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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for CIDEB |
Gene summary |
Gene information | Gene symbol | CIDEB | Gene ID | 27141 |
Gene name | cell death-inducing DFFA-like effector b | |
Synonyms | - | |
Cytomap | 14q12 | |
Type of gene | protein-coding | |
Description | cell death activator CIDE-B | |
Modification date | 20180523 | |
UniProtAcc | Q9UHD4 | |
Context | PubMed: CIDEB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CIDEB | GO:0006915 | apoptotic process | 12429024 |
CIDEB | GO:0010942 | positive regulation of cell death | 12595532 |
CIDEB | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 12595532 |
CIDEB | GO:0097202 | activation of cysteine-type endopeptidase activity | 12595532 |
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Exon skipping events across known transcript of Ensembl for CIDEB from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CIDEB |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CIDEB |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_112080 | 14 | 24774811:24774971:24775152:24775343:24775579:24775667 | 24775152:24775343 | ENSG00000136305.7 | ENST00000554411.1,ENST00000258807.5,ENST00000336557.5 |
exon_skip_112082 | 14 | 24776576:24776721:24777023:24777126:24777684:24777944 | 24777023:24777126 | ENSG00000136305.7 | ENST00000258807.5,ENST00000336557.5 |
exon_skip_112094 | 14 | 24777023:24777126:24777684:24778036:24779854:24779924 | 24777684:24778036 | ENSG00000136305.7 | ENST00000258807.5 |
exon_skip_112098 | 14 | 24777684:24778036:24779612:24779754:24779854:24779924 | 24779612:24779754 | ENSG00000136305.7 | ENST00000336557.5 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CIDEB |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_112080 | 14 | 24774811:24774971:24775152:24775343:24775579:24775667 | 24775152:24775343 | ENSG00000136305.7 | ENST00000554411.1,ENST00000336557.5,ENST00000258807.5 |
exon_skip_112082 | 14 | 24776576:24776721:24777023:24777126:24777684:24777944 | 24777023:24777126 | ENSG00000136305.7 | ENST00000336557.5,ENST00000258807.5 |
exon_skip_112094 | 14 | 24777023:24777126:24777684:24778036:24779854:24779924 | 24777684:24778036 | ENSG00000136305.7 | ENST00000258807.5 |
exon_skip_112098 | 14 | 24777684:24778036:24779612:24779754:24779854:24779924 | 24779612:24779754 | ENSG00000136305.7 | ENST00000336557.5 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CIDEB |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CIDEB |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CIDEB |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
CESC | TCGA-EA-A3QD-01 | exon_skip_112080 | 24775153 | 24775343 | 24775181 | 24775181 | Nonsense_Mutation | G | A | p.Q167* |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
NCIH211_LUNG | 24777024 | 24777126 | 24777030 | 24777030 | Nonsense_Mutation | A | T | p.L12* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CIDEB |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CIDEB |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CIDEB |
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RelatedDrugs for CIDEB |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CIDEB |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |