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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ALOX15B |
 Gene summary |
| Gene information | Gene symbol | ALOX15B | Gene ID | 247 |
| Gene name | arachidonate 15-lipoxygenase, type B | |
| Synonyms | 15-LOX-2 | |
| Cytomap | 17p13.1 | |
| Type of gene | protein-coding | |
| Description | arachidonate 15-lipoxygenase B15-LOX-B15S-lipoxygenasearachidonate 15-lipoxygenase 2arachidonate 15-lipoxygenase type IIarachidonate 15-lipoxygenase, second typearachidonate omega(6) lipoxygenaselinoleate 13-lipoxygenase 15-LOb | |
| Modification date | 20180519 | |
| UniProtAcc | O15296 | |
| Context | PubMed: ALOX15B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ALOX15B | GO:0008285 | negative regulation of cell proliferation | 11839751 |
| ALOX15B | GO:0019369 | arachidonic acid metabolic process | 9177185|10542053|10625675|24497644 |
| ALOX15B | GO:0045786 | negative regulation of cell cycle | 11839751 |
| ALOX15B | GO:0045926 | negative regulation of growth | 11839751 |
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Exon skipping events across known transcript of Ensembl for ALOX15B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ALOX15B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ALOX15B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_149007 | 17 | 7946106:7946202:7948146:7948319:7948555:7948702 | 7948146:7948319 | ENSG00000179593.11 | ENST00000572022.1,ENST00000380173.2,ENST00000380183.4,ENST00000573359.1,ENST00000571240.1 |
| exon_skip_149011 | 17 | 7948558:7948702:7948800:7949004:7950224:7950381 | 7948800:7949004 | ENSG00000179593.11 | ENST00000380173.2,ENST00000573359.1 |
| exon_skip_149014 | 17 | 7948805:7949004:7949985:7950072:7950224:7950381 | 7949985:7950072 | ENSG00000179593.11 | ENST00000572022.1,ENST00000380183.4,ENST00000571240.1 |
| exon_skip_149019 | 17 | 7950224:7950394:7950575:7950697:7950881:7950982 | 7950575:7950697 | ENSG00000179593.11 | ENST00000380173.2,ENST00000380183.4,ENST00000571240.1 |
| exon_skip_149021 | 17 | 7950224:7950394:7950611:7950697:7950881:7950982 | 7950611:7950697 | ENSG00000179593.11 | ENST00000572022.1 |
| exon_skip_149028 | 17 | 7950611:7950697:7950881:7950982:7951062:7951233 | 7950881:7950982 | ENSG00000179593.11 | ENST00000572022.1,ENST00000380173.2,ENST00000380183.4,ENST00000571240.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ALOX15B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_149007 | 17 | 7946106:7946202:7948146:7948319:7948555:7948702 | 7948146:7948319 | ENSG00000179593.11 | ENST00000380183.4,ENST00000572022.1,ENST00000380173.2,ENST00000571240.1,ENST00000573359.1 |
| exon_skip_149011 | 17 | 7948558:7948702:7948800:7949004:7950224:7950381 | 7948800:7949004 | ENSG00000179593.11 | ENST00000380173.2,ENST00000573359.1 |
| exon_skip_149014 | 17 | 7948805:7949004:7949985:7950072:7950224:7950381 | 7949985:7950072 | ENSG00000179593.11 | ENST00000380183.4,ENST00000572022.1,ENST00000571240.1 |
| exon_skip_149019 | 17 | 7950224:7950394:7950575:7950697:7950881:7950982 | 7950575:7950697 | ENSG00000179593.11 | ENST00000380183.4,ENST00000380173.2,ENST00000571240.1 |
| exon_skip_149021 | 17 | 7950224:7950394:7950611:7950697:7950881:7950982 | 7950611:7950697 | ENSG00000179593.11 | ENST00000572022.1 |
| exon_skip_149028 | 17 | 7950611:7950697:7950881:7950982:7951062:7951233 | 7950881:7950982 | ENSG00000179593.11 | ENST00000380183.4,ENST00000572022.1,ENST00000380173.2,ENST00000571240.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ALOX15B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380183 | 7948146 | 7948319 | Frame-shift |
| ENST00000380183 | 7950575 | 7950697 | Frame-shift |
| ENST00000380183 | 7950881 | 7950982 | Frame-shift |
| ENST00000380183 | 7949985 | 7950072 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380183 | 7948146 | 7948319 | Frame-shift |
| ENST00000380183 | 7950575 | 7950697 | Frame-shift |
| ENST00000380183 | 7950881 | 7950982 | Frame-shift |
| ENST00000380183 | 7949985 | 7950072 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ALOX15B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380183 | 2756 | 676 | 7949985 | 7950072 | 1340 | 1426 | 400 | 429 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380183 | 2756 | 676 | 7949985 | 7950072 | 1340 | 1426 | 400 | 429 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15296 | 400 | 429 | 401 | 429 | Alternative sequence | ID=VSP_003142;Note=In isoform B and isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11839751;Dbxref=PMID:11839751 |
| O15296 | 400 | 429 | 1 | 676 | Chain | ID=PRO_0000220700;Note=Arachidonate 15-lipoxygenase B |
| O15296 | 400 | 429 | 125 | 676 | Domain | Note=Lipoxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726 |
| O15296 | 400 | 429 | 397 | 402 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| O15296 | 400 | 429 | 403 | 406 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| O15296 | 400 | 429 | 409 | 419 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| O15296 | 400 | 429 | 426 | 430 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15296 | 400 | 429 | 401 | 429 | Alternative sequence | ID=VSP_003142;Note=In isoform B and isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11839751;Dbxref=PMID:11839751 |
| O15296 | 400 | 429 | 1 | 676 | Chain | ID=PRO_0000220700;Note=Arachidonate 15-lipoxygenase B |
| O15296 | 400 | 429 | 125 | 676 | Domain | Note=Lipoxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726 |
| O15296 | 400 | 429 | 397 | 402 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| O15296 | 400 | 429 | 403 | 406 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| O15296 | 400 | 429 | 409 | 419 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
| O15296 | 400 | 429 | 426 | 430 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NRE |
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SNVs in the skipped exons for ALOX15B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ESCA | TCGA-L5-A4OR-01 | exon_skip_149007 | 7948147 | 7948319 | 7948301 | 7948301 | Frame_Shift_Del | C | - | p.L278fs |
| ESCA | TCGA-L5-A4OR-01 | exon_skip_149007 | 7948147 | 7948319 | 7948301 | 7948301 | Frame_Shift_Del | C | - | p.S277fs |
| LIHC | TCGA-CC-5258-01 | exon_skip_149014 | 7949986 | 7950072 | 7950032 | 7950032 | Frame_Shift_Del | C | - | p.A416fs |
| DLBC | TCGA-G8-6909-01 | exon_skip_149014 | 7949986 | 7950072 | 7950009 | 7950009 | Nonsense_Mutation | C | G | p.Y408X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 7948147 | 7948319 | 7948153 | 7948153 | Missense_Mutation | C | T | p.A228V |
| HCC2935_LUNG | 7948147 | 7948319 | 7948185 | 7948185 | Missense_Mutation | G | T | p.A239S |
| HCC15_LUNG | 7948147 | 7948319 | 7948185 | 7948185 | Missense_Mutation | G | A | p.A239T |
| LS513_LARGE_INTESTINE | 7948801 | 7949004 | 7948805 | 7948805 | Missense_Mutation | G | T | p.S334I |
| CORL24_LUNG | 7948801 | 7949004 | 7948823 | 7948823 | Missense_Mutation | A | G | p.N340S |
| EFM192A_BREAST | 7948801 | 7949004 | 7948834 | 7948834 | Missense_Mutation | T | C | p.F344L |
| R262_CENTRAL_NERVOUS_SYSTEM | 7948801 | 7949004 | 7948863 | 7948863 | Missense_Mutation | G | C | p.W353C |
| SARC9371_BONE | 7948801 | 7949004 | 7948894 | 7948894 | Missense_Mutation | G | A | p.E364K |
| HEC108_ENDOMETRIUM | 7948801 | 7949004 | 7948897 | 7948897 | Missense_Mutation | T | C | p.F365L |
| NCIH660_PROSTATE | 7948801 | 7949004 | 7948946 | 7948946 | Missense_Mutation | C | T | p.P381L |
| SNU1040_LARGE_INTESTINE | 7948801 | 7949004 | 7948986 | 7948986 | Missense_Mutation | C | A | p.H394Q |
| TCCSUP_URINARY_TRACT | 7949986 | 7950072 | 7950021 | 7950021 | Missense_Mutation | C | G | p.I412M |
| MFE280_ENDOMETRIUM | 7949986 | 7950072 | 7950053 | 7950053 | Missense_Mutation | C | T | p.P423L |
| SNU1214_UPPER_AERODIGESTIVE_TRACT | 7950612 | 7950697 | 7950661 | 7950661 | Missense_Mutation | A | T | p.I515F |
| SNU1214_UPPER_AERODIGESTIVE_TRACT | 7950576 | 7950697 | 7950661 | 7950661 | Missense_Mutation | A | T | p.I515F |
| MM383_SKIN | 7950882 | 7950982 | 7950935 | 7950935 | Missense_Mutation | G | A | p.V545M |
| SNU1040_LARGE_INTESTINE | 7950882 | 7950982 | 7950968 | 7950968 | Missense_Mutation | G | A | p.V556I |
| COLO684_ENDOMETRIUM | 7949986 | 7950072 | 7950004 | 7950004 | Nonsense_Mutation | C | T | p.R407* |
| KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 7948147 | 7948319 | 7948147 | 7948147 | Splice_Site | A | G | p.E226G |
| TGW_AUTONOMIC_GANGLIA | 7948147 | 7948319 | 7948147 | 7948147 | Splice_Site | A | G | p.E226G |
| JHUEM7_ENDOMETRIUM | 7948147 | 7948319 | 7948319 | 7948319 | Splice_Site | G | A | p.E283E |
| 639V_URINARY_TRACT | 7948147 | 7948319 | 7948319 | 7948319 | Splice_Site | G | T | p.E283D |
| NCIH661_LUNG | 7950882 | 7950982 | 7950882 | 7950882 | Splice_Site | G | C | p.G527A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ALOX15B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ALOX15B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ALOX15B |
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RelatedDrugs for ALOX15B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ALOX15B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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