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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for LRP10 |
 Gene summary |
| Gene information | Gene symbol | LRP10 | Gene ID | 26020 |
| Gene name | LDL receptor related protein 10 | |
| Synonyms | LRP-10|LRP9|MST087|MSTP087 | |
| Cytomap | 14q11.2 | |
| Type of gene | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 10 | |
| Modification date | 20180519 | |
| UniProtAcc | Q7Z4F1 | |
| Context | PubMed: LRP10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for LRP10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for LRP10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for LRP10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_105210 | 14 | 23341512:23341546:23341946:23341991:23342519:23342655 | 23341946:23341991 | ENSG00000197324.4 | ENST00000546834.1 |
| exon_skip_105212 | 14 | 23341946:23341991:23342519:23342655:23344263:23344454 | 23342519:23342655 | ENSG00000197324.4 | ENST00000546834.1,ENST00000359591.4 |
| exon_skip_105214 | 14 | 23342519:23342655:23344263:23344454:23344563:23344674 | 23344263:23344454 | ENSG00000197324.4 | ENST00000553002.1,ENST00000546834.1,ENST00000359591.4 |
| exon_skip_105230 | 14 | 23344344:23344454:23344563:23345581:23345897:23346027 | 23344563:23345581 | ENSG00000197324.4 | ENST00000551466.1,ENST00000546834.1,ENST00000359591.4 |
| exon_skip_105249 | 14 | 23345477:23345581:23345897:23346027:23346148:23346262 | 23345897:23346027 | ENSG00000197324.4 | ENST00000551466.1,ENST00000546834.1,ENST00000359591.4 |
| exon_skip_105254 | 14 | 23346184:23346262:23346635:23346805:23347192:23347252 | 23346635:23346805 | ENSG00000197324.4 | ENST00000470660.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for LRP10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_105210 | 14 | 23341512:23341546:23341946:23341991:23342519:23342655 | 23341946:23341991 | ENSG00000197324.4 | ENST00000546834.1 |
| exon_skip_105212 | 14 | 23341946:23341991:23342519:23342655:23344263:23344454 | 23342519:23342655 | ENSG00000197324.4 | ENST00000359591.4,ENST00000546834.1 |
| exon_skip_105214 | 14 | 23342519:23342655:23344263:23344454:23344563:23344674 | 23344263:23344454 | ENSG00000197324.4 | ENST00000359591.4,ENST00000546834.1,ENST00000553002.1 |
| exon_skip_105230 | 14 | 23344344:23344454:23344563:23345581:23345897:23346027 | 23344563:23345581 | ENSG00000197324.4 | ENST00000359591.4,ENST00000546834.1,ENST00000551466.1 |
| exon_skip_105249 | 14 | 23345477:23345581:23345897:23346027:23346148:23346262 | 23345897:23346027 | ENSG00000197324.4 | ENST00000359591.4,ENST00000546834.1,ENST00000551466.1 |
| exon_skip_105254 | 14 | 23346184:23346262:23346635:23346805:23347192:23347252 | 23346635:23346805 | ENSG00000197324.4 | ENST00000470660.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for LRP10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359591 | 23342519 | 23342655 | Frame-shift |
| ENST00000359591 | 23344263 | 23344454 | Frame-shift |
| ENST00000359591 | 23344563 | 23345581 | Frame-shift |
| ENST00000359591 | 23345897 | 23346027 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359591 | 23342519 | 23342655 | Frame-shift |
| ENST00000359591 | 23344263 | 23344454 | Frame-shift |
| ENST00000359591 | 23344563 | 23345581 | Frame-shift |
| ENST00000359591 | 23345897 | 23346027 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for LRP10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for LRP10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
LRP10_LIHC_exon_skip_105230_psi_boxplot.png |
