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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TEX2

check button Gene summary
Gene informationGene symbol

TEX2

Gene ID

55852

Gene nametestis expressed 2
SynonymsHT008|TMEM96
Cytomap

17q23.3

Type of geneprotein-coding
Descriptiontestis-expressed protein 2testis expressed sequence 2testis-expressed sequence 2 proteintransmembrane protein 96
Modification date20180523
UniProtAcc

Q8IWB9

ContextPubMed: TEX2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for TEX2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TEX2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TEX2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_2924041762232306:62232327:62238160:62238293:62248459:6224855962238160:62238293ENSG00000136478.3ENST00000258991.3,ENST00000583097.1,ENST00000584379.1
exon_skip_2924061762248459:62248559:62254684:62254831:62265527:6226577562254684:62254831ENSG00000136478.3ENST00000583501.1,ENST00000258991.3,ENST00000583097.1,ENST00000584379.1,ENST00000577489.1
exon_skip_2924071762254684:62254831:62265527:62265775:62270918:6227124962265527:62265775ENSG00000136478.3ENST00000583501.1,ENST00000583097.1,ENST00000584379.1
exon_skip_2924091762254684:62254831:62265527:62265796:62270918:6227124962265527:62265796ENSG00000136478.3ENST00000258991.3
exon_skip_2924101762272254:62272455:62289933:62291602:62340527:6234058762289933:62291602ENSG00000136478.3ENST00000584379.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TEX2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_2924041762232306:62232327:62238160:62238293:62248459:6224855962238160:62238293ENSG00000136478.3ENST00000258991.3,ENST00000583097.1,ENST00000584379.1
exon_skip_2924061762248459:62248559:62254684:62254831:62265527:6226577562254684:62254831ENSG00000136478.3ENST00000258991.3,ENST00000583097.1,ENST00000584379.1,ENST00000583501.1,ENST00000577489.1
exon_skip_2924071762254684:62254831:62265527:62265775:62270918:6227124962265527:62265775ENSG00000136478.3ENST00000583097.1,ENST00000584379.1,ENST00000583501.1
exon_skip_2924091762254684:62254831:62265527:62265796:62270918:6227124962265527:62265796ENSG00000136478.3ENST00000258991.3
exon_skip_2924101762272254:62272455:62289933:62291602:62340527:6234058762289933:62291602ENSG00000136478.3ENST00000584379.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TEX2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000058437962289933622916023UTR-3CDS
ENST000005830976223816062238293Frame-shift
ENST000005843796223816062238293Frame-shift
ENST000005830976226552762265775Frame-shift
ENST000005843796226552762265775Frame-shift
ENST000005830976225468462254831In-frame
ENST000005843796225468462254831In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000058437962289933622916023UTR-3CDS
ENST000005830976223816062238293Frame-shift
ENST000005843796223816062238293Frame-shift
ENST000005830976226552762265775Frame-shift
ENST000005843796226552762265775Frame-shift
ENST000005830976225468462254831In-frame
ENST000005843796225468462254831In-frame

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Infer the effects of exon skipping event on protein functional features for TEX2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000058309748691127622546846225483125982744808857
ENST0000058437948421127622546846225483125842730808857

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000058309748691127622546846225483125982744808857
ENST0000058437948421127622546846225483125842730808857

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8IWB980885711127ChainID=PRO_0000244479;Note=Testis-expressed protein 2
Q8IWB980885711127ChainID=PRO_0000244479;Note=Testis-expressed protein 2
Q8IWB9808857816821Compositional biasNote=Poly-Glu
Q8IWB9808857816821Compositional biasNote=Poly-Glu
Q8IWB98088578161101DomainNote=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
Q8IWB98088578161101DomainNote=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
Q8IWB9808857815815Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPJ0
Q8IWB9808857815815Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPJ0
Q8IWB9808857835835Sequence conflictNote=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8IWB9808857835835Sequence conflictNote=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8IWB980885711127ChainID=PRO_0000244479;Note=Testis-expressed protein 2
Q8IWB980885711127ChainID=PRO_0000244479;Note=Testis-expressed protein 2
Q8IWB9808857816821Compositional biasNote=Poly-Glu
Q8IWB9808857816821Compositional biasNote=Poly-Glu
Q8IWB98088578161101DomainNote=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
Q8IWB98088578161101DomainNote=SMP-LTD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01194
Q8IWB9808857815815Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPJ0
Q8IWB9808857815815Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6ZPJ0
Q8IWB9808857835835Sequence conflictNote=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8IWB9808857835835Sequence conflictNote=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305


