ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for NTRK2

Gene summary

Gene information	Gene symbol	NTRK2
	Gene ID	4915
	Gene name	neurotrophic receptor tyrosine kinase 2
	Synonyms	EIEE58\|GP145-TrkB\|OBHD\|TRKB\|trk-B
	Cytomap	9q21.33
	Type of gene	protein-coding
	Description	BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
	Modification date	20180523
	UniProtAcc	Q16620
	Context	PubMed: NTRK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for NTRK2 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for NTRK2

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for NTRK2

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_496755	9	87283465:87283700:87284216:87284338:87284594:87284803	87284216:87284338	ENSG00000148053.11	ENST00000376213.1
exon_skip_496761	9	87284249:87284338:87284594:87284803:87285291:87285875	87284594:87284803	ENSG00000148053.11	ENST00000376213.1,ENST00000376214.1
exon_skip_496764	9	87339138:87339271:87342568:87342874:87356806:87356842	87342568:87342874	ENSG00000148053.11	ENST00000376208.1,ENST00000376213.1,ENST00000395866.2,ENST00000323115.4,ENST00000395882.1,ENST00000304053.6,ENST00000376214.1,ENST00000359847.3,ENST00000277120.3
exon_skip_496769	9	87342607:87342874:87356806:87356842:87359887:87359988	87356806:87356842	ENSG00000148053.11	ENST00000376208.1,ENST00000376213.1,ENST00000395866.2,ENST00000323115.4,ENST00000395882.1,ENST00000304053.6,ENST00000376214.1,ENST00000359847.3,ENST00000277120.3
exon_skip_496774	9	87366900:87367000:87475954:87476002:87482157:87482346	87475954:87476002	ENSG00000148053.11	ENST00000304053.6,ENST00000376214.1,ENST00000277120.3
exon_skip_496775	9	87482157:87482346:87549076:87549207:87563376:87563549	87549076:87549207	ENSG00000148053.11	ENST00000376213.1,ENST00000323115.4,ENST00000376214.1,ENST00000277120.3
exon_skip_496776	9	87563376:87563549:87570197:87570432:87635120:87635279	87570197:87570432	ENSG00000148053.11	ENST00000376213.1,ENST00000323115.4,ENST00000376214.1,ENST00000277120.3

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for NTRK2

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_496755	9	87283465:87283700:87284216:87284338:87284594:87284803	87284216:87284338	ENSG00000148053.11	ENST00000376213.1
exon_skip_496761	9	87284249:87284338:87284594:87284803:87285291:87285875	87284594:87284803	ENSG00000148053.11	ENST00000376214.1,ENST00000376213.1
exon_skip_496764	9	87339138:87339271:87342568:87342874:87356806:87356842	87342568:87342874	ENSG00000148053.11	ENST00000376214.1,ENST00000376213.1,ENST00000395882.1,ENST00000376208.1,ENST00000304053.6,ENST00000277120.3,ENST00000323115.4,ENST00000359847.3,ENST00000395866.2
exon_skip_496769	9	87342607:87342874:87356806:87356842:87359887:87359988	87356806:87356842	ENSG00000148053.11	ENST00000376214.1,ENST00000376213.1,ENST00000395882.1,ENST00000376208.1,ENST00000304053.6,ENST00000277120.3,ENST00000323115.4,ENST00000359847.3,ENST00000395866.2
exon_skip_496774	9	87366900:87367000:87475954:87476002:87482157:87482346	87475954:87476002	ENSG00000148053.11	ENST00000376214.1,ENST00000304053.6,ENST00000277120.3
exon_skip_496775	9	87482157:87482346:87549076:87549207:87563376:87563549	87549076:87549207	ENSG00000148053.11	ENST00000376214.1,ENST00000376213.1,ENST00000277120.3,ENST00000323115.4
exon_skip_496776	9	87563376:87563549:87570197:87570432:87635120:87635279	87570197:87570432	ENSG00000148053.11	ENST00000376214.1,ENST00000376213.1,ENST00000277120.3,ENST00000323115.4

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for NTRK2

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000376213	87284216	87284338	5UTR-5UTR
ENST00000376213	87284594	87284803	5UTR-5UTR
ENST00000323115	87549076	87549207	Frame-shift
ENST00000376213	87549076	87549207	Frame-shift
ENST00000323115	87570197	87570432	Frame-shift
ENST00000376213	87570197	87570432	Frame-shift
ENST00000323115	87342568	87342874	In-frame
ENST00000376213	87342568	87342874	In-frame
ENST00000323115	87356806	87356842	In-frame
ENST00000376213	87356806	87356842	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000376213	87284216	87284338	5UTR-5UTR
ENST00000376213	87284594	87284803	5UTR-5UTR
ENST00000323115	87549076	87549207	Frame-shift
ENST00000376213	87549076	87549207	Frame-shift
ENST00000323115	87570197	87570432	Frame-shift
ENST00000376213	87570197	87570432	Frame-shift
ENST00000323115	87342568	87342874	In-frame
ENST00000376213	87342568	87342874	In-frame
ENST00000323115	87356806	87356842	In-frame
ENST00000376213	87356806	87356842	In-frame

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Infer the effects of exon skipping event on protein functional features for NTRK2

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000323115	3725	822	87342568	87342874	1207	1512	284	386
ENST00000376213	5577	822	87342568	87342874	1792	2097	284	386
ENST00000323115	3725	822	87356806	87356842	1513	1548	386	398
ENST00000376213	5577	822	87356806	87356842	2098	2133	386	398

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000323115	3725	822	87342568	87342874	1207	1512	284	386
ENST00000376213	5577	822	87342568	87342874	1792	2097	284	386
ENST00000323115	3725	822	87356806	87356842	1513	1548	386	398
ENST00000376213	5577	822	87356806	87356842	2098	2133	386	398

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q16620	284	386	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	300	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	300	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	328	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	328	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	284	386	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	284	386	302	345	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114,ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	302	345	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114,ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	295	365	Domain	Note=Ig-like C2-type 2
Q16620	284	386	295	365	Domain	Note=Ig-like C2-type 2
Q16620	284	386	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	284	386	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	284	386	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	353	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	353	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	309	309	Natural variant	ID=VAR_016320;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|Ref.5
Q16620	284	386	309	309	Natural variant	ID=VAR_016320;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|Ref.5
Q16620	284	386	338	338	Natural variant	ID=VAR_011973;Note=N->Y;Dbxref=dbSNP:rs1047856
Q16620	284	386	338	338	Natural variant	ID=VAR_011973;Note=N->Y;Dbxref=dbSNP:rs1047856
Q16620	284	386	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	284	386	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	386	398	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	386	398	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	386	398	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	386	398	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q16620	284	386	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	285	292	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	300	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	300	308	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	314	319	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	322	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	328	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	328	337	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	339	350	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	357	364	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	369	376	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	380	382	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5MO9
Q16620	284	386	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	284	386	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	284	386	302	345	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114,ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	302	345	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114,ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	295	365	Domain	Note=Ig-like C2-type 2
Q16620	284	386	295	365	Domain	Note=Ig-like C2-type 2
Q16620	284	386	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	284	386	325	325	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	284	386	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	338	338	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:7574684;Dbxref=PMID:7574684
Q16620	284	386	353	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	353	355	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1WWB
Q16620	284	386	309	309	Natural variant	ID=VAR_016320;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|Ref.5
Q16620	284	386	309	309	Natural variant	ID=VAR_016320;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|Ref.5
Q16620	284	386	338	338	Natural variant	ID=VAR_011973;Note=N->Y;Dbxref=dbSNP:rs1047856
Q16620	284	386	338	338	Natural variant	ID=VAR_011973;Note=N->Y;Dbxref=dbSNP:rs1047856
Q16620	284	386	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	284	386	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	386	398	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	386	398	32	822	Chain	ID=PRO_0000016727;Note=BDNF/NT-3 growth factors receptor
Q16620	386	398	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q16620	386	398	32	430	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

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SNVs in the skipped exons for NTRK2

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LUAD	TCGA-05-4390-01	exon_skip_496764	87342569	87342874	87342645	87342645	Frame_Shift_Del	C	-	p.N310fs
BLCA	TCGA-DK-A3IL-01	exon_skip_496769	87356807	87356842	87356831	87356837	Frame_Shift_Del	TAATTTA	-	p.V395fs
BLCA	TCGA-DK-A3IL-01	exon_skip_496769	87356807	87356842	87356831	87356837	Frame_Shift_Del	TAATTTA	-	p.VIY395fs

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
NCIH661_LUNG	87342569	87342874	87342637	87342637	Missense_Mutation	A	C	p.K308Q
SUIT2_PANCREAS	87342569	87342874	87342651	87342651	Missense_Mutation	A	C	p.K312N
JHOS2_OVARY	87342569	87342874	87342656	87342656	Missense_Mutation	C	T	p.A314V
NCIH513_PLEURA	87342569	87342874	87342676	87342676	Missense_Mutation	G	T	p.G321W
SISO_CERVIX	87342569	87342874	87342716	87342716	Missense_Mutation	T	G	p.I334R
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	87342569	87342874	87342716	87342716	Missense_Mutation	T	G	p.I334R
JHU028_LUNG	87549077	87549207	87549084	87549084	Missense_Mutation	G	C	p.Q531H
NUGC3_STOMACH	87549077	87549207	87549193	87549193	Missense_Mutation	T	A	p.L568M
BHY_UPPER_AERODIGESTIVE_TRACT	87549077	87549207	87549195	87549195	Missense_Mutation	G	C	p.L568F
KPNYS_AUTONOMIC_GANGLIA	87549077	87549207	87549195	87549195	Missense_Mutation	G	C	p.L568F
NCIH69_LUNG	87549077	87549207	87549200	87549200	Missense_Mutation	C	T	p.A570V
CAMA1_BREAST	87570198	87570432	87570241	87570241	Missense_Mutation	C	G	p.P645A
HEC59_ENDOMETRIUM	87570198	87570432	87570259	87570259	Missense_Mutation	T	C	p.S651P
NCIH1793_LUNG	87342569	87342874	87342873	87342873	Splice_Site	T	C	p.D386D

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NTRK2

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NTRK2

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NTRK2

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RelatedDrugs for NTRK2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	Q16620	DB00321	Amitriptyline	BDNF/NT-3 growth factors receptor	small molecule	approved
	Q16620	DB11823	Esketamine	BDNF/NT-3 growth factors receptor	small molecule	approved\|investigational
	Q16620	DB12010	Fostamatinib	BDNF/NT-3 growth factors receptor	small molecule	approved\|investigational

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RelatedDiseases for NTRK2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
NTRK2	C0011570	Mental Depression	5	PSYGENET
NTRK2	C0011581	Depressive disorder	5	PSYGENET
NTRK2	C0041696	Unipolar Depression	5	PSYGENET
NTRK2	C0525045	Mood Disorders	5	PSYGENET
NTRK2	C1269683	Major Depressive Disorder	5	PSYGENET
NTRK2	C0005586	Bipolar Disorder	3	CTD_human;PSYGENET
NTRK2	C0036341	Schizophrenia	2	PSYGENET
NTRK2	C0038220	Status Epilepticus	2	CTD_human
NTRK2	C0236736	Cocaine-Related Disorders	2	CTD_human
NTRK2	C0424295	Hyperactive behavior	2	CTD_human
NTRK2	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
NTRK2	C0004114	Astrocytoma	1	CTD_human
NTRK2	C0004352	Autistic Disorder	1	CTD_human
NTRK2	C0008073	Developmental Disabilities	1	CTD_human
NTRK2	C0013415	Dysthymic Disorder	1	PSYGENET
NTRK2	C0017638	Glioma	1	CTD_human
NTRK2	C0020505	Hyperphagia	1	CTD_human;HPO
NTRK2	C0027819	Neuroblastoma	1	CTD_human
NTRK2	C0028754	Obesity	1	CTD_human;HPO
NTRK2	C0036349	Paranoid Schizophrenia	1	PSYGENET
NTRK2	C0678807	prenatal alcohol exposure	1	PSYGENET
NTRK2	C0752347	Lewy Body Disease	1	CTD_human
NTRK2	C3146244	Alcohol Related Birth Defect	1	PSYGENET
NTRK2	C3151303	Obesity, Hyperphagia, and Developmental Delay	1	UNIPROT

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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