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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PKN3 |
 Gene summary |
| Gene information | Gene symbol | PKN3 | Gene ID | 29941 |
| Gene name | protein kinase N3 | |
| Synonyms | UTDP4-1 | |
| Cytomap | 9q34.11 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase N3protein kinase PKN-betaprotein-kinase C-related kinase 3 | |
| Modification date | 20180523 | |
| UniProtAcc | Q6P5Z2 | |
| Context | PubMed: PKN3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PKN3 | GO:0010631 | epithelial cell migration | 21754995 |
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Exon skipping events across known transcript of Ensembl for PKN3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PKN3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PKN3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_499821 | 9 | 131475395:131475477:131475556:131475666:131475777:131475921 | 131475556:131475666 | ENSG00000160447.6 | ENST00000291906.4,ENST00000483521.1 |
| exon_skip_499824 | 9 | 131475777:131475921:131476324:131476400:131476475:131476644 | 131476324:131476400 | ENSG00000160447.6 | ENST00000291906.4 |
| exon_skip_499825 | 9 | 131476884:131476943:131477076:131477144:131477450:131477514 | 131477076:131477144 | ENSG00000160447.6 | ENST00000485301.1,ENST00000291906.4 |
| exon_skip_499826 | 9 | 131477450:131477514:131477647:131477739:131479025:131479202 | 131477647:131477739 | ENSG00000160447.6 | ENST00000291906.4 |
| exon_skip_499827 | 9 | 131477647:131477739:131479025:131479202:131480603:131480666 | 131479025:131479202 | ENSG00000160447.6 | ENST00000291906.4 |
| exon_skip_499828 | 9 | 131479025:131479202:131480603:131480666:131480827:131480904 | 131480603:131480666 | ENSG00000160447.6 | ENST00000485301.1,ENST00000291906.4 |
| exon_skip_499832 | 9 | 131480603:131480666:131480827:131480904:131481964:131482107 | 131480827:131480904 | ENSG00000160447.6 | ENST00000485301.1,ENST00000291906.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PKN3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_499821 | 9 | 131475395:131475477:131475556:131475666:131475777:131475921 | 131475556:131475666 | ENSG00000160447.6 | ENST00000291906.4,ENST00000483521.1 |
| exon_skip_499824 | 9 | 131475777:131475921:131476324:131476400:131476475:131476644 | 131476324:131476400 | ENSG00000160447.6 | ENST00000291906.4 |
| exon_skip_499825 | 9 | 131476884:131476943:131477076:131477144:131477450:131477514 | 131477076:131477144 | ENSG00000160447.6 | ENST00000291906.4,ENST00000485301.1 |
| exon_skip_499826 | 9 | 131477450:131477514:131477647:131477739:131479025:131479202 | 131477647:131477739 | ENSG00000160447.6 | ENST00000291906.4 |
| exon_skip_499827 | 9 | 131477647:131477739:131479025:131479202:131480603:131480666 | 131479025:131479202 | ENSG00000160447.6 | ENST00000291906.4 |
| exon_skip_499828 | 9 | 131479025:131479202:131480603:131480666:131480827:131480904 | 131480603:131480666 | ENSG00000160447.6 | ENST00000291906.4,ENST00000485301.1 |
| exon_skip_499832 | 9 | 131480603:131480666:131480827:131480904:131481964:131482107 | 131480827:131480904 | ENSG00000160447.6 | ENST00000291906.4,ENST00000485301.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PKN3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000291906 | 131475556 | 131475666 | Frame-shift |
| ENST00000291906 | 131476324 | 131476400 | Frame-shift |
| ENST00000291906 | 131477076 | 131477144 | Frame-shift |
| ENST00000291906 | 131477647 | 131477739 | Frame-shift |
| ENST00000291906 | 131480827 | 131480904 | Frame-shift |
| ENST00000291906 | 131479025 | 131479202 | In-frame |
| ENST00000291906 | 131480603 | 131480666 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000291906 | 131475556 | 131475666 | Frame-shift |
| ENST00000291906 | 131476324 | 131476400 | Frame-shift |
| ENST00000291906 | 131477076 | 131477144 | Frame-shift |
| ENST00000291906 | 131477647 | 131477739 | Frame-shift |
| ENST00000291906 | 131480827 | 131480904 | Frame-shift |
| ENST00000291906 | 131479025 | 131479202 | In-frame |
| ENST00000291906 | 131480603 | 131480666 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PKN3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000291906 | 3392 | 889 | 131479025 | 131479202 | 2202 | 2378 | 603 | 661 |
| ENST00000291906 | 3392 | 889 | 131480603 | 131480666 | 2379 | 2441 | 662 | 682 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000291906 | 3392 | 889 | 131479025 | 131479202 | 2202 | 2378 | 603 | 661 |
| ENST00000291906 | 3392 | 889 | 131480603 | 131480666 | 2379 | 2441 | 662 | 682 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P5Z2 | 603 | 661 | 1 | 889 | Chain | ID=PRO_0000055725;Note=Serine/threonine-protein kinase N3 |
| Q6P5Z2 | 603 | 661 | 559 | 818 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P5Z2 | 603 | 661 | 627 | 627 | Sequence conflict | Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q6P5Z2 | 603 | 661 | 636 | 636 | Sequence conflict | Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q6P5Z2 | 662 | 682 | 1 | 889 | Chain | ID=PRO_0000055725;Note=Serine/threonine-protein kinase N3 |
| Q6P5Z2 | 662 | 682 | 559 | 818 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P5Z2 | 603 | 661 | 1 | 889 | Chain | ID=PRO_0000055725;Note=Serine/threonine-protein kinase N3 |
| Q6P5Z2 | 603 | 661 | 559 | 818 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q6P5Z2 | 603 | 661 | 627 | 627 | Sequence conflict | Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q6P5Z2 | 603 | 661 | 636 | 636 | Sequence conflict | Note=C->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q6P5Z2 | 662 | 682 | 1 | 889 | Chain | ID=PRO_0000055725;Note=Serine/threonine-protein kinase N3 |
| Q6P5Z2 | 662 | 682 | 559 | 818 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
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SNVs in the skipped exons for PKN3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-EY-A212-01 | exon_skip_499828 | 131480604 | 131480666 | 131480644 | 131480644 | Frame_Shift_Del | C | - | p.H676fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_499832 | 131480828 | 131480904 | 131480860 | 131480860 | Frame_Shift_Del | C | - | p.A694fs |
| KIRP | TCGA-5P-A9K6-01 | exon_skip_499825 | 131477077 | 131477144 | 131477092 | 131477093 | Frame_Shift_Ins | - | AT | p.H534fs |
| UCEC | TCGA-FI-A2EX-01 | exon_skip_499828 | 131480604 | 131480666 | 131480610 | 131480610 | Nonsense_Mutation | C | G | p.Y664* |
| KIRC | TCGA-B0-4811-01 | exon_skip_499832 | 131480828 | 131480904 | 131480826 | 131480826 | Splice_Site | A | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PCI15A_UPPER_AERODIGESTIVE_TRACT | 131477648 | 131477739 | 131477734 | 131477737 | Frame_Shift_Del | AGAG | - | p.IE601fs |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131480604 | 131480666 | 131480648 | 131480650 | In_Frame_Del | AGA | - | p.K679del |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131475557 | 131475666 | 131475590 | 131475590 | Missense_Mutation | G | A | p.R339H |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131476325 | 131476400 | 131476355 | 131476355 | Missense_Mutation | C | T | p.R423W |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131476325 | 131476400 | 131476380 | 131476380 | Missense_Mutation | G | A | p.R431H |
| OUMS23_LARGE_INTESTINE | 131476325 | 131476400 | 131476380 | 131476380 | Missense_Mutation | G | A | p.R431H |
| SW684_SOFT_TISSUE | 131477077 | 131477144 | 131477089 | 131477089 | Missense_Mutation | C | T | p.P533S |
| SW48_LARGE_INTESTINE | 131477077 | 131477144 | 131477137 | 131477137 | Missense_Mutation | C | T | p.P549S |
| EN_ENDOMETRIUM | 131479026 | 131479202 | 131479037 | 131479037 | Missense_Mutation | A | G | p.E607G |
| NCIH2172_LUNG | 131479026 | 131479202 | 131479076 | 131479076 | Missense_Mutation | C | A | p.P620H |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 131479026 | 131479202 | 131479144 | 131479144 | Missense_Mutation | C | T | p.P643S |
| MKN7_STOMACH | 131480604 | 131480666 | 131480609 | 131480609 | Missense_Mutation | A | G | p.Y664C |
| ASH3_THYROID | 131480604 | 131480666 | 131480609 | 131480609 | Missense_Mutation | A | G | p.Y664C |
| TE15_OESOPHAGUS | 131480604 | 131480666 | 131480609 | 131480609 | Missense_Mutation | A | G | p.Y664C |
| CORL303_LUNG | 131480604 | 131480666 | 131480658 | 131480658 | Missense_Mutation | C | G | p.I680M |
| MFE296_ENDOMETRIUM | 131480828 | 131480904 | 131480847 | 131480847 | Missense_Mutation | C | T | p.L690F |
| NCIH2141_LUNG | 131480828 | 131480904 | 131480860 | 131480860 | Missense_Mutation | C | A | p.A694D |
| TE9_OESOPHAGUS | 131480828 | 131480904 | 131480889 | 131480889 | Missense_Mutation | G | A | p.G704R |
| SNUC5_LARGE_INTESTINE | 131477077 | 131477144 | 131477078 | 131477078 | Splice_Site | G | A | p.R529H |
| CCK81_LARGE_INTESTINE | 131479026 | 131479202 | 131479027 | 131479027 | Splice_Site | C | T | p.L604L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PKN3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PKN3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PKN3 |
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RelatedDrugs for PKN3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PKN3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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