LRP10_LUAD_exon_skip_105230_psi_boxplot.png |
LRP10_THCA_exon_skip_105230_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_105212 | 23342520 | 23342655 | 23342530 | 23342530 | Frame_Shift_Del | C | - | p.D30fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_105212 | 23342520 | 23342655 | 23342530 | 23342530 | Frame_Shift_Del | C | - | p.D30fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_105214 | 23344264 | 23344454 | 23344373 | 23344373 | Frame_Shift_Del | G | - | p.G110fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_105230 | 23344564 | 23345581 | 23344805 | 23344805 | Frame_Shift_Del | C | - | p.H216fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_105230 | 23344564 | 23345581 | 23344869 | 23344870 | Frame_Shift_Ins | - | C | p.P238fs |
| HNSC | TCGA-CV-A6JU-01 | exon_skip_105249 | 23345898 | 23346027 | 23345929 | 23345930 | Frame_Shift_Ins | - | A | p.D486fs |
| THCA | TCGA-EL-A3ZR-01 | exon_skip_105230 | 23344564 | 23345581 | 23345001 | 23345001 | Nonsense_Mutation | C | T | p.Q282* |
| THCA | TCGA-EL-A3ZR-01 | exon_skip_105230 | 23344564 | 23345581 | 23345001 | 23345001 | Nonsense_Mutation | C | T | p.Q282X |
| LUAD | TCGA-55-8096-01 | exon_skip_105230 | 23344564 | 23345581 | 23345405 | 23345405 | Nonsense_Mutation | G | A | p.W416* |
| LUSC | TCGA-51-4081-01 | exon_skip_105212 | 23342520 | 23342655 | 23342656 | 23342656 | Splice_Site | G | T | p.R72_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-55-8096-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_105230 | |
| Skipped exon start: 23344564 | |
| Skipped exon end: 23345581 | |
| Mutation start: 23345405 | |
| Mutation end: 23345405 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.W416* | |
exon_skip_105230_LUAD_TCGA-55-8096-01.png | |
exon_skip_286364_LUAD_TCGA-55-8096-01.png | |
 | Sample: TCGA-EL-A3ZR-01 |
| Cancer type: THCA | |
| ESID: exon_skip_105230 | |
| Skipped exon start: 23344564 | |
| Skipped exon end: 23345581 | |
| Mutation start: 23345001 | |
| Mutation end: 23345001 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.Q282X | |
| Sample: TCGA-EL-A3ZR-01 |
| Cancer type: THCA | |
| ESID: exon_skip_105230 | |
| Skipped exon start: 23344564 | |
| Skipped exon end: 23345581 | |
| Mutation start: 23345001 | |
| Mutation end: 23345001 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.Q282* | |
exon_skip_105230_THCA_TCGA-EL-A3ZR-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23342520 | 23342655 | 23342530 | 23342530 | Frame_Shift_Del | C | - | p.D30fs |
| RH18_SOFT_TISSUE | 23344564 | 23345581 | 23345154 | 23345155 | Frame_Shift_Del | AG | - | p.S333fs |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23345898 | 23346027 | 23345906 | 23345906 | Frame_Shift_Del | C | - | p.A478fs |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23344564 | 23345581 | 23344689 | 23344690 | Frame_Shift_Ins | - | CCTT | p.-179fs |
| NCIBL2009_MATCHED_NORMAL_TISSUE | 23341947 | 23341991 | 23341956 | 23341956 | Missense_Mutation | T | C | p.L15P |
| UBLC1_URINARY_TRACT | 23341947 | 23341991 | 23341989 | 23341989 | Missense_Mutation | A | G | p.H26R |
| KURAMOCHI_OVARY | 23342520 | 23342655 | 23342597 | 23342597 | Missense_Mutation | T | A | p.S53T |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23342520 | 23342655 | 23342618 | 23342618 | Missense_Mutation | C | A | p.L60I |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23342520 | 23342655 | 23342618 | 23342618 | Missense_Mutation | C | A | p.L60I |
