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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SPRED3 |
 Gene summary |
| Gene information | Gene symbol | SPRED3 | Gene ID | 399473 |
| Gene name | sprouty related EVH1 domain containing 3 | |
| Synonyms | Eve-3|spred-3 | |
| Cytomap | 19q13.2 | |
| Type of gene | protein-coding | |
| Description | sprouty-related, EVH1 domain-containing protein 3 | |
| Modification date | 20180519 | |
| UniProtAcc | Q2MJR0 | |
| Context | PubMed: SPRED3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SPRED3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SPRED3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SPRED3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_306543 | 19 | 38880694:38880792:38880938:38881119:38882585:38882754 | 38880938:38881119 | ENSG00000188766.8 | ENST00000587947.1 |
| exon_skip_306546 | 19 | 38882851:38882928:38885282:38885426:38886119:38886788 | 38885282:38885426 | ENSG00000188766.8 | ENST00000586301.1,ENST00000587013.1,ENST00000338502.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SPRED3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_306543 | 19 | 38880694:38880792:38880938:38881119:38882585:38882754 | 38880938:38881119 | ENSG00000188766.8 | ENST00000587947.1 |
| exon_skip_306544 | 19 | 38882851:38882928:38885000:38885116:38885282:38885310 | 38885000:38885116 | ENSG00000188766.8 | ENST00000586958.1 |
| exon_skip_306546 | 19 | 38882851:38882928:38885282:38885426:38886119:38886788 | 38885282:38885426 | ENSG00000188766.8 | ENST00000587013.1,ENST00000586301.1,ENST00000338502.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SPRED3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338502 | 38885282 | 38885426 | In-frame |
| ENST00000586301 | 38885282 | 38885426 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338502 | 38885282 | 38885426 | In-frame |
| ENST00000586301 | 38885282 | 38885426 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SPRED3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000338502 | 1436 | 410 | 38885282 | 38885426 | 527 | 670 | 141 | 189 |
| ENST00000586301 | 1383 | 410 | 38885282 | 38885426 | 554 | 697 | 141 | 189 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000338502 | 1436 | 410 | 38885282 | 38885426 | 527 | 670 | 141 | 189 |
| ENST00000586301 | 1383 | 410 | 38885282 | 38885426 | 554 | 697 | 141 | 189 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q2MJR0 | 141 | 189 | 142 | 152 | Alternative sequence | ID=VSP_042949;Note=In isoform 2. SHVDSDSSSSH->LSQYFRHMLCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 142 | 152 | Alternative sequence | ID=VSP_042949;Note=In isoform 2. SHVDSDSSSSH->LSQYFRHMLCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 153 | 410 | Alternative sequence | ID=VSP_042950;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 153 | 410 | Alternative sequence | ID=VSP_042950;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 1 | 410 | Chain | ID=PRO_0000247431;Note=Sprouty-related%2C EVH1 domain-containing protein 3 |
| Q2MJR0 | 141 | 189 | 1 | 410 | Chain | ID=PRO_0000247431;Note=Sprouty-related%2C EVH1 domain-containing protein 3 |
| Q2MJR0 | 141 | 189 | 117 | 153 | Compositional bias | Note=Ser-rich |
| Q2MJR0 | 141 | 189 | 117 | 153 | Compositional bias | Note=Ser-rich |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q2MJR0 | 141 | 189 | 142 | 152 | Alternative sequence | ID=VSP_042949;Note=In isoform 2. SHVDSDSSSSH->LSQYFRHMLCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 142 | 152 | Alternative sequence | ID=VSP_042949;Note=In isoform 2. SHVDSDSSSSH->LSQYFRHMLCP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 153 | 410 | Alternative sequence | ID=VSP_042950;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 153 | 410 | Alternative sequence | ID=VSP_042950;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16478641;Dbxref=PMID:16478641 |
| Q2MJR0 | 141 | 189 | 1 | 410 | Chain | ID=PRO_0000247431;Note=Sprouty-related%2C EVH1 domain-containing protein 3 |
| Q2MJR0 | 141 | 189 | 1 | 410 | Chain | ID=PRO_0000247431;Note=Sprouty-related%2C EVH1 domain-containing protein 3 |
| Q2MJR0 | 141 | 189 | 117 | 153 | Compositional bias | Note=Ser-rich |
| Q2MJR0 | 141 | 189 | 117 | 153 | Compositional bias | Note=Ser-rich |
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SNVs in the skipped exons for SPRED3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_306543 | 38880939 | 38881119 | 38881005 | 38881005 | Frame_Shift_Del | G | - | p.V21fs |
| UCEC | TCGA-D1-A17H-01 | exon_skip_306543 | 38880939 | 38881119 | 38881005 | 38881005 | Frame_Shift_Del | G | - | p.V21fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_306543 | 38880939 | 38881119 | 38881012 | 38881012 | Frame_Shift_Del | G | - | p.G25fs |
| COAD | TCGA-D5-6928-01 | exon_skip_306543 | 38880939 | 38881119 | 38881062 | 38881062 | Frame_Shift_Del | G | - | p.E40fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_306546 | 38885283 | 38885426 | 38885350 | 38885350 | Frame_Shift_Del | C | - | p.A208fs |
| HNSC | TCGA-CR-5248-01 | exon_skip_306546 | 38885283 | 38885426 | 38885397 | 38885397 | Frame_Shift_Del | C | - | p.P180fs |
| HNSC | TCGA-CR-5248-01 | exon_skip_306546 | 38885283 | 38885426 | 38885397 | 38885397 | Frame_Shift_Del | C | - | p.P225fs |
| COAD | TCGA-AD-6889-01 | exon_skip_306543 | 38880939 | 38881119 | 38881004 | 38881005 | Frame_Shift_Ins | - | G | p.V21fs |
| COAD | TCGA-AA-3492-01 | exon_skip_306543 | 38880939 | 38881119 | 38881061 | 38881062 | Frame_Shift_Ins | - | G | p.E40fs |
| LUAD | TCGA-17-Z053-01 | exon_skip_306546 | 38885283 | 38885426 | 38885396 | 38885397 | Frame_Shift_Ins | - | C | p.TP223fs |
| LUAD | TCGA-64-1677-01 | exon_skip_306546 | 38885283 | 38885426 | 38885396 | 38885397 | Frame_Shift_Ins | - | C | p.TP223fs |
| LUSC | TCGA-43-2578-01 | exon_skip_306546 | 38885283 | 38885426 | 38885282 | 38885282 | Splice_Site | G | T | p.S142_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH820_LUNG | 38880939 | 38881119 | 38881048 | 38881048 | Missense_Mutation | G | A | p.G36R |
| 22RV1_PROSTATE | 38880939 | 38881119 | 38881108 | 38881108 | Missense_Mutation | C | T | p.R56W |
| SUIT2_PANCREAS | 38885283 | 38885426 | 38885407 | 38885407 | Missense_Mutation | G | T | p.R183L |
| OC316_OVARY | 38885283 | 38885426 | 38885421 | 38885421 | Missense_Mutation | G | A | p.A188T |
| OC314_OVARY | 38885283 | 38885426 | 38885421 | 38885421 | Missense_Mutation | G | A | p.A188T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SPRED3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SPRED3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SPRED3 |
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RelatedDrugs for SPRED3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPRED3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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