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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PAIP2 |
 Gene summary |
| Gene information | Gene symbol | PAIP2 | Gene ID | 51247 |
| Gene name | poly(A) binding protein interacting protein 2 | |
| Synonyms | PAIP-2|PAIP2A | |
| Cytomap | 5q31.2 | |
| Type of gene | protein-coding | |
| Description | polyadenylate-binding protein-interacting protein 2PABC1-interacting protein 2PABP-interacting protein 2polyA-binding protein-interacting protein 2 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9BPZ3 | |
| Context | PubMed: PAIP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PAIP2 | GO:0045947 | negative regulation of translational initiation | 11172725 |
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Exon skipping events across known transcript of Ensembl for PAIP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PAIP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PAIP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_437968 | 5 | 138677607:138677669:138679018:138679095:138699447:138699611 | 138679018:138679095 | ENSG00000120727.8 | ENST00000507415.1 |
| exon_skip_437971 | 5 | 138677550:138677669:138699447:138699611:138700252:138700429 | 138699447:138699611 | ENSG00000120727.8 | ENST00000265192.4,ENST00000510409.1 |
| exon_skip_437972 | 5 | 138677607:138677669:138699447:138699611:138704421:138704487 | 138699447:138699611 | ENSG00000120727.8 | ENST00000511706.1 |
| exon_skip_437985 | 5 | 138699447:138699611:138700252:138700432:138704421:138704487 | 138700252:138700432 | ENSG00000120727.8 | ENST00000265192.4,ENST00000510080.1,ENST00000394795.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PAIP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_437968 | 5 | 138677607:138677669:138679018:138679095:138699447:138699611 | 138679018:138679095 | ENSG00000120727.8 | ENST00000507415.1 |
| exon_skip_437971 | 5 | 138677550:138677669:138699447:138699611:138700252:138700429 | 138699447:138699611 | ENSG00000120727.8 | ENST00000265192.4,ENST00000510409.1 |
| exon_skip_437972 | 5 | 138677607:138677669:138699447:138699611:138704421:138704487 | 138699447:138699611 | ENSG00000120727.8 | ENST00000511706.1 |
| exon_skip_437978 | 5 | 138677550:138677669:138700252:138700432:138704421:138704487 | 138700252:138700432 | ENSG00000120727.8 | ENST00000511381.1 |
| exon_skip_437985 | 5 | 138699447:138699611:138700252:138700432:138704421:138704487 | 138700252:138700432 | ENSG00000120727.8 | ENST00000265192.4,ENST00000394795.2,ENST00000510080.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PAIP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265192 | 138699447 | 138699611 | 5CDS-5UTR |
| ENST00000265192 | 138700252 | 138700432 | In-frame |
| ENST00000394795 | 138700252 | 138700432 | In-frame |
| ENST00000510080 | 138700252 | 138700432 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265192 | 138699447 | 138699611 | 5CDS-5UTR |
| ENST00000265192 | 138700252 | 138700432 | In-frame |
| ENST00000394795 | 138700252 | 138700432 | In-frame |
| ENST00000510080 | 138700252 | 138700432 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PAIP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265192 | 1476 | 127 | 138700252 | 138700432 | 314 | 493 | 46 | 106 |
| ENST00000394795 | 2311 | 127 | 138700252 | 138700432 | 1130 | 1309 | 46 | 106 |
| ENST00000510080 | 875 | 127 | 138700252 | 138700432 | 331 | 510 | 46 | 106 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265192 | 1476 | 127 | 138700252 | 138700432 | 314 | 493 | 46 | 106 |
| ENST00000394795 | 2311 | 127 | 138700252 | 138700432 | 1130 | 1309 | 46 | 106 |
| ENST00000510080 | 875 | 127 | 138700252 | 138700432 | 331 | 510 | 46 | 106 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BPZ3 | 46 | 106 | 1 | 127 | Chain | ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2 |
| Q9BPZ3 | 46 | 106 | 1 | 127 | Chain | ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2 |
| Q9BPZ3 | 46 | 106 | 1 | 127 | Chain | ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2 |
| Q9BPZ3 | 46 | 106 | 33 | 72 | Compositional bias | Note=Glu-rich |
| Q9BPZ3 | 46 | 106 | 33 | 72 | Compositional bias | Note=Glu-rich |
| Q9BPZ3 | 46 | 106 | 33 | 72 | Compositional bias | Note=Glu-rich |
| Q9BPZ3 | 46 | 106 | 22 | 75 | Region | Note=PABPC1-interacting motif-1 (PAM1) |
| Q9BPZ3 | 46 | 106 | 22 | 75 | Region | Note=PABPC1-interacting motif-1 (PAM1) |
| Q9BPZ3 | 46 | 106 | 22 | 75 | Region | Note=PABPC1-interacting motif-1 (PAM1) |
| Q9BPZ3 | 46 | 106 | 105 | 120 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Q9BPZ3 | 46 | 106 | 105 | 120 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Q9BPZ3 | 46 | 106 | 105 | 120 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Q9BPZ3 | 46 | 106 | 98 | 98 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9BPZ3 | 46 | 106 | 98 | 98 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9BPZ3 | 46 | 106 | 98 | 98 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BPZ3 | 46 | 106 | 1 | 127 | Chain | ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2 |
| Q9BPZ3 | 46 | 106 | 1 | 127 | Chain | ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2 |
| Q9BPZ3 | 46 | 106 | 1 | 127 | Chain | ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2 |
| Q9BPZ3 | 46 | 106 | 33 | 72 | Compositional bias | Note=Glu-rich |
| Q9BPZ3 | 46 | 106 | 33 | 72 | Compositional bias | Note=Glu-rich |
| Q9BPZ3 | 46 | 106 | 33 | 72 | Compositional bias | Note=Glu-rich |
| Q9BPZ3 | 46 | 106 | 22 | 75 | Region | Note=PABPC1-interacting motif-1 (PAM1) |
| Q9BPZ3 | 46 | 106 | 22 | 75 | Region | Note=PABPC1-interacting motif-1 (PAM1) |
| Q9BPZ3 | 46 | 106 | 22 | 75 | Region | Note=PABPC1-interacting motif-1 (PAM1) |
| Q9BPZ3 | 46 | 106 | 105 | 120 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Q9BPZ3 | 46 | 106 | 105 | 120 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Q9BPZ3 | 46 | 106 | 105 | 120 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Q9BPZ3 | 46 | 106 | 98 | 98 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9BPZ3 | 46 | 106 | 98 | 98 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9BPZ3 | 46 | 106 | 98 | 98 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for PAIP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_437972 exon_skip_437971 | 138699448 | 138699611 | 138699580 | 138699580 | Frame_Shift_Del | G | - | p.W36fs |
| SKCM | TCGA-EB-A5UN-06 | exon_skip_437985 | 138700253 | 138700432 | 138700376 | 138700376 | Nonsense_Mutation | C | T | p.Q88* |
| SKCM | TCGA-ER-A19N-06 | exon_skip_437985 | 138700253 | 138700432 | 138700376 | 138700376 | Nonsense_Mutation | C | T | p.Q88* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CA922_UPPER_AERODIGESTIVE_TRACT | 138699448 | 138699611 | 138699517 | 138699517 | Missense_Mutation | A | G | p.N15S |
| COLO824_BREAST | 138699448 | 138699611 | 138699519 | 138699519 | Missense_Mutation | G | A | p.E16K |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 138699448 | 138699611 | 138699521 | 138699521 | Missense_Mutation | A | C | p.E16D |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 138699448 | 138699611 | 138699521 | 138699521 | Missense_Mutation | A | C | p.E16D |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 138699448 | 138699611 | 138699521 | 138699521 | Missense_Mutation | A | C | p.E16D |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 138699448 | 138699611 | 138699554 | 138699554 | Missense_Mutation | T | G | p.D27E |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 138699448 | 138699611 | 138699554 | 138699554 | Missense_Mutation | T | G | p.D27E |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 138699448 | 138699611 | 138699554 | 138699554 | Missense_Mutation | T | G | p.D27E |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 138700253 | 138700432 | 138700368 | 138700368 | Missense_Mutation | A | G | p.D85G |
| MFE319_ENDOMETRIUM | 138700253 | 138700432 | 138700388 | 138700388 | Missense_Mutation | A | G | p.N92D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PAIP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PAIP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PAIP2 |
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RelatedDrugs for PAIP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAIP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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