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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for KLK15 |
 Gene summary |
| Gene information | Gene symbol | KLK15 | Gene ID | 55554 |
| Gene name | kallikrein related peptidase 15 | |
| Synonyms | ACO|HSRNASPH | |
| Cytomap | 19q13.33 | |
| Type of gene | protein-coding | |
| Description | kallikrein-15ACO proteasekallikrein-like serine proteaseprostinogen | |
| Modification date | 20180523 | |
| UniProtAcc | Q9H2R5 | |
| Context | PubMed: KLK15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for KLK15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for KLK15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for KLK15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_321276 | 19 | 51329011:51329204:51329876:51330013:51330133:51330417 | 51329876:51330013 | ENSG00000174562.9 | ENST00000326856.4,ENST00000598239.1 |
| exon_skip_321277 | 19 | 51329011:51329204:51329876:51330013:51330251:51330417 | 51329876:51330013 | ENSG00000174562.9 | ENST00000602114.1 |
| exon_skip_321280 | 19 | 51330283:51330417:51330917:51331068:51334705:51334748 | 51330917:51331068 | ENSG00000174562.9 | ENST00000326856.4,ENST00000596931.1,ENST00000602114.1 |
| exon_skip_321281 | 19 | 51330283:51330417:51330917:51331071:51334705:51334748 | 51330917:51331071 | ENSG00000174562.9 | ENST00000416184.1,ENST00000301421.2,ENST00000598239.1 |
| exon_skip_321287 | 19 | 51330917:51331068:51334705:51334779:51340370:51340469 | 51334705:51334779 | ENSG00000174562.9 | ENST00000326856.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for KLK15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_321276 | 19 | 51329011:51329204:51329876:51330013:51330133:51330417 | 51329876:51330013 | ENSG00000174562.9 | ENST00000326856.4,ENST00000598239.1 |
| exon_skip_321277 | 19 | 51329011:51329204:51329876:51330013:51330251:51330417 | 51329876:51330013 | ENSG00000174562.9 | ENST00000602114.1 |
| exon_skip_321280 | 19 | 51330283:51330417:51330917:51331068:51334705:51334748 | 51330917:51331068 | ENSG00000174562.9 | ENST00000326856.4,ENST00000596931.1,ENST00000602114.1 |
| exon_skip_321281 | 19 | 51330283:51330417:51330917:51331071:51334705:51334748 | 51330917:51331071 | ENSG00000174562.9 | ENST00000416184.1,ENST00000301421.2,ENST00000598239.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for KLK15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000598239 | 51329876 | 51330013 | Frame-shift |
| ENST00000598239 | 51330917 | 51331071 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000598239 | 51329876 | 51330013 | Frame-shift |
| ENST00000598239 | 51330917 | 51331071 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for KLK15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for KLK15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CESC | TCGA-DS-A1OC-01 | exon_skip_321280 | 51330918 | 51331068 | 51331009 | 51331009 | Nonsense_Mutation | G | A | p.Q35* |
| CESC | TCGA-DS-A1OC-01 | exon_skip_321281 | 51330918 | 51331071 | 51331009 | 51331009 | Nonsense_Mutation | G | A | p.Q35* |
| LUSC | TCGA-60-2724-01 | exon_skip_321276 exon_skip_321277 | 51329877 | 51330013 | 51330015 | 51330015 | Splice_Site | T | A | p.V161_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC108_ENDOMETRIUM | 51329877 | 51330013 | 51329884 | 51329884 | Missense_Mutation | G | A | p.S204F |
| NCIH1793_LUNG | 51329877 | 51330013 | 51329900 | 51329900 | Missense_Mutation | C | A | p.G199C |
| CORL24_LUNG | 51329877 | 51330013 | 51329993 | 51329993 | Missense_Mutation | G | A | p.H168Y |
| HKA1_SKIN | 51329877 | 51330013 | 51330005 | 51330005 | Missense_Mutation | G | A | p.P164S |
| HEC59_ENDOMETRIUM | 51330918 | 51331071 | 51330937 | 51330937 | Missense_Mutation | C | T | p.A60T |
| HEC59_ENDOMETRIUM | 51330918 | 51331068 | 51330937 | 51330937 | Missense_Mutation | C | T | p.A60T |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 51330918 | 51331071 | 51330991 | 51330991 | Missense_Mutation | G | A | p.R42C |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 51330918 | 51331068 | 51330991 | 51330991 | Missense_Mutation | G | A | p.R42C |
| MDAMB468_BREAST | 51330918 | 51331071 | 51331012 | 51331012 | Missense_Mutation | A | G | p.W35R |
| MDAMB468_BREAST | 51330918 | 51331068 | 51331012 | 51331012 | Missense_Mutation | A | G | p.W35R |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 51330918 | 51331071 | 51331029 | 51331029 | Missense_Mutation | G | A | p.A29V |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 51330918 | 51331068 | 51331029 | 51331029 | Missense_Mutation | G | A | p.A29V |
| LC1F_LUNG | 51334706 | 51334779 | 51334738 | 51334738 | Missense_Mutation | A | T | p.L4H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KLK15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KLK15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KLK15 |
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RelatedDrugs for KLK15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLK15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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