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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for SMPD4

check button Gene summary
Gene informationGene symbol

SMPD4

Gene ID

55627

Gene namesphingomyelin phosphodiesterase 4
SynonymsNET13|NSMASE-3|NSMASE3|SKNY
Cytomap

2q21.1

Type of geneprotein-coding
Descriptionsphingomyelin phosphodiesterase 4neutral sphingomyelinase 3neutral sphingomyelinase IIIsphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Modification date20180519
UniProtAcc

Q9NXE4

ContextPubMed: SMPD4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SMPD4

GO:0006685

sphingomyelin catabolic process

16517606

SMPD4

GO:0046475

glycerophospholipid catabolic process

16517606

SMPD4

GO:0046513

ceramide biosynthetic process

16517606

SMPD4

GO:0071356

cellular response to tumor necrosis factor

16517606


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Exon skipping events across known transcript of Ensembl for SMPD4 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for SMPD4

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for SMPD4

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3434442130910318:130910457:130910615:130910744:130910891:130911023130910615:130910744ENSG00000136699.15ENST00000453750.1,ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000452225.2,ENST00000339679.7,ENST00000491128.1,ENST00000454468.1,ENST00000443958.2,ENST00000431183.2,ENST00000482171.1,ENST00000426662.2,ENST00000409031.1,ENST00000433118.1
exon_skip_3434482130910682:130910744:130910891:130911023:130911274:130911508130910891:130911023ENSG00000136699.15ENST00000453750.1,ENST00000491319.2,ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000452225.2,ENST00000339679.7,ENST00000491128.1,ENST00000454468.1,ENST00000443958.2,ENST00000431183.2,ENST00000482171.1,ENST00000426662.2,ENST00000409031.1,ENS
exon_skip_3434542130912668:130912832:130913607:130913708:130914157:130914199130913607:130913708ENSG00000136699.15ENST00000453750.1,ENST00000457039.2,ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000452225.2,ENST00000339679.7,ENST00000454468.1,ENST00000443958.2,ENST00000435455.1,ENST00000431183.2,ENST00000426662.2,ENST00000409031.1,ENST00000433118.1
exon_skip_3434572130912668:130912832:130913625:130913708:130914157:130914199130913625:130913708ENSG00000136699.15ENST00000451542.1
exon_skip_3434592130913625:130913708:130914157:130914248:130921946:130922018130914157:130914248ENSG00000136699.15ENST00000473720.1,ENST00000426662.2
exon_skip_3434622130914157:130914248:130914823:130914969:130921946:130922018130914823:130914969ENSG00000136699.15ENST00000453750.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000443958.2,ENST00000451542.1,ENST00000431183.2
exon_skip_3434672130914933:130914969:130915756:130915838:130918758:130918845130915756:130915838ENSG00000136699.15ENST00000452225.2
exon_skip_3434722130914933:130914969:130917085:130917207:130918758:130918845130917085:130917207ENSG00000136699.15ENST00000433118.1
exon_skip_3434772130914933:130914969:130918758:130918845:130921946:130922018130918758:130918845ENSG00000136699.15ENST00000439886.1,ENST00000454468.1,ENST00000439029.1,ENST00000409031.1
exon_skip_3434792130914933:130914969:130921946:130922018:130925030:130925163130921946:130922018ENSG00000136699.15ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000443958.2,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2
exon_skip_3434822130915756:130915838:130918758:130918845:130921946:130922018130918758:130918845ENSG00000136699.15ENST00000452225.2
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENSG00000136699.15ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENSG00000136699.15ENST00000439029.1,ENST00000433118.1
exon_skip_3434952130925049:130925163:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000439029.1,ENST00000433118.1
exon_skip_3435002130930406:130930468:130930851:130930927:130931086:130931177130930851:130930927ENSG00000136699.15ENST00000351288.6,ENST00000412570.1,ENST00000441135.1,ENST00000409031.1
exon_skip_3435082130930406:130930468:130931086:130931229:130932486:130932573130931086:130931229ENSG00000136699.15ENST00000339679.7
exon_skip_3435102130930406:130930468:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000431183.2
exon_skip_3435152130930851:130930927:130931086:130931177:130932486:130932573130931086:130931177ENSG00000136699.15ENST00000412570.1
exon_skip_3435182130930851:130930927:130931086:130931229:130932486:130932573130931086:130931229ENSG00000136699.15ENST00000351288.6,ENST00000441135.1,ENST00000409031.1
exon_skip_3435192130931086:130931229:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000351288.6,ENST00000339679.7,ENST00000441135.1,ENST00000409031.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for SMPD4

