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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ICOSLG |
 Gene summary |
| Gene information | Gene symbol | ICOSLG | Gene ID | 23308 |
| Gene name | inducible T cell costimulator ligand | |
| Synonyms | B7-H2|B7H2|B7RP-1|B7RP1|CD275|GL50|ICOS-L|ICOSL|LICOS | |
| Cytomap | 21q22.3 | |
| Type of gene | protein-coding | |
| Description | ICOS ligandB7 homolog 2B7 homologue 2B7-like protein Gl50B7-related protein 1inducible T-cell co-stimulator ligandtransmembrane protein B7-H2 ICOS ligand | |
| Modification date | 20180523 | |
| UniProtAcc | O75144 | |
| Context | PubMed: ICOSLG [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ICOSLG from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ICOSLG |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ICOSLG |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_362558 | 21 | 45655154:45655445:45656749:45657100:45658330:45658371 | 45656749:45657100 | ENSG00000160223.12 | ENST00000344330.4,ENST00000407780.3,ENST00000400379.3 |
| exon_skip_362561 | 21 | 45655154:45655445:45658330:45658371:45660686:45660723 | 45658330:45658371 | ENSG00000160223.12 | ENST00000400377.3 |
| exon_skip_362562 | 21 | 45656749:45657100:45658330:45658371:45660686:45660723 | 45658330:45658371 | ENSG00000160223.12 | ENST00000407780.3,ENST00000400379.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ICOSLG |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_362558 | 21 | 45655154:45655445:45656749:45657100:45658330:45658371 | 45656749:45657100 | ENSG00000160223.12 | ENST00000344330.4,ENST00000407780.3,ENST00000400379.3 |
| exon_skip_362561 | 21 | 45655154:45655445:45658330:45658371:45660686:45660723 | 45658330:45658371 | ENSG00000160223.12 | ENST00000400377.3 |
| exon_skip_362562 | 21 | 45656749:45657100:45658330:45658371:45660686:45660723 | 45658330:45658371 | ENSG00000160223.12 | ENST00000407780.3,ENST00000400379.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ICOSLG |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407780 | 45658330 | 45658371 | Frame-shift |
| ENST00000407780 | 45656749 | 45657100 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407780 | 45658330 | 45658371 | Frame-shift |
| ENST00000407780 | 45656749 | 45657100 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ICOSLG |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000407780 | 7097 | 302 | 45656749 | 45657100 | 184 | 534 | 18 | 135 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000407780 | 7097 | 302 | 45656749 | 45657100 | 184 | 534 | 18 | 135 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75144 | 18 | 135 | 18 | 134 | Alternative sequence | ID=VSP_054718;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O75144 | 18 | 135 | 19 | 302 | Chain | ID=PRO_0000014803;Note=ICOS ligand |
| O75144 | 18 | 135 | 37 | 113 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| O75144 | 18 | 135 | 19 | 129 | Domain | Note=Ig-like V-type |
| O75144 | 18 | 135 | 70 | 70 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 |
| O75144 | 18 | 135 | 102 | 102 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 |
| O75144 | 18 | 135 | 128 | 128 | Natural variant | ID=VAR_049880;Note=V->I;Dbxref=dbSNP:rs11558819 |
| O75144 | 18 | 135 | 1 | 18 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O75144 | 18 | 135 | 19 | 256 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75144 | 18 | 135 | 18 | 134 | Alternative sequence | ID=VSP_054718;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O75144 | 18 | 135 | 19 | 302 | Chain | ID=PRO_0000014803;Note=ICOS ligand |
| O75144 | 18 | 135 | 37 | 113 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| O75144 | 18 | 135 | 19 | 129 | Domain | Note=Ig-like V-type |
| O75144 | 18 | 135 | 70 | 70 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 |
| O75144 | 18 | 135 | 102 | 102 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 |
| O75144 | 18 | 135 | 128 | 128 | Natural variant | ID=VAR_049880;Note=V->I;Dbxref=dbSNP:rs11558819 |
| O75144 | 18 | 135 | 1 | 18 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O75144 | 18 | 135 | 19 | 256 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for ICOSLG |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AD-6889-01 | exon_skip_362558 | 45656750 | 45657100 | 45656840 | 45656840 | Frame_Shift_Del | G | - | p.Q106fs |
| COAD | TCGA-CK-5916-01 | exon_skip_362558 | 45656750 | 45657100 | 45656840 | 45656840 | Frame_Shift_Del | G | - | p.Q106fs |
| COAD | TCGA-CM-6674-01 | exon_skip_362558 | 45656750 | 45657100 | 45656840 | 45656840 | Frame_Shift_Del | G | - | p.Q106fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_362558 | 45656750 | 45657100 | 45656975 | 45656975 | Frame_Shift_Del | T | - | p.T61fs |
| KIRC | TCGA-B0-5697-01 | exon_skip_362558 | 45656750 | 45657100 | 45656924 | 45656925 | Frame_Shift_Ins | - | G | p.S78fs |
| DLBC | TCGA-FA-A6HN-01 | exon_skip_362558 | 45656750 | 45657100 | 45656994 | 45656994 | Nonsense_Mutation | C | T | p.W54X |
| UCEC | TCGA-BK-A0C9-01 | exon_skip_362562 exon_skip_362561 | 45658331 | 45658371 | 45658337 | 45658337 | Nonsense_Mutation | G | A | p.R17* |
| UCS | TCGA-ND-A4WC-01 | exon_skip_362562 exon_skip_362561 | 45658331 | 45658371 | 45658337 | 45658337 | Nonsense_Mutation | G | A | p.R17* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCT15_LARGE_INTESTINE | 45656750 | 45657100 | 45656879 | 45656879 | Missense_Mutation | G | A | p.R93W |
| NCIH2347_LUNG | 45656750 | 45657100 | 45656906 | 45656906 | Missense_Mutation | C | A | p.A84S |
| HS746T_STOMACH | 45656750 | 45657100 | 45656956 | 45656956 | Missense_Mutation | A | T | p.I67N |
| HEC251_ENDOMETRIUM | 45656750 | 45657100 | 45657029 | 45657029 | Missense_Mutation | T | G | p.S43R |
| HCC2279_LUNG | 45656750 | 45657100 | 45657067 | 45657067 | Missense_Mutation | C | T | p.G30D |
| NB1643_AUTONOMIC_GANGLIA | 45656750 | 45657100 | 45657084 | 45657084 | Missense_Mutation | T | A | p.E24D |
| DV90_LUNG | 45658331 | 45658371 | 45658346 | 45658346 | Missense_Mutation | T | C | p.S14G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ICOSLG |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ICOSLG |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ICOSLG |
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RelatedDrugs for ICOSLG |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ICOSLG |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ICOSLG | C0007570 | Celiac Disease | 1 | CTD_human |
| ICOSLG | C0009324 | Ulcerative Colitis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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