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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAP3K10 |
 Gene summary |
| Gene information | Gene symbol | MAP3K10 | Gene ID | 4294 |
| Gene name | mitogen-activated protein kinase kinase kinase 10 | |
| Synonyms | MEKK10|MLK2|MST | |
| Cytomap | 19q13.2 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 10MKN28 derived nonreceptor_type serine/threonine kinaseMKN28 kinasemixed lineage kinase 2protein kinase MST | |
| Modification date | 20180523 | |
| UniProtAcc | Q02779 | |
| Context | PubMed: MAP3K10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP3K10 | GO:0018105 | peptidyl-serine phosphorylation | 19801649 |
| MAP3K10 | GO:0018107 | peptidyl-threonine phosphorylation | 19801649 |
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Exon skipping events across known transcript of Ensembl for MAP3K10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAP3K10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAP3K10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307030 | 19 | 40698151:40698361:40698544:40698620:40704281:40704418 | 40698544:40698620 | ENSG00000130758.3 | ENST00000593906.1 |
| exon_skip_307031 | 19 | 40698544:40698620:40704281:40704418:40710391:40710523 | 40704281:40704418 | ENSG00000130758.3 | ENST00000593906.1 |
| exon_skip_307045 | 19 | 40704349:40704462:40710391:40710540:40711027:40711203 | 40710391:40710540 | ENSG00000130758.3 | ENST00000597986.1,ENST00000253055.3 |
| exon_skip_307061 | 19 | 40711027:40711203:40711817:40712064:40715009:40715109 | 40711817:40712064 | ENSG00000130758.3 | ENST00000594951.1,ENST00000253055.3 |
| exon_skip_307072 | 19 | 40718982:40719095:40719423:40720128:40720876:40721435 | 40719423:40720128 | ENSG00000130758.3 | ENST00000597986.1,ENST00000253055.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAP3K10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307030 | 19 | 40698151:40698361:40698544:40698620:40704281:40704418 | 40698544:40698620 | ENSG00000130758.3 | ENST00000593906.1 |
| exon_skip_307031 | 19 | 40698544:40698620:40704281:40704418:40710391:40710523 | 40704281:40704418 | ENSG00000130758.3 | ENST00000593906.1 |
| exon_skip_307045 | 19 | 40704349:40704462:40710391:40710540:40711027:40711203 | 40710391:40710540 | ENSG00000130758.3 | ENST00000253055.3,ENST00000597986.1 |
| exon_skip_307061 | 19 | 40711027:40711203:40711817:40712064:40715009:40715109 | 40711817:40712064 | ENSG00000130758.3 | ENST00000253055.3,ENST00000594951.1 |
| exon_skip_307072 | 19 | 40718982:40719095:40719423:40720128:40720876:40721435 | 40719423:40720128 | ENSG00000130758.3 | ENST00000253055.3,ENST00000597986.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAP3K10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000253055 | 40710391 | 40710540 | Frame-shift |
| ENST00000253055 | 40711817 | 40712064 | Frame-shift |
| ENST00000253055 | 40719423 | 40720128 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000253055 | 40710391 | 40710540 | Frame-shift |
| ENST00000253055 | 40711817 | 40712064 | Frame-shift |
| ENST00000253055 | 40719423 | 40720128 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP3K10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000253055 | 3453 | 954 | 40719423 | 40720128 | 2126 | 2830 | 612 | 847 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000253055 | 3453 | 954 | 40719423 | 40720128 | 2126 | 2830 | 612 | 847 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q02779 | 612 | 847 | 1 | 954 | Chain | ID=PRO_0000086259;Note=Mitogen-activated protein kinase kinase kinase 10 |
| Q02779 | 612 | 847 | 807 | 807 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q02779 | 612 | 847 | 818 | 818 | Sequence conflict | Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q02779 | 612 | 847 | 1 | 954 | Chain | ID=PRO_0000086259;Note=Mitogen-activated protein kinase kinase kinase 10 |
| Q02779 | 612 | 847 | 807 | 807 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q02779 | 612 | 847 | 818 | 818 | Sequence conflict | Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for MAP3K10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_307061 | 40711818 | 40712064 | 40711977 | 40711977 | Frame_Shift_Del | C | - | p.P450fs |
| COAD | TCGA-D5-6928-01 | exon_skip_307072 | 40719424 | 40720128 | 40719462 | 40719462 | Frame_Shift_Del | C | - | p.V625fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_307072 | 40719424 | 40720128 | 40719462 | 40719462 | Frame_Shift_Del | C | - | p.P627fs |
| LUAD | TCGA-L9-A443-01 | exon_skip_307045 | 40710392 | 40710540 | 40710420 | 40710421 | Frame_Shift_Ins | - | C | p.G298fs |
| STAD | TCGA-CG-5721-01 | exon_skip_307061 | 40711818 | 40712064 | 40712065 | 40712065 | Splice_Site | G | A | . |
| STAD | TCGA-CG-5721-01 | exon_skip_307061 | 40711818 | 40712064 | 40712065 | 40712065 | Splice_Site | G | A | p.G479_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CW2_LARGE_INTESTINE | 40719424 | 40720128 | 40719462 | 40719462 | Frame_Shift_Del | C | - | p.P627fs |
| EN_ENDOMETRIUM | 40719424 | 40720128 | 40719469 | 40719469 | Frame_Shift_Del | C | - | p.S628fs |
| KNS42_CENTRAL_NERVOUS_SYSTEM | 40719424 | 40720128 | 40719820 | 40719820 | Frame_Shift_Del | C | - | p.T745fs |
| SNU175_LARGE_INTESTINE | 40704282 | 40704418 | 40704339 | 40704339 | Missense_Mutation | C | T | p.T247M |
| HEC151_ENDOMETRIUM | 40704282 | 40704418 | 40704353 | 40704353 | Missense_Mutation | G | A | p.A252T |
| DIFI_LARGE_INTESTINE | 40704282 | 40704418 | 40704357 | 40704357 | Missense_Mutation | G | A | p.R253H |
| HUH1_LIVER | 40704282 | 40704418 | 40704367 | 40704367 | Missense_Mutation | C | A | p.H256Q |
| SNU1040_LARGE_INTESTINE | 40704282 | 40704418 | 40704401 | 40704401 | Missense_Mutation | G | A | p.A268T |
| NCIH524_LUNG | 40710392 | 40710540 | 40710455 | 40710455 | Missense_Mutation | G | T | p.L309F |
| LU134A_LUNG | 40710392 | 40710540 | 40710459 | 40710459 | Missense_Mutation | G | A | p.V311M |
| SNU1040_LARGE_INTESTINE | 40710392 | 40710540 | 40710529 | 40710529 | Missense_Mutation | G | A | p.R334H |
| SW48_LARGE_INTESTINE | 40711818 | 40712064 | 40711824 | 40711824 | Missense_Mutation | C | T | p.R399W |
| SKLMS1_SOFT_TISSUE | 40711818 | 40712064 | 40711829 | 40711829 | Missense_Mutation | C | A | p.S400R |
| SW1463_LARGE_INTESTINE | 40711818 | 40712064 | 40711866 | 40711866 | Missense_Mutation | C | T | p.R413C |
| LI7_LIVER | 40711818 | 40712064 | 40711891 | 40711891 | Missense_Mutation | G | A | p.R421Q |
| NUGC3_STOMACH | 40711818 | 40712064 | 40711914 | 40711914 | Missense_Mutation | C | T | p.R429C |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 40711818 | 40712064 | 40711914 | 40711914 | Missense_Mutation | C | T | p.R429C |
| HEC251_ENDOMETRIUM | 40711818 | 40712064 | 40711951 | 40711951 | Missense_Mutation | T | G | p.L441R |
| SW1353_BONE | 40711818 | 40712064 | 40711993 | 40711993 | Missense_Mutation | G | A | p.R455H |
| HS766T_PANCREAS | 40711818 | 40712064 | 40712031 | 40712031 | Missense_Mutation | C | T | p.R468W |
| NCIH2106_LUNG | 40719424 | 40720128 | 40719564 | 40719564 | Missense_Mutation | C | T | p.P660S |
| MFE319_ENDOMETRIUM | 40719424 | 40720128 | 40719775 | 40719775 | Missense_Mutation | G | A | p.R730H |
| EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 40719424 | 40720128 | 40719780 | 40719780 | Missense_Mutation | G | A | p.E732K |
| HS695T_SKIN | 40719424 | 40720128 | 40719786 | 40719786 | Missense_Mutation | G | A | p.V734M |
| SNU503_LARGE_INTESTINE | 40719424 | 40720128 | 40719786 | 40719786 | Missense_Mutation | G | A | p.V734M |
| MDAMB134VI_BREAST | 40719424 | 40720128 | 40719810 | 40719810 | Missense_Mutation | C | T | p.P742S |
| EFO27_OVARY | 40719424 | 40720128 | 40719862 | 40719862 | Missense_Mutation | G | A | p.R759H |
| RL952_ENDOMETRIUM | 40719424 | 40720128 | 40719895 | 40719895 | Missense_Mutation | C | T | p.A770V |
| SAOS2_BONE | 40719424 | 40720128 | 40719921 | 40719921 | Missense_Mutation | T | C | p.S779P |
| SW626_OVARY | 40719424 | 40720128 | 40719921 | 40719921 | Missense_Mutation | T | C | p.S779P |
| SYO1_SOFT_TISSUE | 40719424 | 40720128 | 40719921 | 40719921 | Missense_Mutation | T | C | p.S779P |
| UPCISCC152_UPPER_AERODIGESTIVE_TRACT | 40719424 | 40720128 | 40719921 | 40719921 | Missense_Mutation | T | C | p.S779P |
| MFE319_ENDOMETRIUM | 40719424 | 40720128 | 40719922 | 40719922 | Missense_Mutation | C | T | p.S779F |
| SW684_SOFT_TISSUE | 40719424 | 40720128 | 40719922 | 40719922 | Missense_Mutation | C | T | p.S779F |
| HEC1A_ENDOMETRIUM | 40719424 | 40720128 | 40719930 | 40719930 | Missense_Mutation | G | A | p.A782T |
| OVK18_OVARY | 40719424 | 40720128 | 40719934 | 40719934 | Missense_Mutation | C | T | p.P783L |
| BT12_SOFT_TISSUE | 40719424 | 40720128 | 40719936 | 40719936 | Missense_Mutation | A | C | p.T784P |
| SKPNDW_BONE | 40719424 | 40720128 | 40719936 | 40719936 | Missense_Mutation | A | C | p.T784P |
| RL952_ENDOMETRIUM | 40719424 | 40720128 | 40720095 | 40720095 | Missense_Mutation | C | T | p.R837W |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 40719424 | 40720128 | 40720096 | 40720096 | Missense_Mutation | G | A | p.R837Q |
| OVMANA_OVARY | 40719424 | 40720128 | 40720096 | 40720096 | Missense_Mutation | G | A | p.R837Q |
| UW228_CENTRAL_NERVOUS_SYSTEM | 40719424 | 40720128 | 40720114 | 40720114 | Missense_Mutation | C | T | p.A843V |
| SCH_STOMACH | 40710392 | 40710540 | 40710426 | 40710426 | Nonsense_Mutation | G | T | p.E300* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP3K10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K10 |
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RelatedDrugs for MAP3K10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q02779 | DB12010 | Fostamatinib | Mitogen-activated protein kinase kinase kinase 10 | small molecule | approved|investigational |
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RelatedDiseases for MAP3K10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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