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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for UBE2W |
 Gene summary |
| Gene information | Gene symbol | UBE2W | Gene ID | 55284 |
| Gene name | ubiquitin conjugating enzyme E2 W | |
| Synonyms | UBC-16|UBC16 | |
| Cytomap | 8q21.11 | |
| Type of gene | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 WE2 ubiquitin-conjugating enzyme WN-terminal E2 ubiquitin-conjugating enzymeN-terminus-conjugating E2ubiquitin carrier protein Wubiquitin conjugating enzyme E2 W (putative)ubiquitin conjugating enzyme E2W (putative)u | |
| Modification date | 20180523 | |
| UniProtAcc | Q96B02 | |
| Context | PubMed: UBE2W [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| UBE2W | GO:0006513 | protein monoubiquitination | 19111657|20061386 |
| UBE2W | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
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Exon skipping events across known transcript of Ensembl for UBE2W from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for UBE2W |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for UBE2W |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_490349 | 8 | 74722708:74722864:74737381:74737484:74742615:74742707 | 74737381:74737484 | ENSG00000104343.15 | ENST00000453587.2,ENST00000419880.3,ENST00000517608.1,ENST00000602593.1,ENST00000602969.1 |
| exon_skip_490350 | 8 | 74742615:74742707:74782503:74782536:74791042:74791110 | 74782503:74782536 | ENSG00000104343.15 | ENST00000419880.3,ENST00000602969.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for UBE2W |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_490349 | 8 | 74722708:74722864:74737381:74737484:74742615:74742707 | 74737381:74737484 | ENSG00000104343.15 | ENST00000453587.2,ENST00000517608.1,ENST00000602969.1,ENST00000602593.1,ENST00000419880.3 |
| exon_skip_490350 | 8 | 74742615:74742707:74782503:74782536:74791042:74791110 | 74782503:74782536 | ENSG00000104343.15 | ENST00000602969.1,ENST00000419880.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for UBE2W |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000602593 | 74737381 | 74737484 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000602593 | 74737381 | 74737484 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for UBE2W |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for UBE2W |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
UBE2W_SKCM_exon_skip_490350_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_490349 | 74737382 | 74737484 | 74737412 | 74737412 | Frame_Shift_Del | A | - | p.F89fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_490349 | 74737382 | 74737484 | 74737415 | 74737415 | Frame_Shift_Del | T | - | p.K88fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_490349 | 74737382 | 74737484 | 74737415 | 74737415 | Frame_Shift_Del | T | - | p.K88fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_490349 | 74737382 | 74737484 | 74737415 | 74737415 | Frame_Shift_Del | T | - | p.K88fs |
| PCPG | TCGA-RW-A68F-01 | exon_skip_490349 | 74737382 | 74737484 | 74737421 | 74737421 | Frame_Shift_Del | T | - | p.L86fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_490349 | 74737382 | 74737484 | 74737430 | 74737430 | Frame_Shift_Del | A | - | p.F83fs |
| SKCM | TCGA-EE-A2A2-06 | exon_skip_490350 | 74782504 | 74782536 | 74782503 | 74782503 | Splice_Site | C | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-EE-A2A2-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_490350 | |
| Skipped exon start: 74782504 | |
| Skipped exon end: 74782536 | |
| Mutation start: 74782503 | |
| Mutation end: 74782503 | |
| Mutation type: Splice_Site | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: . | |
exon_skip_303493_SKCM_TCGA-EE-A2A2-06.png | |
exon_skip_314480_SKCM_TCGA-EE-A2A2-06.png | |
exon_skip_318867_SKCM_TCGA-EE-A2A2-06.png | |
exon_skip_325522_SKCM_TCGA-EE-A2A2-06.png | |
exon_skip_457065_SKCM_TCGA-EE-A2A2-06.png | |
exon_skip_490350_SKCM_TCGA-EE-A2A2-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU1040_LARGE_INTESTINE | 74737382 | 74737484 | 74737433 | 74737433 | Frame_Shift_Del | T | - | p.K53fs |
| NCIH747_LARGE_INTESTINE | 74737382 | 74737484 | 74737393 | 74737393 | Missense_Mutation | C | T | p.D67N |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 74737382 | 74737484 | 74737383 | 74737383 | Splice_Site | T | C | p.Q70R |
| CCK81_LARGE_INTESTINE | 74737382 | 74737484 | 74737383 | 74737383 | Splice_Site | T | C | p.Q70R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for UBE2W |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for UBE2W |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for UBE2W |
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RelatedDrugs for UBE2W |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2W |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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