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SNVs in the skipped exons for TEX2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_292404
62238161622382936223818962238189Frame_Shift_DelG-p.L933fs
LIHCTCGA-G3-A3CJ-01exon_skip_292404
62238161622382936223827362238273Frame_Shift_DelT-p.M905fs
LIHCTCGA-DD-A1EG-01exon_skip_292406
62254685622548316225469062254690Frame_Shift_DelT-p.I863fs
STADTCGA-BR-6852-01exon_skip_292407
62265528622657756226556662265566Frame_Shift_DelG-p.L803fs
STADTCGA-BR-6852-01exon_skip_292409
62265528622657966226556662265566Frame_Shift_DelG-p.L803fs
UCECTCGA-BS-A0TJ-01exon_skip_292407
62265528622657756226556662265566Frame_Shift_DelG-p.L803fs
UCECTCGA-BS-A0TJ-01exon_skip_292409
62265528622657966226556662265566Frame_Shift_DelG-p.L803fs
LIHCTCGA-DD-A39Y-01exon_skip_292410
62289934622916026229064762290647Frame_Shift_DelC-p.E312fs
LIHCTCGA-DD-A39Y-01exon_skip_292410
62289934622916026229097262290972Frame_Shift_DelT-p.K202fs
LIHCTCGA-DD-A1EG-01exon_skip_292410
62289934622916026229126762291267Frame_Shift_DelG-p.P104fs
LIHCTCGA-DD-A39Y-01exon_skip_292410
62289934622916026229126762291267Frame_Shift_DelG-p.P104fs
LIHCTCGA-DD-A1EG-01exon_skip_292410
62289934622916026229140162291401Frame_Shift_DelC-p.G59fs
COADTCGA-CM-4744-01exon_skip_292404
62238161622382936223825862238259Frame_Shift_Ins-Cp.S910fs
STADTCGA-BR-8591-01exon_skip_292407
62265528622657756226557762265578Frame_Shift_Ins-Gp.Q799fs
STADTCGA-BR-8591-01exon_skip_292409
62265528622657966226557762265578Frame_Shift_Ins-Gp.Q799fs
STADTCGA-BR-8591-01exon_skip_292407
62265528622657756226557862265579Frame_Shift_Ins-Gp.Q799fs
STADTCGA-BR-8591-01exon_skip_292409
62265528622657966226557862265579Frame_Shift_Ins-Gp.Q799fs
LUADTCGA-86-8358-01exon_skip_292410
62289934622916026229028062290281Frame_Shift_Ins-Cp.E433fs
LIHCTCGA-BC-A112-01exon_skip_292410
62289934622916026229131962291320Frame_Shift_Ins-Gp.P87fs
UCECTCGA-B5-A0JY-01exon_skip_292404
62238161622382936223817762238177Nonsense_MutationCAp.E937*
BLCATCGA-XF-AAMZ-01exon_skip_292410
62289934622916026229056362290563Nonsense_MutationCAp.E339*
LUSCTCGA-66-2789-01exon_skip_292410
62289934622916026229061062290610Nonsense_MutationGCp.S323*
COADTCGA-G4-6588-01exon_skip_292406
62254685622548316225468362254683Splice_SiteAG.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SISO_CERVIX62289934622916026229028162290281Frame_Shift_DelC-p.E433fs
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229028162290281Frame_Shift_DelC-p.E433fs
CW2_LARGE_INTESTINE62289934622916026229074462290744Frame_Shift_DelA-p.F278fs
HMEL_BREAST62289934622916026229141562291416Frame_Shift_DelAC-p.Y55fs
HEC265_ENDOMETRIUM62289934622916026229122762291228Frame_Shift_Ins-Ap.L117fs
HEC108_ENDOMETRIUM62289934622916026229107462291076In_Frame_DelAGA-p.S168del
NCIH1694_LUNG62254685622548316225480862254808Missense_MutationCGp.E816D
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62254685622548316225482062254821Missense_MutationAAGGp.V812A
HEC6_ENDOMETRIUM62265528622657966226555662265556Missense_MutationGAp.A799V
HEC6_ENDOMETRIUM62265528622657756226555662265556Missense_MutationGAp.A799V
MEWO_SKIN62265528622657966226558062265580Missense_MutationGAp.P791L
MEWO_SKIN62265528622657756226558062265580Missense_MutationGAp.P791L
NCIBL1395_MATCHED_NORMAL_TISSUE62265528622657966226561162265611Missense_MutationCAp.G781C
NCIBL1395_MATCHED_NORMAL_TISSUE62265528622657756226561162265611Missense_MutationCAp.G781C
NCIH1395_LUNG62265528622657966226561162265611Missense_MutationCAp.G781C
NCIH1395_LUNG62265528622657756226561162265611Missense_MutationCAp.G781C
M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62265528622657966226564662265646Missense_MutationCGp.R769P
M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62265528622657756226564662265646Missense_MutationCGp.R769P
