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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLCO1C1 |
 Gene summary |
| Gene information | Gene symbol | SLCO1C1 | Gene ID | 53919 |
| Gene name | solute carrier organic anion transporter family member 1C1 | |
| Synonyms | OATP-F|OATP1|OATP14|OATP1C1|OATPF|OATPRP5|SLC21A14 | |
| Cytomap | 12p12.2 | |
| Type of gene | protein-coding | |
| Description | solute carrier organic anion transporter family member 1C1OAT-RP-5OATP-14organic anion transporter Forganic anion transporter polypeptide-related protein 5organic anion transporting polypeptide 14solute carrier family 21 (organic anion transporter), | |
| Modification date | 20180523 | |
| UniProtAcc | Q9NYB5 | |
| Context | PubMed: SLCO1C1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SLCO1C1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLCO1C1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLCO1C1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_80589 | 12 | 20848683:20848741:20852485:20852639:20854251:20854393 | 20852485:20852639 | ENSG00000139155.4 | ENST00000266509.2,ENST00000545604.1,ENST00000540354.1,ENST00000381552.1 |
| exon_skip_80593 | 12 | 20848683:20848741:20858882:20859015:20864319:20864444 | 20858882:20859015 | ENSG00000139155.4 | ENST00000545102.1 |
| exon_skip_80596 | 12 | 20852485:20852639:20854251:20854393:20858882:20859015 | 20854251:20854393 | ENSG00000139155.4 | ENST00000266509.2,ENST00000545604.1,ENST00000540354.1,ENST00000381552.1 |
| exon_skip_80598 | 12 | 20864319:20864444:20868072:20868219:20870065:20870164 | 20868072:20868219 | ENSG00000139155.4 | ENST00000266509.2,ENST00000539415.1,ENST00000545604.1,ENST00000545102.1,ENST00000381552.1 |
| exon_skip_80600 | 12 | 20893117:20893302:20896238:20896303:20903608:20903726 | 20896238:20896303 | ENSG00000139155.4 | ENST00000266509.2,ENST00000539415.1,ENST00000545604.1,ENST00000545102.1,ENST00000540354.1,ENST00000381552.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLCO1C1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_80589 | 12 | 20848683:20848741:20852485:20852639:20854251:20854393 | 20852485:20852639 | ENSG00000139155.4 | ENST00000545604.1,ENST00000540354.1,ENST00000266509.2,ENST00000381552.1 |
| exon_skip_80591 | 12 | 20848683:20848741:20852485:20852639:20864319:20864444 | 20852485:20852639 | ENSG00000139155.4 | ENST00000539415.1 |
| exon_skip_80593 | 12 | 20848683:20848741:20858882:20859015:20864319:20864444 | 20858882:20859015 | ENSG00000139155.4 | ENST00000545102.1 |
| exon_skip_80596 | 12 | 20852485:20852639:20854251:20854393:20858882:20859015 | 20854251:20854393 | ENSG00000139155.4 | ENST00000545604.1,ENST00000540354.1,ENST00000266509.2,ENST00000381552.1 |
| exon_skip_80598 | 12 | 20864319:20864444:20868072:20868219:20870065:20870164 | 20868072:20868219 | ENSG00000139155.4 | ENST00000545604.1,ENST00000539415.1,ENST00000266509.2,ENST00000381552.1,ENST00000545102.1 |
| exon_skip_80600 | 12 | 20893117:20893302:20896238:20896303:20903608:20903726 | 20896238:20896303 | ENSG00000139155.4 | ENST00000545604.1,ENST00000539415.1,ENST00000540354.1,ENST00000266509.2,ENST00000381552.1,ENST00000545102.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLCO1C1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000266509 | 20852485 | 20852639 | 5CDS-5UTR |
| ENST00000266509 | 20854251 | 20854393 | Frame-shift |
| ENST00000266509 | 20896238 | 20896303 | Frame-shift |
| ENST00000266509 | 20868072 | 20868219 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000266509 | 20852485 | 20852639 | 5CDS-5UTR |
| ENST00000266509 | 20854251 | 20854393 | Frame-shift |
| ENST00000266509 | 20896238 | 20896303 | Frame-shift |
| ENST00000266509 | 20868072 | 20868219 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLCO1C1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000266509 | 3382 | 712 | 20868072 | 20868219 | 898 | 1044 | 176 | 225 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000266509 | 3382 | 712 | 20868072 | 20868219 | 898 | 1044 | 176 | 225 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NYB5 | 176 | 225 | 177 | 225 | Alternative sequence | ID=VSP_042882;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NYB5 | 176 | 225 | 1 | 712 | Chain | ID=PRO_0000191054;Note=Solute carrier organic anion transporter family member 1C1 |
| Q9NYB5 | 176 | 225 | 135 | 184 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9NYB5 | 176 | 225 | 214 | 232 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9NYB5 | 176 | 225 | 185 | 213 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NYB5 | 176 | 225 | 177 | 225 | Alternative sequence | ID=VSP_042882;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NYB5 | 176 | 225 | 1 | 712 | Chain | ID=PRO_0000191054;Note=Solute carrier organic anion transporter family member 1C1 |
| Q9NYB5 | 176 | 225 | 135 | 184 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9NYB5 | 176 | 225 | 214 | 232 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9NYB5 | 176 | 225 | 185 | 213 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for SLCO1C1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_80589 | 20852486 | 20852639 | 20852530 | 20852530 | Frame_Shift_Del | A | - | p.E7fs |
| BLCA | TCGA-XF-A9ST-01 | exon_skip_80589 | 20852486 | 20852639 | 20852615 | 20852615 | Frame_Shift_Del | G | - | p.K35fs |
| KIRP | TCGA-UZ-A9PL-01 | exon_skip_80596 | 20854252 | 20854393 | 20854365 | 20854365 | Frame_Shift_Del | G | - | p.V81fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_80598 | 20868073 | 20868219 | 20868112 | 20868112 | Frame_Shift_Del | T | - | p.V190fs |
| READ | TCGA-AG-A002-01 | exon_skip_80589 | 20852486 | 20852639 | 20852529 | 20852529 | Nonsense_Mutation | G | T | p.E7X |
| SKCM | TCGA-W3-AA1V-06 | exon_skip_80589 | 20852486 | 20852639 | 20852529 | 20852529 | Nonsense_Mutation | G | T | p.E7* |
| LUSC | TCGA-18-3421-01 | exon_skip_80593 | 20858883 | 20859015 | 20858882 | 20858882 | Splice_Site | G | A | p.G91_splice |
| STAD | TCGA-BR-6452-01 | exon_skip_80593 | 20858883 | 20859015 | 20859017 | 20859017 | Splice_Site | T | C | p.Q135_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| TOV21G_OVARY | 20868073 | 20868219 | 20868161 | 20868161 | Frame_Shift_Del | T | - | p.P206fs |
| VMRCLCD_LUNG | 20852486 | 20852639 | 20852578 | 20852578 | Missense_Mutation | C | A | p.P23H |
| MDAMB436_BREAST | 20854252 | 20854393 | 20854260 | 20854260 | Missense_Mutation | G | C | p.L46F |
| LOUNH91_LUNG | 20854252 | 20854393 | 20854300 | 20854300 | Missense_Mutation | G | A | p.E60K |
| KYSE510_OESOPHAGUS | 20854252 | 20854393 | 20854333 | 20854333 | Missense_Mutation | G | C | p.E71Q |
| HO1N1_UPPER_AERODIGESTIVE_TRACT | 20854252 | 20854393 | 20854367 | 20854367 | Missense_Mutation | G | T | p.G82V |
| KPNYS_AUTONOMIC_GANGLIA | 20858883 | 20859015 | 20858888 | 20858888 | Missense_Mutation | C | A | p.L93I |
| NCIH446_LUNG | 20858883 | 20859015 | 20858889 | 20858889 | Missense_Mutation | T | C | p.L93P |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 20858883 | 20859015 | 20858904 | 20858904 | Missense_Mutation | T | C | p.F98S |
| FADU_UPPER_AERODIGESTIVE_TRACT | 20858883 | 20859015 | 20858921 | 20858921 | Missense_Mutation | G | A | p.A104T |
| NCIH2029_LUNG | 20858883 | 20859015 | 20858930 | 20858930 | Missense_Mutation | C | T | p.H107Y |
| LB1047EBV_MATCHED_NORMAL_TISSUE | 20868073 | 20868219 | 20868100 | 20868100 | Missense_Mutation | T | G | p.M186R |
| LB1047RCC_KIDNEY | 20868073 | 20868219 | 20868100 | 20868100 | Missense_Mutation | T | G | p.M186R |
| HEC251_ENDOMETRIUM | 20868073 | 20868219 | 20868107 | 20868107 | Missense_Mutation | T | G | p.I188M |
| HCC2998_LARGE_INTESTINE | 20868073 | 20868219 | 20868132 | 20868132 | Missense_Mutation | C | T | p.R197C |
| LB831BLC_URINARY_TRACT | 20868073 | 20868219 | 20868133 | 20868133 | Missense_Mutation | G | A | p.R197H |
| SNU1040_LARGE_INTESTINE | 20868073 | 20868219 | 20868135 | 20868135 | Missense_Mutation | G | A | p.G198R |
| NCIH64_LUNG | 20868073 | 20868219 | 20868166 | 20868166 | Missense_Mutation | G | T | p.G208V |
| SISO_CERVIX | 20868073 | 20868219 | 20868214 | 20868214 | Missense_Mutation | A | G | p.Y224C |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 20868073 | 20868219 | 20868214 | 20868214 | Missense_Mutation | A | G | p.Y224C |
| VMRCLCD_LUNG | 20868073 | 20868219 | 20868214 | 20868214 | Missense_Mutation | A | G | p.Y224C |
| KYSE410_OESOPHAGUS | 20896239 | 20896303 | 20896267 | 20896267 | Missense_Mutation | G | C | p.A588P |
| HCC2998_LARGE_INTESTINE | 20852486 | 20852639 | 20852529 | 20852529 | Nonsense_Mutation | G | T | p.E7* |
| FU97_STOMACH | 20896239 | 20896303 | 20896258 | 20896258 | Nonsense_Mutation | A | T | p.K585* |
| KYSE510_OESOPHAGUS | 20858883 | 20859015 | 20858884 | 20858884 | Splice_Site | G | A | p.G91G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLCO1C1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLCO1C1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLCO1C1 |
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RelatedDrugs for SLCO1C1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLCO1C1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLCO1C1 | C0011570 | Mental Depression | 1 | PSYGENET |
| SLCO1C1 | C0011581 | Depressive disorder | 1 | PSYGENET |
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