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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MAOA

check button Gene summary
Gene informationGene symbol

MAOA

Gene ID

4128

Gene namemonoamine oxidase A
SynonymsBRNRS|MAO-A
Cytomap

Xp11.3

Type of geneprotein-coding
Descriptionamine oxidase [flavin-containing] Amonoamine oxidase type A
Modification date20180519
UniProtAcc

P21397

ContextPubMed: MAOA [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for MAOA from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for MAOA

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for MAOA

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_509850X43515549:43515662:43517109:43517217:43542760:4354285543517109:43517217ENSG00000189221.5ENST00000542639.1,ENST00000497485.1
exon_skip_509853X43517109:43517217:43542760:43542855:43552537:4355267543542760:43542855ENSG00000189221.5ENST00000542639.1,ENST00000497485.1
exon_skip_509856X43542760:43542855:43552537:43552675:43571118:4357122343552537:43552675ENSG00000189221.5ENST00000542639.1,ENST00000497485.1,ENST00000338702.3
exon_skip_509857X43552537:43552675:43571118:43571223:43571951:4357204343571118:43571223ENSG00000189221.5ENST00000542639.1,ENST00000497485.1,ENST00000338702.3
exon_skip_509859X43571951:43572043:43587419:43587561:43590487:4359062943587419:43587561ENSG00000189221.5ENST00000542639.1,ENST00000497485.1,ENST00000338702.3
exon_skip_509861X43591945:43592042:43595473:43595527:43599927:4359998543595473:43595527ENSG00000189221.5ENST00000542639.1,ENST00000338702.3
exon_skip_509863X43601196:43601294:43603040:43603152:43603355:4360341843603040:43603152ENSG00000189221.5ENST00000542639.1,ENST00000338702.3

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for MAOA

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_509850X43515549:43515662:43517109:43517217:43542760:4354285543517109:43517217ENSG00000189221.5ENST00000542639.1,ENST00000497485.1
exon_skip_509853X43517109:43517217:43542760:43542855:43552537:4355267543542760:43542855ENSG00000189221.5ENST00000542639.1,ENST00000497485.1
exon_skip_509856X43542760:43542855:43552537:43552675:43571118:4357122343552537:43552675ENSG00000189221.5ENST00000338702.3,ENST00000542639.1,ENST00000497485.1
exon_skip_509857X43552537:43552675:43571118:43571223:43571951:4357204343571118:43571223ENSG00000189221.5ENST00000338702.3,ENST00000542639.1,ENST00000497485.1
exon_skip_509859X43571951:43572043:43587419:43587561:43590487:4359062943587419:43587561ENSG00000189221.5ENST00000338702.3,ENST00000542639.1,ENST00000497485.1
exon_skip_509861X43591945:43592042:43595473:43595527:43599927:4359998543595473:43595527ENSG00000189221.5ENST00000338702.3,ENST00000542639.1
exon_skip_509863X43601196:43601294:43603040:43603152:43603355:4360341843603040:43603152ENSG00000189221.5ENST00000338702.3,ENST00000542639.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MAOA

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003387024358741943587561Frame-shift
ENST000003387024360304043603152Frame-shift
ENST000003387024355253743552675In-frame
ENST000003387024357111843571223In-frame
ENST000003387024359547343595527In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003387024358741943587561Frame-shift
ENST000003387024360304043603152Frame-shift
ENST000003387024355253743552675In-frame
ENST000003387024357111843571223In-frame
ENST000003387024359547343595527In-frame

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Infer the effects of exon skipping event on protein functional features for MAOA

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003387024032527435525374355267529242956102
ENST0000033870240325274357111843571223430534102137
ENST000003387024032527435954734359552711761229351368

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003387024032527435525374355267529242956102
ENST0000033870240325274357111843571223430534102137
ENST000003387024032527435954734359552711761229351368

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P21397561021133Alternative sequenceID=VSP_045173;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P21397561025457Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5X
P21397561026166Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397561028890Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213975610294101Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397561021527ChainID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
P21397561027583HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397561021497Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
P21397561025860TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213971021371133Alternative sequenceID=VSP_045173;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P21397102137104108Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397102137110112Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213971021371527ChainID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
P21397102137118136HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213971021371497Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
P21397351368348354Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213973513681527ChainID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
P21397351368355361HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397351368366381HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213973513681497Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P21397561021133Alternative sequenceID=VSP_045173;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P21397561025457Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5X
P21397561026166Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397561028890Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213975610294101Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397561021527ChainID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
P21397561027583HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397561021497Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
P21397561025860TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213971021371133Alternative sequenceID=VSP_045173;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P21397102137104108Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397102137110112Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213971021371527ChainID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
P21397102137118136HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213971021371497Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214
P21397351368348354Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213973513681527ChainID=PRO_0000099850;Note=Amine oxidase [flavin-containing] A
P21397351368355361HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P21397351368366381HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5Y
P213973513681497Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18391214;Dbxref=PMID:18391214


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SNVs in the skipped exons for MAOA

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
UCECTCGA-B5-A0K9-01exon_skip_509857
43571119435712234357112743571128Frame_Shift_DelAT-p.T105fs
STADTCGA-BR-4362-01exon_skip_509859
43587420435875614358752043587520Frame_Shift_DelG-p.C201fs
LIHCTCGA-DD-A3A0-01exon_skip_509861
43595474435955274359549043595490Frame_Shift_DelA-p.K357fs
ACCTCGA-OR-A5LR-01exon_skip_509861
43595474435955274359552143595530Frame_Shift_DelAAATAAGGTA-p.367_369del
BRCATCGA-BH-A0H9-01exon_skip_509863
43603041436031524360304543603046Frame_Shift_Ins-Tp.R424fs
UCECTCGA-AP-A056-01exon_skip_509853
43542761435428554354283543542835Nonsense_MutationGTp.G50*
SKCMTCGA-FS-A4F5-06exon_skip_509857
43571119435712234357115943571159Nonsense_MutationGAp.W116*
SKCMTCGA-FS-A4F5-06exon_skip_509857
43571119435712234357115943571159Nonsense_MutationGAp.W116X
UCECTCGA-AX-A0J0-01exon_skip_509853
43542761435428554354275943542759Splice_SiteAGe2-2

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE43542761435428554354279843542799Missense_MutationTAATp.S38C
BICR18_UPPER_AERODIGESTIVE_TRACT43542761435428554354285043542850Missense_MutationAGp.I55V
BICR18_UPPER_AERODIGESTIVE_TRACT43542761435428554354285243542852Missense_MutationAGp.I55M
NCIH2347_LUNG43552538435526754355257143552571Missense_MutationGCp.A68P
P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE43552538435526754355265543552655Missense_MutationCTp.R96C
HCC2998_LARGE_INTESTINE43571119435712234357113743571137Missense_MutationCTp.R109W
HOP92_LUNG43587420435875614358743143587431Missense_MutationGTp.R172L
SNGM_ENDOMETRIUM43587420435875614358746643587466Missense_MutationTGp.S184A
NUGC3_STOMACH43603041436031524360305243603052Missense_MutationACp.Q425P
SISO_CERVIX43603041436031524360305743603057Missense_MutationGAp.V427M
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE43603041436031524360305743603057Missense_MutationGAp.V427M
HCT15_LARGE_INTESTINE43603041436031524360313343603133Missense_MutationGAp.G452E
MFHINO_SOFT_TISSUE43552538435526754355254143552541Nonsense_MutationGTp.E58*
SNUC5_LARGE_INTESTINE43603041436031524360313843603138Nonsense_MutationCTp.R454*
WM1799_SKIN43587420435875614358741943587420Splice_SiteGGAAp.R168K

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAOA

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAOA


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAOA


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RelatedDrugs for MAOA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P21397DB00780PhenelzineAmine oxidase [flavin-containing] Asmall moleculeapproved
P21397DB00805MinaprineAmine oxidase [flavin-containing] Asmall moleculeapproved
P21397DB01247IsocarboxazidAmine oxidase [flavin-containing] Asmall moleculeapproved
P21397DB01626PargylineAmine oxidase [flavin-containing] Asmall moleculeapproved
P21397DB00191PhentermineAmine oxidase [flavin-containing] Asmall moleculeapproved|illicit
P21397DB01577MetamfetamineAmine oxidase [flavin-containing] Asmall moleculeapproved|illicit
P21397DB00182AmphetamineAmine oxidase [flavin-containing] Asmall moleculeapproved|illicit|investigational
P21397DB00752TranylcypromineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
P21397DB00909ZonisamideAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
P21397DB01168ProcarbazineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
P21397DB01171MoclobemideAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
P21397DB01171MoclobemideAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
P21397DB00721ProcaineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational|vet_approved
P21397DB01037SelegilineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational|vet_approved
P21397DB04820NialamideAmine oxidase [flavin-containing] Asmall moleculeapproved|withdrawn
P21397DB04821NomifensineAmine oxidase [flavin-containing] Asmall moleculeapproved|withdrawn
P21397DB04832ZimelidineAmine oxidase [flavin-containing] Asmall moleculeapproved|withdrawn

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RelatedDiseases for MAOA

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
MAOAC0001973Alcoholic Intoxication, Chronic5PSYGENET
MAOAC0005586Bipolar Disorder5PSYGENET
MAOAC0011570Mental Depression5PSYGENET
MAOAC0011581Depressive disorder5PSYGENET
MAOAC0041696Unipolar Depression5PSYGENET
MAOAC0525045Mood Disorders5PSYGENET
MAOAC1269683Major Depressive Disorder5PSYGENET
MAOAC0003431Antisocial Personality Disorder3CTD_human
MAOAC0004352Autistic Disorder3CTD_human;HPO
MAOAC0019151Hepatic Encephalopathy3CTD_human
MAOAC0036341Schizophrenia2PSYGENET
MAOAC0085762Alcohol abuse2PSYGENET
MAOAC0270458Severe major depression with psychotic features2PSYGENET
MAOAC2362914clinical depression2PSYGENET
MAOAC0004936Mental disorders1CTD_human
MAOAC0005587Depression, Bipolar1PSYGENET
MAOAC0009241Cognition Disorders1CTD_human
MAOAC0013415Dysthymic Disorder1PSYGENET
MAOAC0014175Endometriosis1CTD_human
MAOAC0020179Huntington Disease1CTD_human
MAOAC0020649Hypotension1CTD_human
MAOAC0026848Myopathy1CTD_human
MAOAC0030567Parkinson Disease1CTD_human
MAOAC0031511Pheochromocytoma1CTD_human
MAOAC0033054Prenatal Exposure Delayed Effects1CTD_human
MAOAC0033975Psychotic Disorders1PSYGENET
MAOAC0600427Cocaine Dependence1PSYGENET
MAOAC0745744End Stage Liver Disease1CTD_human
MAOAC1136249Mental Retardation, X-Linked1CTD_human
MAOAC1285261Fetal Nutrition Disorders1CTD_human
MAOAC2063866Depressive Disorder, Treatment-Resistant1PSYGENET