AN3CA_ENDOMETRIUM62265528622657966226568562265685Missense_MutationAGp.M756T
AN3CA_ENDOMETRIUM62265528622657756226568562265685Missense_MutationAGp.M756T
SNU1077_ENDOMETRIUM62265528622657966226569262265692Missense_MutationCGp.E754Q
SNU1077_ENDOMETRIUM62265528622657756226569262265692Missense_MutationCGp.E754Q
NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026228998162289981Missense_MutationGTp.H533N
FADU_UPPER_AERODIGESTIVE_TRACT62289934622916026229001362290013Missense_MutationTCp.H522R
CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229001462290014Missense_MutationGAp.H522Y
TGBC11TKB_STOMACH62289934622916026229001662290016Missense_MutationGAp.A521V
MDAMB453_BREAST62289934622916026229015462290154Missense_MutationGAp.T475M
HEC108_ENDOMETRIUM62289934622916026229021262290212Missense_MutationGTp.L456I
HEC6_ENDOMETRIUM62289934622916026229025062290250Missense_MutationGAp.P443L
P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229028062290280Missense_MutationTCp.E433G
NCIH510_LUNG62289934622916026229028362290283Missense_MutationCAp.G432V
GP5D_LARGE_INTESTINE62289934622916026229029262290292Missense_MutationTAp.E429V
NCIH2286_LUNG62289934622916026229037762290377Missense_MutationCAp.V401F
KNS60_CENTRAL_NERVOUS_SYSTEM62289934622916026229046762290467Missense_MutationTGp.K371Q
NCIH1623_LUNG62289934622916026229047862290478Missense_MutationCGp.S367T
HS706T_BONE62289934622916026229063862290638Missense_MutationCTp.G314S
MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229070062290700Missense_MutationCTp.R293H
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229075462290754Missense_MutationCTp.R275H
SNU899_UPPER_AERODIGESTIVE_TRACT62289934622916026229079162290791Missense_MutationCAp.A263S
KMH2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229081262290812Missense_MutationTCp.T256A
SARC9371_BONE62289934622916026229082162290821Missense_MutationGAp.P253S
SNUC5_LARGE_INTESTINE62289934622916026229089962290899Missense_MutationGAp.R227W
BICR56_UPPER_AERODIGESTIVE_TRACT62289934622916026229093962290939Missense_MutationCGp.L213F
SKUT1_SOFT_TISSUE62289934622916026229095662290956Missense_MutationCTp.A208T
LNCAPCLONEFGC_PROSTATE62289934622916026229098262290982Missense_MutationAGp.V199A
OC316_OVARY62289934622916026229113962291139Missense_MutationATp.S147T
OC314_OVARY62289934622916026229113962291139Missense_MutationATp.S147T
HS281T_FIBROBLAST62289934622916026229115662291156Missense_MutationGAp.S141L
HCC2998_LARGE_INTESTINE62289934622916026229115662291156Missense_MutationGAp.S141L
SARC9371_BONE62289934622916026229115962291159Missense_MutationGAp.S140L
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229118762291187Missense_MutationGAp.P131S
KPNYS_AUTONOMIC_GANGLIA62289934622916026229124862291249Missense_MutationGGAAp.S110F
DMS53_LUNG62289934622916026229129462291295Missense_MutationGCCTp.A95R
GDM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE62289934622916026229130662291306Missense_MutationGAp.S91L
T98G_CENTRAL_NERVOUS_SYSTEM62289934622916026229132262291322Missense_MutationCTp.A86T
HEC151_ENDOMETRIUM62289934622916026229147562291475Missense_MutationCTp.A35T
NCIH2731_PLEURA62289934622916026229147562291475Missense_MutationCTp.A35T
HEC108_ENDOMETRIUM62289934622916026229154062291540Missense_MutationGAp.T13I
SNU1040_LARGE_INTESTINE62289934622916026229070462290704Nonsense_MutationGAp.R292*
VMRCRCW_KIDNEY62254685622548316225468662254686Splice_SiteTAp.K857M

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TEX2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEX2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEX2


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RelatedDrugs for TEX2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEX2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource