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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for HUNK |
 Gene summary |
| Gene information | Gene symbol | HUNK | Gene ID | 30811 |
| Gene name | hormonally up-regulated Neu-associated kinase | |
| Synonyms | - | |
| Cytomap | 21q22.11 | |
| Type of gene | protein-coding | |
| Description | hormonally up-regulated neu tumor-associated kinaseB19hormonally upregulated Neu-associated kinasehormonally upregulated neu tumor-associated kinaseserine/threonine protein kinase MAK-V | |
| Modification date | 20180523 | |
| UniProtAcc | P57058 | |
| Context | PubMed: HUNK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for HUNK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for HUNK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for HUNK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_359261 | 21 | 33296863:33297072:33312476:33312532:33318347:33318483 | 33312476:33312532 | ENSG00000142149.4 | ENST00000270112.2,ENST00000430354.1 |
| exon_skip_359263 | 21 | 33312476:33312532:33318347:33318483:33331154:33331282 | 33318347:33318483 | ENSG00000142149.4 | ENST00000270112.2 |
| exon_skip_359264 | 21 | 33318347:33318483:33331154:33331282:33340561:33340646 | 33331154:33331282 | ENSG00000142149.4 | ENST00000270112.2 |
| exon_skip_359267 | 21 | 33355838:33355922:33362441:33362489:33368080:33368240 | 33362441:33362489 | ENSG00000142149.4 | ENST00000270112.2,ENST00000439107.1,ENST00000465574.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for HUNK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_359261 | 21 | 33296863:33297072:33312476:33312532:33318347:33318483 | 33312476:33312532 | ENSG00000142149.4 | ENST00000270112.2,ENST00000430354.1 |
| exon_skip_359264 | 21 | 33318347:33318483:33331154:33331282:33340561:33340646 | 33331154:33331282 | ENSG00000142149.4 | ENST00000270112.2 |
| exon_skip_359267 | 21 | 33355838:33355922:33362441:33362489:33368080:33368240 | 33362441:33362489 | ENSG00000142149.4 | ENST00000270112.2,ENST00000465574.1,ENST00000439107.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for HUNK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000270112 | 33312476 | 33312532 | Frame-shift |
| ENST00000270112 | 33318347 | 33318483 | Frame-shift |
| ENST00000270112 | 33331154 | 33331282 | Frame-shift |
| ENST00000270112 | 33362441 | 33362489 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000270112 | 33312476 | 33312532 | Frame-shift |
| ENST00000270112 | 33331154 | 33331282 | Frame-shift |
| ENST00000270112 | 33362441 | 33362489 | In-frame |
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Infer the effects of exon skipping event on protein functional features for HUNK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000270112 | 7402 | 714 | 33362441 | 33362489 | 1618 | 1665 | 419 | 435 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000270112 | 7402 | 714 | 33362441 | 33362489 | 1618 | 1665 | 419 | 435 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57058 | 419 | 435 | 1 | 714 | Chain | ID=PRO_0000086004;Note=Hormonally up-regulated neu tumor-associated kinase |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57058 | 419 | 435 | 1 | 714 | Chain | ID=PRO_0000086004;Note=Hormonally up-regulated neu tumor-associated kinase |
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SNVs in the skipped exons for HUNK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_359263 | 33318348 | 33318483 | 33318460 | 33318460 | Frame_Shift_Del | C | - | p.G241fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCC1359_LUNG | 33312477 | 33312532 | 33312505 | 33312505 | Missense_Mutation | G | C | p.D195H |
| NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 33331155 | 33331282 | 33331223 | 33331223 | Missense_Mutation | C | A | p.A272D |
| NCIH1734_LUNG | 33362442 | 33362489 | 33362484 | 33362484 | Missense_Mutation | G | T | p.V434L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HUNK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HUNK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HUNK |
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RelatedDrugs for HUNK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HUNK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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