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3434442130910318:130910457:130910615:130910744:130910891:130911023130910615:130910744ENSG00000136699.15ENST00000454468.1,ENST00000412570.1,ENST00000433118.1,ENST00000351288.6,ENST00000491128.1,ENST00000482171.1,ENST00000439886.1,ENST00000409031.1,ENST00000431183.2,ENST00000453750.1,ENST00000443958.2,ENST00000339679.7,ENST00000452225.2,ENST00000426662.2
exon_skip_3434482130910682:130910744:130910891:130911023:130911274:130911508130910891:130911023ENSG00000136699.15ENST00000454468.1,ENST00000412570.1,ENST00000433118.1,ENST00000351288.6,ENST00000491128.1,ENST00000482171.1,ENST00000439886.1,ENST00000409031.1,ENST00000431183.2,ENST00000453750.1,ENST00000443958.2,ENST00000339679.7,ENST00000452225.2,ENST00000426662.2,ENS
exon_skip_3434542130912668:130912832:130913607:130913708:130914157:130914199130913607:130913708ENSG00000136699.15ENST00000454468.1,ENST00000412570.1,ENST00000433118.1,ENST00000351288.6,ENST00000439886.1,ENST00000409031.1,ENST00000431183.2,ENST00000453750.1,ENST00000443958.2,ENST00000339679.7,ENST00000452225.2,ENST00000426662.2,ENST00000457039.2,ENST00000435455.1
exon_skip_3434572130912668:130912832:130913625:130913708:130914157:130914199130913625:130913708ENSG00000136699.15ENST00000451542.1
exon_skip_3434592130913625:130913708:130914157:130914248:130921946:130922018130914157:130914248ENSG00000136699.15ENST00000426662.2,ENST00000473720.1
exon_skip_3434612130914157:130914199:130914823:130914969:130921946:130922018130914823:130914969ENSG00000136699.15ENST00000435455.1
exon_skip_3434622130914157:130914248:130914823:130914969:130921946:130922018130914823:130914969ENSG00000136699.15ENST00000412570.1,ENST00000351288.6,ENST00000431183.2,ENST00000453750.1,ENST00000443958.2,ENST00000339679.7,ENST00000451542.1
exon_skip_3434672130914933:130914969:130915756:130915838:130918758:130918845130915756:130915838ENSG00000136699.15ENST00000452225.2
exon_skip_3434722130914933:130914969:130917085:130917207:130918758:130918845130917085:130917207ENSG00000136699.15ENST00000433118.1
exon_skip_3434772130914933:130914969:130918758:130918845:130921946:130922018130918758:130918845ENSG00000136699.15ENST00000454468.1,ENST00000439886.1,ENST00000409031.1,ENST00000439029.1
exon_skip_3434792130914933:130914969:130921946:130922018:130925030:130925163130921946:130922018ENSG00000136699.15ENST00000412570.1,ENST00000351288.6,ENST00000431183.2,ENST00000443958.2,ENST00000339679.7,ENST00000451542.1,ENST00000435455.1
exon_skip_3434822130915756:130915838:130918758:130918845:130921946:130922018130918758:130918845ENSG00000136699.15ENST00000452225.2
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENSG00000136699.15ENST00000454468.1,ENST00000412570.1,ENST00000351288.6,ENST00000439886.1,ENST00000409031.1,ENST00000431183.2,ENST00000339679.7,ENST00000430682.1,ENST00000451542.1,ENST00000435455.1
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENSG00000136699.15ENST00000433118.1,ENST00000439029.1
exon_skip_3434852130921946:130922018:130925030:130925163:130934126:130934210130925030:130925163ENSG00000136699.15ENST00000443958.2,ENST00000452225.2,ENST00000426662.2,ENST00000473720.1
exon_skip_3434892130921946:130922018:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000453750.1
exon_skip_3434952130925049:130925163:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000433118.1,ENST00000439029.1
exon_skip_3435002130930406:130930468:130930851:130930927:130931086:130931177130930851:130930927ENSG00000136699.15ENST00000412570.1,ENST00000351288.6,ENST00000409031.1,ENST00000441135.1
exon_skip_3435012130930406:130930468:130930851:130930927:130932486:130932573130930851:130930927ENSG00000136699.15ENST00000454468.1
exon_skip_3435082130930406:130930468:130931086:130931229:130932486:130932573130931086:130931229ENSG00000136699.15ENST00000339679.7
exon_skip_3435102130930406:130930468:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000431183.2
exon_skip_3435152130930851:130930927:130931086:130931177:130932486:130932573130931086:130931177ENSG00000136699.15ENST00000412570.1
exon_skip_3435182130930851:130930927:130931086:130931229:130932486:130932573130931086:130931229ENSG00000136699.15ENST00000351288.6,ENST00000409031.1,ENST00000441135.1
exon_skip_3435192130931086:130931229:130932486:130932573:130934126:130934210130932486:130932573ENSG00000136699.15ENST00000351288.6,ENST00000409031.1,ENST00000339679.7,ENST00000441135.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for SMPD4

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000409031130913607130913708Frame-shift
ENST00000409031130925030130925163Frame-shift
ENST00000409031130930851130930927Frame-shift
ENST00000409031130931086130931229Frame-shift
ENST00000409031130910615130910744In-frame
ENST00000409031130910891130911023In-frame
ENST00000409031130918758130918845In-frame
ENST00000409031130932486130932573In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000409031130913607130913708Frame-shift
ENST00000409031130925030130925163Frame-shift
ENST00000409031130930851130930927Frame-shift
ENST00000409031130931086130931229Frame-shift
ENST00000409031130910615130910744In-frame
ENST00000409031130910891130911023In-frame
ENST00000409031130918758130918845In-frame
ENST00000409031130932486130932573In-frame

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Infer the effects of exon skipping event on protein functional features for SMPD4

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000004090314913866130932486130932573130613925281
ENST00000409031491386613091875813091884521312217327356
ENST00000409031491386613091089113091102331603291670714
ENST00000409031491386613091061513091074432923420714757

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000004090314913866130932486130932573130613925281
ENST00000409031491386613091875813091884521312217327356
ENST00000409031491386613091089113091102331603291670714
ENST00000409031491386613091061513091074432923420714757

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for SMPD4

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_343444
130910616130910744130910702130910702Frame_Shift_DelC-p.D729fs
LIHCTCGA-DD-A3A0-01exon_skip_343444
130910616130910744130910702130910702Frame_Shift_DelC-p.D729fs
LIHCTCGA-DD-A39Y-01exon_skip_343448
130910892130911023130910956130910956Frame_Shift_DelT-p.K693fs
LIHCTCGA-DD-A3A0-01exon_skip_343448
130910892130911023130910956130910956Frame_Shift_DelT-p.K693fs
LIHCTCGA-G3-A3CJ-01exon_skip_343448
130910892130911023130910956130910956Frame_Shift_DelT-p.K693fs
LIHCTCGA-DD-A39Y-01exon_skip_343477
exon_skip_343482
130918759130918845130918795130918795Frame_Shift_DelG-p.P344fs
COADTCGA-AZ-6598-01exon_skip_343479
130921947130922018130921967130921967Frame_Shift_DelT-p.M321fs
STADTCGA-HF-A5NB-01exon_skip_343479
130921947130922018130921967130921967Frame_Shift_DelT-p.M321fs
STADTCGA-HU-A4H8-01exon_skip_343479
130921947130922018130921967130921967Frame_Shift_DelT-p.M321fs
CESCTCGA-IR-A3LK-01exon_skip_343444
130910616130910744130910714130910714Nonsense_MutationCAp.E725*
UCECTCGA-D1-A176-01exon_skip_343448
130910892130911023130910890130910890Splice_SiteAGe18+2
UCECTCGA-D1-A176-01exon_skip_343448
130910892130911023130910890130910890Splice_SiteAGp.Q714_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
NCIH69_LUNG130910616130910744130910666130910666Missense_MutationCGp.A741P
HEC1A_ENDOMETRIUM130910616130910744130910666130910666Missense_MutationCTp.A741T
SUM149PT_BREAST130910616130910744130910687130910687Missense_MutationGAp.P734S
JHUEM7_ENDOMETRIUM130910616130910744130910728130910728Missense_MutationCTp.R720Q
NCIH1836_LUNG130910892130911023130910924130910924Missense_MutationCTp.G704R
OVK18_OVARY130910892130911023130910945130910945Missense_MutationCTp.D697N
SNU81_LARGE_INTESTINE130913608130913708130913613130913613Missense_MutationCAp.E467D
SNU398_LIVER130913626130913708130913633130913633Missense_MutationGTp.Q461K
SNU398_LIVER130913608130913708130913633130913633Missense_MutationGTp.Q461K
SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130913626130913708130913666130913666Missense_MutationCTp.A450T
SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130913608130913708130913666130913666Missense_MutationCTp.A450T
NCIH1436_LUNG130913626130913708130913671130913671Missense_MutationCAp.R448L
NCIH1436_LUNG130913608130913708130913671130913671Missense_MutationCAp.R448L
HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130914824130914969130914827130914827Missense_MutationTGp.K404T
HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130914824130914969130914827130914827Missense_MutationTGp.K404T
LN443_CENTRAL_NERVOUS_SYSTEM130918759130918845130918794130918794Missense_MutationCTp.A345T
SISO_CERVIX130918759130918845130918820130918820Missense_MutationCTp.S336N
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130918759130918845130918820130918820Missense_MutationCTp.S336N
MKN74_STOMACH130918759130918845130918826130918826Missense_MutationCTp.R334Q
A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130918759130918845130918826130918826Missense_MutationCTp.R334Q
FUOV1_OVARY130918759130918845130918826130918826Missense_MutationCTp.R334Q
MKN28_STOMACH130918759130918845130918826130918826Missense_MutationCTp.R334Q
SNU1041_UPPER_AERODIGESTIVE_TRACT130918759130918845130918839130918839Missense_MutationCGp.V330L
MC1010_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130921947130922018130921949130921949Missense_MutationTCp.K327E
GP2D_LARGE_INTESTINE130921947130922018130921965130921965Missense_MutationCTp.M321I
GP5D_LARGE_INTESTINE130921947130922018130921965130921965Missense_MutationCTp.M321I
BT549_BREAST130925031130925163130925064130925064Missense_MutationGAp.P6L
SNU175_LARGE_INTESTINE130925031130925163130925090130925090Missense_MutationTCp.T284A
EFE184_ENDOMETRIUM130925031130925163130925119130925119Missense_MutationCTp.S274N
CAL51_BREAST130925031130925163130925150130925150Missense_MutationGAp.P264S
BC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE130930852130930927130930854130930854Missense_MutationGAp.P154S
EFO27_OVARY130931087130931229130931094130931094Missense_MutationCTp.D127N
EFO27_OVARY130931087130931177130931094130931094Missense_MutationCTp.D127N
RL952_ENDOMETRIUM130931087130931229130931109130931109Missense_MutationCTp.V122M
RL952_ENDOMETRIUM130931087130931177130931109130931109Missense_MutationCTp.V122M
NCIH2023_LUNG130931087130931229130931124130931124Missense_MutationCAp.V117L
NCIH2023_LUNG130931087130931177130931124130931124Missense_MutationCAp.V117L
PFSK1_CENTRAL_NERVOUS_SYSTEM130931087130931229130931201130931201Missense_MutationACp.V91G
JHU029_UPPER_AERODIGESTIVE_TRACT130932487130932573130932504130932504Missense_MutationCGp.E76Q
SNU81_LARGE_INTESTINE130932487130932573130932522130932522Missense_MutationCAp.D70Y
SNU1040_LARGE_INTESTINE130932487130932573130932530130932530Missense_MutationTCp.Q67R
HS939T_SKIN130910616130910744130910696130910697Nonsense_MutationCCAAp.E731*
HS939T_SKIN130910616130910744130910696130910696Nonsense_MutationCAp.E731*
LS411N_LARGE_INTESTINE130921947130922018130921964130921964Nonsense_MutationGAp.Q322*
SNU1040_LARGE_INTESTINE130931087130931229130931206130931206Nonsense_MutationCTp.W89*
HOS_BONE130910616130910744130910744130910744Splice_SiteTCp.I715V

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SMPD4

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1GBMrs10909567chr2:130925088C/T1.95e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1COADrs10909567chr2:130925088C/T9.00e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1ESCArs10909567chr2:130925088C/T1.86e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1HNSCrs10909567chr2:130925088C/T3.55e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1BRCArs10909567chr2:130925088C/T4.88e-06
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1LAMLrs10909567chr2:130925088C/T2.64e-06
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1LGGrs10909567chr2:130925088C/T3.13e-05
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1KIRCrs10909567chr2:130925088C/T2.23e-03
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1LUADrs10909567chr2:130925088C/T8.05e-05
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1LIHCrs10909567chr2:130925088C/T1.77e-05
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1LUSCrs10909567chr2:130925088C/T2.20e-11
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1OVrs10909567chr2:130925088C/T1.91e-10
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1PRADrs10909567chr2:130925088C/T2.31e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1THYMrs10909567chr2:130925088C/T7.81e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1STADrs10909567chr2:130925088C/T3.27e-05
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1STADrs10909567chr2:130925088C/T8.42e-04
exon_skip_3434842130921946:130922018:130925030:130925163:130932486:130932573130925030:130925163ENST00000439029.1,ENST00000433118.1THCArs10909567chr2:130925088C/T1.03e-03
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1GBMrs10909567chr2:130925088C/T1.95e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1COADrs10909567chr2:130925088C/T9.00e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1ESCArs10909567chr2:130925088C/T1.86e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1HNSCrs10909567chr2:130925088C/T3.55e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1BRCArs10909567chr2:130925088C/T4.88e-06
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1LAMLrs10909567chr2:130925088C/T2.64e-06
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1LGGrs10909567chr2:130925088C/T3.13e-05
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1KIRCrs10909567chr2:130925088C/T2.23e-03
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1LUADrs10909567chr2:130925088C/T8.05e-05
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1LIHCrs10909567chr2:130925088C/T1.77e-05
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1LUSCrs10909567chr2:130925088C/T2.20e-11
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1OVrs10909567chr2:130925088C/T1.91e-10
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1PRADrs10909567chr2:130925088C/T2.31e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1THYMrs10909567chr2:130925088C/T7.81e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1STADrs10909567chr2:130925088C/T3.27e-05
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1STADrs10909567chr2:130925088C/T8.42e-04
exon_skip_3434832130921946:130922018:130925030:130925163:130929921:130930028130925030:130925163ENST00000439886.1,ENST00000351288.6,ENST00000412570.1,ENST00000339679.7,ENST00000454468.1,ENST00000451542.1,ENST00000435455.1,ENST00000431183.2,ENST00000409031.1,ENST00000430682.1THCArs10909567chr2:130925088C/T1.03e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SMPD4


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SMPD4


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RelatedDrugs for SMPD4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMPD4

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource