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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RBM11 |
 Gene summary |
| Gene information | Gene symbol | RBM11 | Gene ID | 54033 |
| Gene name | RNA binding motif protein 11 | |
| Synonyms | - | |
| Cytomap | 21q11.2 | |
| Type of gene | protein-coding | |
| Description | splicing regulator RBM11putative RNA-binding protein 11 | |
| Modification date | 20180523 | |
| UniProtAcc | P57052 | |
| Context | PubMed: RBM11 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RBM11 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21984414 |
| RBM11 | GO:0034599 | cellular response to oxidative stress | 21984414 |
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Exon skipping events across known transcript of Ensembl for RBM11 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RBM11 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RBM11 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358905 | 21 | 15588498:15588603:15591873:15592046:15593417:15593490 | 15591873:15592046 | ENSG00000185272.9 | ENST00000468788.1 |
| exon_skip_358906 | 21 | 15588498:15588603:15591883:15592046:15593417:15593490 | 15591883:15592046 | ENSG00000185272.9 | ENST00000400577.3,ENST00000461088.1 |
| exon_skip_358911 | 21 | 15593417:15593490:15596758:15596858:15599200:15599705 | 15596758:15596858 | ENSG00000185272.9 | ENST00000400577.3,ENST00000468643.1,ENST00000495055.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RBM11 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_358905 | 21 | 15588498:15588603:15591873:15592046:15593417:15593490 | 15591873:15592046 | ENSG00000185272.9 | ENST00000468788.1 |
| exon_skip_358906 | 21 | 15588498:15588603:15591883:15592046:15593417:15593490 | 15591883:15592046 | ENSG00000185272.9 | ENST00000461088.1,ENST00000400577.3 |
| exon_skip_358911 | 21 | 15593417:15593490:15596758:15596858:15599200:15599705 | 15596758:15596858 | ENSG00000185272.9 | ENST00000468643.1,ENST00000495055.1,ENST00000400577.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RBM11 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000400577 | 15591883 | 15592046 | Frame-shift |
| ENST00000400577 | 15596758 | 15596858 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000400577 | 15591883 | 15592046 | Frame-shift |
| ENST00000400577 | 15596758 | 15596858 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RBM11 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RBM11 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
RBM11_CESC_exon_skip_358911_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-D3-A3MU-06 | exon_skip_358911 | 15596759 | 15596858 | 15596777 | 15596777 | Frame_Shift_Del | G | - | p.V117fs |
| PRAD | TCGA-VP-A87D-01 | exon_skip_358905 exon_skip_358906 | 15591874 | 15592046 | 15592040 | 15592040 | Nonsense_Mutation | C | T | p.R85* |
| PRAD | TCGA-VP-A87D-01 | exon_skip_358905 exon_skip_358906 | 15591884 | 15592046 | 15592040 | 15592040 | Nonsense_Mutation | C | T | p.R85* |
| SKCM | TCGA-FS-A1ZW-06 | exon_skip_358905 exon_skip_358906 | 15591874 | 15592046 | 15592040 | 15592040 | Nonsense_Mutation | C | T | p.R85* |
| SKCM | TCGA-FS-A1ZW-06 | exon_skip_358905 exon_skip_358906 | 15591884 | 15592046 | 15592040 | 15592040 | Nonsense_Mutation | C | T | p.R85* |
| CESC | TCGA-EK-A3GK-01 | exon_skip_358911 | 15596759 | 15596858 | 15596832 | 15596832 | Nonsense_Mutation | C | T | p.Q136* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-EK-A3GK-01 |
| Cancer type: CESC | |
| ESID: exon_skip_358911 | |
| Skipped exon start: 15596759 | |
| Skipped exon end: 15596858 | |
| Mutation start: 15596832 | |
| Mutation end: 15596832 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.Q136* | |
exon_skip_322487_CESC_TCGA-EK-A3GK-01.png | |
exon_skip_358911_CESC_TCGA-EK-A3GK-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH838_LUNG | 15596759 | 15596858 | 15596777 | 15596777 | Frame_Shift_Del | G | - | p.V117fs |
| HCC2998_LARGE_INTESTINE | 15591874 | 15592046 | 15591939 | 15591939 | Missense_Mutation | C | A | p.S51Y |
| HCC2998_LARGE_INTESTINE | 15591884 | 15592046 | 15591939 | 15591939 | Missense_Mutation | C | A | p.S51Y |
| MZ1PC_PANCREAS | 15591874 | 15592046 | 15591945 | 15591945 | Missense_Mutation | G | A | p.G53E |
| MZ1PC_PANCREAS | 15591884 | 15592046 | 15591945 | 15591945 | Missense_Mutation | G | A | p.G53E |
| TUHR14TKB_KIDNEY | 15591874 | 15592046 | 15591958 | 15591958 | Missense_Mutation | T | A | p.F57L |
| TUHR14TKB_KIDNEY | 15591884 | 15592046 | 15591958 | 15591958 | Missense_Mutation | T | A | p.F57L |
| SW684_SOFT_TISSUE | 15591874 | 15592046 | 15591972 | 15591972 | Missense_Mutation | C | T | p.S62L |
| SW684_SOFT_TISSUE | 15591884 | 15592046 | 15591972 | 15591972 | Missense_Mutation | C | T | p.S62L |
| SNU475_LIVER | 15591874 | 15592046 | 15592004 | 15592004 | Missense_Mutation | A | C | p.I73L |
| SNU475_LIVER | 15591884 | 15592046 | 15592004 | 15592004 | Missense_Mutation | A | C | p.I73L |
| CHLA32_BONE | 15591874 | 15592046 | 15592008 | 15592008 | Missense_Mutation | G | A | p.R74H |
| CHLA32_BONE | 15591884 | 15592046 | 15592008 | 15592008 | Missense_Mutation | G | A | p.R74H |
| HCT15_LARGE_INTESTINE | 15591874 | 15592046 | 15592037 | 15592037 | Missense_Mutation | T | C | p.Y84H |
| HCT15_LARGE_INTESTINE | 15591884 | 15592046 | 15592037 | 15592037 | Missense_Mutation | T | C | p.Y84H |
| MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15591874 | 15592046 | 15592038 | 15592038 | Missense_Mutation | A | G | p.Y84C |
| MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15591884 | 15592046 | 15592038 | 15592038 | Missense_Mutation | A | G | p.Y84C |
| SNU387_LIVER | 15596759 | 15596858 | 15596775 | 15596775 | Missense_Mutation | G | A | p.V117M |
| KARPAS1106P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15591874 | 15592046 | 15591885 | 15591885 | Splice_Site | C | T | p.A33V |
| KARPAS1106P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 15591884 | 15592046 | 15591885 | 15591885 | Splice_Site | C | T | p.A33V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RBM11 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RBM11 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RBM11 |
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RelatedDrugs for RBM11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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