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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for WDR33

check button Gene summary
Gene informationGene symbol

WDR33

Gene ID

55339

Gene nameWD repeat domain 33
SynonymsNET14|WDC146
Cytomap

2q14.3

Type of geneprotein-coding
Descriptionpre-mRNA 3' end processing protein WDR33WD repeat-containing protein 33WD repeat-containing protein WDC146
Modification date20180523
UniProtAcc

Q9C0J8

ContextPubMed: WDR33 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for WDR33 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for WDR33

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for WDR33

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3433112128466250:128466466:128467063:128467156:128467266:128467430128467063:128467156ENSG00000136709.7ENST00000322313.4
exon_skip_3433142128467266:128467430:128471156:128471595:128474728:128474837128471156:128471595ENSG00000136709.7ENST00000322313.4
exon_skip_3433202128471156:128471595:128474728:128474837:128476838:128477927128474728:128474837ENSG00000136709.7ENST00000322313.4
exon_skip_3433212128480826:128480921:128481906:128482017:128482460:128482539128481906:128482017ENSG00000136709.7ENST00000322313.4
exon_skip_3433232128484225:128484351:128520635:128520733:128522401:128522553128520635:128520733ENSG00000136709.7ENST00000436787.1,ENST00000322313.4
exon_skip_3433292128526506:128526575:128528351:128528578:128568585:128568721128528351:128528578ENSG00000136709.7ENST00000409658.3,ENST00000393006.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for WDR33

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3433112128466250:128466466:128467063:128467156:128467266:128467430128467063:128467156ENSG00000136709.7ENST00000322313.4
exon_skip_3433142128467266:128467430:128471156:128471595:128474728:128474837128471156:128471595ENSG00000136709.7ENST00000322313.4
exon_skip_3433202128471156:128471595:128474728:128474837:128476838:128477927128474728:128474837ENSG00000136709.7ENST00000322313.4
exon_skip_3433212128480826:128480921:128481906:128482017:128482460:128482539128481906:128482017ENSG00000136709.7ENST00000322313.4
exon_skip_3433232128484225:128484351:128520635:128520733:128522401:128522553128520635:128520733ENSG00000136709.7ENST00000322313.4,ENST00000436787.1
exon_skip_3433292128526506:128526575:128528351:128528578:128568585:128568721128528351:128528578ENSG00000136709.7ENST00000393006.1,ENST00000409658.3

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for WDR33

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000322313128471156128471595Frame-shift
ENST00000322313128474728128474837Frame-shift
ENST00000322313128520635128520733Frame-shift
ENST00000322313128467063128467156In-frame
ENST00000322313128481906128482017In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000322313128471156128471595Frame-shift
ENST00000322313128474728128474837Frame-shift
ENST00000322313128520635128520733Frame-shift
ENST00000322313128467063128467156In-frame
ENST00000322313128481906128482017In-frame

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Infer the effects of exon skipping event on protein functional features for WDR33

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003223139488133612848190612848201712451355362398
ENST00000322313948813361284670631284671563632372411571188

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003223139488133612848190612848201712451355362398
ENST00000322313948813361284670631284671563632372411571188

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9C0J83623983271336Alternative sequenceID=VSP_041334;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
Q9C0J8362398368370Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
Q9C0J8362398378383Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
Q9C0J8362398387397Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
Q9C0J836239821336ChainID=PRO_0000051382;Note=pre-mRNA 3' end processing protein WDR33
Q9C0J8362398329369RepeatNote=WD 6
Q9C0J8362398373412RepeatNote=WD 7
Q9C0J8115711883271336Alternative sequenceID=VSP_041334;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
Q9C0J81157118821336ChainID=PRO_0000051382;Note=pre-mRNA 3' end processing protein WDR33


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9C0J83623983271336Alternative sequenceID=VSP_041334;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
Q9C0J8362398368370Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
Q9C0J8362398378383Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
Q9C0J8362398387397Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:6F9N
Q9C0J836239821336ChainID=PRO_0000051382;Note=pre-mRNA 3' end processing protein WDR33
Q9C0J8362398329369RepeatNote=WD 6
Q9C0J8362398373412RepeatNote=WD 7
Q9C0J8115711883271336Alternative sequenceID=VSP_041334;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334
Q9C0J81157118821336ChainID=PRO_0000051382;Note=pre-mRNA 3' end processing protein WDR33


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SNVs in the skipped exons for WDR33

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
WDR33_LUSC_exon_skip_343314_psi_boxplot.png
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WDR33_PAAD_exon_skip_343314_psi_boxplot.png
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check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
BLCATCGA-GC-A3RB-01exon_skip_343314
128471157128471595128471200128471200Frame_Shift_DelG-p.R1089fs
LIHCTCGA-DD-A39Y-01exon_skip_343321
128481907128482017128481975128481975Frame_Shift_DelC-p.G376fs
LIHCTCGA-G3-A3CJ-01exon_skip_343323
128520636128520733128520664128520664Frame_Shift_DelA-p.L232fs
LIHCTCGA-G3-A3CJ-01exon_skip_343329
128528352128528578128528356128528356Frame_Shift_DelA-p.L67fs
LIHCTCGA-DD-A1EG-01exon_skip_343329
128528352128528578128528390128528390Frame_Shift_DelT-p.T56fs
LIHCTCGA-DD-A3A0-01exon_skip_343329
128528352128528578128528390128528390Frame_Shift_DelT-p.T56fs
LIHCTCGA-DD-A39Y-01exon_skip_343329
128528352128528578128528454128528454Frame_Shift_DelT-p.Q36fs
LIHCTCGA-DD-A39Y-01exon_skip_343329
128528352128528578128528521128528521Frame_Shift_DelA-p.F12fs
LIHCTCGA-DD-A3A0-01exon_skip_343329
128528352128528578128528521128528521Frame_Shift_DelA-p.F12fs
KIRCTCGA-B0-5119-01exon_skip_343321
128481907128482017128481936128481937Frame_Shift_Ins-ATp.I389fs
KIRCTCGA-B0-5119-01exon_skip_343321
128481907128482017128481936128481937Frame_Shift_Ins-ATp.T389fs
LUSCTCGA-66-2763-01exon_skip_343314
128471157128471595128471191128471191Nonsense_MutationCAp.E1092*
PAADTCGA-IB-7651-01exon_skip_343314
128471157128471595128471362128471362Nonsense_MutationGAp.R1035*
PAADTCGA-IB-7651-01exon_skip_343314
128471157128471595128471362128471362Nonsense_MutationGAp.R1035X
STADTCGA-HU-8602-01exon_skip_343323
128520636128520733128520648128520648Nonsense_MutationTAp.R238*
STADTCGA-HU-8602-01exon_skip_343323
128520636128520733128520648128520648Nonsense_MutationTAp.R238X
STADTCGA-D7-A6EZ-01exon_skip_343311
128467064128467156128467158128467158Splice_SiteTA.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
WDR33_128467266_128467430_128471156_128471595_128474728_128474837_TCGA-IB-7651-01Sample: TCGA-IB-7651-01
Cancer type: PAAD
ESID: exon_skip_343314
Skipped exon start: 128471157
Skipped exon end: 128471595
Mutation start: 128471362
Mutation end: 128471362
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.R1035X
WDR33_128467266_128467430_128471156_128471595_128474728_128474837_TCGA-IB-7651-01Sample: TCGA-IB-7651-01
Cancer type: PAAD
ESID: exon_skip_343314
Skipped exon start: 128471157
Skipped exon end: 128471595
Mutation start: 128471362
Mutation end: 128471362
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.R1035*
exon_skip_113241_PAAD_TCGA-IB-7651-01.png
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exon_skip_115380_PAAD_TCGA-IB-7651-01.png
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exon_skip_124564_PAAD_TCGA-IB-7651-01.png
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exon_skip_135806_PAAD_TCGA-IB-7651-01.png
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exon_skip_139341_PAAD_TCGA-IB-7651-01.png
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exon_skip_153733_PAAD_TCGA-IB-7651-01.png
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exon_skip_155805_PAAD_TCGA-IB-7651-01.png
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exon_skip_18053_PAAD_TCGA-IB-7651-01.png
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exon_skip_18056_PAAD_TCGA-IB-7651-01.png
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exon_skip_23067_PAAD_TCGA-IB-7651-01.png
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exon_skip_287059_PAAD_TCGA-IB-7651-01.png
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exon_skip_294631_PAAD_TCGA-IB-7651-01.png
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exon_skip_298512_PAAD_TCGA-IB-7651-01.png
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exon_skip_306900_PAAD_TCGA-IB-7651-01.png
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exon_skip_307723_PAAD_TCGA-IB-7651-01.png
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exon_skip_315960_PAAD_TCGA-IB-7651-01.png
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exon_skip_324675_PAAD_TCGA-IB-7651-01.png
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exon_skip_330351_PAAD_TCGA-IB-7651-01.png
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exon_skip_334330_PAAD_TCGA-IB-7651-01.png
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exon_skip_341784_PAAD_TCGA-IB-7651-01.png
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exon_skip_343314_PAAD_TCGA-IB-7651-01.png
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exon_skip_348329_PAAD_TCGA-IB-7651-01.png
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exon_skip_354232_PAAD_TCGA-IB-7651-01.png
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exon_skip_370626_PAAD_TCGA-IB-7651-01.png
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exon_skip_377740_PAAD_TCGA-IB-7651-01.png
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exon_skip_385032_PAAD_TCGA-IB-7651-01.png
