|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for TRIM35 |
 Gene summary |
| Gene information | Gene symbol | TRIM35 | Gene ID | 23087 |
| Gene name | tripartite motif containing 35 | |
| Synonyms | HLS5|MAIR | |
| Cytomap | 8p21.2 | |
| Type of gene | protein-coding | |
| Description | tripartite motif-containing protein 35hemopoietic lineage switch protein 5 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9UPQ4 | |
| Context | PubMed: TRIM35 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM35 | GO:0043065 | positive regulation of apoptotic process | 14662771 |
| TRIM35 | GO:0045087 | innate immune response | 18248090 |
| TRIM35 | GO:0045930 | negative regulation of mitotic cell cycle | 14662771 |
| TRIM35 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
Top |
Exon skipping events across known transcript of Ensembl for TRIM35 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for TRIM35 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for TRIM35 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_488861 | 8 | 27143325:27143654:27145552:27145644:27146678:27146797 | 27145552:27145644 | ENSG00000104228.8 | ENST00000521283.1 |
| exon_skip_488862 | 8 | 27146678:27146797:27147672:27147695:27151596:27151652 | 27147672:27147695 | ENSG00000104228.8 | ENST00000521283.1,ENST00000305364.4 |
| exon_skip_488863 | 8 | 27151596:27151827:27155980:27156076:27168317:27168373 | 27155980:27156076 | ENSG00000104228.8 | ENST00000519219.1 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for TRIM35 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_488861 | 8 | 27143325:27143654:27145552:27145644:27146678:27146797 | 27145552:27145644 | ENSG00000104228.8 | ENST00000521283.1 |
| exon_skip_488862 | 8 | 27146678:27146797:27147672:27147695:27151596:27151652 | 27147672:27147695 | ENSG00000104228.8 | ENST00000305364.4,ENST00000521283.1 |
| exon_skip_488863 | 8 | 27151596:27151827:27155980:27156076:27168317:27168373 | 27155980:27156076 | ENSG00000104228.8 | ENST00000519219.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TRIM35 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305364 | 27147672 | 27147695 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305364 | 27147672 | 27147695 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for TRIM35 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
SNVs in the skipped exons for TRIM35 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-BS-A0U8-01 | exon_skip_488862 | 27147673 | 27147695 | 27147674 | 27147674 | Nonsense_Mutation | G | A | p.R262_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 27145553 | 27145644 | 27145560 | 27145560 | Missense_Mutation | C | T | p.R330H |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 27145553 | 27145644 | 27145579 | 27145579 | Missense_Mutation | C | T | p.V324I |
| MOGGUVW_CENTRAL_NERVOUS_SYSTEM | 27145553 | 27145644 | 27145600 | 27145600 | Missense_Mutation | C | T | p.V317M |
| HCT15_LARGE_INTESTINE | 27145553 | 27145644 | 27145611 | 27145611 | Missense_Mutation | C | T | p.G313D |
| NCIH2731_PLEURA | 27155981 | 27156076 | 27156045 | 27156045 | Missense_Mutation | C | T | p.R156Q |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM35 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM35 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM35 |
Top |
RelatedDrugs for TRIM35 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIM35 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|