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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MAST2

check button Gene summary
Gene informationGene symbol

MAST2

Gene ID

23139

Gene namemicrotubule associated serine/threonine kinase 2
SynonymsMAST205|MTSSK
Cytomap

1p34.1

Type of geneprotein-coding
Descriptionmicrotubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinase
Modification date20180523
UniProtAcc

Q6P0Q8

ContextPubMed: MAST2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for MAST2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for MAST2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for MAST2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_5932146295110:46295253:46348035:46348067:46425057:4642514946348035:46348067ENSG00000086015.16ENST00000372009.2,ENST00000361297.2
exon_skip_5939146348038:46348067:46425057:46425149:46463395:4646347146425057:46425149ENSG00000086015.16ENST00000372009.2,ENST00000361297.2
exon_skip_5940146379259:46379386:46383010:46383205:46425057:4642514946383010:46383205ENSG00000086015.16ENST00000372008.2
exon_skip_5943146425057:46425149:46463395:46463471:46468476:4646855546463395:46463471ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2,ENST00000482881.1
exon_skip_5948146463395:46463471:46468476:46468555:46471912:4647206746468476:46468555ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2,ENST00000482881.1
exon_skip_5950146473967:46474043:46476401:46476611:46485267:4648536946476401:46476611ENSG00000086015.16ENST00000372008.2,ENST00000361297.2
exon_skip_5952146476401:46476611:46485267:46485369:46487621:4648775446485267:46485369ENSG00000086015.16ENST00000372008.2,ENST00000361297.2
exon_skip_5954146488904:46488990:46489443:46489652:46491348:4649148746489443:46489652ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2
exon_skip_5955146489443:46489652:46491348:46491487:46493402:4649353546491348:46491487ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2
exon_skip_5957146493402:46493535:46494439:46494605:46495137:4649523946494439:46494605ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2
exon_skip_5961146494439:46494605:46495137:46495239:46495502:4649562546495137:46495239ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2
exon_skip_5962146495137:46495239:46495502:46495625:46495800:4649591046495502:46495625ENSG00000086015.16ENST00000372009.2,ENST00000372008.2,ENST00000361297.2,ENST00000477968.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for MAST2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_5932146295110:46295253:46348035:46348067:46425057:4642514946348035:46348067ENSG00000086015.16ENST00000361297.2,ENST00000372009.2
exon_skip_5939146348038:46348067:46425057:46425149:46463395:4646347146425057:46425149ENSG00000086015.16ENST00000361297.2,ENST00000372009.2
exon_skip_5940146379259:46379386:46383010:46383205:46425057:4642514946383010:46383205ENSG00000086015.16ENST00000372008.2
exon_skip_5943146425057:46425149:46463395:46463471:46468476:4646855546463395:46463471ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2,ENST00000482881.1
exon_skip_5948146463395:46463471:46468476:46468555:46471912:4647206746468476:46468555ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2,ENST00000482881.1
exon_skip_5950146473967:46474043:46476401:46476611:46485267:4648536946476401:46476611ENSG00000086015.16ENST00000361297.2,ENST00000372008.2
exon_skip_5952146476401:46476611:46485267:46485369:46487621:4648775446485267:46485369ENSG00000086015.16ENST00000361297.2,ENST00000372008.2
exon_skip_5954146488904:46488990:46489443:46489652:46491348:4649148746489443:46489652ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2
exon_skip_5955146489443:46489652:46491348:46491487:46493402:4649353546491348:46491487ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2
exon_skip_5957146493402:46493535:46494439:46494605:46495137:4649523946494439:46494605ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2
exon_skip_5961146494439:46494605:46495137:46495239:46495502:4649562546495137:46495239ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2
exon_skip_5962146495137:46495239:46495502:46495625:46495800:4649591046495502:46495625ENSG00000086015.16ENST00000361297.2,ENST00000372009.2,ENST00000372008.2,ENST00000477968.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MAST2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003612974634803546348067Frame-shift
ENST000003612974642505746425149Frame-shift
ENST000003612974646339546463471Frame-shift
ENST000003612974646847646468555Frame-shift
ENST000003612974648944346489652Frame-shift
ENST000003612974649134846491487Frame-shift
ENST000003612974649443946494605Frame-shift
ENST000003612974647640146476611In-frame
ENST000003612974648526746485369In-frame
ENST000003612974649513746495239In-frame
ENST000003612974649550246495625In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003612974634803546348067Frame-shift
ENST000003612974642505746425149Frame-shift
ENST000003612974646339546463471Frame-shift
ENST000003612974646847646468555Frame-shift
ENST000003612974648944346489652Frame-shift
ENST000003612974649134846491487Frame-shift
ENST000003612974649443946494605Frame-shift
ENST000003612974647640146476611In-frame
ENST000003612974648526746485369In-frame
ENST000003612974649513746495239In-frame
ENST000003612974649550246495625In-frame

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Infer the effects of exon skipping event on protein functional features for MAST2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036129757551798464764014647661112621471326396
ENST0000036129757551798464852674648536914721573396430
ENST0000036129757551798464951374649523925022603739773
ENST0000036129757551798464955024649562526042726773814

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036129757551798464764014647661112621471326396
ENST0000036129757551798464852674648536914721573396430
ENST0000036129757551798464951374649523925022603739773
ENST0000036129757551798464955024649562526042726773814