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exon_skip_390031_PAAD_TCGA-IB-7651-01.png
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exon_skip_422548_PAAD_TCGA-IB-7651-01.png
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exon_skip_424536_PAAD_TCGA-IB-7651-01.png
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exon_skip_431753_PAAD_TCGA-IB-7651-01.png
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exon_skip_432982_PAAD_TCGA-IB-7651-01.png
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exon_skip_435489_PAAD_TCGA-IB-7651-01.png
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exon_skip_435729_PAAD_TCGA-IB-7651-01.png
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exon_skip_441705_PAAD_TCGA-IB-7651-01.png
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exon_skip_448879_PAAD_TCGA-IB-7651-01.png
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exon_skip_468347_PAAD_TCGA-IB-7651-01.png
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exon_skip_494000_PAAD_TCGA-IB-7651-01.png
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exon_skip_494029_PAAD_TCGA-IB-7651-01.png
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exon_skip_499410_PAAD_TCGA-IB-7651-01.png
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exon_skip_499695_PAAD_TCGA-IB-7651-01.png
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exon_skip_499697_PAAD_TCGA-IB-7651-01.png
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exon_skip_79905_PAAD_TCGA-IB-7651-01.png
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exon_skip_80096_PAAD_TCGA-IB-7651-01.png
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exon_skip_95924_PAAD_TCGA-IB-7651-01.png
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check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
C33A_CERVIX128471157128471595128471197128471197Frame_Shift_DelC-p.D1090fs
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE128471157128471595128471239128471239Frame_Shift_DelC-p.A1076fs
DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE128471157128471595128471298128471298Frame_Shift_DelG-p.P1056fs
MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE128474729128474837128474736128474736Frame_Shift_DelG-p.P954fs
LC2AD_LUNG128467064128467156128467070128467070Missense_MutationCGp.E1187Q
LOVO_LARGE_INTESTINE128467064128467156128467100128467100Missense_MutationGAp.R1177W
LS411N_LARGE_INTESTINE128467064128467156128467100128467100Missense_MutationGAp.R1177W
D502MG_CENTRAL_NERVOUS_SYSTEM128467064128467156128467103128467103Missense_MutationCTp.G1176R
NCIH146_LUNG128471157128471595128471203128471203Missense_MutationGAp.P1088S
A253_SALIVARY_GLAND128471157128471595128471209128471209Missense_MutationGAp.R1086C
SNU1040_LARGE_INTESTINE128471157128471595128471223128471223Missense_MutationCAp.R1081M
SW48_LARGE_INTESTINE128471157128471595128471280128471280Missense_MutationCTp.S1062N
RL952_ENDOMETRIUM128471157128471595128471325128471325Missense_MutationCTp.R1047Q
KLE_ENDOMETRIUM128471157128471595128471524128471524Missense_MutationGCp.P981A
ZR751_BREAST128471157128471595128471545128471545Missense_MutationGAp.R974W
YMB1E_BREAST128471157128471595128471545128471545Missense_MutationGAp.R974W
UMUC14_URINARY_TRACT128471157128471595128471553128471553Missense_MutationGAp.S971L
MEWO_SKIN128471157128471595128471572128471572Missense_MutationGAp.H965Y
SNU175_LARGE_INTESTINE128471157128471595128471586128471586Missense_MutationCTp.R960H
GP2D_LARGE_INTESTINE128471157128471595128471586128471586Missense_MutationCTp.R960H
GP5D_LARGE_INTESTINE128471157128471595128471586128471586Missense_MutationCTp.R960H
LS180_LARGE_INTESTINE128481907128482017128481971128481971Missense_MutationTCp.I378V
HEC50B_ENDOMETRIUM128481907128482017128482007128482007Missense_MutationCGp.E366Q
NCIH2087_LUNG128520636128520733128520647128520647Missense_MutationCTp.R238K
SNU1040_LARGE_INTESTINE128520636128520733128520663128520663Missense_MutationGAp.R233C
OC314_OVARY128528352128528578128528354128528354Missense_MutationCTp.E68K
KMS34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE128528352128528578128528366128528366Missense_MutationTGp.I64L
SNUC2B_LARGE_INTESTINE128528352128528578128528380128528380Missense_MutationTCp.Y59C
UACC893_BREAST128528352128528578128528404128528404Missense_MutationGTp.A51D
NCIH650_LUNG128528352128528578128528528128528528Missense_MutationGAp.R10C
BE2M17_AUTONOMIC_GANGLIA128528352128528578128528533128528533Missense_MutationGTp.P8H
LB996RCC_KIDNEY128471157128471595128471176128471176Nonsense_MutationGAp.R1097*
SNU1040_LARGE_INTESTINE128471157128471595128471326128471326Nonsense_MutationGAp.R1047*
MM127_SKIN128471157128471595128471594128471594Splice_SiteATp.G957G

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR33

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR33


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR33


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RelatedDrugs for WDR33

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR33

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource