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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for KIF21A |
 Gene summary |
| Gene information | Gene symbol | KIF21A | Gene ID | 55605 |
| Gene name | kinesin family member 21A | |
| Synonyms | CFEOM1|FEOM1|FEOM3A | |
| Cytomap | 12q12 | |
| Type of gene | protein-coding | |
| Description | kinesin-like protein KIF21Akinesin-like protein KIF2renal carcinoma antigen NY-REN-62 | |
| Modification date | 20180523 | |
| UniProtAcc | Q7Z4S6 | |
| Context | PubMed: KIF21A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for KIF21A from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for KIF21A |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for KIF21A |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_91121 | 12 | 39688225:39688319:39695281:39695481:39696766:39696937 | 39695281:39695481 | ENSG00000139116.13 | ENST00000544797.2,ENST00000552961.1,ENST00000361418.5,ENST00000541463.2,ENST00000395670.3,ENST00000547733.1,ENST00000551264.1,ENST00000361961.3 |
| exon_skip_91124 | 12 | 39701366:39701531:39703387:39703568:39705218:39705355 | 39703387:39703568 | ENSG00000139116.13 | ENST00000544797.2,ENST00000552961.1,ENST00000361418.5,ENST00000541463.2,ENST00000395670.3,ENST00000551264.1,ENST00000361961.3 |
| exon_skip_91129 | 12 | 39703553:39703568:39705218:39705355:39711874:39712003 | 39705218:39705355 | ENSG00000139116.13 | ENST00000544797.2,ENST00000541463.2 |
| exon_skip_91130 | 12 | 39703553:39703568:39705218:39705355:39713707:39713815 | 39705218:39705355 | ENSG00000139116.13 | ENST00000551264.1 |
| exon_skip_91132 | 12 | 39705218:39705355:39709030:39709042:39709733:39709772 | 39709030:39709042 | ENSG00000139116.13 | ENST00000361418.5,ENST00000361961.3 |
| exon_skip_91135 | 12 | 39705218:39705355:39709733:39709772:39713707:39713815 | 39709733:39709772 | ENSG00000139116.13 | ENST00000552961.1 |
| exon_skip_91137 | 12 | 39705218:39705355:39711874:39712003:39713707:39713815 | 39711874:39712003 | ENSG00000139116.13 | ENST00000544797.2,ENST00000541463.2 |
| exon_skip_91138 | 12 | 39705218:39705355:39713707:39713815:39716469:39716684 | 39713707:39713815 | ENSG00000139116.13 | ENST00000551264.1 |
| exon_skip_91140 | 12 | 39709733:39709772:39711874:39712003:39713707:39713815 | 39711874:39712003 | ENSG00000139116.13 | ENST00000361418.5,ENST00000395670.3,ENST00000361961.3 |
| exon_skip_91142 | 12 | 39713791:39713815:39715149:39716684:39719640:39719695 | 39715149:39716684 | ENSG00000139116.13 | ENST00000547108.1 |
| exon_skip_91143 | 12 | 39713791:39713815:39716469:39716684:39719640:39719695 | 39716469:39716684 | ENSG00000139116.13 | ENST00000544797.2,ENST00000552961.1,ENST00000361418.5,ENST00000541463.2,ENST00000395670.3,ENST00000551264.1,ENST00000361961.3 |
| exon_skip_91144 | 12 | 39719640:39719695:39720065:39720126:39724547:39724713 | 39720065:39720126 | ENSG00000139116.13 | ENST00000544797.2,ENST00000552475.1,ENST00000547108.1,ENST00000551264.1 |
| exon_skip_91146 | 12 | 39720065:39720126:39724043:39724064:39724547:39724713 | 39724043:39724064 | ENSG00000139116.13 | ENST00000552961.1,ENST00000361418.5,ENST00000541463.2,ENST00000361961.3 |
| exon_skip_91147 | 12 | 39726838:39726909:39727013:39727082:39730897:39731005 | 39727013:39727082 | ENSG00000139116.13 | ENST00000544797.2,ENST00000546817.1,ENST00000552961.1,ENST00000361418.5,ENST00000547108.1,ENST00000395670.3,ENST00000361961.3 |
| exon_skip_91148 | 12 | 39735835:39735926:39740267:39740306:39745578:39745782 | 39740267:39740306 | ENSG00000139116.13 | ENST00000361418.5,ENST00000395670.3 |
| exon_skip_91149 | 12 | 39735835:39735926:39745578:39745782:39750633:39750697 | 39745578:39745782 | ENSG00000139116.13 | ENST00000544797.2,ENST00000541463.2,ENST00000361961.3 |
