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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK32C |
 Gene summary |
| Gene information | Gene symbol | STK32C | Gene ID | 282974 |
| Gene name | serine/threonine kinase 32C | |
| Synonyms | PKE|YANK3 | |
| Cytomap | 10q26.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 32CPKE protein kinasetesticular tissue protein Li 187yet another novel kinase 3 | |
| Modification date | 20180523 | |
| UniProtAcc | Q86UX6 | |
| Context | PubMed: STK32C [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for STK32C from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK32C |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK32C |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_54971 | 10 | 134022537:134022605:134022798:134022868:134036144:134036272 | 134022798:134022868 | ENSG00000165752.12 | ENST00000462160.1 |
| exon_skip_54972 | 10 | 134036144:134036276:134036364:134036490:134037910:134038027 | 134036364:134036490 | ENSG00000165752.12 | ENST00000368622.1,ENST00000462160.1,ENST00000298630.3,ENST00000368625.4 |
| exon_skip_54973 | 10 | 134037910:134038027:134038736:134038840:134039030:134039120 | 134038736:134038840 | ENSG00000165752.12 | ENST00000368622.1,ENST00000462160.1,ENST00000298630.3,ENST00000368625.4 |
| exon_skip_54976 | 10 | 134041480:134041632:134059403:134059459:134121075:134121444 | 134059403:134059459 | ENSG00000165752.12 | ENST00000298630.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK32C |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_54971 | 10 | 134022537:134022605:134022798:134022868:134036144:134036272 | 134022798:134022868 | ENSG00000165752.12 | ENST00000462160.1 |
| exon_skip_54972 | 10 | 134036144:134036276:134036364:134036490:134037910:134038027 | 134036364:134036490 | ENSG00000165752.12 | ENST00000462160.1,ENST00000368622.1,ENST00000298630.3,ENST00000368625.4 |
| exon_skip_54973 | 10 | 134037910:134038027:134038736:134038840:134039030:134039120 | 134038736:134038840 | ENSG00000165752.12 | ENST00000462160.1,ENST00000368622.1,ENST00000298630.3,ENST00000368625.4 |
| exon_skip_54976 | 10 | 134041480:134041632:134059403:134059459:134121075:134121444 | 134059403:134059459 | ENSG00000165752.12 | ENST00000298630.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK32C |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for STK32C |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for STK32C |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_54973 | 134038737 | 134038840 | 134038758 | 134038758 | Frame_Shift_Del | G | - | p.A168fs |
| UCEC | TCGA-D1-A17M-01 | exon_skip_54973 | 134038737 | 134038840 | 134038818 | 134038819 | Frame_Shift_Del | AA | - | p.F278fs |
| HNSC | TCGA-CV-A6K1-01 | exon_skip_54973 | 134038737 | 134038840 | 134038745 | 134038745 | Nonsense_Mutation | G | A | p.R173* |
| SARC | TCGA-KF-A41W-01 | exon_skip_54976 | 134059404 | 134059459 | 134059421 | 134059421 | Nonsense_Mutation | T | A | p.K114* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HOP92_LUNG | 134038737 | 134038840 | 134038757 | 134038757 | Missense_Mutation | A | T | p.Y169N |
| KOSC2_UPPER_AERODIGESTIVE_TRACT | 134038737 | 134038840 | 134038765 | 134038765 | Missense_Mutation | A | C | p.V166G |
| EN_ENDOMETRIUM | 134059404 | 134059459 | 134059436 | 134059436 | Missense_Mutation | G | T | p.L109I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK32C |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK32C |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK32C |
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RelatedDrugs for STK32C |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK32C |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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