5,ENST00000544045.1 |
| exon_skip_7716 | 1 | 89294163:89294306:89298426:89298534:89298759:89298840 | 89298426:89298534 | ENSG00000065243.14 | ENST00000370521.3,ENST00000370505.3,ENST00000370513.5,ENST00000544045.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PKN2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370521 | 89206670 | 89206971 | Frame-shift |
| ENST00000370521 | 89236034 | 89236152 | Frame-shift |
| ENST00000370521 | 89237103 | 89237249 | Frame-shift |
| ENST00000370521 | 89271573 | 89271700 | Frame-shift |
| ENST00000370521 | 89250321 | 89250507 | In-frame |
| ENST00000370521 | 89270073 | 89270217 | In-frame |
| ENST00000370521 | 89279239 | 89279416 | In-frame |
| ENST00000370521 | 89287623 | 89287686 | In-frame |
| ENST00000370521 | 89298426 | 89298534 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370521 | 89206670 | 89206971 | Frame-shift |
| ENST00000370521 | 89236034 | 89236152 | Frame-shift |
| ENST00000370521 | 89237103 | 89237249 | Frame-shift |
| ENST00000370521 | 89271573 | 89271700 | Frame-shift |
| ENST00000370521 | 89250321 | 89250507 | In-frame |
| ENST00000370521 | 89270073 | 89270217 | In-frame |
| ENST00000370521 | 89279239 | 89279416 | In-frame |
| ENST00000370521 | 89287623 | 89287686 | In-frame |
| ENST00000370521 | 89298426 | 89298534 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PKN2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370521 | 6138 | 984 | 89250321 | 89250507 | 1345 | 1530 | 328 | 390 |
| ENST00000370521 | 6138 | 984 | 89270073 | 89270217 | 1641 | 1784 | 427 | 475 |
| ENST00000370521 | 6138 | 984 | 89279239 | 89279416 | 2462 | 2638 | 701 | 759 |
| ENST00000370521 | 6138 | 984 | 89287623 | 89287686 | 2639 | 2701 | 760 | 780 |
| ENST00000370521 | 6138 | 984 | 89298426 | 89298534 | 2922 | 3029 | 854 | 890 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370521 | 6138 | 984 | 89250321 | 89250507 | 1345 | 1530 | 328 | 390 |
| ENST00000370521 | 6138 | 984 | 89270073 | 89270217 | 1641 | 1784 | 427 | 475 |
| ENST00000370521 | 6138 | 984 | 89279239 | 89279416 | 2462 | 2638 | 701 | 759 |
| ENST00000370521 | 6138 | 984 | 89287623 | 89287686 | 2639 | 2701 | 760 | 780 |
| ENST00000370521 | 6138 | 984 | 89298426 | 89298534 | 2922 | 3029 | 854 | 890 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16513 | 328 | 390 | 327 | 329 | Alternative sequence | ID=VSP_042182;Note=In isoform 5. LTG->MNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q16513 | 328 | 390 | 375 | 390 | Alternative sequence | ID=VSP_042183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q16513 | 328 | 390 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 328 | 390 | 330 | 463 | Domain | Note=C2 |
| Q16513 | 328 | 390 | 360 | 360 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID |
| Q16513 | 328 | 390 | 362 | 362 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q16513 | 328 | 390 | 382 | 463 | Region | Note=Necessary to rescue apical junction formation;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16513 | 427 | 475 | 428 | 475 | Alternative sequence | ID=VSP_042184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q16513 | 427 | 475 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 427 | 475 | 330 | 463 | Domain | Note=C2 |
| Q16513 | 427 | 475 | 382 | 463 | Region | Note=Necessary to rescue apical junction formation;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16513 | 701 | 759 | 723 | 729 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 732 | 738 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 701 | 759 | 657 | 916 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16513 | 701 | 759 | 699 | 714 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 745 | 749 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 756 | 774 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 700 | 701 | Site | Note=Cleavage%3B by caspase-3 |
| Q16513 | 760 | 780 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 760 | 780 | 657 | 916 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16513 | 760 | 780 | 756 | 774 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 760 | 780 | 775 | 777 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 854 | 890 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 854 | 890 | 657 | 916 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16513 | 854 | 890 | 862 | 871 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 854 | 890 | 882 | 891 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16513 | 328 | 390 | 327 | 329 | Alternative sequence | ID=VSP_042182;Note=In isoform 5. LTG->MNS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q16513 | 328 | 390 | 375 | 390 | Alternative sequence | ID=VSP_042183;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q16513 | 328 | 390 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 328 | 390 | 330 | 463 | Domain | Note=C2 |
| Q16513 | 328 | 390 | 360 | 360 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID |
| Q16513 | 328 | 390 | 362 | 362 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q16513 | 328 | 390 | 382 | 463 | Region | Note=Necessary to rescue apical junction formation;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16513 | 427 | 475 | 428 | 475 | Alternative sequence | ID=VSP_042184;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q16513 | 427 | 475 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 427 | 475 | 330 | 463 | Domain | Note=C2 |
| Q16513 | 427 | 475 | 382 | 463 | Region | Note=Necessary to rescue apical junction formation;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16513 | 701 | 759 | 723 | 729 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 732 | 738 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 701 | 759 | 657 | 916 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16513 | 701 | 759 | 699 | 714 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 745 | 749 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 756 | 774 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 701 | 759 | 700 | 701 | Site | Note=Cleavage%3B by caspase-3 |
| Q16513 | 760 | 780 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 760 | 780 | 657 | 916 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16513 | 760 | 780 | 756 | 774 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 760 | 780 | 775 | 777 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 854 | 890 | 1 | 984 | Chain | ID=PRO_0000055722;Note=Serine/threonine-protein kinase N2 |
| Q16513 | 854 | 890 | 657 | 916 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q16513 | 854 | 890 | 862 | 871 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
| Q16513 | 854 | 890 | 882 | 891 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRS |
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SNVs in the skipped exons for PKN2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_7702 | 89206671 | 89206971 | 89206692 | 89206692 | Frame_Shift_Del | T | - | p.F24fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7702 | 89206671 | 89206971 | 89206717 | 89206717 | Frame_Shift_Del | A | - | p.Q32fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_7702 | 89206671 | 89206971 | 89206717 | 89206717 | Frame_Shift_Del | A | - | p.Q32fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7702 | 89206671 | 89206971 | 89206728 | 89206728 | Frame_Shift_Del | T | - | p.D35fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7702 | 89206671 | 89206971 | 89206728 | 89206728 | Frame_Shift_Del | T | - | p.F36fs |
| COAD | TCGA-CK-5916-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.D75fs |
| STAD | TCGA-BR-4280-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.D75fs |
| STAD | TCGA-BR-4280-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.K76fs |
| STAD | TCGA-BR-4370-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.D75fs |
| STAD | TCGA-BR-A4QL-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.D75fs |
| STAD | TCGA-BR-A4QL-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.K76fs |
| STAD | TCGA-CG-5728-01 | exon_skip_7702 | 89206671 | 89206971 | 89206848 | 89206848 | Frame_Shift_Del | A | - | p.D75fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7702 | 89206671 | 89206971 | 89206893 | 89206893 | Frame_Shift_Del | A | - | p.K92fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7703 | 89236035 | 89236152 | 89236085 | 89236085 | Frame_Shift_Del | A | - | p.T185fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7703 | 89236035 | 89236152 | 89236085 | 89236085 | Frame_Shift_Del | A | - | p.T185fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7703 | 89236035 | 89236152 | 89236124 | 89236124 | Frame_Shift_Del | C | - | p.V198fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_7703 | 89236035 | 89236152 | 89236142 | 89236142 | Frame_Shift_Del | T | - | p.A204fs |
| UCEC | TCGA-AP-A0LP-01 | exon_skip_7706 | 89237104 | 89237249 | 89237219 | 89237219 | Frame_Shift_Del | A | - | p.G246fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7711 | 89270074 | 89270217 | 89270151 | 89270151 | Frame_Shift_Del | T | - | p.D453fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7711 | 89270074 | 89270217 | 89270163 | 89270163 | Frame_Shift_Del | C | - | p.N457fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_7711 | 89270074 | 89270217 | 89270187 | 89270187 | Frame_Shift_Del | T | - | p.Y465fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7714 | 89279240 | 89279416 | 89279305 | 89279305 | Frame_Shift_Del | T | - | p.L723fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7714 | 89279240 | 89279416 | 89279320 | 89279320 | Frame_Shift_Del | A | - | p.Q728fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7716 | 89298427 | 89298534 | 89298458 | 89298458 | Frame_Shift_Del | T | - | p.V865fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_7716 | 89298427 | 89298534 | 89298458 | 89298458 | Frame_Shift_Del | T | - | p.V865fs |
| UCEC | TCGA-D1-A176-01 | exon_skip_7702 | 89206671 | 89206971 | 89206802 | 89206803 | Frame_Shift_Ins | - | A | p.L60fs |
| PRAD | TCGA-CH-5750-01 | exon_skip_7702 | 89206671 | 89206971 | 89206847 | 89206848 | Frame_Shift_Ins | - | A | p.D75fs |
| PRAD | TCGA-CH-5750-01 | exon_skip_7702 | 89206671 | 89206971 | 89206847 | 89206848 | Frame_Shift_Ins | - | A | p.EK75fs |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_7703 | 89236035 | 89236152 | 89236101 | 89236101 | Nonsense_Mutation | C | T | p.R191* |
| STAD | TCGA-D7-6524-01 | exon_skip_7703 | 89236035 | 89236152 | 89236101 | 89236101 | Nonsense_Mutation | C | T | p.R191* |
| STAD | TCGA-D7-6524-01 | exon_skip_7703 | 89236035 | 89236152 | 89236101 | 89236101 | Nonsense_Mutation | C | T | p.R191X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CCK81_LARGE_INTESTINE | 89279240 | 89279416 | 89279292 | 89279292 | Frame_Shift_Del | T | - | p.F719fs |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89206671 | 89206971 | 89206683 | 89206683 | Missense_Mutation | A | G | p.S21G |
| KMBC2_URINARY_TRACT | 89206671 | 89206971 | 89206732 | 89206732 | Missense_Mutation | C | T | p.S37L |
| HSC3_UPPER_AERODIGESTIVE_TRACT | 89206671 | 89206971 | 89206741 | 89206741 | Missense_Mutation | T | G | p.M40R |
| MERO25_LUNG | 89206671 | 89206971 | 89206764 | 89206764 | Missense_Mutation | A | C | p.I48L |
| SNGM_ENDOMETRIUM | 89206671 | 89206971 | 89206840 | 89206840 | Missense_Mutation | C | T | p.T73I |
| SCLC22H_LUNG | 89206671 | 89206971 | 89206893 | 89206893 | Missense_Mutation | A | G | p.K91E |
| SCLC21H_LUNG | 89206671 | 89206971 | 89206893 | 89206893 | Missense_Mutation | A | G | p.K91E |
| LS180_LARGE_INTESTINE | 89206671 | 89206971 | 89206927 | 89206927 | Missense_Mutation | A | G | p.E102G |
| SNU620_STOMACH | 89236035 | 89236152 | 89236050 | 89236050 | Missense_Mutation | G | A | p.G174S |
| CW2_LARGE_INTESTINE | 89236035 | 89236152 | 89236150 | 89236150 | Missense_Mutation | A | G | p.N207S |
| SNU407_LARGE_INTESTINE | 89237104 | 89237249 | 89237122 | 89237122 | Missense_Mutation | C | A | p.P214H |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89237104 | 89237249 | 89237125 | 89237125 | Missense_Mutation | T | A | p.L215H |
| SH4_SKIN | 89237104 | 89237249 | 89237127 | 89237127 | Missense_Mutation | G | C | p.E216Q |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89237104 | 89237249 | 89237142 | 89237142 | Missense_Mutation | G | C | p.E221Q |
| EFE184_ENDOMETRIUM | 89237104 | 89237249 | 89237178 | 89237178 | Missense_Mutation | G | A | p.A233T |
| NCIH69_LUNG | 89250322 | 89250507 | 89250455 | 89250455 | Missense_Mutation | T | A | p.S373R |
| DETROIT562_UPPER_AERODIGESTIVE_TRACT | 89250322 | 89250507 | 89250461 | 89250461 | Missense_Mutation | T | A | p.S375R |
| NCIH2066_LUNG | 89250322 | 89250507 | 89250461 | 89250461 | Missense_Mutation | T | A | p.S375R |
| HCT116_LARGE_INTESTINE | 89270074 | 89270217 | 89270168 | 89270168 | Missense_Mutation | G | A | p.R459Q |
| COGN278_AUTONOMIC_GANGLIA | 89271574 | 89271700 | 89271618 | 89271618 | Missense_Mutation | C | G | p.P574R |
| NOS1_BONE | 89279240 | 89279416 | 89279375 | 89279375 | Missense_Mutation | G | A | p.M746I |
| MKN1_STOMACH | 89298427 | 89298534 | 89298496 | 89298496 | Missense_Mutation | A | G | p.R878G |
| SNU81_LARGE_INTESTINE | 89206671 | 89206971 | 89206812 | 89206812 | Nonsense_Mutation | G | T | p.E64* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PKN2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_7703 | 1 | 89225904:89226059:89236034:89236152:89237103:89237249 | 89236034:89236152 | ENST00000316005.7,ENST00000370513.5,ENST00000370505.3,ENST00000370521.3 | BRCA | rs7541301 | chr1:89236029 | T/A | 5.79e-04 |
| exon_skip_7703 | 1 | 89225904:89226059:89236034:89236152:89237103:89237249 | 89236034:89236152 | ENST00000316005.7,ENST00000370513.5,ENST00000370505.3,ENST00000370521.3 | BRCA | rs7541301 | chr1:89236029 | T/A | 5.80e-04 |
| exon_skip_7712 | 1 | 89271179:89271354:89271573:89271700:89272995:89273126 | 89271573:89271700 | ENST00000370513.5,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1 | BRCA | rs786906 | chr1:89271574 | T/C | 9.39e-04 |
| exon_skip_7712 | 1 | 89271179:89271354:89271573:89271700:89272995:89273126 | 89271573:89271700 | ENST00000370513.5,ENST00000370505.3,ENST00000370521.3,ENST00000544045.1 | BRCA | rs786906 | chr1:89271574 | T/C | 9.40e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PKN2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PKN2 |
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RelatedDrugs for PKN2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q16513 | DB12010 | Fostamatinib | Serine/threonine-protein kinase N2 | small molecule | approved|investigational |
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RelatedDiseases for PKN2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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