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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for IL11RA |
 Gene summary |
| Gene information | Gene symbol | IL11RA | Gene ID | 3590 |
| Gene name | interleukin 11 receptor subunit alpha | |
| Synonyms | CRSDA | |
| Cytomap | 9p13.3 | |
| Type of gene | protein-coding | |
| Description | interleukin-11 receptor subunit alphaIL-11 receptor subunit alphaIL-11R subunit alphainterleukin 11 receptor, alphainterleukin-11 receptor alpha chain | |
| Modification date | 20180523 | |
| UniProtAcc | Q14626 | |
| Context | PubMed: IL11RA [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for IL11RA from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for IL11RA |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for IL11RA |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_495606 | 9 | 34655214:34655314:34655601:34655662:34656735:34656905 | 34655601:34655662 | ENSG00000137070.13 | ENST00000556792.1,ENST00000478802.2,ENST00000441545.2,ENST00000602473.1,ENST00000378817.4,ENST00000318041.9,ENST00000555981.1,ENST00000555003.1,ENST00000556531.1 |
| exon_skip_495607 | 9 | 34655214:34655314:34655601:34655662:34657031:34657146 | 34655601:34655662 | ENSG00000137070.13 | ENST00000557298.1 |
| exon_skip_495609 | 9 | 34655214:34655314:34656735:34656905:34657031:34657146 | 34656735:34656905 | ENSG00000137070.13 | ENST00000555247.1 |
| exon_skip_495610 | 9 | 34655601:34655662:34656735:34656905:34657031:34657146 | 34656735:34656905 | ENSG00000137070.13 | ENST00000556792.1,ENST00000478802.2,ENST00000441545.2,ENST00000602473.1,ENST00000378817.4,ENST00000318041.9,ENST00000555981.1,ENST00000555003.1,ENST00000556531.1 |
| exon_skip_495611 | 9 | 34657417:34657584:34658516:34658680:34659755:34659897 | 34658516:34658680 | ENSG00000137070.13 | ENST00000555247.1,ENST00000441545.2,ENST00000602473.1,ENST00000378817.4,ENST00000318041.9,ENST00000557298.1,ENST00000555003.1 |
| exon_skip_495614 | 9 | 34659882:34659897:34660270:34660390:34660500:34660597 | 34660270:34660390 | ENSG00000137070.13 | ENST00000555247.1,ENST00000441545.2,ENST00000602473.1,ENST00000378817.4,ENST00000318041.9,ENST00000466082.1,ENST00000557298.1,ENST00000555003.1 |
| exon_skip_495616 | 9 | 34660500:34660597:34660800:34660933:34661478:34661652 | 34660800:34660933 | ENSG00000137070.13 | ENST00000466082.1 |
| exon_skip_495618 | 9 | 34660500:34660597:34660850:34660933:34661478:34661652 | 34660850:34660933 | ENSG00000137070.13 | ENST00000555247.1,ENST00000441545.2,ENST00000318041.9,ENST00000557298.1,ENST00000555003.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for IL11RA |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_495606 | 9 | 34655214:34655314:34655601:34655662:34656735:34656905 | 34655601:34655662 | ENSG00000137070.13 | ENST00000555003.1,ENST00000441545.2,ENST00000556792.1,ENST00000318041.9,ENST00000378817.4,ENST00000556531.1,ENST00000555981.1,ENST00000478802.2,ENST00000602473.1 |
| exon_skip_495607 | 9 | 34655214:34655314:34655601:34655662:34657031:34657146 | 34655601:34655662 | ENSG00000137070.13 | ENST00000557298.1 |
| exon_skip_495609 | 9 | 34655214:34655314:34656735:34656905:34657031:34657146 | 34656735:34656905 | ENSG00000137070.13 | ENST00000555247.1 |
| exon_skip_495610 | 9 | 34655601:34655662:34656735:34656905:34657031:34657146 | 34656735:34656905 | ENSG00000137070.13 | ENST00000555003.1,ENST00000441545.2,ENST00000556792.1,ENST00000318041.9,ENST00000378817.4,ENST00000556531.1,ENST00000555981.1,ENST00000478802.2,ENST00000602473.1 |
| exon_skip_495611 | 9 | 34657417:34657584:34658516:34658680:34659755:34659897 | 34658516:34658680 | ENSG00000137070.13 | ENST00000555003.1,ENST00000555247.1,ENST00000441545.2,ENST00000318041.9,ENST00000378817.4,ENST00000557298.1,ENST00000602473.1 |
| exon_skip_495614 | 9 | 34659882:34659897:34660270:34660390:34660500:34660597 | 34660270:34660390 | ENSG00000137070.13 | ENST00000555003.1,ENST00000555247.1,ENST00000441545.2,ENST00000318041.9,ENST00000378817.4,ENST00000557298.1,ENST00000602473.1,ENST00000466082.1 |
| exon_skip_495616 | 9 | 34660500:34660597:34660800:34660933:34661478:34661652 | 34660800:34660933 | ENSG00000137070.13 | ENST00000466082.1 |
| exon_skip_495618 | 9 | 34660500:34660597:34660850:34660933:34661478:34661652 | 34660850:34660933 | ENSG00000137070.13 | ENST00000555003.1,ENST00000555247.1,ENST00000441545.2,ENST00000318041.9,ENST00000557298.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for IL11RA |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000318041 | 34655601 | 34655662 | Frame-shift |
| ENST00000441545 | 34655601 | 34655662 | Frame-shift |
| ENST00000555003 | 34655601 | 34655662 | Frame-shift |
| ENST00000318041 | 34656735 | 34656905 | Frame-shift |
| ENST00000441545 | 34656735 | 34656905 | Frame-shift |
| ENST00000555003 | 34656735 | 34656905 | Frame-shift |
| ENST00000318041 | 34658516 | 34658680 | Frame-shift |
| ENST00000441545 | 34658516 | 34658680 | Frame-shift |
| ENST00000555003 | 34658516 | 34658680 | Frame-shift |
| ENST00000318041 | 34660850 | 34660933 | Frame-shift |
| ENST00000441545 | 34660850 | 34660933 | Frame-shift |
| ENST00000555003 | 34660850 | 34660933 | Frame-shift |
| ENST00000318041 | 34660270 | 34660390 | In-frame |
| ENST00000441545 | 34660270 | 34660390 | In-frame |
| ENST00000555003 | 34660270 | 34660390 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000318041 | 34655601 | 34655662 | Frame-shift |
| ENST00000441545 | 34655601 | 34655662 | Frame-shift |
| ENST00000555003 | 34655601 | 34655662 | Frame-shift |
| ENST00000318041 | 34656735 | 34656905 | Frame-shift |
| ENST00000441545 | 34656735 | 34656905 | Frame-shift |
| ENST00000555003 | 34656735 | 34656905 | Frame-shift |
| ENST00000318041 | 34658516 | 34658680 | Frame-shift |
| ENST00000441545 | 34658516 | 34658680 | Frame-shift |
| ENST00000555003 | 34658516 | 34658680 | Frame-shift |
| ENST00000318041 | 34660850 | 34660933 | Frame-shift |
| ENST00000441545 | 34660850 | 34660933 | Frame-shift |
| ENST00000555003 | 34660850 | 34660933 | Frame-shift |
| ENST00000318041 | 34660270 | 34660390 | In-frame |
| ENST00000441545 | 34660270 | 34660390 | In-frame |
| ENST00000555003 | 34660270 | 34660390 | In-frame |
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Infer the effects of exon skipping event on protein functional features for IL11RA |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000318041 | 1745 | 422 | 34660270 | 34660390 | 1018 | 1137 | 317 | 357 |
| ENST00000441545 | 1717 | 422 | 34660270 | 34660390 | 995 | 1114 | 317 | 357 |
| ENST00000555003 | 3025 | 422 | 34660270 | 34660390 | 2309 | 2428 | 317 | 357 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000318041 | 1745 | 422 | 34660270 | 34660390 | 1018 | 1137 | 317 | 357 |
| ENST00000441545 | 1717 | 422 | 34660270 | 34660390 | 995 | 1114 | 317 | 357 |
| ENST00000555003 | 3025 | 422 | 34660270 | 34660390 | 2309 | 2428 | 317 | 357 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14626 | 317 | 357 | 23 | 422 | Chain | ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha |
| Q14626 | 317 | 357 | 23 | 422 | Chain | ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha |
| Q14626 | 317 | 357 | 23 | 422 | Chain | ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha |
| Q14626 | 317 | 357 | 220 | 317 | Domain | Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q14626 | 317 | 357 | 220 | 317 | Domain | Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q14626 | 317 | 357 | 220 | 317 | Domain | Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q14626 | 317 | 357 | 24 | 370 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q14626 | 317 | 357 | 24 | 370 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q14626 | 317 | 357 | 24 | 370 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14626 | 317 | 357 | 23 | 422 | Chain | ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha |
| Q14626 | 317 | 357 | 23 | 422 | Chain | ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha |
| Q14626 | 317 | 357 | 23 | 422 | Chain | ID=PRO_0000010913;Note=Interleukin-11 receptor subunit alpha |
| Q14626 | 317 | 357 | 220 | 317 | Domain | Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q14626 | 317 | 357 | 220 | 317 | Domain | Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q14626 | 317 | 357 | 220 | 317 | Domain | Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q14626 | 317 | 357 | 24 | 370 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q14626 | 317 | 357 | 24 | 370 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q14626 | 317 | 357 | 24 | 370 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for IL11RA |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BRCA | TCGA-A8-A07B-01 | exon_skip_495607 exon_skip_495606 | 34655602 | 34655662 | 34655616 | 34655616 | Nonsense_Mutation | C | T | p.Q39* |
| ESCA | TCGA-IG-A7DP-01 | exon_skip_495607 exon_skip_495606 | 34655602 | 34655662 | 34655616 | 34655616 | Nonsense_Mutation | C | T | p.Q39X |
| MESO | TCGA-UD-AABZ-01 | exon_skip_495609 exon_skip_495610 | 34656736 | 34656905 | 34656750 | 34656750 | Nonsense_Mutation | G | A | p.W59* |
| BRCA | TCGA-A2-A0T2-01 | exon_skip_495607 exon_skip_495606 | 34655602 | 34655662 | 34655600 | 34655600 | Splice_Site | A | G | e2-2 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KYSE520_OESOPHAGUS | 34655602 | 34655662 | 34655658 | 34655658 | Missense_Mutation | G | T | p.A53S |
| HCC2998_LARGE_INTESTINE | 34658517 | 34658680 | 34658520 | 34658520 | Missense_Mutation | G | A | p.R217H |
| TOV21G_OVARY | 34658517 | 34658680 | 34658639 | 34658639 | Missense_Mutation | C | T | p.R257C |
| A704_KIDNEY | 34658517 | 34658680 | 34658640 | 34658640 | Missense_Mutation | G | A | p.R257H |
| CW2_LARGE_INTESTINE | 34658517 | 34658680 | 34658640 | 34658640 | Missense_Mutation | G | A | p.R257H |
| IM95_STOMACH | 34660271 | 34660390 | 34660307 | 34660307 | Missense_Mutation | T | C | p.L330P |
| AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 34660271 | 34660390 | 34660313 | 34660313 | Missense_Mutation | C | G | p.T332R |
| NCIH1155_LUNG | 34660271 | 34660390 | 34660390 | 34660390 | Splice_Site | G | A | p.D358N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL11RA |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL11RA |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL11RA |
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RelatedDrugs for IL11RA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q14626 | DB00038 | Oprelvekin | Interleukin-11 receptor subunit alpha | biotech | approved|investigational |
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RelatedDiseases for IL11RA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| IL11RA | C0919267 | ovarian neoplasm | 1 | CTD_human |
| IL11RA | C3280073 | CRANIOSYNOSTOSIS AND DENTAL ANOMALIES | 1 | ORPHANET;UNIPROT |
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