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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for IL7 |
 Gene summary |
| Gene information | Gene symbol | IL7 | Gene ID | 3574 |
| Gene name | interleukin 7 | |
| Synonyms | IL-7 | |
| Cytomap | 8q21.13 | |
| Type of gene | protein-coding | |
| Description | interleukin-7 | |
| Modification date | 20180519 | |
| UniProtAcc | P13232 | |
| Context | PubMed: IL7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IL7 | GO:0001961 | positive regulation of cytokine-mediated signaling pathway | 11418668 |
| IL7 | GO:0019221 | cytokine-mediated signaling pathway | 11418668 |
| IL7 | GO:0032722 | positive regulation of chemokine production | 11418668 |
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Exon skipping events across known transcript of Ensembl for IL7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for IL7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for IL7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_490491 | 8 | 79645947:79646067:79648708:79648762:79650738:79650805 | 79648708:79648762 | ENSG00000104432.8 | ENST00000520317.1,ENST00000263851.4 |
| exon_skip_490492 | 8 | 79645947:79646067:79648708:79648762:79652236:79652311 | 79648708:79648762 | ENSG00000104432.8 | ENST00000520215.1,ENST00000520269.1 |
| exon_skip_490496 | 8 | 79648708:79648762:79650738:79650870:79652236:79652311 | 79650738:79650870 | ENSG00000104432.8 | ENST00000519833.1,ENST00000520317.1,ENST00000518982.1,ENST00000263851.4 |
| exon_skip_490497 | 8 | 79648708:79648762:79652236:79652317:79710306:79710443 | 79652236:79652317 | ENSG00000104432.8 | ENST00000520269.1 |
| exon_skip_490498 | 8 | 79648708:79648762:79652236:79652317:79710362:79710443 | 79652236:79652317 | ENSG00000104432.8 | ENST00000520215.1 |
| exon_skip_490499 | 8 | 79652236:79652317:79659128:79659331:79710306:79710443 | 79659128:79659331 | ENSG00000104432.8 | ENST00000518982.1 |
| exon_skip_490500 | 8 | 79652236:79652317:79710306:79710443:79717147:79717163 | 79710306:79710443 | ENSG00000104432.8 | ENST00000263851.4,ENST00000520269.1 |
| exon_skip_490501 | 8 | 79652236:79652317:79710362:79710443:79717147:79717163 | 79710362:79710443 | ENSG00000104432.8 | ENST00000520317.1,ENST00000520215.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for IL7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_490491 | 8 | 79645947:79646067:79648708:79648762:79650738:79650805 | 79648708:79648762 | ENSG00000104432.8 | ENST00000263851.4,ENST00000520317.1 |
| exon_skip_490492 | 8 | 79645947:79646067:79648708:79648762:79652236:79652311 | 79648708:79648762 | ENSG00000104432.8 | ENST00000520269.1,ENST00000520215.1 |
| exon_skip_490496 | 8 | 79648708:79648762:79650738:79650870:79652236:79652311 | 79650738:79650870 | ENSG00000104432.8 | ENST00000519833.1,ENST00000263851.4,ENST00000518982.1,ENST00000520317.1 |
| exon_skip_490497 | 8 | 79648708:79648762:79652236:79652317:79710306:79710443 | 79652236:79652317 | ENSG00000104432.8 | ENST00000520269.1 |
| exon_skip_490499 | 8 | 79652236:79652317:79659128:79659331:79710306:79710443 | 79659128:79659331 | ENSG00000104432.8 | ENST00000518982.1 |
| exon_skip_490500 | 8 | 79652236:79652317:79710306:79710443:79717147:79717163 | 79710306:79710443 | ENSG00000104432.8 | ENST00000263851.4,ENST00000520269.1 |
| exon_skip_490501 | 8 | 79652236:79652317:79710362:79710443:79717147:79717163 | 79710362:79710443 | ENSG00000104432.8 | ENST00000520215.1,ENST00000520317.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for IL7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263851 | 79710306 | 79710443 | Frame-shift |
| ENST00000263851 | 79648708 | 79648762 | In-frame |
| ENST00000263851 | 79650738 | 79650870 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263851 | 79710306 | 79710443 | Frame-shift |
| ENST00000263851 | 79648708 | 79648762 | In-frame |
| ENST00000263851 | 79650738 | 79650870 | In-frame |
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Infer the effects of exon skipping event on protein functional features for IL7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263851 | 2093 | 177 | 79650738 | 79650870 | 830 | 961 | 76 | 120 |
| ENST00000263851 | 2093 | 177 | 79648708 | 79648762 | 962 | 1015 | 120 | 138 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263851 | 2093 | 177 | 79650738 | 79650870 | 830 | 961 | 76 | 120 |
| ENST00000263851 | 2093 | 177 | 79648708 | 79648762 | 962 | 1015 | 120 | 138 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P13232 | 76 | 120 | 77 | 138 | Alternative sequence | ID=VSP_047580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 76 | 120 | 77 | 120 | Alternative sequence | ID=VSP_042926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 76 | 120 | 26 | 177 | Chain | ID=PRO_0000015623;Note=Interleukin-7 |
| P13232 | 76 | 120 | 27 | 166 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 76 | 120 | 59 | 154 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 76 | 120 | 72 | 117 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 76 | 120 | 95 | 95 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P13232 | 76 | 120 | 116 | 116 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P13232 | 76 | 120 | 77 | 89 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DI2 |
| P13232 | 76 | 120 | 99 | 115 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DI2 |
| P13232 | 120 | 138 | 77 | 138 | Alternative sequence | ID=VSP_047580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 120 | 138 | 77 | 120 | Alternative sequence | ID=VSP_042926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 120 | 138 | 26 | 177 | Chain | ID=PRO_0000015623;Note=Interleukin-7 |
| P13232 | 120 | 138 | 27 | 166 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 120 | 138 | 59 | 154 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P13232 | 76 | 120 | 77 | 138 | Alternative sequence | ID=VSP_047580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 76 | 120 | 77 | 120 | Alternative sequence | ID=VSP_042926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 76 | 120 | 26 | 177 | Chain | ID=PRO_0000015623;Note=Interleukin-7 |
| P13232 | 76 | 120 | 27 | 166 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 76 | 120 | 59 | 154 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 76 | 120 | 72 | 117 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 76 | 120 | 95 | 95 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P13232 | 76 | 120 | 116 | 116 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P13232 | 76 | 120 | 77 | 89 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DI2 |
| P13232 | 76 | 120 | 99 | 115 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DI2 |
| P13232 | 120 | 138 | 77 | 138 | Alternative sequence | ID=VSP_047580;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 120 | 138 | 77 | 120 | Alternative sequence | ID=VSP_042926;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| P13232 | 120 | 138 | 26 | 177 | Chain | ID=PRO_0000015623;Note=Interleukin-7 |
| P13232 | 120 | 138 | 27 | 166 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
| P13232 | 120 | 138 | 59 | 154 | Disulfide bond | Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19141282,ECO:0000269|PubMed:9407080;Dbxref=PMID:19141282,PMID:9407080 |
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SNVs in the skipped exons for IL7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_490497 exon_skip_490498 | 79652237 | 79652317 | 79652264 | 79652264 | Frame_Shift_Del | A | - | p.F67fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_490497 exon_skip_490498 | 79652237 | 79652317 | 79652264 | 79652264 | Frame_Shift_Del | A | - | p.F67fs |
| UCEC | TCGA-AX-A06H-01 | exon_skip_490497 exon_skip_490498 | 79652237 | 79652317 | 79652264 | 79652264 | Frame_Shift_Del | A | - | p.F67fs |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_490497 exon_skip_490498 | 79652237 | 79652317 | 79652263 | 79652264 | Frame_Shift_Ins | - | A | p.L67fs |
| LUSC | TCGA-21-5787-01 | exon_skip_490496 | 79650739 | 79650870 | 79650857 | 79650857 | Nonsense_Mutation | A | T | p.L81* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH684_LIVER | 79650739 | 79650870 | 79650762 | 79650764 | In_Frame_Del | TTG | - | p.T112del |
| CW2_LARGE_INTESTINE | 79648709 | 79648762 | 79648717 | 79648717 | Missense_Mutation | T | C | p.K136E |
| ESO26_OESOPHAGUS | 79650739 | 79650870 | 79650754 | 79650754 | Missense_Mutation | C | G | p.L115F |
| HEC59_ENDOMETRIUM | 79650739 | 79650870 | 79650848 | 79650848 | Missense_Mutation | G | A | p.A84V |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 79650739 | 79650870 | 79650851 | 79650851 | Missense_Mutation | C | T | p.R83H |
| HEC59_ENDOMETRIUM | 79710307 | 79710443 | 79710323 | 79710323 | Missense_Mutation | C | T | p.S44N |
| EB3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 79710307 | 79710443 | 79710390 | 79710390 | Missense_Mutation | C | T | p.V22I |
| EB3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 79710363 | 79710443 | 79710390 | 79710390 | Missense_Mutation | C | T | p.V22I |
| JHUEM7_ENDOMETRIUM | 79652237 | 79652317 | 79652305 | 79652305 | Nonsense_Mutation | C | A | p.E54* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL7 |
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RelatedDrugs for IL7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| IL7 | C0024312 | Lymphopenia | 1 | CTD_human |
| IL7 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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