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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for GRK5 |
 Gene summary |
| Gene information | Gene symbol | GRK5 | Gene ID | 2869 |
| Gene name | G protein-coupled receptor kinase 5 | |
| Synonyms | GPRK5 | |
| Cytomap | 10q26.11 | |
| Type of gene | protein-coding | |
| Description | G protein-coupled receptor kinase 5FP2025g protein-coupled receptor kinase GRK5 | |
| Modification date | 20180519 | |
| UniProtAcc | P34947 | |
| Context | PubMed: GRK5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| GRK5 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
| GRK5 | GO:0043066 | negative regulation of apoptotic process | 20124405 |
| GRK5 | GO:0046777 | protein autophosphorylation | 14976207 |
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Exon skipping events across known transcript of Ensembl for GRK5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for GRK5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for GRK5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_45367 | 10 | 121086027:121086123:121140326:121140439:121156206:121156284 | 121140326:121140439 | ENSG00000198873.10 | ENST00000392870.2 |
| exon_skip_45370 | 10 | 121156206:121156284:121182677:121182778:121184504:121184597 | 121182677:121182778 | ENSG00000198873.10 | ENST00000369108.3,ENST00000392870.2 |
| exon_skip_45374 | 10 | 121190898:121191039:121196162:121196353:121199242:121199280 | 121196162:121196353 | ENSG00000198873.10 | ENST00000369108.3,ENST00000392870.2 |
| exon_skip_45375 | 10 | 121196162:121196353:121199242:121199280:121201510:121201600 | 121199242:121199280 | ENSG00000198873.10 | ENST00000369108.3,ENST00000392870.2 |
| exon_skip_45376 | 10 | 121199242:121199280:121201510:121201600:121203055:121203264 | 121201510:121201600 | ENSG00000198873.10 | ENST00000369108.3,ENST00000392870.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for GRK5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_45367 | 10 | 121086027:121086123:121140326:121140439:121156206:121156284 | 121140326:121140439 | ENSG00000198873.10 | ENST00000392870.2 |
| exon_skip_45370 | 10 | 121156206:121156284:121182677:121182778:121184504:121184597 | 121182677:121182778 | ENSG00000198873.10 | ENST00000392870.2,ENST00000369108.3 |
| exon_skip_45374 | 10 | 121190898:121191039:121196162:121196353:121199242:121199280 | 121196162:121196353 | ENSG00000198873.10 | ENST00000392870.2,ENST00000369108.3 |
| exon_skip_45375 | 10 | 121196162:121196353:121199242:121199280:121201510:121201600 | 121199242:121199280 | ENSG00000198873.10 | ENST00000392870.2,ENST00000369108.3 |
| exon_skip_45376 | 10 | 121199242:121199280:121201510:121201600:121203055:121203264 | 121201510:121201600 | ENSG00000198873.10 | ENST00000392870.2,ENST00000369108.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for GRK5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392870 | 121140326 | 121140439 | Frame-shift |
| ENST00000392870 | 121182677 | 121182778 | Frame-shift |
| ENST00000392870 | 121196162 | 121196353 | Frame-shift |
| ENST00000392870 | 121199242 | 121199280 | Frame-shift |
| ENST00000392870 | 121201510 | 121201600 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392870 | 121140326 | 121140439 | Frame-shift |
| ENST00000392870 | 121182677 | 121182778 | Frame-shift |
| ENST00000392870 | 121196162 | 121196353 | Frame-shift |
| ENST00000392870 | 121199242 | 121199280 | Frame-shift |
| ENST00000392870 | 121201510 | 121201600 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GRK5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392870 | 2671 | 590 | 121201510 | 121201600 | 1297 | 1386 | 322 | 352 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392870 | 2671 | 590 | 121201510 | 121201600 | 1297 | 1386 | 322 | 352 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P34947 | 322 | 352 | 325 | 327 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TND |
| P34947 | 322 | 352 | 1 | 590 | Chain | ID=PRO_0000085971;Note=G protein-coupled receptor kinase 5 |
| P34947 | 322 | 352 | 186 | 448 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P34947 | 322 | 352 | 330 | 332 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TND |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P34947 | 322 | 352 | 325 | 327 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TND |
| P34947 | 322 | 352 | 1 | 590 | Chain | ID=PRO_0000085971;Note=G protein-coupled receptor kinase 5 |
| P34947 | 322 | 352 | 186 | 448 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P34947 | 322 | 352 | 330 | 332 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TND |
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SNVs in the skipped exons for GRK5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_45376 | 121201511 | 121201600 | 121201551 | 121201551 | Frame_Shift_Del | C | - | p.I336fs |
| ESCA | TCGA-Z6-A8JE-01 | exon_skip_45370 | 121182678 | 121182778 | 121182726 | 121182726 | Nonsense_Mutation | G | T | p.E130* |
| ESCA | TCGA-Z6-A8JE-01 | exon_skip_45370 | 121182678 | 121182778 | 121182726 | 121182726 | Nonsense_Mutation | G | T | p.E130X |
| THYM | TCGA-XU-AAXW-01 | exon_skip_45374 | 121196163 | 121196353 | 121196184 | 121196184 | Nonsense_Mutation | G | T | p.E254X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU520_STOMACH | 121196163 | 121196353 | 121196283 | 121196284 | Frame_Shift_Ins | - | G | p.R287fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 121140327 | 121140439 | 121140339 | 121140339 | Missense_Mutation | G | A | p.C54Y |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 121140327 | 121140439 | 121140437 | 121140437 | Missense_Mutation | G | A | p.V87M |
| NCIH513_PLEURA | 121196163 | 121196353 | 121196203 | 121196203 | Missense_Mutation | G | T | p.C260F |
| SNU1040_LARGE_INTESTINE | 121196163 | 121196353 | 121196299 | 121196299 | Missense_Mutation | C | T | p.A292V |
| SARC9371_BONE | 121201511 | 121201600 | 121201512 | 121201512 | Splice_Site | C | T | p.G323G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GRK5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GRK5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GRK5 |
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RelatedDrugs for GRK5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRK5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GRK5 | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| GRK5 | C0023895 | Liver diseases | 1 | CTD_human |
| GRK5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| GRK5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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