| exon_skip_91150 | 12 | 39751052:39751239:39751979:39752175:39756899:39757015 | 39751979:39752175 | ENSG00000139116.13 | ENST00000544797.2,ENST00000361418.5,ENST00000541463.2,ENST00000552908.1,ENST00000395670.3,ENST00000361961.3 |
| exon_skip_91151 | 12 | 39751979:39752175:39756899:39757015:39760151:39760319 | 39756899:39757015 | ENSG00000139116.13 | ENST00000544797.2,ENST00000361418.5,ENST00000541463.2,ENST00000552908.1,ENST00000395670.3,ENST00000361961.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for KIF21A |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_91121 | 12 | 39688225:39688319:39695281:39695481:39696766:39696937 | 39695281:39695481 | ENSG00000139116.13 | ENST00000547733.1,ENST00000361961.3,ENST00000395670.3,ENST00000551264.1,ENST00000552961.1,ENST00000544797.2,ENST00000361418.5,ENST00000541463.2 |
| exon_skip_91124 | 12 | 39701366:39701531:39703387:39703568:39705218:39705355 | 39703387:39703568 | ENSG00000139116.13 | ENST00000361961.3,ENST00000395670.3,ENST00000551264.1,ENST00000552961.1,ENST00000544797.2,ENST00000361418.5,ENST00000541463.2 |
| exon_skip_91128 | 12 | 39703553:39703568:39705216:39705355:39713707:39713815 | 39705216:39705355 | ENSG00000139116.13 | ENST00000547745.1 |
| exon_skip_91129 | 12 | 39703553:39703568:39705218:39705355:39711874:39712003 | 39705218:39705355 | ENSG00000139116.13 | ENST00000544797.2,ENST00000541463.2 |
| exon_skip_91130 | 12 | 39703553:39703568:39705218:39705355:39713707:39713815 | 39705218:39705355 | ENSG00000139116.13 | ENST00000551264.1 |
| exon_skip_91132 | 12 | 39705218:39705355:39709030:39709042:39709733:39709772 | 39709030:39709042 | ENSG00000139116.13 | ENST00000361961.3,ENST00000361418.5 |
| exon_skip_91135 | 12 | 39705218:39705355:39709733:39709772:39713707:39713815 | 39709733:39709772 | ENSG00000139116.13 | ENST00000552961.1 |
| exon_skip_91137 | 12 | 39705218:39705355:39711874:39712003:39713707:39713815 | 39711874:39712003 | ENSG00000139116.13 | ENST00000544797.2,ENST00000541463.2 |
| exon_skip_91138 | 12 | 39705218:39705355:39713707:39713815:39716469:39716684 | 39713707:39713815 | ENSG00000139116.13 | ENST00000551264.1 |
| exon_skip_91140 | 12 | 39709733:39709772:39711874:39712003:39713707:39713815 | 39711874:39712003 | ENSG00000139116.13 | ENST00000361961.3,ENST00000395670.3,ENST00000361418.5 |
| exon_skip_91142 | 12 | 39713791:39713815:39715149:39716684:39719640:39719695 | 39715149:39716684 | ENSG00000139116.13 | ENST00000547108.1 |
| exon_skip_91143 | 12 | 39713791:39713815:39716469:39716684:39719640:39719695 | 39716469:39716684 | ENSG00000139116.13 | ENST00000361961.3,ENST00000395670.3,ENST00000551264.1,ENST00000552961.1,ENST00000544797.2,ENST00000361418.5,ENST00000541463.2 |
| exon_skip_91144 | 12 | 39719640:39719695:39720065:39720126:39724547:39724713 | 39720065:39720126 | ENSG00000139116.13 | ENST00000551264.1,ENST00000544797.2,ENST00000547108.1,ENST00000552475.1 |
| exon_skip_91145 | 12 | 39719640:39719695:39720065:39720147:39724547:39724713 | 39720065:39720147 | ENSG00000139116.13 | ENST00000395670.3 |
| exon_skip_91146 | 12 | 39720065:39720126:39724043:39724064:39724547:39724713 | 39724043:39724064 | ENSG00000139116.13 | ENST00000361961.3,ENST00000552961.1,ENST00000361418.5,ENST00000541463.2 |
| exon_skip_91147 | 12 | 39726838:39726909:39727013:39727082:39730897:39731005 | 39727013:39727082 | ENSG00000139116.13 | ENST00000361961.3,ENST00000395670.3,ENST00000552961.1,ENST00000544797.2,ENST00000361418.5,ENST00000547108.1,ENST00000546817.1 |
| exon_skip_91148 | 12 | 39735835:39735926:39740267:39740306:39745578:39745782 | 39740267:39740306 | ENSG00000139116.13 | ENST00000395670.3,ENST00000361418.5 |
| exon_skip_91149 | 12 | 39735835:39735926:39745578:39745782:39750633:39750697 | 39745578:39745782 | ENSG00000139116.13 | ENST00000361961.3,ENST00000544797.2,ENST00000541463.2 |
| exon_skip_91150 | 12 | 39751052:39751239:39751979:39752175:39756899:39757015 | 39751979:39752175 | ENSG00000139116.13 | ENST00000361961.3,ENST00000395670.3,ENST00000544797.2,ENST00000361418.5,ENST00000541463.2,ENST00000552908.1 |
| exon_skip_91151 | 12 | 39751979:39752175:39756899:39757015:39760151:39760319 | 39756899:39757015 | ENSG00000139116.13 | ENST00000361961.3,ENST00000395670.3,ENST00000544797.2,ENST00000361418.5,ENST00000541463.2,ENST00000552908.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for KIF21A |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361418 | 39695281 | 39695481 | Frame-shift |
| ENST00000361418 | 39703387 | 39703568 | Frame-shift |
| ENST00000361418 | 39716469 | 39716684 | Frame-shift |
| ENST00000361418 | 39751979 | 39752175 | Frame-shift |
| ENST00000361418 | 39756899 | 39757015 | Frame-shift |
| ENST00000361418 | 39709030 | 39709042 | In-frame |
| ENST00000361418 | 39711874 | 39712003 | In-frame |
| ENST00000361418 | 39724043 | 39724064 | In-frame |
| ENST00000361418 | 39727013 | 39727082 | In-frame |
| ENST00000361418 | 39740267 | 39740306 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361418 | 39695281 | 39695481 | Frame-shift |
| ENST00000361418 | 39703387 | 39703568 | Frame-shift |
| ENST00000361418 | 39716469 | 39716684 | Frame-shift |
| ENST00000361418 | 39751979 | 39752175 | Frame-shift |
| ENST00000361418 | 39756899 | 39757015 | Frame-shift |
| ENST00000361418 | 39709030 | 39709042 | In-frame |
| ENST00000361418 | 39711874 | 39712003 | In-frame |
| ENST00000361418 | 39724043 | 39724064 | In-frame |
| ENST00000361418 | 39727013 | 39727082 | In-frame |
| ENST00000361418 | 39740267 | 39740306 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIF21A |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000361418 | 5061 | 1674 | 39740267 | 39740306 | 1690 | 1728 | 558 | 570 |
| ENST00000361418 | 5061 | 1674 | 39727013 | 39727082 | 2435 | 2503 | 806 | 829 |
| ENST00000361418 | 5061 | 1674 | 39711874 | 39712003 | 3796 | 3924 | 1260 | 1302 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000361418 | 5061 | 1674 | 39740267 | 39740306 | 1690 | 1728 | 558 | 570 |
| ENST00000361418 | 5061 | 1674 | 39727013 | 39727082 | 2435 | 2503 | 806 | 829 |
| ENST00000361418 | 5061 | 1674 | 39711874 | 39712003 | 3796 | 3924 | 1260 | 1302 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for KIF21A |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
KIF21A_COAD_exon_skip_91135_psi_boxplot.png |
KIF21A_STAD_exon_skip_91143_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_91121 | 39695282 | 39695481 | 39695396 | 39695396 | Frame_Shift_Del | C | - | p.G1607fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_91121 | 39695282 | 39695481 | 39695396 | 39695396 | Frame_Shift_Del | C | - | p.G1607fs |
| BLCA | TCGA-FD-A6TC-01 | exon_skip_91130 exon_skip_91129 | 39705219 | 39705355 | 39705303 | 39705303 | Frame_Shift_Del | G | - | p.Q1339fs |
| COAD | TCGA-F4-6856-01 | exon_skip_91138 | 39713708 | 39713815 | 39713784 | 39713784 | Frame_Shift_Del | T | - | p.I1215fs |
| STAD | TCGA-F1-6177-01 | exon_skip_91138 | 39713708 | 39713815 | 39713784 | 39713784 | Frame_Shift_Del | T | - | p.I1235fs |
| LIHC | TCGA-BC-A3KG-01 | exon_skip_91147 | 39727014 | 39727082 | 39727022 | 39727022 | Frame_Shift_Del | T | - | p.T827fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_91147 | 39727014 | 39727082 | 39727037 | 39727037 | Frame_Shift_Del | C | - | p.V822fs |
| COAD | TCGA-AZ-6598-01 | exon_skip_91149 | 39745579 | 39745782 | 39745580 | 39745580 | Frame_Shift_Del | T | - | p.S558fs |
| STAD | TCGA-CD-A4MI-01 | exon_skip_91149 | 39745579 | 39745782 | 39745623 | 39745623 | Frame_Shift_Del | T | - | p.D544fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_91149 | 39745579 | 39745782 | 39745682 | 39745682 | Frame_Shift_Del | A | - | p.S524fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_91149 | 39745579 | 39745782 | 39745735 | 39745735 | Frame_Shift_Del | T | - | p.N506fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_91149 | 39745579 | 39745782 | 39745735 | 39745735 | Frame_Shift_Del | T | - | p.N506fs |
| STAD | TCGA-BR-8078-01 | exon_skip_91149 | 39745579 | 39745782 | 39745735 | 39745735 | Frame_Shift_Del | T | - | p.N506fs |
| LIHC | TCGA-DD-A3A0-01 | 39756900 | 39757015 | 39756913 | 39756913 | Frame_Shift_Del | G | - | p.L336fs | |
| ESCA | TCGA-IG-A97H-01 | exon_skip_91124 | 39703388 | 39703568 | 39703470 | 39703471 | Frame_Shift_Ins | - | A | p.Q1400fs |
| ESCA | TCGA-IG-A97H-01 | exon_skip_91124 | 39703388 | 39703568 | 39703470 | 39703471 | Frame_Shift_Ins | - | A | p.T1399fs |
| COAD | TCGA-A6-5665-01 | exon_skip_91135 | 39709734 | 39709772 | 39709745 | 39709746 | Frame_Shift_Ins | - | GA | p.S1312fs |
| SARC | TCGA-3B-A9HX-01 | exon_skip_91138 | 39713708 | 39713815 | 39713783 | 39713784 | Frame_Shift_Ins | - | T | p.S1235fs |
| TGCT | TCGA-2G-AAL5-01 | exon_skip_91138 | 39713708 | 39713815 | 39713783 | 39713784 | Frame_Shift_Ins | - | T | p.S1235fs |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_91149 | 39745579 | 39745782 | 39745622 | 39745623 | Frame_Shift_Ins | - | T | p.D544fs |
| UCS | TCGA-N7-A4Y0-01 | exon_skip_91149 | 39745579 | 39745782 | 39745622 | 39745623 | Frame_Shift_Ins | - | T | p.F544fs |
| BLCA | TCGA-G2-A2EO-01 | exon_skip_91124 | 39703388 | 39703568 | 39703448 | 39703448 | Nonsense_Mutation | G | C | p.S1406* |
| BLCA | TCGA-G2-A2EO-01 | exon_skip_91124 | 39703388 | 39703568 | 39703448 | 39703448 | Nonsense_Mutation | G | C | p.S1407* |
| HNSC | TCGA-CN-4723-01 | exon_skip_91138 | 39713708 | 39713815 | 39713804 | 39713804 | Nonsense_Mutation | G | C | p.S1228* |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_91142 | 39715150 | 39716684 | 39716543 | 39716543 | Nonsense_Mutation | C | A | p.E1200* |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_91142 | 39715150 | 39716684 | 39716543 | 39716543 | Nonsense_Mutation | C | A | p.E1200X |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_91143 | 39716470 | 39716684 | 39716543 | 39716543 | Nonsense_Mutation | C | A | p.E1200* |
| STAD | TCGA-VQ-A8P2-01 | exon_skip_91143 | 39716470 | 39716684 | 39716543 | 39716543 | Nonsense_Mutation | C | A | p.E1200X |
| BLCA | TCGA-XF-AAN2-01 | exon_skip_91142 | 39715150 | 39716684 | 39716623 | 39716623 | Nonsense_Mutation | G | C | p.S1173* |
| BLCA | TCGA-XF-AAN2-01 | exon_skip_91143 | 39716470 | 39716684 | 39716623 | 39716623 | Nonsense_Mutation | G | C | p.S1173* |
| DLBC | TCGA-G8-6909-01 | exon_skip_91142 | 39715150 | 39716684 | 39716675 | 39716675 | Nonsense_Mutation | T | A | p.R1156X |
| DLBC | TCGA-G8-6909-01 | exon_skip_91143 | 39716470 | 39716684 | 39716675 | 39716675 | Nonsense_Mutation | T | A | p.R1156X |
| LIHC | TCGA-UB-A7MB-01 | exon_skip_91147 | 39727014 | 39727082 | 39727052 | 39727052 | Nonsense_Mutation | T | A | p.R817* |
| LIHC | TCGA-UB-A7MB-01 | exon_skip_91147 | 39727014 | 39727082 | 39727052 | 39727052 | Nonsense_Mutation | T | A | p.R817X |
| SKCM | TCGA-D3-A8GI-06 | exon_skip_91149 | 39745579 | 39745782 | 39745742 | 39745742 | Nonsense_Mutation | G | A | p.R504* |
| LUAD | TCGA-55-6985-01 | exon_skip_91124 | 39703388 | 39703568 | 39703569 | 39703569 | Splice_Site | C | A | p.D1366_splice |
| READ | TCGA-CL-5917-01 | exon_skip_91138 | 39713708 | 39713815 | 39713817 | 39713817 | Splice_Site | T | C | . |
| STAD | TCGA-HU-A4GX-01 | exon_skip_91143 | 39716470 | 39716684 | 39716468 | 39716468 | Splice_Site | A | G | . |
| STAD | TCGA-HU-A4GX-01 | exon_skip_91143 | 39716470 | 39716684 | 39716468 | 39716468 | Splice_Site | A | G | p.I1224_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-HU-A4GX-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91143 | |
| Skipped exon start: 39716470 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716468 | |
| Mutation end: 39716468 | |
| Mutation type: Splice_Site | |
| Reference seq: A | |
| Mutation seq: G | |
| AAchange: . | |
| Sample: TCGA-HU-A4GX-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91143 | |
| Skipped exon start: 39716470 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716468 | |
| Mutation end: 39716468 | |
| Mutation type: Splice_Site | |
| Reference seq: A | |
| Mutation seq: G | |
| AAchange: p.I1224_splice | |
exon_skip_314019_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_3151_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_339350_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_339351_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_339352_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_353916_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_376639_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_377238_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_42171_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_425815_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_432212_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_4414_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_458618_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_459316_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_91143_STAD_TCGA-HU-A4GX-01.png | |
exon_skip_95945_STAD_TCGA-HU-A4GX-01.png | |
 | Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91143 | |
| Skipped exon start: 39716470 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200X | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91142 | |
| Skipped exon start: 39715150 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200X | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91143 | |
| Skipped exon start: 39716470 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200* | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91142 | |
| Skipped exon start: 39715150 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200* | |
exon_skip_102588_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_122541_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_128780_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_143382_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_143383_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_148114_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_287192_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_291811_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_320689_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_320690_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_328488_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_356820_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_356824_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_375393_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_381459_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_3837_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_387613_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_431990_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_440277_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_443275_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_448545_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_470847_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_481483_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_5195_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_5826_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_74538_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_91142_STAD_TCGA-VQ-A8P2-01.png | |
exon_skip_91143_STAD_TCGA-VQ-A8P2-01.png | |
 | Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91143 | |
| Skipped exon start: 39716470 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200X | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91142 | |
| Skipped exon start: 39715150 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200X | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91143 | |
| Skipped exon start: 39716470 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200* | |
| Sample: TCGA-VQ-A8P2-01 |
| Cancer type: STAD | |
| ESID: exon_skip_91142 | |
| Skipped exon start: 39715150 | |
| Skipped exon end: 39716684 | |
| Mutation start: 39716543 | |
| Mutation end: 39716543 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: p.E1200* | |
| exon_skip_102588_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_122541_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_128780_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_143382_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_143383_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_148114_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_287192_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_291811_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_320689_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_320690_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_328488_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_356820_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_356824_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_375393_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_381459_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_3837_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_387613_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_431990_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_440277_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_443275_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_448545_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_470847_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_481483_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_5195_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_5826_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_74538_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_91142_STAD_TCGA-VQ-A8P2-01.png | |
| exon_skip_91143_STAD_TCGA-VQ-A8P2-01.png | |
 | Sample: TCGA-A6-5665-01 |
| Cancer type: COAD | |
| ESID: exon_skip_91135 | |
| Skipped exon start: 39709734 | |
| Skipped exon end: 39709772 | |
| Mutation start: 39709745 | |
| Mutation end: 39709746 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: GA | |
| AAchange: p.S1312fs | |
exon_skip_11611_COAD_TCGA-A6-5665-01.png | |
exon_skip_11615_COAD_TCGA-A6-5665-01.png | |
exon_skip_11638_COAD_TCGA-A6-5665-01.png | |
exon_skip_11641_COAD_TCGA-A6-5665-01.png | |
exon_skip_141199_COAD_TCGA-A6-5665-01.png | |
exon_skip_145709_COAD_TCGA-A6-5665-01.png | |
exon_skip_290233_COAD_TCGA-A6-5665-01.png | |
exon_skip_297638_COAD_TCGA-A6-5665-01.png | |
exon_skip_303317_COAD_TCGA-A6-5665-01.png | |
exon_skip_339648_COAD_TCGA-A6-5665-01.png | |
exon_skip_347690_COAD_TCGA-A6-5665-01.png | |
exon_skip_389258_COAD_TCGA-A6-5665-01.png | |
exon_skip_389265_COAD_TCGA-A6-5665-01.png | |
exon_skip_434039_COAD_TCGA-A6-5665-01.png | |
exon_skip_434040_COAD_TCGA-A6-5665-01.png | |
exon_skip_438605_COAD_TCGA-A6-5665-01.png | |
exon_skip_91135_COAD_TCGA-A6-5665-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC59_ENDOMETRIUM | 39695282 | 39695481 | 39695396 | 39695396 | Frame_Shift_Del | C | - | p.G1606fs |
| JHH7_LIVER | 39713708 | 39713815 | 39713731 | 39713731 | Frame_Shift_Del | T | - | p.K1252fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39716470 | 39716684 | 39716506 | 39716506 | Frame_Shift_Del | G | - | p.S1212fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39715150 | 39716684 | 39716506 | 39716506 | Frame_Shift_Del | G | - | p.S1212fs |
| HEC151_ENDOMETRIUM | 39727014 | 39727082 | 39727052 | 39727052 | Frame_Shift_Del | T | - | p.R817fs |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39727014 | 39727082 | 39727052 | 39727052 | Frame_Shift_Del | T | - | p.R817fs |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39745579 | 39745782 | 39745682 | 39745682 | Frame_Shift_Del | A | - | p.S524fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39716470 | 39716684 | 39716508 | 39716509 | Frame_Shift_Ins | - | A | p.L1211fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39715150 | 39716684 | 39716508 | 39716509 | Frame_Shift_Ins | - | A | p.L1211fs |
| HS766T_PANCREAS | 39745579 | 39745782 | 39745622 | 39745623 | Frame_Shift_Ins | - | T | p.D544fs |
| JL1_PLEURA | 39745579 | 39745782 | 39745622 | 39745623 | Frame_Shift_Ins | - | T | p.D544fs |
| SKMEL31_SKIN | 39745579 | 39745782 | 39745622 | 39745623 | Frame_Shift_Ins | - | T | p.D544fs |
| HSC1_SKIN | 39695282 | 39695481 | 39695374 | 39695374 | Missense_Mutation | C | T | p.M1613I |
| SW756_CERVIX | 39695282 | 39695481 | 39695408 | 39695408 | Missense_Mutation | C | A | p.G1602V |
| NCIH630_LARGE_INTESTINE | 39695282 | 39695481 | 39695426 | 39695426 | Missense_Mutation | T | C | p.H1596R |
| DV90_LUNG | 39695282 | 39695481 | 39695447 | 39695447 | Missense_Mutation | G | A | p.A1589V |
| KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39695282 | 39695481 | 39695472 | 39695472 | Missense_Mutation | T | C | p.N1581D |
| HCC2998_LARGE_INTESTINE | 39703388 | 39703568 | 39703397 | 39703397 | Missense_Mutation | C | T | p.R1423Q |
| KM12_LARGE_INTESTINE | 39703388 | 39703568 | 39703426 | 39703426 | Missense_Mutation | C | A | p.W1413C |
| TT_OESOPHAGUS | 39703388 | 39703568 | 39703566 | 39703566 | Missense_Mutation | G | A | p.R1367C |
| ES5_BONE | 39705219 | 39705355 | 39705248 | 39705248 | Missense_Mutation | G | A | p.T1356I |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39705219 | 39705355 | 39705267 | 39705267 | Missense_Mutation | C | T | p.V1350M |
| NCIH358_LUNG | 39705219 | 39705355 | 39705297 | 39705297 | Missense_Mutation | T | A | p.I1340F |
| NCIH1623_LUNG | 39705219 | 39705355 | 39705336 | 39705336 | Missense_Mutation | G | A | p.P1327S |
| RKN_SOFT_TISSUE | 39709031 | 39709042 | 39709040 | 39709040 | Missense_Mutation | G | A | p.S1317F |
| NCIH2196_LUNG | 39709031 | 39709042 | 39709040 | 39709040 | Missense_Mutation | G | A | p.S1317F |
| SF172_CENTRAL_NERVOUS_SYSTEM | 39711875 | 39712003 | 39711883 | 39711883 | Missense_Mutation | C | A | p.Q1300H |
| HLFA_FIBROBLAST | 39711875 | 39712003 | 39711909 | 39711909 | Missense_Mutation | C | A | p.V1292F |
| P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39711875 | 39712003 | 39711927 | 39711927 | Missense_Mutation | C | T | p.V1286I |
| LNCAPCLONEFGC_PROSTATE | 39713708 | 39713815 | 39713723 | 39713723 | Missense_Mutation | G | A | p.A1255V |
| H2369_PLEURA | 39713708 | 39713815 | 39713781 | 39713781 | Missense_Mutation | G | C | p.P1236A |
| SCH_STOMACH | 39713708 | 39713815 | 39713795 | 39713795 | Missense_Mutation | G | A | p.S1231L |
| HCC1500_BREAST | 39716470 | 39716684 | 39716604 | 39716604 | Missense_Mutation | A | C | p.D1179E |
| HCC1500_BREAST | 39715150 | 39716684 | 39716604 | 39716604 | Missense_Mutation | A | C | p.D1179E |
| KNS62_LUNG | 39716470 | 39716684 | 39716661 | 39716661 | Missense_Mutation | C | A | p.Q1160H |
| KNS62_LUNG | 39715150 | 39716684 | 39716661 | 39716661 | Missense_Mutation | C | A | p.Q1160H |
| MKN1_STOMACH | 39716470 | 39716684 | 39716665 | 39716665 | Missense_Mutation | G | C | p.T1159S |
| MKN1_STOMACH | 39715150 | 39716684 | 39716665 | 39716665 | Missense_Mutation | G | C | p.T1159S |
| NBSUSSR_AUTONOMIC_GANGLIA | 39716470 | 39716684 | 39716665 | 39716665 | Missense_Mutation | G | C | p.T1159S |
| NBSUSSR_AUTONOMIC_GANGLIA | 39715150 | 39716684 | 39716665 | 39716665 | Missense_Mutation | G | C | p.T1159S |
| CJM_SKIN | 39716470 | 39716684 | 39716665 | 39716665 | Missense_Mutation | G | C | p.T1159S |
| CJM_SKIN | 39715150 | 39716684 | 39716665 | 39716665 | Missense_Mutation | G | C | p.T1159S |
| A253_SALIVARY_GLAND | 39716470 | 39716684 | 39716671 | 39716671 | Missense_Mutation | G | C | p.T1157S |
| A253_SALIVARY_GLAND | 39715150 | 39716684 | 39716671 | 39716671 | Missense_Mutation | G | C | p.T1157S |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39720066 | 39720126 | 39720093 | 39720093 | Missense_Mutation | G | T | p.P1125H |
| LNZTA3WT4_CENTRAL_NERVOUS_SYSTEM | 39720066 | 39720126 | 39720100 | 39720100 | Missense_Mutation | C | A | p.D1123Y |
| SLR26_KIDNEY | 39727014 | 39727082 | 39727028 | 39727028 | Missense_Mutation | G | A | p.R825C |
| LAN6_AUTONOMIC_GANGLIA | 39740268 | 39740306 | 39740274 | 39740274 | Missense_Mutation | T | G | p.E569A |
| IGROV1_OVARY | 39751980 | 39752175 | 39752008 | 39752008 | Missense_Mutation | A | G | p.L396P |
| SF268_CENTRAL_NERVOUS_SYSTEM | 39751980 | 39752175 | 39752027 | 39752027 | Missense_Mutation | G | A | p.R390C |
| HUH6_LIVER | 39751980 | 39752175 | 39752098 | 39752098 | Missense_Mutation | T | C | p.N366S |
| HUH6CLONE5_LIVER | 39751980 | 39752175 | 39752098 | 39752098 | Missense_Mutation | T | C | p.N366S |
| HT115_LARGE_INTESTINE | 39751980 | 39752175 | 39752102 | 39752102 | Missense_Mutation | C | T | p.A365T |
| CW2_LARGE_INTESTINE | 39751980 | 39752175 | 39752122 | 39752122 | Missense_Mutation | G | A | p.T358M |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39751980 | 39752175 | 39752122 | 39752122 | Missense_Mutation | G | A | p.T358M |
| NCIH1437_LUNG | 39756900 | 39757015 | 39756952 | 39756952 | Missense_Mutation | A | T | p.Y323N |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39756900 | 39757015 | 39756957 | 39756957 | Missense_Mutation | A | G | p.V321A |
| JHU029_UPPER_AERODIGESTIVE_TRACT | 39756900 | 39757015 | 39756977 | 39756977 | Missense_Mutation | C | G | p.K314N |
| GRANTA519_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39756900 | 39757015 | 39756980 | 39756980 | Missense_Mutation | G | C | p.D313E |
| PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39711875 | 39712003 | 39711890 | 39711890 | Nonsense_Mutation | G | T | p.S1298* |
| EN_ENDOMETRIUM | 39713708 | 39713815 | 39713746 | 39713746 | Nonsense_Mutation | A | C | p.Y1247* |
| HCC2998_LARGE_INTESTINE | 39727014 | 39727082 | 39727043 | 39727043 | Nonsense_Mutation | C | A | p.E820* |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39745579 | 39745782 | 39745580 | 39745580 | Splice_Site | T | - | p.R558fs |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIF21A |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KIF21A |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KIF21A |
Top |
RelatedDrugs for KIF21A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KIF21A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| KIF21A | C1851102 | Fibrosis Of Extraocular Muscles, Congenital, 1 | 4 | ORPHANET;UNIPROT |
| KIF21A | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
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