|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for TMEM145 |
 Gene summary |
| Gene information | Gene symbol | TMEM145 | Gene ID | 284339 |
| Gene name | transmembrane protein 145 | |
| Synonyms | - | |
| Cytomap | 19q13.2 | |
| Type of gene | protein-coding | |
| Description | transmembrane protein 145 | |
| Modification date | 20180329 | |
| UniProtAcc | Q8NBT3 | |
| Context | PubMed: TMEM145 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for TMEM145 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for TMEM145 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for TMEM145 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307700 | 19 | 42818423:42818498:42818572:42818680:42818764:42818846 | 42818572:42818680 | ENSG00000167619.7 | ENST00000598766.1 |
| exon_skip_307701 | 19 | 42818423:42818498:42818602:42818680:42818764:42818846 | 42818602:42818680 | ENSG00000167619.7 | ENST00000595775.1,ENST00000301204.3,ENST00000601020.1 |
| exon_skip_307706 | 19 | 42821021:42821115:42821860:42822033:42824468:42824589 | 42821860:42822033 | ENSG00000167619.7 | ENST00000598766.1,ENST00000301204.3 |
| exon_skip_307708 | 19 | 42824510:42824589:42825471:42825529:42825726:42825927 | 42825471:42825529 | ENSG00000167619.7 | ENST00000601644.1 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for TMEM145 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307700 | 19 | 42818423:42818498:42818572:42818680:42818764:42818846 | 42818572:42818680 | ENSG00000167619.7 | ENST00000598766.1 |
| exon_skip_307701 | 19 | 42818423:42818498:42818602:42818680:42818764:42818846 | 42818602:42818680 | ENSG00000167619.7 | ENST00000595775.1,ENST00000301204.3,ENST00000601020.1 |
| exon_skip_307706 | 19 | 42821021:42821115:42821860:42822033:42824468:42824589 | 42821860:42822033 | ENSG00000167619.7 | ENST00000301204.3,ENST00000598766.1 |
| exon_skip_307708 | 19 | 42824510:42824589:42825471:42825529:42825726:42825927 | 42825471:42825529 | ENSG00000167619.7 | ENST00000601644.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TMEM145 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301204 | 42821860 | 42822033 | Frame-shift |
| ENST00000301204 | 42818602 | 42818680 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301204 | 42821860 | 42822033 | Frame-shift |
| ENST00000301204 | 42818602 | 42818680 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for TMEM145 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000301204 | 1785 | 493 | 42818602 | 42818680 | 237 | 314 | 65 | 91 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000301204 | 1785 | 493 | 42818602 | 42818680 | 237 | 314 | 65 | 91 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NBT3 | 65 | 91 | 1 | 493 | Chain | ID=PRO_0000280355;Note=Transmembrane protein 145 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NBT3 | 65 | 91 | 1 | 493 | Chain | ID=PRO_0000280355;Note=Transmembrane protein 145 |
Top |
SNVs in the skipped exons for TMEM145 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
TMEM145_LUAD_exon_skip_307706_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-BC-A112-01 | exon_skip_307700 | 42818573 | 42818680 | 42818580 | 42818581 | Frame_Shift_Ins | - | C | p.A68fs |
| KIRC | TCGA-AK-3430-01 | exon_skip_307706 | 42821861 | 42822033 | 42821885 | 42821886 | Frame_Shift_Ins | - | AC | p.Y309fs |
| ESCA | TCGA-JY-A6FH-01 | exon_skip_307706 | 42821861 | 42822033 | 42821921 | 42821921 | Nonsense_Mutation | G | T | p.G321* |
| ESCA | TCGA-JY-A6FH-01 | exon_skip_307706 | 42821861 | 42822033 | 42821921 | 42821921 | Nonsense_Mutation | G | T | p.G321X |
| LUAD | TCGA-44-5644-01 | exon_skip_307706 | 42821861 | 42822033 | 42821921 | 42821921 | Nonsense_Mutation | G | T | p.G345* |
| CESC | TCGA-Q1-A73O-01 | exon_skip_307706 | 42821861 | 42822033 | 42821970 | 42821970 | Nonsense_Mutation | C | G | p.S337* |
| UCEC | TCGA-AX-A0J1-01 | exon_skip_307706 | 42821861 | 42822033 | 42821975 | 42821975 | Nonsense_Mutation | C | T | p.R339* |
| THCA | TCGA-EL-A4KD-01 | exon_skip_307706 | 42821861 | 42822033 | 42821993 | 42821993 | Nonsense_Mutation | C | T | p.Q345X |
| THCA | TCGA-EL-A4KD-01 | exon_skip_307706 | 42821861 | 42822033 | 42821993 | 42821993 | Nonsense_Mutation | C | T | p.Q369* |
| ESCA | TCGA-Z6-A8JD-01 | exon_skip_307700 | 42818573 | 42818680 | 42818572 | 42818572 | Splice_Site | G | T | e3-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-44-5644-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_307706 | |
| Skipped exon start: 42821861 | |
| Skipped exon end: 42822033 | |
| Mutation start: 42821921 | |
| Mutation end: 42821921 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.G345* | |
exon_skip_307706_LUAD_TCGA-44-5644-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IGROV1_OVARY | 42818573 | 42818680 | 42818612 | 42818612 | Missense_Mutation | T | C | p.C69R |
| IGROV1_OVARY | 42818603 | 42818680 | 42818612 | 42818612 | Missense_Mutation | T | C | p.C69R |
| SLVL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42818573 | 42818680 | 42818642 | 42818642 | Missense_Mutation | C | A | p.P79T |
| SLVL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42818603 | 42818680 | 42818642 | 42818642 | Missense_Mutation | C | A | p.P79T |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 42821861 | 42822033 | 42821889 | 42821889 | Missense_Mutation | C | T | p.T310M |
| C32_SKIN | 42821861 | 42822033 | 42821913 | 42821913 | Missense_Mutation | G | A | p.G318E |
| TT2609C02_THYROID | 42821861 | 42822033 | 42821934 | 42821934 | Missense_Mutation | C | T | p.A325V |
| LN382_CENTRAL_NERVOUS_SYSTEM | 42821861 | 42822033 | 42822008 | 42822008 | Missense_Mutation | C | T | p.P350S |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM145 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TMEM145 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TMEM145 |
Top |
RelatedDrugs for TMEM145 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TMEM145 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|