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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC37A1 |
 Gene summary |
| Gene information | Gene symbol | SLC37A1 | Gene ID | 54020 |
| Gene name | solute carrier family 37 member 1 | |
| Synonyms | G3PP | |
| Cytomap | 21q22.3 | |
| Type of gene | protein-coding | |
| Description | glucose-6-phosphate exchanger SLC37A1G-3-P permeaseG-3-P transporterglycerol-3-phosphate permeaseglycerol-3-phosphate transportersolute carrier family 37 (glucose-6-phosphate transporter), member 1solute carrier family 37 (glycerol-3-phosphate trans | |
| Modification date | 20180329 | |
| UniProtAcc | P57057 | |
| Context | PubMed: SLC37A1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC37A1 | GO:0015760 | glucose-6-phosphate transport | 21949678 |
| SLC37A1 | GO:0035435 | phosphate ion transmembrane transport | 21949678 |
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Exon skipping events across known transcript of Ensembl for SLC37A1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC37A1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC37A1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_360185 | 21 | 43934001:43934034:43934740:43934827:43938386:43938620 | 43934740:43934827 | ENSG00000160190.9 | ENST00000471277.1 |
| exon_skip_360187 | 21 | 43934740:43934827:43934979:43935045:43938386:43938617 | 43934979:43935045 | ENSG00000160190.9 | ENST00000398343.2 |
| exon_skip_360190 | 21 | 43945885:43945967:43954807:43954940:43955581:43955660 | 43954807:43954940 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| exon_skip_360193 | 21 | 43959621:43959757:43962513:43962590:43963545:43963712 | 43962513:43962590 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| exon_skip_360194 | 21 | 43963626:43963712:43967212:43967250:43974171:43974252 | 43967212:43967250 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| exon_skip_360195 | 21 | 43974171:43974252:43979067:43979199:43982187:43982278 | 43979067:43979199 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| exon_skip_360196 | 21 | 43983924:43983987:43984817:43984903:43985936:43985985 | 43984817:43984903 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| exon_skip_360202 | 21 | 43988469:43988548:43994927:43995025:43999845:43999910 | 43994927:43995025 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| exon_skip_360213 | 21 | 43994927:43995025:43999845:43999910:44000454:44001550 | 43999845:43999910 | ENSG00000160190.9 | ENST00000352133.2,ENST00000398341.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC37A1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_360185 | 21 | 43934001:43934034:43934740:43934827:43938386:43938620 | 43934740:43934827 | ENSG00000160190.9 | ENST00000471277.1 |
| exon_skip_360187 | 21 | 43934740:43934827:43934979:43935045:43938386:43938617 | 43934979:43935045 | ENSG00000160190.9 | ENST00000398343.2 |
| exon_skip_360190 | 21 | 43945885:43945967:43954807:43954940:43955581:43955660 | 43954807:43954940 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| exon_skip_360193 | 21 | 43959621:43959757:43962513:43962590:43963545:43963712 | 43962513:43962590 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| exon_skip_360194 | 21 | 43963626:43963712:43967212:43967250:43974171:43974252 | 43967212:43967250 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| exon_skip_360195 | 21 | 43974171:43974252:43979067:43979199:43982187:43982278 | 43979067:43979199 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| exon_skip_360196 | 21 | 43983924:43983987:43984817:43984903:43985936:43985985 | 43984817:43984903 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| exon_skip_360202 | 21 | 43988469:43988548:43994927:43995025:43999845:43999910 | 43994927:43995025 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| exon_skip_360213 | 21 | 43994927:43995025:43999845:43999910:44000454:44001550 | 43999845:43999910 | ENSG00000160190.9 | ENST00000398341.3,ENST00000352133.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC37A1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000352133 | 43954807 | 43954940 | Frame-shift |
| ENST00000398341 | 43954807 | 43954940 | Frame-shift |
| ENST00000352133 | 43962513 | 43962590 | Frame-shift |
| ENST00000398341 | 43962513 | 43962590 | Frame-shift |
| ENST00000352133 | 43967212 | 43967250 | Frame-shift |
| ENST00000398341 | 43967212 | 43967250 | Frame-shift |
| ENST00000352133 | 43984817 | 43984903 | Frame-shift |
| ENST00000398341 | 43984817 | 43984903 | Frame-shift |
| ENST00000352133 | 43994927 | 43995025 | Frame-shift |
| ENST00000398341 | 43994927 | 43995025 | Frame-shift |
| ENST00000352133 | 43999845 | 43999910 | Frame-shift |
| ENST00000398341 | 43999845 | 43999910 | Frame-shift |
| ENST00000352133 | 43979067 | 43979199 | In-frame |
| ENST00000398341 | 43979067 | 43979199 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000352133 | 43954807 | 43954940 | Frame-shift |
| ENST00000398341 | 43954807 | 43954940 | Frame-shift |
| ENST00000352133 | 43962513 | 43962590 | Frame-shift |
| ENST00000398341 | 43962513 | 43962590 | Frame-shift |
| ENST00000352133 | 43967212 | 43967250 | Frame-shift |
| ENST00000398341 | 43967212 | 43967250 | Frame-shift |
| ENST00000352133 | 43984817 | 43984903 | Frame-shift |
| ENST00000398341 | 43984817 | 43984903 | Frame-shift |
| ENST00000352133 | 43994927 | 43995025 | Frame-shift |
| ENST00000398341 | 43994927 | 43995025 | Frame-shift |
| ENST00000352133 | 43999845 | 43999910 | Frame-shift |
| ENST00000398341 | 43999845 | 43999910 | Frame-shift |
| ENST00000352133 | 43979067 | 43979199 | In-frame |
| ENST00000398341 | 43979067 | 43979199 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC37A1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000352133 | 3681 | 533 | 43979067 | 43979199 | 1832 | 1963 | 283 | 327 |
| ENST00000398341 | 3111 | 533 | 43979067 | 43979199 | 1262 | 1393 | 283 | 327 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000352133 | 3681 | 533 | 43979067 | 43979199 | 1832 | 1963 | 283 | 327 |
| ENST00000398341 | 3111 | 533 | 43979067 | 43979199 | 1262 | 1393 | 283 | 327 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57057 | 283 | 327 | 1 | 533 | Chain | ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1 |
| P57057 | 283 | 327 | 1 | 533 | Chain | ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1 |
| P57057 | 283 | 327 | 303 | 303 | Sequence conflict | Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P57057 | 283 | 327 | 303 | 303 | Sequence conflict | Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P57057 | 283 | 327 | 304 | 324 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P57057 | 283 | 327 | 304 | 324 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57057 | 283 | 327 | 1 | 533 | Chain | ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1 |
| P57057 | 283 | 327 | 1 | 533 | Chain | ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1 |
| P57057 | 283 | 327 | 303 | 303 | Sequence conflict | Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P57057 | 283 | 327 | 303 | 303 | Sequence conflict | Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P57057 | 283 | 327 | 304 | 324 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P57057 | 283 | 327 | 304 | 324 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for SLC37A1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-55-8506-01 | exon_skip_360190 | 43954808 | 43954940 | 43954890 | 43954890 | Frame_Shift_Del | C | - | p.A74fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_360190 | 43954808 | 43954940 | 43954937 | 43954937 | Frame_Shift_Del | T | - | p.F90fs |
| BRCA | TCGA-E2-A15A-06 | exon_skip_360196 | 43984818 | 43984903 | 43984830 | 43984831 | Frame_Shift_Ins | - | AG | p.G384fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43954808 | 43954940 | 43954890 | 43954890 | Frame_Shift_Del | C | - | p.A74fs |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43979068 | 43979199 | 43979143 | 43979143 | Frame_Shift_Del | G | - | p.G309fs |
| MCC13_SKIN | 43954808 | 43954940 | 43954895 | 43954895 | Missense_Mutation | C | T | p.H76Y |
| SW684_SOFT_TISSUE | 43954808 | 43954940 | 43954934 | 43954934 | Missense_Mutation | C | T | p.P89S |
| NCIH740_LUNG | 43962514 | 43962590 | 43962553 | 43962553 | Missense_Mutation | G | T | p.V176F |
| LS180_LARGE_INTESTINE | 43962514 | 43962590 | 43962577 | 43962577 | Missense_Mutation | T | G | p.F184V |
| A375_SKIN | 43967213 | 43967250 | 43967234 | 43967234 | Missense_Mutation | C | T | p.S251F |
| COLO792_SKIN | 43967213 | 43967250 | 43967237 | 43967237 | Missense_Mutation | C | T | p.S252F |
| FTC133_THYROID | 43979068 | 43979199 | 43979080 | 43979080 | Missense_Mutation | C | G | p.Q288E |
| HUCCT1_BILIARY_TRACT | 43979068 | 43979199 | 43979092 | 43979092 | Missense_Mutation | C | T | p.L292F |
| HEC108_ENDOMETRIUM | 43979068 | 43979199 | 43979128 | 43979128 | Missense_Mutation | G | A | p.V304I |
| SNU407_LARGE_INTESTINE | 43979068 | 43979199 | 43979128 | 43979128 | Missense_Mutation | G | A | p.V304I |
| SNU840_OVARY | 43979068 | 43979199 | 43979149 | 43979149 | Missense_Mutation | G | A | p.G311S |
| TUHR14TKB_KIDNEY | 43979068 | 43979199 | 43979178 | 43979178 | Missense_Mutation | C | G | p.F320L |
| SAT_UPPER_AERODIGESTIVE_TRACT | 43979068 | 43979199 | 43979178 | 43979178 | Missense_Mutation | C | G | p.F320L |
| GP2D_LARGE_INTESTINE | 43984818 | 43984903 | 43984832 | 43984832 | Missense_Mutation | G | A | p.G384S |
| GP5D_LARGE_INTESTINE | 43984818 | 43984903 | 43984832 | 43984832 | Missense_Mutation | G | A | p.G384S |
| SNU1040_LARGE_INTESTINE | 43999846 | 43999910 | 43999877 | 43999877 | Missense_Mutation | G | A | p.S518N |
| TGBC11TKB_STOMACH | 43967213 | 43967250 | 43967214 | 43967214 | Splice_Site | T | G | p.H244Q |
| TK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43967213 | 43967250 | 43967214 | 43967214 | Splice_Site | T | G | p.H244Q |
| CCLFPEDS0008T_SOFT_TISSUE | 43967213 | 43967250 | 43967249 | 43967249 | Splice_Site | C | T | p.T256M |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43967213 | 43967250 | 43967249 | 43967249 | Splice_Site | C | T | p.T256M |
| PLCPRF5_LIVER | 43967213 | 43967250 | 43967249 | 43967249 | Splice_Site | C | G | p.T256R |
| SW756_CERVIX | 43967213 | 43967250 | 43967250 | 43967250 | Splice_Site | G | C | p.T256T |
| HEC1B_ENDOMETRIUM | 43984818 | 43984903 | 43984903 | 43984903 | Splice_Site | G | A | p.T407T |
| MDST8_LARGE_INTESTINE | 43999846 | 43999910 | 43999909 | 43999909 | Splice_Site | C | T | p.P529S |
| SW48_LARGE_INTESTINE | 43999846 | 43999910 | 43999910 | 43999910 | Splice_Site | C | T | p.P529L |
| ROS50_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43999846 | 43999910 | 43999910 | 43999910 | Splice_Site | C | T | p.P529L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC37A1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC37A1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC37A1 |
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RelatedDrugs for SLC37A1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC37A1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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