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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TSSK4 |
 Gene summary |
| Gene information | Gene symbol | TSSK4 | Gene ID | 283629 |
| Gene name | testis specific serine kinase 4 | |
| Synonyms | C14orf20|STK22E|TSK-4|TSK4|TSSK5 | |
| Cytomap | 14q12 | |
| Type of gene | protein-coding | |
| Description | testis-specific serine/threonine-protein kinase 4serine/threonine kinase 22Eserine/threonine-protein kinase 22E | |
| Modification date | 20180523 | |
| UniProtAcc | Q6SA08 | |
| Context | PubMed: TSSK4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TSSK4 | GO:0006468 | protein phosphorylation | 15964553 |
| TSSK4 | GO:0032793 | positive regulation of CREB transcription factor activity | 15964553 |
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Exon skipping events across known transcript of Ensembl for TSSK4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TSSK4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TSSK4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_105721 | 14 | 24675714:24675929:24676351:24676715:24677169:24677454 | 24676351:24676715 | ENSG00000139908.10 | ENST00000287913.6,ENST00000556621.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TSSK4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_105721 | 14 | 24675714:24675929:24676351:24676715:24677169:24677454 | 24676351:24676715 | ENSG00000139908.10 | ENST00000556621.1,ENST00000287913.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TSSK4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TSSK4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TSSK4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_105721 | 24676352 | 24676715 | 24676482 | 24676482 | Frame_Shift_Del | T | - | p.F201fs |
| COAD | TCGA-CM-6162-01 | exon_skip_105721 | 24676352 | 24676715 | 24676644 | 24676644 | Frame_Shift_Del | A | - | p.L244fs |
| LUAD | TCGA-05-4249-01 | exon_skip_105721 | 24676352 | 24676715 | 24676508 | 24676508 | Nonsense_Mutation | T | A | p.C199* |
| LUAD | TCGA-05-4249-01 | exon_skip_105721 | 24676352 | 24676715 | 24676508 | 24676508 | Nonsense_Mutation | T | A | p.C209* |
| STAD | TCGA-BR-8487-01 | exon_skip_105721 | 24676352 | 24676715 | 24676542 | 24676542 | Nonsense_Mutation | C | T | p.R211* |
| STAD | TCGA-BR-8487-01 | exon_skip_105721 | 24676352 | 24676715 | 24676542 | 24676542 | Nonsense_Mutation | C | T | p.R221X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH2085_LUNG | 24676352 | 24676715 | 24676368 | 24676368 | Missense_Mutation | A | C | p.N153H |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24676352 | 24676715 | 24676386 | 24676386 | Missense_Mutation | T | C | p.W159R |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 24676352 | 24676715 | 24676590 | 24676590 | Missense_Mutation | G | A | p.V227I |
| MM415_SKIN | 24676352 | 24676715 | 24676684 | 24676684 | Missense_Mutation | C | T | p.P258L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSSK4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSSK4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSSK4 |
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RelatedDrugs for TSSK4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSSK4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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