| UMUC1_URINARY_TRACT | 23344264 | 23344454 | 23344307 | 23344307 | Missense_Mutation | C | G | p.L87V |
| CAL54_KIDNEY | 23344264 | 23344454 | 23344310 | 23344310 | Missense_Mutation | C | T | p.R88C |
| NCIH1385_LUNG | 23344264 | 23344454 | 23344365 | 23344365 | Missense_Mutation | A | T | p.Q106L |
| GSS_STOMACH | 23344264 | 23344454 | 23344380 | 23344380 | Missense_Mutation | A | G | p.N111S |
| NCIH1915_LUNG | 23344564 | 23345581 | 23344608 | 23344608 | Missense_Mutation | C | T | p.R151C |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23344564 | 23345581 | 23344611 | 23344611 | Missense_Mutation | T | C | p.C152R |
| SW48_LARGE_INTESTINE | 23344564 | 23345581 | 23344638 | 23344638 | Missense_Mutation | G | A | p.G161R |
| MM426_SKIN | 23344564 | 23345581 | 23344660 | 23344660 | Missense_Mutation | G | A | p.G168D |
| SNUC4_LARGE_INTESTINE | 23344564 | 23345581 | 23344716 | 23344716 | Missense_Mutation | G | A | p.V187I |
| MEWO_SKIN | 23344564 | 23345581 | 23344720 | 23344720 | Missense_Mutation | C | T | p.P188L |
| HKA1_SKIN | 23344564 | 23345581 | 23344801 | 23344801 | Missense_Mutation | C | T | p.S215F |
| KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23344564 | 23345581 | 23344849 | 23344849 | Missense_Mutation | G | A | p.R231Q |
| RERFLCAD2_LUNG | 23344564 | 23345581 | 23344945 | 23344945 | Missense_Mutation | G | T | p.R263L |
| WM88_SKIN | 23344564 | 23345581 | 23345043 | 23345043 | Missense_Mutation | C | T | p.R296C |
| HEC6_ENDOMETRIUM | 23344564 | 23345581 | 23345092 | 23345092 | Missense_Mutation | A | G | p.D312G |
| HEC265_ENDOMETRIUM | 23344564 | 23345581 | 23345290 | 23345290 | Missense_Mutation | C | T | p.A378V |
| HS742T_FIBROBLAST | 23344564 | 23345581 | 23345371 | 23345371 | Missense_Mutation | G | A | p.R405Q |
| DOV13_OVARY | 23344564 | 23345581 | 23345424 | 23345424 | Missense_Mutation | G | T | p.D423Y |
| 2313287_STOMACH | 23344564 | 23345581 | 23345472 | 23345472 | Missense_Mutation | C | T | p.R439C |
| CW2_LARGE_INTESTINE | 23344564 | 23345581 | 23345476 | 23345476 | Missense_Mutation | A | G | p.K440R |
| COLO741_SKIN | 23344564 | 23345581 | 23345493 | 23345493 | Missense_Mutation | G | C | p.V446L |
| HEC151_ENDOMETRIUM | 23345898 | 23346027 | 23345918 | 23345918 | Missense_Mutation | G | A | p.R482Q |
| MUTZ5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23345898 | 23346027 | 23345918 | 23345918 | Missense_Mutation | G | A | p.R482Q |
| DOV13_OVARY | 23345898 | 23346027 | 23345920 | 23345920 | Missense_Mutation | A | C | p.M483L |
| C4I_CERVIX | 23345898 | 23346027 | 23345963 | 23345963 | Missense_Mutation | G | A | p.G497E |
| NB14_AUTONOMIC_GANGLIA | 23345898 | 23346027 | 23346019 | 23346019 | Missense_Mutation | C | A | p.P516T |
| HEC59_ENDOMETRIUM | 23346636 | 23346805 | 23346711 | 23346711 | Missense_Mutation | C | T | p.A706V |
| M14_SKIN | 23344564 | 23345581 | 23344626 | 23344626 | Nonsense_Mutation | C | T | p.Q157* |
| MDAMB435S_SKIN | 23344564 | 23345581 | 23344626 | 23344626 | Nonsense_Mutation | C | T | p.Q157* |
| SNUC4_LARGE_INTESTINE | 23342520 | 23342655 | 23342521 | 23342521 | Splice_Site | T | G | p.A27A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LRP10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LRP10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LRP10 |
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RelatedDrugs for LRP10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRP10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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