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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF620 |
 Gene summary |
| Gene information | Gene symbol | ZNF620 | Gene ID | 253639 |
| Gene name | zinc finger protein 620 | |
| Synonyms | - | |
| Cytomap | 3p22.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 620 | |
| Modification date | 20180523 | |
| UniProtAcc | Q6ZNG0 | |
| Context | PubMed: ZNF620 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF620 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF620 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF620 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_373202 | 3 | 40547794:40547867:40550146:40550265:40552960:40553087 | 40550146:40550265 | ENSG00000177842.7 | ENST00000433723.2 |
| exon_skip_373204 | 3 | 40547794:40547867:40552960:40553087:40553892:40553963 | 40552960:40553087 | ENSG00000177842.7 | ENST00000314529.6,ENST00000420891.1 |
| exon_skip_373211 | 3 | 40552960:40553087:40553892:40554006:40557350:40557435 | 40553892:40554006 | ENSG00000177842.7 | ENST00000314529.6,ENST00000420891.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF620 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_373202 | 3 | 40547794:40547867:40550146:40550265:40552960:40553087 | 40550146:40550265 | ENSG00000177842.7 | ENST00000433723.2 |
| exon_skip_373204 | 3 | 40547794:40547867:40552960:40553087:40553892:40553963 | 40552960:40553087 | ENSG00000177842.7 | ENST00000420891.1,ENST00000314529.6 |
| exon_skip_373211 | 3 | 40552960:40553087:40553892:40554006:40557350:40557435 | 40553892:40554006 | ENSG00000177842.7 | ENST00000420891.1,ENST00000314529.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF620 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314529 | 40552960 | 40553087 | Frame-shift |
| ENST00000314529 | 40553892 | 40554006 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314529 | 40552960 | 40553087 | Frame-shift |
| ENST00000314529 | 40553892 | 40554006 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF620 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314529 | 3308 | 422 | 40553892 | 40554006 | 301 | 414 | 50 | 88 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314529 | 3308 | 422 | 40553892 | 40554006 | 301 | 414 | 50 | 88 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6ZNG0 | 50 | 88 | 1 | 114 | Alternative sequence | ID=VSP_016040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6ZNG0 | 50 | 88 | 1 | 422 | Chain | ID=PRO_0000047691;Note=Zinc finger protein 620 |
| Q6ZNG0 | 50 | 88 | 11 | 82 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6ZNG0 | 50 | 88 | 1 | 114 | Alternative sequence | ID=VSP_016040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6ZNG0 | 50 | 88 | 1 | 422 | Chain | ID=PRO_0000047691;Note=Zinc finger protein 620 |
| Q6ZNG0 | 50 | 88 | 11 | 82 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
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SNVs in the skipped exons for ZNF620 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AY-6197-01 | exon_skip_373211 | 40553893 | 40554006 | 40553936 | 40553937 | Frame_Shift_Ins | - | G | p.Q65fs |
| BRCA | TCGA-AO-A12E-01 | exon_skip_373211 | 40553893 | 40554006 | 40554007 | 40554007 | Splice_Site | G | T | e3+1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| GP2D_LARGE_INTESTINE | 40552961 | 40553087 | 40553040 | 40553040 | Missense_Mutation | T | C | p.L35P |
| GP5D_LARGE_INTESTINE | 40552961 | 40553087 | 40553040 | 40553040 | Missense_Mutation | T | C | p.L35P |
| KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 40552961 | 40553087 | 40553067 | 40553067 | Missense_Mutation | A | C | p.Y44S |
| SW48_LARGE_INTESTINE | 40552961 | 40553087 | 40553075 | 40553075 | Missense_Mutation | G | A | p.V47M |
| C33A_CERVIX | 40553893 | 40554006 | 40553899 | 40553899 | Missense_Mutation | C | T | p.P53L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF620 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF620 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF620 |
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RelatedDrugs for ZNF620 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF620 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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