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q6P0Q8326396327396Alternative sequenceID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6P0Q832639611798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q8326396388388Natural variantID=VAR_040773;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs11211247,PMID:12117771,PMID:17344846
Q6P0Q8396430327396Alternative sequenceID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6P0Q839643011798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q873977311798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q8739773512785DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q6P0Q877381411798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q8773814512785DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q6P0Q8773814786854DomainNote=AGC-kinase C-terminal


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q6P0Q8326396327396Alternative sequenceID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6P0Q832639611798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q8326396388388Natural variantID=VAR_040773;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs11211247,PMID:12117771,PMID:17344846
Q6P0Q8396430327396Alternative sequenceID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6P0Q839643011798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q873977311798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q8739773512785DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q6P0Q877381411798ChainID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2
Q6P0Q8773814512785DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q6P0Q8773814786854DomainNote=AGC-kinase C-terminal


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SNVs in the skipped exons for MAST2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_5940
46383011463832054638311646383116Frame_Shift_DelT-p.A22fs
LIHCTCGA-DD-A1EG-01exon_skip_5943
46463396464634714646345446463454Frame_Shift_DelT-p.S217fs
LIHCTCGA-DD-A1EG-01exon_skip_5952
46485268464853694648534146485341Frame_Shift_DelC-p.A421fs
LIHCTCGA-G3-A3CJ-01exon_skip_5952
46485268464853694648534546485345Frame_Shift_DelC-p.R422fs
COADTCGA-A6-6780-01exon_skip_5957
46494440464946054649455946494559Frame_Shift_DelT-p.P724fs
HNSCTCGA-BA-6873-01exon_skip_5957
46494440464946054649455946494559Frame_Shift_DelT-p.P724fs
UCECTCGA-BK-A0C9-01exon_skip_5957
46494440464946054649455946494559Frame_Shift_DelT-p.P724fs
LIHCTCGA-BC-A3KG-01exon_skip_5961
46495138464952394649517346495173Frame_Shift_DelC-p.P753fs
LIHCTCGA-DD-A39Y-01exon_skip_5962
46495503464956254649558446495584Frame_Shift_DelT-p.I801fs
COADTCGA-G4-6588-01exon_skip_5957
46494440464946054649455846494559Frame_Shift_Ins-Tp.P724fs

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE46463396464634714646340646463406Frame_Shift_DelT-p.P201fs
SNU1196_BILIARY_TRACT46476402464766114647645346476453Frame_Shift_DelC-p.P344fs
LS180_LARGE_INTESTINE46494440464946054649455946494559Frame_Shift_DelT-p.P724fs
CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE46494440464946054649455946494559Frame_Shift_DelT-p.P724fs
NCIH630_LARGE_INTESTINE46494440464946054649455946494559Frame_Shift_DelT-p.P724fs
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE46495138464952394649517346495173Frame_Shift_DelC-p.P753fs
NALM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE46425058464251494642506346425063Missense_MutationGAp.R169Q
SNU175_LARGE_INTESTINE46425058464251494642507446425074Missense_MutationCTp.R173C
MDAMB453_BREAST46425058464251494642507946425079Missense_MutationGCp.K174N
KINGS1_CENTRAL_NERVOUS_SYSTEM46425058464251494642512046425120Missense_MutationGAp.R188Q
HEC108_ENDOMETRIUM46425058464251494642512246425122Missense_MutationCTp.P189S
CW2_LARGE_INTESTINE46463396464634714646340546463405Missense_MutationCAp.P201H
HS618T_FIBROBLAST46476402464766114647646246476462Missense_MutationGAp.V347M
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE46476402464766114647648946476489Missense_MutationAGp.S356G
SNU175_LARGE_INTESTINE46476402464766114647648946476489Missense_MutationACp.S356R
HT1197_URINARY_TRACT46476402464766114647657046476570Missense_MutationTGp.F383V
T98G_CENTRAL_NERVOUS_SYSTEM46485268464853694648529246485292Missense_MutationGAp.E405K
CAL851_BREAST46489444464896524648947646489476Missense_MutationGAp.R535Q
MON_SOFT_TISSUE46491349464914874649139946491399Missense_MutationAGp.M611V
SNUC2A_LARGE_INTESTINE46491349464914874649140546491405Missense_MutationCTp.R613C
MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE46491349464914874649140546491405Missense_MutationCTp.R613C
SNUC2B_LARGE_INTESTINE46491349464914874649140546491405Missense_MutationCTp.R613C
JHUEM1_ENDOMETRIUM46491349464914874649147746491477Missense_MutationAGp.K637E
KM12_LARGE_INTESTINE46494440464946054649456946494569Missense_MutationGTp.D728Y
ME180_CERVIX46495503464956254649553946495539Missense_MutationCTp.T786I
SF767_CENTRAL_NERVOUS_SYSTEM46495503464956254649553946495539Missense_MutationCTp.T786I
TC71_BONE46495503464956254649554446495544Missense_MutationCAp.L788M
MEWO_SKIN46495503464956254649556546495565Missense_MutationCTp.R795C
G402_SOFT_TISSUE46485268464853694648529046485290Nonsense_MutationCGp.S404*
NCIH3122_LUNG46495503464956254649550446495504Splice_SiteCGp.G774G

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAST2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAST2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAST2


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RelatedDrugs for MAST2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAST2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource