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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for HLA-G

check button Gene summary
Gene informationGene symbol

HLA-G

Gene ID

3135

Gene namemajor histocompatibility complex, class I, G
SynonymsMHC-G
Cytomap

6p22.1

Type of geneprotein-coding
DescriptionHLA class I histocompatibility antigen, alpha chain GHLA G antigenHLA-G histocompatibility antigen, class I, GMHC class I antigen GMHC class Ib antigenb2 microglobulinmutant MHC class I antigenmutant MHC class Ib antigen
Modification date20180527
UniProtAcc

P17693

ContextPubMed: HLA-G [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
HLA-G

GO:0002767

immune response-inhibiting cell surface receptor signaling pathway

20702625

HLA-G

GO:0032735

positive regulation of interleukin-12 production

20702625

HLA-G

GO:0042130

negative regulation of T cell proliferation

20702625

HLA-G

GO:2001199

negative regulation of dendritic cell differentiation

20702625


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Exon skipping events across known transcript of Ensembl for HLA-G from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for HLA-G

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for HLA-G

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_449014629795823:29796093:29796319:29796595:29797194:2979734829796319:29796595ENSG00000204632.7ENST00000428701.1,ENST00000376828.2,ENST00000360323.6,ENST00000478355.1
exon_skip_449020629795935:29796093:29797194:29797470:29797592:2979770929797194:29797470ENSG00000204632.7ENST00000478519.1,ENST00000376818.3
exon_skip_449024629796319:29796595:29797194:29797470:29797592:2979770929797194:29797470ENSG00000204632.7ENST00000428701.1,ENST00000376828.2,ENST00000360323.6
exon_skip_449025629798154:29798187:29798329:29798377:29798544:2979890229798329:29798377ENSG00000204632.7ENST00000478519.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for HLA-G

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_449014629795823:29796093:29796319:29796595:29797194:2979734829796319:29796595ENSG00000204632.7ENST00000376828.2,ENST00000428701.1,ENST00000360323.6,ENST00000478355.1
exon_skip_449020629795935:29796093:29797194:29797470:29797592:2979770929797194:29797470ENSG00000204632.7ENST00000376818.3,ENST00000478519.1
exon_skip_449025629798154:29798187:29798329:29798377:29798544:2979890229798329:29798377ENSG00000204632.7ENST00000478519.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for HLA-G

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003603232979631929796595In-frame
ENST000004287012979631929796595In-frame
ENST000003603232979719429797470In-frame
ENST000004287012979719429797470In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003603232979631929796595In-frame
ENST000004287012979631929796595In-frame

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Infer the effects of exon skipping event on protein functional features for HLA-G

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036032314443382979631929796595368643114206
ENST0000042870115953382979631929796595522797114206
ENST0000036032314443382979719429797470644919206298
ENST00000428701159533829797194297974707981073206298

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036032314443382979631929796595368643114206
ENST0000042870115953382979631929796595522797114206

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P17693114206115298Alternative sequenceID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206115298Alternative sequenceID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206115206Alternative sequenceID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206115206Alternative sequenceID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206116116Alternative sequenceID=VSP_059193;Note=In isoform 7. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206116116Alternative sequenceID=VSP_059193;Note=In isoform 7. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206117338Alternative sequenceID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206117338Alternative sequenceID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206113115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYP
P17693114206113115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYP
P17693114206118132Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206118132Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206134142Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206134142Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206145150Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206145150Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206157161Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206157161Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P1769311420625338ChainID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
P1769311420625338ChainID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
P17693114206125188Disulfide bondOntology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
P17693114206125188Disulfide bondOntology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
P17693114206162173HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206162173HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206176185HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206176185HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206187198HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206187198HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206200203HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206200203HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P1769311420625114RegionNote=Alpha-1
P1769311420625114RegionNote=Alpha-1
P17693114206115206RegionNote=Alpha-2
P17693114206115206RegionNote=Alpha-2
P1769311420625308Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1769311420625308Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17693206298115298Alternative sequenceID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693206298115298Alternative sequenceID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693206298115206Alternative sequenceID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693206298115206Alternative sequenceID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693206298117338Alternative sequenceID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693206298117338Alternative sequenceID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693206298207298Alternative sequenceID=VSP_059196;Note=In isoform 4. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7589701,ECO:0000269|PubMed:8183892;Dbxref=PMID:7589701,PMID:8183892
P17693206298207298Alternative sequenceID=VSP_059196;Note=In isoform 4. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7589701,ECO:0000269|PubMed:8183892;Dbxref=PMID:7589701,PMID:8183892
P17693206298207207Alternative sequenceID=VSP_059195;Note=In isoform 2 and isoform 6. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693206298207207Alternative sequenceID=VSP_059195;Note=In isoform 2 and isoform 6. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693206298210218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298210218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298222235Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298222235Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298238243Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298238243Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298246248Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298246248Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298261263Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298261263Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298265274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298265274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298281286Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298281286Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298290292Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298290292Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298294296Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298294296Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P1769320629825338ChainID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
P1769320629825338ChainID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
P17693206298227283Disulfide bondOntology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
P17693206298227283Disulfide bondOntology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
P17693206298209299DomainNote=Ig-like C1-type
P17693206298209299DomainNote=Ig-like C1-type
P17693206298249251HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YDP
P17693206298249251HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YDP
P17693206298278280HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298278280HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298115206RegionNote=Alpha-2
P17693206298115206RegionNote=Alpha-2
P17693206298207298RegionNote=Alpha-3
P17693206298207298RegionNote=Alpha-3
P1769320629825308Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1769320629825308Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17693206298219221TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693206298219221TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P17693114206115298Alternative sequenceID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206115298Alternative sequenceID=VSP_059191;Note=In isoform 3. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206115206Alternative sequenceID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206115206Alternative sequenceID=VSP_059192;Note=In isoform 2 and isoform 6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1570318;Dbxref=PMID:1570318
P17693114206116116Alternative sequenceID=VSP_059193;Note=In isoform 7. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206116116Alternative sequenceID=VSP_059193;Note=In isoform 7. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206117338Alternative sequenceID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206117338Alternative sequenceID=VSP_059194;Note=In isoform 7. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11137219;Dbxref=PMID:11137219
P17693114206113115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYP
P17693114206113115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DYP
P17693114206118132Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206118132Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206134142Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206134142Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206145150Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206145150Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206157161Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206157161Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P1769311420625338ChainID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
P1769311420625338ChainID=PRO_0000018886;Note=HLA class I histocompatibility antigen%2C alpha chain G
P17693114206125188Disulfide bondOntology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
P17693114206125188Disulfide bondOntology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:16455647;Dbxref=PMID:16455647
P17693114206162173HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206162173HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206176185HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206176185HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206187198HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206187198HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206200203HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P17693114206200203HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KYO
P1769311420625114RegionNote=Alpha-1
P1769311420625114RegionNote=Alpha-1
P17693114206115206RegionNote=Alpha-2
P17693114206115206RegionNote=Alpha-2
P1769311420625308Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1769311420625308Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255


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SNVs in the skipped exons for HLA-G

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
BRCATCGA-BH-A0AU-01exon_skip_449014
29796320297965952979643529796435Frame_Shift_DelC-p.L154fs
DLBCTCGA-G8-6326-01exon_skip_449014
29796320297965952979643529796435Frame_Shift_DelC-p.D153fs
LIHCTCGA-DD-A39Y-01exon_skip_449024
exon_skip_449020
29797195297974702979719629797196Frame_Shift_DelC-p.D207fs

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
ISTMES1_PLEURA29797195297974702979745529797458Frame_Shift_DelCTCA-p.LM294fs
KMH2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979651529796516Frame_Shift_Ins-CAp.R180fs
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979651529796516Frame_Shift_Ins-CAp.R180fs
ISTMES1_PLEURA29797195297974702979746029797461Frame_Shift_Ins-CACCp.L296fs
VMRCLCD_LUNG29796320297965952979633229796332Missense_MutationTGp.L119R
C33A_CERVIX29796320297965952979638029796380Missense_MutationGAp.R135H
HEC59_ENDOMETRIUM29796320297965952979638329796383Missense_MutationGTp.G136V
JHUEM2_ENDOMETRIUM29796320297965952979642129796421Missense_MutationGAp.A149T
NCIH1755_LUNG29796320297965952979643029796430Missense_MutationGCp.E152Q
SW684_SOFT_TISSUE29796320297965952979643029796430Missense_MutationGAp.E152K
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979643929796439Missense_MutationCTp.R155C
RERFLCSQ1_LUNG29796320297965952979653529796535Missense_MutationAGp.T187A
CADOES1_BONE29796320297965952979653629796536Missense_MutationCTp.T187M
CAOV4_OVARY29796320297965952979653629796536Missense_MutationCTp.T187M
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979653629796536Missense_MutationCTp.T187M
EPLC272H_LUNG29796320297965952979653629796536Missense_MutationCTp.T187M
HCC70_BREAST29796320297965952979653629796536Missense_MutationCTp.T187M
HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979653629796536Missense_MutationCTp.T187M
NCIH2347_LUNG29796320297965952979653629796536Missense_MutationCTp.T187M
OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979653629796536Missense_MutationCTp.T187M
OVTOKO_OVARY29796320297965952979653629796536Missense_MutationCTp.T187M
PANC0213_PANCREAS29796320297965952979653629796536Missense_MutationCTp.T187M
RERFLCSQ1_LUNG29796320297965952979653629796536Missense_MutationCAp.T187K
SF126_CENTRAL_NERVOUS_SYSTEM29796320297965952979653629796536Missense_MutationCTp.T187M
SNU387_LIVER29796320297965952979653629796536Missense_MutationCTp.T187M
SNU423_LIVER29796320297965952979653629796536Missense_MutationCTp.T187M
SNU5_STOMACH29796320297965952979653629796536Missense_MutationCTp.T187M
TE9_OESOPHAGUS29796320297965952979653629796536Missense_MutationCTp.T187M
SNU1033_LARGE_INTESTINE29796320297965952979654629796546Missense_MutationGCp.E190D
A498_KIDNEY29796320297965952979658629796586Missense_MutationCGp.Q204E
BICR22_UPPER_AERODIGESTIVE_TRACT29796320297965952979658629796586Missense_MutationCGp.Q204E
HS611T_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979658629796586Missense_MutationCGp.Q204E
MELJUSO_SKIN29796320297965952979658629796586Missense_MutationCGp.Q204E
MJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29796320297965952979658629796586Missense_MutationCGp.Q204E
RPMI7951_SKIN29796320297965952979658629796586Missense_MutationCGp.Q204E
HEC59_ENDOMETRIUM29796320297965952979658729796587Missense_MutationACp.Q204P
HCC70_BREAST29797195297974702979721229797212Missense_MutationGAp.V213M
M00921_SKIN29797195297974702979726129797261Missense_MutationCTp.A229V
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE29797195297974702979726629797266Missense_MutationGTp.G231C
CHLA218_BONE29797195297974702979726729797267Missense_MutationGAp.G231D
NCIH1417_LUNG29797195297974702979731729797317Missense_MutationCAp.Q248K
SCMCRM2_SOFT_TISSUE29797195297974702979737729797377Missense_MutationTCp.W268R
PL4_PANCREAS29797195297974702979741229797412Missense_MutationGTp.Q279H
HEC108_ENDOMETRIUM29797195297974702979741929797419Missense_MutationAGp.T282A
MFE319_ENDOMETRIUM29797195297974702979719529797196Splice_Site-Cp.DP207fs

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HLA-G

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HLA-G


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HLA-G


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RelatedDrugs for HLA-G

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HLA-G

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
HLA-GC0005586Bipolar Disorder1PSYGENET