ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for PXK

Gene summary

Gene information	Gene symbol	PXK
	Gene ID	54899
	Gene name	PX domain containing serine/threonine kinase like
	Synonyms	MONAKA\|SLOB
	Cytomap	3p14.3
	Type of gene	protein-coding
	Description	PX domain-containing protein kinase-like proteinPX ser/thr kinase v2PX serine/threonine kinasemodulator of Na,K-ATPase long form
	Modification date	20180523
	UniProtAcc	Q7Z7A4
	Context	PubMed: PXK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for PXK from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for PXK

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for PXK

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_375690	3	58318713:58318817:58351600:58351651:58355157:58355205	58351600:58351651	ENSG00000168297.11	ENST00000477308.1,ENST00000484288.1
exon_skip_375692	3	58318713:58318817:58355157:58355205:58368240:58368405	58355157:58355205	ENSG00000168297.11	ENST00000383715.4,ENST00000302779.5,ENST00000479241.1
exon_skip_375694	3	58318713:58318817:58368240:58368427:58376308:58376386	58368240:58368427	ENSG00000168297.11	ENST00000463280.1,ENST00000383716.3
exon_skip_375695	3	58351600:58351651:58355157:58355205:58368240:58368405	58355157:58355205	ENSG00000168297.11	ENST00000477308.1,ENST00000356151.2,ENST00000491164.1,ENST00000484288.1
exon_skip_375697	3	58355157:58355205:58368240:58368427:58376308:58376386	58368240:58368427	ENSG00000168297.11	ENST00000383715.4,ENST00000302779.5,ENST00000356151.2,ENST00000484288.1,ENST00000479241.1
exon_skip_375698	3	58383331:58383449:58385025:58385104:58389588:58389637	58385025:58385104	ENSG00000168297.11	ENST00000477308.1,ENST00000383715.4,ENST00000463280.1,ENST00000302779.5,ENST00000356151.2,ENST00000459676.2,ENST00000484288.1,ENST00000479241.1,ENST00000383716.3,ENST00000468776.1,ENST00000536660.1,ENST00000479134.1
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENSG00000168297.11	ENST00000479134.1
exon_skip_375704	3	58395819:58395886:58398627:58398690:58410478:58410785	58398627:58398690	ENSG00000168297.11	ENST00000477308.1,ENST00000302779.5,ENST00000356151.2,ENST00000383716.3,ENST00000468776.1,ENST00000536660.1
exon_skip_375709	3	58398630:58398690:58406262:58406295:58410478:58410785	58406262:58406295	ENSG00000168297.11	ENST00000463280.1,ENST00000493474.1
exon_skip_375710	3	58398630:58398690:58409187:58409221:58410478:58410785	58409187:58409221	ENSG00000168297.11	ENST00000479241.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for PXK

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_375690	3	58318713:58318817:58351600:58351651:58355157:58355205	58351600:58351651	ENSG00000168297.11	ENST00000484288.1,ENST00000477308.1
exon_skip_375692	3	58318713:58318817:58355157:58355205:58368240:58368405	58355157:58355205	ENSG00000168297.11	ENST00000302779.5,ENST00000383715.4,ENST00000479241.1
exon_skip_375694	3	58318713:58318817:58368240:58368427:58376308:58376386	58368240:58368427	ENSG00000168297.11	ENST00000383716.3,ENST00000463280.1
exon_skip_375695	3	58351600:58351651:58355157:58355205:58368240:58368405	58355157:58355205	ENSG00000168297.11	ENST00000356151.2,ENST00000484288.1,ENST00000477308.1,ENST00000491164.1
exon_skip_375697	3	58355157:58355205:58368240:58368427:58376308:58376386	58368240:58368427	ENSG00000168297.11	ENST00000356151.2,ENST00000302779.5,ENST00000383715.4,ENST00000484288.1,ENST00000479241.1
exon_skip_375698	3	58383331:58383449:58385025:58385104:58389588:58389637	58385025:58385104	ENSG00000168297.11	ENST00000356151.2,ENST00000468776.1,ENST00000302779.5,ENST00000383716.3,ENST00000463280.1,ENST00000383715.4,ENST00000484288.1,ENST00000479241.1,ENST00000536660.1,ENST00000477308.1,ENST00000479134.1,ENST00000459676.2
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENSG00000168297.11	ENST00000479134.1
exon_skip_375704	3	58395819:58395886:58398627:58398690:58410478:58410785	58398627:58398690	ENSG00000168297.11	ENST00000356151.2,ENST00000468776.1,ENST00000302779.5,ENST00000383716.3,ENST00000536660.1,ENST00000477308.1
exon_skip_375709	3	58398630:58398690:58406262:58406295:58410478:58410785	58406262:58406295	ENSG00000168297.11	ENST00000463280.1,ENST00000493474.1
exon_skip_375710	3	58398630:58398690:58409187:58409221:58410478:58410785	58409187:58409221	ENSG00000168297.11	ENST00000479241.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for PXK

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000356151	58368240	58368427	Frame-shift
ENST00000356151	58385025	58385104	Frame-shift
ENST00000356151	58355157	58355205	In-frame
ENST00000356151	58398627	58398690	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000356151	58368240	58368427	Frame-shift
ENST00000356151	58385025	58385104	Frame-shift
ENST00000356151	58355157	58355205	In-frame
ENST00000356151	58398627	58398690	In-frame

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Infer the effects of exon skipping event on protein functional features for PXK

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000356151	2054	578	58355157	58355205	263	310	51	67
ENST00000356151	2054	578	58398627	58398690	1575	1637	488	509

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000356151	2054	578	58355157	58355205	263	310	51	67
ENST00000356151	2054	578	58398627	58398690	1575	1637	488	509

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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SNVs in the skipped exons for PXK

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
STAD	TCGA-HU-A4GQ-01	exon_skip_375694 exon_skip_375697	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.P77fs
STAD	TCGA-HU-A4GQ-01	exon_skip_375694 exon_skip_375697	58368241	58368427	58368271	58368272	Frame_Shift_Ins	-	A	p.P77fs
UCEC	TCGA-AX-A05Z-01	exon_skip_375690	58351601	58351651	58351613	58351613	Nonsense_Mutation	C	T	p.R39*
UCEC	TCGA-D1-A16X-01	exon_skip_375698	58385026	58385104	58385103	58385103	Nonsense_Mutation	C	A	p.C148*
OV	TCGA-04-1336-01	exon_skip_375694 exon_skip_375697	58368241	58368427	58368240	58368240	Splice_Site	G	T	e4-1
GBM	TCGA-06-0171-02	exon_skip_375698	58385026	58385104	58385105	58385105	Splice_Site	G	A	p.P394_splice

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
CADOES1_BONE	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
CAL148_BREAST	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
CAOV3_OVARY	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
CL11_LARGE_INTESTINE	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
CORL311_LUNG	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
EB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
HCC1833_LUNG	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
HCC2157_BREAST	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
HSC3_UPPER_AERODIGESTIVE_TRACT	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
HT144_SKIN	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
HT55_LARGE_INTESTINE	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
KMS18_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
LOXIMVI_SKIN	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
MDAMB157_BREAST	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
MDAMB468_BREAST	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
NCIH1563_LUNG	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
NCIH1648_LUNG	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
NCIH2029_LUNG	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
NCIH2087_LUNG	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
NMCG1_CENTRAL_NERVOUS_SYSTEM	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
OC314_OVARY	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
SNU520_STOMACH	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
TTC642_SOFT_TISSUE	58368241	58368427	58368270	58368271	Frame_Shift_Ins	-	A	p.K78fs
SNU81_LARGE_INTESTINE	58351601	58351651	58351614	58351614	Missense_Mutation	G	A	p.R39Q
MFE319_ENDOMETRIUM	58351601	58351651	58351626	58351626	Missense_Mutation	G	A	p.G43E
RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58368241	58368427	58368266	58368266	Missense_Mutation	C	A	p.P76H
HT115_LARGE_INTESTINE	58368241	58368427	58368287	58368287	Missense_Mutation	A	G	p.N83S
LC41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58368241	58368427	58368304	58368304	Missense_Mutation	A	G	p.I89V
OSC19_UPPER_AERODIGESTIVE_TRACT	58368241	58368427	58368304	58368304	Missense_Mutation	A	G	p.I89V
CJM_SKIN	58368241	58368427	58368304	58368304	Missense_Mutation	A	G	p.I89V
HT29_LARGE_INTESTINE	58385026	58385104	58385029	58385029	Missense_Mutation	C	T	p.A369V
P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58385026	58385104	58385062	58385062	Missense_Mutation	G	T	p.C380F
BICR18_UPPER_AERODIGESTIVE_TRACT	58385026	58385104	58385082	58385082	Missense_Mutation	A	G	p.I387V
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58385026	58385104	58385082	58385082	Missense_Mutation	A	G	p.I387V
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58385026	58385104	58385082	58385082	Missense_Mutation	A	G	p.I387V
JMSU1_URINARY_TRACT	58385026	58385104	58385098	58385098	Missense_Mutation	A	G	p.Q392R
SKN3_UPPER_AERODIGESTIVE_TRACT	58385026	58385104	58385098	58385098	Missense_Mutation	A	G	p.Q392R
SUDHL6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	58398628	58398690	58398658	58398658	Missense_Mutation	C	G	p.S499C
VMRCRCZ_KIDNEY	58368241	58368427	58368241	58368241	Splice_Site	A	T	p.I68F
CASKI_CERVIX	58398628	58398690	58398687	58398695	Splice_Site	TCAGGTTAG	-	p.SG509del

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PXK

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	GBM	rs4681851	chr3:58395891	C/G	7.43e-15
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	COAD	rs4681851	chr3:58395891	C/G	3.90e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	COAD	rs4681851	chr3:58395891	C/G	3.90e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BLCA	rs4681851	chr3:58395891	C/G	8.38e-10
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BLCA	rs4681851	chr3:58395891	C/G	8.39e-10
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	ESCA	rs4681851	chr3:58395891	C/G	2.68e-22
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	ESCA	rs4681851	chr3:58395891	C/G	6.57e-06
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	ESCA	rs4681851	chr3:58395891	C/G	7.06e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	HNSC	rs4681851	chr3:58395891	C/G	6.10e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	HNSC	rs4681851	chr3:58395891	C/G	6.15e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BRCA	rs4681851	chr3:58395891	C/G	9.06e-46
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BRCA	rs4681851	chr3:58395891	C/G	3.21e-22
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BRCA	rs4681851	chr3:58395891	C/G	3.24e-22
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BRCA	rs56384862	chr3:58395863	A/G	3.93e-07
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	BRCA	rs4681851	chr3:58395891	C/G	7.25e-06
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LAML	rs4681851	chr3:58395891	C/G	1.19e-13
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LGG	rs4681851	chr3:58395891	C/G	1.04e-79
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LGG	rs4681851	chr3:58395891	C/G	2.12e-10
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LGG	rs4681851	chr3:58395891	C/G	2.13e-10
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LGG	rs4681851	chr3:58395891	C/G	1.67e-06
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LGG	rs56384862	chr3:58395863	A/G	1.25e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LGG	rs56384862	chr3:58395863	A/G	2.92e-03
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	KIRC	rs4681851	chr3:58395891	C/G	3.60e-04
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	KIRC	rs4681851	chr3:58395891	C/G	3.60e-04
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LUAD	rs4681851	chr3:58395891	C/G	4.19e-07
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	LUAD	rs4681851	chr3:58395891	C/G	4.19e-07
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	MESO	rs4681851	chr3:58395891	C/G	3.78e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	MESO	rs4681851	chr3:58395891	C/G	3.78e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	OV	rs4681851	chr3:58395891	C/G	4.97e-48
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	OV	rs4681851	chr3:58395891	C/G	1.79e-10
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	OV	rs4681851	chr3:58395891	C/G	1.28e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	OV	rs4681851	chr3:58395891	C/G	1.29e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	OV	rs56384862	chr3:58395863	A/G	5.82e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	OV	rs4681851	chr3:58395891	C/G	9.91e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	PAAD	rs4681851	chr3:58395891	C/G	4.10e-04
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	PAAD	rs4681851	chr3:58395891	C/G	4.12e-04
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	PAAD	rs56384862	chr3:58395863	A/G	1.00e-03
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	PAAD	rs56384862	chr3:58395863	A/G	1.01e-03
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	PRAD	rs4681851	chr3:58395891	C/G	1.22e-11
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	PRAD	rs4681851	chr3:58395891	C/G	1.22e-11
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	SARC	rs4681851	chr3:58395891	C/G	1.81e-13
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THYM	rs4681851	chr3:58395891	C/G	1.06e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THYM	rs4681851	chr3:58395891	C/G	1.06e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	TGCT	rs4681851	chr3:58395891	C/G	2.05e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	TGCT	rs4681851	chr3:58395891	C/G	2.05e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	SKCM	rs4681851	chr3:58395891	C/G	1.67e-04
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	STAD	rs4681851	chr3:58395891	C/G	1.52e-35
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	STAD	rs4681851	chr3:58395891	C/G	3.30e-06
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	STAD	rs4681851	chr3:58395891	C/G	3.69e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	STAD	rs4681851	chr3:58395891	C/G	3.69e-05
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THCA	rs4681851	chr3:58395891	C/G	1.50e-84
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THCA	rs4681851	chr3:58395891	C/G	1.40e-18
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THCA	rs4681851	chr3:58395891	C/G	1.41e-18
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THCA	rs4681851	chr3:58395891	C/G	3.13e-09
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THCA	rs56384862	chr3:58395863	A/G	6.70e-08
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	THCA	rs4681851	chr3:58395891	C/G	3.74e-06
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	UCEC	rs4681851	chr3:58395891	C/G	6.83e-04
exon_skip_375700	3	58395342:58395345:58395816:58395886:58410478:58410785	58395816:58395886	ENST00000479134.1	UCEC	rs4681851	chr3:58395891	C/G	6.83e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PXK

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PXK

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RelatedDrugs for PXK

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PXK

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PXK	C0003873	Rheumatoid Arthritis	1	CTD_human
PXK	C0024141	Lupus Erythematosus, Systemic	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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