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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for MRPL35 |
Gene summary |
Gene information | Gene symbol | MRPL35 | Gene ID | 51318 |
Gene name | mitochondrial ribosomal protein L35 | |
Synonyms | L35mt|MRP-L35 | |
Cytomap | 2p11.2 | |
Type of gene | protein-coding | |
Description | 39S ribosomal protein L35, mitochondrialmitochondrial large ribosomal subunit protein bL35m | |
Modification date | 20180522 | |
UniProtAcc | Q9NZE8 | |
Context | PubMed: MRPL35 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MRPL35 from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MRPL35 |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MRPL35 |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_327456 | 2 | 86426585:86426656:86433228:86433418:86434305:86434450 | 86433228:86433418 | ENSG00000132313.10 | ENST00000409180.1,ENST00000337109.4 |
exon_skip_327458 | 2 | 86433228:86433418:86434305:86434450:86437602:86437736 | 86434305:86434450 | ENSG00000132313.10 | ENST00000409180.1,ENST00000254644.8,ENST00000337109.4 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MRPL35 |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_327456 | 2 | 86426585:86426656:86433228:86433418:86434305:86434450 | 86433228:86433418 | ENSG00000132313.10 | ENST00000337109.4,ENST00000409180.1 |
exon_skip_327458 | 2 | 86433228:86433418:86434305:86434450:86437602:86437736 | 86434305:86434450 | ENSG00000132313.10 | ENST00000254644.8,ENST00000337109.4,ENST00000409180.1 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MRPL35 |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000337109 | 86433228 | 86433418 | Frame-shift |
ENST00000337109 | 86434305 | 86434450 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000337109 | 86433228 | 86433418 | Frame-shift |
ENST00000337109 | 86434305 | 86434450 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MRPL35 |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MRPL35 |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
LIHC | TCGA-DD-A3A0-01 | exon_skip_327456 | 86433229 | 86433418 | 86433393 | 86433393 | Frame_Shift_Del | G | - | p.G70fs |
LGG | TCGA-FG-A87Q-01 | exon_skip_327458 | 86434306 | 86434450 | 86434352 | 86434352 | Frame_Shift_Del | C | - | p.L94fs |
LIHC | TCGA-DD-A3A0-01 | exon_skip_327458 | 86434306 | 86434450 | 86434361 | 86434361 | Frame_Shift_Del | T | - | p.F97fs |
LIHC | TCGA-BC-A3KG-01 | exon_skip_327458 | 86434306 | 86434450 | 86434434 | 86434434 | Frame_Shift_Del | T | - | p.L121fs |
LIHC | TCGA-G3-AAV0-01 | exon_skip_327458 | 86434306 | 86434450 | 86434440 | 86434440 | Frame_Shift_Del | T | - | p.V123X |
PAAD | TCGA-FZ-5922-01 | exon_skip_327456 | 86433229 | 86433418 | 86433365 | 86433366 | Frame_Shift_Ins | - | A | p.H61fs |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
MERO14_LUNG | 86433229 | 86433418 | 86433277 | 86433283 | Frame_Shift_Del | GTGTCAA | - | p.CVK31fs |
MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 86433229 | 86433418 | 86433283 | 86433283 | Missense_Mutation | A | G | p.K33R |
HS729_SOFT_TISSUE | 86433229 | 86433418 | 86433354 | 86433354 | Missense_Mutation | A | G | p.T57A |
IGR1_SKIN | 86434306 | 86434450 | 86434312 | 86434313 | Missense_Mutation | CC | TT | p.P81S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MRPL35 |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
exon_skip_327456 | 2 | 86426585:86426656:86433228:86433418:86434305:86434450 | 86433228:86433418 | ENST00000409180.1,ENST00000337109.4 | BRCA | rs10901 | chr2:86433240 | C/T | 6.06e-04 |
exon_skip_327456 | 2 | 86426585:86426656:86433228:86433418:86434305:86434450 | 86433228:86433418 | ENST00000409180.1,ENST00000337109.4 | KIRC | rs10901 | chr2:86433240 | C/T | 1.53e-03 |
exon_skip_327456 | 2 | 86426585:86426656:86433228:86433418:86434305:86434450 | 86433228:86433418 | ENST00000409180.1,ENST00000337109.4 | THCA | rs10901 | chr2:86433240 | C/T | 7.17e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MRPL35 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MRPL35 |
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RelatedDrugs for MRPL35 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL35 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |