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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK36 |
 Gene summary |
| Gene information | Gene symbol | STK36 | Gene ID | 27148 |
| Gene name | serine/threonine kinase 36 | |
| Synonyms | FU | |
| Cytomap | 2q35 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 36fused homologtesticular tissue protein Li 188 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9NRP7 | |
| Context | PubMed: STK36 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK36 | GO:0051090 | regulation of DNA binding transcription factor activity | 10806483 |
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Exon skipping events across known transcript of Ensembl for STK36 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK36 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK36 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_333769 | 2 | 219536793:219536938:219537463:219537636:219538347:219538488 | 219537463:219537636 | ENSG00000163482.7 | ENST00000392105.3,ENST00000392106.2 |
| exon_skip_333773 | 2 | 219540751:219541001:219543890:219543984:219544282:219544340 | 219543890:219543984 | ENSG00000163482.7 | ENST00000392105.3,ENST00000295709.3,ENST00000440309.1,ENST00000392106.2,ENST00000424080.1 |
| exon_skip_333784 | 2 | 219549807:219549951:219553113:219553216:219553419:219553504 | 219553113:219553216 | ENSG00000163482.7 | ENST00000414413.1,ENST00000422778.1 |
| exon_skip_333786 | 2 | 219558445:219558544:219558617:219558706:219558986:219559001 | 219558617:219558706 | ENSG00000163482.7 | ENST00000486644.1,ENST00000392105.3,ENST00000492486.1,ENST00000295709.3,ENST00000440309.1,ENST00000392106.2 |
| exon_skip_333787 | 2 | 219558986:219559050:219559247:219559358:219561249:219561324 | 219559247:219559358 | ENSG00000163482.7 | ENST00000295709.3,ENST00000440309.1 |
| exon_skip_333788 | 2 | 219558986:219559050:219559247:219559358:219561312:219561324 | 219559247:219559358 | ENSG00000163482.7 | ENST00000486644.1,ENST00000392105.3 |
| exon_skip_333789 | 2 | 219561761:219561936:219562185:219562333:219562576:219562724 | 219562185:219562333 | ENSG00000163482.7 | ENST00000462031.1,ENST00000392105.3,ENST00000295709.3,ENST00000440309.1,ENST00000392106.2 |
| exon_skip_333796 | 2 | 219562185:219562333:219562576:219562724:219563324:219563424 | 219562576:219562724 | ENSG00000163482.7 | ENST00000462031.1,ENST00000392105.3,ENST00000295709.3,ENST00000440309.1,ENST00000392106.2 |
| exon_skip_333799 | 2 | 219562185:219562333:219562625:219562724:219563324:219563424 | 219562625:219562724 | ENSG00000163482.7 | ENST00000419433.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK36 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_333769 | 2 | 219536793:219536938:219537463:219537636:219538347:219538488 | 219537463:219537636 | ENSG00000163482.7 | ENST00000392106.2,ENST00000392105.3 |
| exon_skip_333773 | 2 | 219540751:219541001:219543890:219543984:219544282:219544340 | 219543890:219543984 | ENSG00000163482.7 | ENST00000295709.3,ENST00000392106.2,ENST00000392105.3,ENST00000440309.1,ENST00000424080.1 |
| exon_skip_333784 | 2 | 219549807:219549951:219553113:219553216:219553419:219553504 | 219553113:219553216 | ENSG00000163482.7 | ENST00000414413.1,ENST00000422778.1 |
| exon_skip_333786 | 2 | 219558445:219558544:219558617:219558706:219558986:219559001 | 219558617:219558706 | ENSG00000163482.7 | ENST00000295709.3,ENST00000392106.2,ENST00000392105.3,ENST00000440309.1,ENST00000492486.1,ENST00000486644.1 |
| exon_skip_333787 | 2 | 219558986:219559050:219559247:219559358:219561249:219561324 | 219559247:219559358 | ENSG00000163482.7 | ENST00000295709.3,ENST00000440309.1 |
| exon_skip_333788 | 2 | 219558986:219559050:219559247:219559358:219561312:219561324 | 219559247:219559358 | ENSG00000163482.7 | ENST00000392105.3,ENST00000486644.1 |
| exon_skip_333789 | 2 | 219561761:219561936:219562185:219562333:219562576:219562724 | 219562185:219562333 | ENSG00000163482.7 | ENST00000295709.3,ENST00000392106.2,ENST00000392105.3,ENST00000440309.1,ENST00000462031.1 |
| exon_skip_333796 | 2 | 219562185:219562333:219562576:219562724:219563324:219563424 | 219562576:219562724 | ENSG00000163482.7 | ENST00000295709.3,ENST00000392106.2,ENST00000392105.3,ENST00000440309.1,ENST00000462031.1 |
| exon_skip_333799 | 2 | 219562185:219562333:219562625:219562724:219563324:219563424 | 219562625:219562724 | ENSG00000163482.7 | ENST00000419433.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK36 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000295709 | 219543890 | 219543984 | Frame-shift |
| ENST00000440309 | 219543890 | 219543984 | Frame-shift |
| ENST00000295709 | 219558617 | 219558706 | Frame-shift |
| ENST00000440309 | 219558617 | 219558706 | Frame-shift |
| ENST00000295709 | 219562185 | 219562333 | Frame-shift |
| ENST00000440309 | 219562185 | 219562333 | Frame-shift |
| ENST00000295709 | 219562576 | 219562724 | Frame-shift |
| ENST00000440309 | 219562576 | 219562724 | Frame-shift |
| ENST00000295709 | 219559247 | 219559358 | In-frame |
| ENST00000440309 | 219559247 | 219559358 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000295709 | 219543890 | 219543984 | Frame-shift |
| ENST00000440309 | 219543890 | 219543984 | Frame-shift |
| ENST00000295709 | 219558617 | 219558706 | Frame-shift |
| ENST00000440309 | 219558617 | 219558706 | Frame-shift |
| ENST00000295709 | 219562185 | 219562333 | Frame-shift |
| ENST00000440309 | 219562185 | 219562333 | Frame-shift |
| ENST00000295709 | 219562576 | 219562724 | Frame-shift |
| ENST00000440309 | 219562576 | 219562724 | Frame-shift |
| ENST00000295709 | 219559247 | 219559358 | In-frame |
| ENST00000440309 | 219559247 | 219559358 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK36 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295709 | 4950 | 1315 | 219559247 | 219559358 | 2680 | 2790 | 800 | 837 |
| ENST00000440309 | 4738 | 1315 | 219559247 | 219559358 | 2560 | 2670 | 800 | 837 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295709 | 4950 | 1315 | 219559247 | 219559358 | 2680 | 2790 | 800 | 837 |
| ENST00000440309 | 4738 | 1315 | 219559247 | 219559358 | 2560 | 2670 | 800 | 837 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NRP7 | 800 | 837 | 1 | 1315 | Chain | ID=PRO_0000229020;Note=Serine/threonine-protein kinase 36 |
| Q9NRP7 | 800 | 837 | 1 | 1315 | Chain | ID=PRO_0000229020;Note=Serine/threonine-protein kinase 36 |
| Q9NRP7 | 800 | 837 | 816 | 816 | Natural variant | ID=VAR_041188;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34271431,PMID:17344846 |
| Q9NRP7 | 800 | 837 | 816 | 816 | Natural variant | ID=VAR_041188;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34271431,PMID:17344846 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NRP7 | 800 | 837 | 1 | 1315 | Chain | ID=PRO_0000229020;Note=Serine/threonine-protein kinase 36 |
| Q9NRP7 | 800 | 837 | 1 | 1315 | Chain | ID=PRO_0000229020;Note=Serine/threonine-protein kinase 36 |
| Q9NRP7 | 800 | 837 | 816 | 816 | Natural variant | ID=VAR_041188;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34271431,PMID:17344846 |
| Q9NRP7 | 800 | 837 | 816 | 816 | Natural variant | ID=VAR_041188;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34271431,PMID:17344846 |
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SNVs in the skipped exons for STK36 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_333786 | 219558618 | 219558706 | 219558632 | 219558632 | Frame_Shift_Del | T | - | p.D754fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_333796 | 219562577 | 219562724 | 219562593 | 219562593 | Frame_Shift_Del | T | - | p.F976fs |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_333787 exon_skip_333788 | 219559248 | 219559358 | 219559356 | 219559356 | Nonsense_Mutation | G | T | p.E837* |
| HNSC | TCGA-CV-7254-01 | exon_skip_333773 | 219543891 | 219543984 | 219543985 | 219543985 | Splice_Site | G | T | p.I260_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 219543891 | 219543984 | 219543978 | 219543978 | Missense_Mutation | G | A | p.V258I |
| COLO678_LARGE_INTESTINE | 219558618 | 219558706 | 219558691 | 219558691 | Missense_Mutation | A | C | p.Q774P |
| TE9_OESOPHAGUS | 219559248 | 219559358 | 219559258 | 219559258 | Missense_Mutation | C | A | p.A804D |
| TE9_OESOPHAGUS | 219559248 | 219559358 | 219559258 | 219559259 | Missense_Mutation | CC | AA | p.A804E |
| HSC2_UPPER_AERODIGESTIVE_TRACT | 219562186 | 219562333 | 219562252 | 219562252 | Missense_Mutation | G | A | p.C943Y |
| SW684_SOFT_TISSUE | 219562186 | 219562333 | 219562282 | 219562282 | Missense_Mutation | C | T | p.S953F |
| JHH7_LIVER | 219562577 | 219562724 | 219562605 | 219562605 | Missense_Mutation | G | A | p.V980M |
| EW8_BONE | 219562626 | 219562724 | 219562662 | 219562662 | Missense_Mutation | G | T | p.D999Y |
| EW8_BONE | 219562577 | 219562724 | 219562662 | 219562662 | Missense_Mutation | G | T | p.D999Y |
| BICR56_UPPER_AERODIGESTIVE_TRACT | 219562626 | 219562724 | 219562716 | 219562716 | Missense_Mutation | C | G | p.L1017V |
| BICR56_UPPER_AERODIGESTIVE_TRACT | 219562577 | 219562724 | 219562716 | 219562716 | Missense_Mutation | C | G | p.L1017V |
| CW2_LARGE_INTESTINE | 219562186 | 219562333 | 219562253 | 219562253 | Nonsense_Mutation | C | A | p.C943* |
| COV504_OVARY | 219558618 | 219558706 | 219558706 | 219558706 | Splice_Site | G | C | p.G779A |
| INA6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 219559248 | 219559358 | 219559248 | 219559248 | Splice_Site | A | T | p.S801C |
| SW480_LARGE_INTESTINE | 219559248 | 219559358 | 219559249 | 219559249 | Splice_Site | G | A | p.S801N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK36 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK36 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK36 |
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RelatedDrugs for STK36 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9NRP7 | DB12010 | Fostamatinib | Serine/threonine-protein kinase 36 | small molecule | approved|investigational |
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RelatedDiseases for STK36 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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